ES2138740T3 - Modificacion de toxinas de clostridium utilizadas como proteinas de transporte. - Google Patents

Modificacion de toxinas de clostridium utilizadas como proteinas de transporte.

Info

Publication number
ES2138740T3
ES2138740T3 ES95921007T ES95921007T ES2138740T3 ES 2138740 T3 ES2138740 T3 ES 2138740T3 ES 95921007 T ES95921007 T ES 95921007T ES 95921007 T ES95921007 T ES 95921007T ES 2138740 T3 ES2138740 T3 ES 2138740T3
Authority
ES
Spain
Prior art keywords
modification
transport proteins
toxin
toxins used
clostridium toxins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95921007T
Other languages
English (en)
Inventor
James Oliver Dolly
Kei Roger Aoki
Larry Allen Wheeler
Michael Elwood Garst
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Allergan Inc
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9410871A external-priority patent/GB9410871D0/en
Priority claimed from GB9410870A external-priority patent/GB9410870D0/en
Application filed by Allergan Inc filed Critical Allergan Inc
Application granted granted Critical
Publication of ES2138740T3 publication Critical patent/ES2138740T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/6415—Toxins or lectins, e.g. clostridial toxins or Pseudomonas exotoxins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/832—Drug, bio-affecting and body treating compositions involving bacterial toxin that has modified amino acid sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)

Abstract

SE FACILITA UN CONJUGADO QUIMICO PARA TRATAR UNA ENFERMEDAD RELACIONADA CON LAS CELULAS NERVIOSAS. ESTE CONJUGADO INCLUYE UNA TOXINA CLOSTRIDIAL ACTIVA O INACTIVA QUE TIENE ESPECIFICIDAD PARA UNA CELULA NERVIOSA DE DESTINO. LA TOXINA SE CONJUGA EN UN MEDICAMENTO U OTRA MOLECULA BIOACTIVA SIN AFECTAR A LA CAPACIDAD DE LA TOXINA PARA ENTRAR EN LA CELULA NERVIOSA DE DESTINO.
ES95921007T 1994-05-31 1995-05-31 Modificacion de toxinas de clostridium utilizadas como proteinas de transporte. Expired - Lifetime ES2138740T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9410871A GB9410871D0 (en) 1994-05-31 1994-05-31 Modification of tetanus toxin for use as a transport protein
GB9410870A GB9410870D0 (en) 1994-05-31 1994-05-31 Modification of botulinum toxins for use as transport proteins

Publications (1)

Publication Number Publication Date
ES2138740T3 true ES2138740T3 (es) 2000-01-16

Family

ID=26304971

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95921007T Expired - Lifetime ES2138740T3 (es) 1994-05-31 1995-05-31 Modificacion de toxinas de clostridium utilizadas como proteinas de transporte.

Country Status (9)

Country Link
US (1) US6203794B1 (es)
EP (1) EP0760681B1 (es)
JP (1) JP3523879B2 (es)
AU (1) AU695623B2 (es)
CA (1) CA2191754C (es)
DE (1) DE69511860T2 (es)
DK (1) DK0760681T3 (es)
ES (1) ES2138740T3 (es)
WO (1) WO1995032738A1 (es)

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AU2340299A (en) * 1998-01-26 1999-08-09 University Of Massachusetts Biologically active hemagglutinin from type a (clostridium botulinum) and methods of use
DE19856052A1 (de) * 1998-12-04 2000-06-08 Deutsches Krebsforsch Konjugat zur Anreicherung in neuronalen Zellen
US20040120891A1 (en) 1998-12-21 2004-06-24 Craig Hill Compounds for intracellular delivery of therapeutic moieties to nerve cells
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Also Published As

Publication number Publication date
CA2191754C (en) 2000-12-12
JP3523879B2 (ja) 2004-04-26
JPH10500988A (ja) 1998-01-27
AU695623B2 (en) 1998-08-20
EP0760681B1 (en) 1999-09-01
DE69511860D1 (de) 1999-10-07
AU2622295A (en) 1995-12-21
DE69511860T2 (de) 2000-02-10
DK0760681T3 (da) 2000-03-27
WO1995032738A1 (en) 1995-12-07
CA2191754A1 (en) 1995-12-07
EP0760681A1 (en) 1997-03-12
US6203794B1 (en) 2001-03-20

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