ES2138601T3 - Ligandos de union del receptor cocaina. - Google Patents
Ligandos de union del receptor cocaina.Info
- Publication number
- ES2138601T3 ES2138601T3 ES92924277T ES92924277T ES2138601T3 ES 2138601 T3 ES2138601 T3 ES 2138601T3 ES 92924277 T ES92924277 T ES 92924277T ES 92924277 T ES92924277 T ES 92924277T ES 2138601 T3 ES2138601 T3 ES 2138601T3
- Authority
- ES
- Spain
- Prior art keywords
- alquilo
- alkyl
- hydrogen
- leaguards
- cocaina
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0446—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K51/0448—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil tropane or nortropane groups, e.g. cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Physics & Mathematics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Peptides Or Proteins (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
NUEVOS COMPONENTES MUESTRAN ALTA AFINIDAD PARA RECEPTORES DE COCAINA ESPECIFICOS EN EL CEREBRO, PARTICULARMENTE SITIOS TRANSPORTADORES DE DOPAMINA, Y TIENEN LA FORMULA (I), EN DONDE Y = CH2R3, CO2R2 O (II), R1 = HIDROGENO, ALQUILO C1-5, R2 = HIDROGENO, ALQUILO C1-6, CICLOALQUILO C3-8, ALCOXI C1-4, ALQUINILO C1-6, HALOGENO O AMINA, R3 = OH, HIDROGENO, ALQUILO C1-6, CICLOALQUILO C38, ALCOXI C1-4, CL, BR, Y, CN, NH2, ALQUILO NHC1-6, ALQUILO OCOC1-6, ALQUILARILO OCOC1-3, A = S, O O NH, X = H, ALQUILO C1-6, CICLOALQUILO C3-8, ALCOXI C1-4, ALQUINILO C1-6, HALOGENO, AMINO, ACILAMINO, Y Z = H, Y, BR, CL, F, CN, CF3NO2, N3, OR1, CO2NH2, CO2R1, ALQUILO C1-6, NR4R5, NHCOR5, NHCO2R6, EN DONDE R4-R6 SON CADA UNO ALQUILO C1-6.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US79264891A | 1991-11-15 | 1991-11-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2138601T3 true ES2138601T3 (es) | 2000-01-16 |
Family
ID=25157598
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES92924277T Expired - Lifetime ES2138601T3 (es) | 1991-11-15 | 1992-11-13 | Ligandos de union del receptor cocaina. |
Country Status (13)
| Country | Link |
|---|---|
| EP (3) | EP0897922B1 (es) |
| JP (1) | JP2852467B2 (es) |
| KR (1) | KR100251339B1 (es) |
| AT (3) | ATE299879T1 (es) |
| AU (1) | AU668371B2 (es) |
| CA (1) | CA2123570C (es) |
| DE (3) | DE69233656D1 (es) |
| DK (1) | DK0644775T3 (es) |
| ES (1) | ES2138601T3 (es) |
| FI (1) | FI942231A0 (es) |
| GR (1) | GR3031579T3 (es) |
| NO (1) | NO313097B1 (es) |
| WO (1) | WO1993009814A1 (es) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7011813B2 (en) | 1990-08-09 | 2006-03-14 | Research Triangle Institute | Cocaine receptor binding ligands |
| US5935953A (en) * | 1990-08-09 | 1999-08-10 | Research Triangle Institute | Methods for controlling invertebrate pests using cocaine receptor binding ligands |
| US6329520B1 (en) * | 1990-08-09 | 2001-12-11 | Research Triangle Institute | Cocaine receptor binding ligands |
| US7189737B2 (en) | 1991-08-09 | 2007-03-13 | Research Triangle Institute | Cocaine receptor binding ligands |
| US6531483B1 (en) | 1990-08-09 | 2003-03-11 | Research Triangle Institute | Cocaine receptor binding ligands |
| DK154192D0 (da) * | 1992-12-23 | 1992-12-23 | Neurosearch As | Heterocycliske forbindelser |
| AU672644B2 (en) * | 1992-12-23 | 1996-10-10 | Neurosearch A/S | Aryl substituted heterocyclic compounds |
| US5554626A (en) * | 1992-12-23 | 1996-09-10 | Neurosearch A/S | Substituted heterocyclic compounds as dopamine-reuptake inhibitors |
| AU671163B2 (en) | 1992-12-23 | 1996-08-15 | Neurosearch A/S | Alkyl substituted heterocyclic compounds |
| AU672052B2 (en) * | 1992-12-23 | 1996-09-19 | Neurosearch A/S | Antidepressant and antiparkinsonian compounds |
| FI96603C (fi) * | 1994-12-30 | 1996-07-25 | Joergen Bergman | Uusi radioisotoopilla leimattu yhdiste, yhdistettä sisältävä seos sekä menetelmä niiden valmistamiseksi |
| US6241963B1 (en) * | 1995-10-19 | 2001-06-05 | The Trustees Of The University Of Pennsylvania | Dopamine and serotonin transporter ligands and imaging agents |
| US5948933A (en) | 1997-07-11 | 1999-09-07 | Organix, Inc. | Tropane analogs and methods for inhibition of monoamine transport |
| US7105678B2 (en) | 1995-11-03 | 2006-09-12 | Organix, Inc. | Boat tropanes |
| US6171576B1 (en) | 1995-11-03 | 2001-01-09 | Organix Inc. | Dopamine transporter imaging agent |
| JP3238414B2 (ja) * | 1996-02-22 | 2001-12-17 | ニューロサーチ・アクティーゼルスカブ | トロパン―誘導体、その製造方法及びその使用方法 |
| JP2002501921A (ja) * | 1998-01-28 | 2002-01-22 | ニューロサーチ、アクティーゼルスカブ | 標識された形での８−アザビシクロ［３．２．１］オクト−２−エン誘導体及び標識された及び標識されていない形での８−アザビシクロ［３．２．１］オクト−２−エン誘導体の使用方法 |
| CA2285516C (en) | 1999-05-12 | 2010-12-07 | President And Fellows Of Harvard College | Dopamine transporter imaging agents |
| DE20120708U1 (de) | 2001-10-09 | 2002-08-01 | Blundell, Paul, Sommerville, Mass. | Tropan-Analoga zur Inhibierung des Monoamin-Transports |
| CA2553649A1 (en) * | 2004-01-22 | 2005-08-04 | Neurosearch A/S | Compounds for the sustained reduction of body weight |
| CA2614833A1 (en) * | 2005-07-12 | 2007-01-18 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition comprising 2, 3-disubstituted tropanes for the treatment of disorders of sexual desire |
| EP1779851A1 (en) | 2005-10-31 | 2007-05-02 | Boehringer Ingelheim Pharma GmbH & Co.KG | Treatment of diabetes |
| GB0922304D0 (en) * | 2009-12-22 | 2010-02-03 | Ge Healthcare Ltd | Radioiodinated compounds |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3813404A (en) * | 1972-11-15 | 1974-05-28 | Sterling Drug Inc | Tropane-2-carboxylates and derivatives |
| US4179567A (en) * | 1978-04-10 | 1979-12-18 | Sterling Drug Inc. | 2-Aryltropane compounds |
| US5128118A (en) * | 1990-08-09 | 1992-07-07 | Research Triangle Institute | Cocaine receptor binding ligands |
-
1992
- 1992-11-13 DE DE69233656T patent/DE69233656D1/de not_active Expired - Lifetime
- 1992-11-13 AT AT98202861T patent/ATE299879T1/de not_active IP Right Cessation
- 1992-11-13 AT AT98203570T patent/ATE338755T1/de not_active IP Right Cessation
- 1992-11-13 EP EP98202861A patent/EP0897922B1/en not_active Expired - Lifetime
- 1992-11-13 WO PCT/US1992/009482 patent/WO1993009814A1/en not_active Ceased
- 1992-11-13 AT AT92924277T patent/ATE182794T1/de active
- 1992-11-13 CA CA002123570A patent/CA2123570C/en not_active Expired - Lifetime
- 1992-11-13 KR KR1019940701635A patent/KR100251339B1/ko not_active Expired - Lifetime
- 1992-11-13 FI FI942231A patent/FI942231A0/fi unknown
- 1992-11-13 EP EP98203570A patent/EP0905135B1/en not_active Expired - Lifetime
- 1992-11-13 EP EP92924277A patent/EP0644775B1/en not_active Expired - Lifetime
- 1992-11-13 DE DE69233536T patent/DE69233536D1/de not_active Expired - Lifetime
- 1992-11-13 DE DE69229744T patent/DE69229744T2/de not_active Expired - Lifetime
- 1992-11-13 ES ES92924277T patent/ES2138601T3/es not_active Expired - Lifetime
- 1992-11-13 JP JP5509307A patent/JP2852467B2/ja not_active Expired - Lifetime
- 1992-11-13 AU AU30645/92A patent/AU668371B2/en not_active Expired
- 1992-11-13 DK DK92924277T patent/DK0644775T3/da active
-
1994
- 1994-05-10 NO NO19941753A patent/NO313097B1/no active IP Right Review Request
-
1999
- 1999-10-21 GR GR990402672T patent/GR3031579T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPH07501074A (ja) | 1995-02-02 |
| EP0644775A4 (en) | 1994-10-19 |
| NO941753D0 (no) | 1994-05-10 |
| WO1993009814A1 (en) | 1993-05-27 |
| AU3064592A (en) | 1993-06-15 |
| EP0897922A2 (en) | 1999-02-24 |
| KR100251339B1 (ko) | 2000-09-01 |
| ATE338755T1 (de) | 2006-09-15 |
| AU668371B2 (en) | 1996-05-02 |
| DE69229744D1 (de) | 1999-09-09 |
| EP0644775B1 (en) | 1999-08-04 |
| EP0897922B1 (en) | 2005-07-20 |
| EP0644775A1 (en) | 1995-03-29 |
| CA2123570C (en) | 2003-11-04 |
| JP2852467B2 (ja) | 1999-02-03 |
| EP0897922A3 (en) | 1999-04-07 |
| DE69233536D1 (de) | 2005-08-25 |
| ATE182794T1 (de) | 1999-08-15 |
| FI942231L (fi) | 1994-05-13 |
| EP0905135A2 (en) | 1999-03-31 |
| DK0644775T3 (da) | 2000-03-06 |
| CA2123570A1 (en) | 1993-05-27 |
| DE69233656D1 (de) | 2006-10-19 |
| EP0905135A3 (en) | 1999-04-14 |
| GR3031579T3 (en) | 2000-01-31 |
| NO313097B1 (no) | 2002-08-12 |
| ATE299879T1 (de) | 2005-08-15 |
| FI942231A7 (fi) | 1994-05-13 |
| EP0905135B1 (en) | 2006-09-06 |
| NO941753L (no) | 1994-05-10 |
| FI942231A0 (fi) | 1994-05-13 |
| DE69229744T2 (de) | 2000-04-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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