ES2138970T3 - Medios de contraste. - Google Patents

Medios de contraste.

Info

Publication number
ES2138970T3
ES2138970T3 ES92907484T ES92907484T ES2138970T3 ES 2138970 T3 ES2138970 T3 ES 2138970T3 ES 92907484 T ES92907484 T ES 92907484T ES 92907484 T ES92907484 T ES 92907484T ES 2138970 T3 ES2138970 T3 ES 2138970T3
Authority
ES
Spain
Prior art keywords
contrast
atoms
increase
image formation
contrast media
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92907484T
Other languages
English (en)
Inventor
Torsten Almen
Arne Berg
C Allen Chang
Michael Droege
Harald Dugstad
Jere D Fellman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amersham Health Salutar Inc
Original Assignee
Nycomed Salutar Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB919106579A external-priority patent/GB9106579D0/en
Application filed by Nycomed Salutar Inc filed Critical Nycomed Salutar Inc
Application granted granted Critical
Publication of ES2138970T3 publication Critical patent/ES2138970T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F11/00—Compounds containing elements of Groups 6 or 16 of the Periodic Table
    • C07F11/005—Compounds containing elements of Groups 6 or 16 of the Periodic Table compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/02—Iron compounds
    • C07F15/025—Iron compounds without a metal-carbon linkage
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/903—Specified use of nanostructure for conversion, containment, or destruction of hazardous material
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/927—Diagnostic contrast agent
    • Y10S977/928—X-ray agent
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/927—Diagnostic contrast agent
    • Y10S977/929—Ultrasound contrast agent

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Devices For Indicating Variable Information By Combining Individual Elements (AREA)
  • Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
  • Liquid Crystal (AREA)
  • Materials For Medical Uses (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Lubricants (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

SE PRESENTA UN MEDIO DE CONTRASTE DE FORMACION DE IMAGENES QUE COMPRENDE UN COMPLEJO MULTINUCLEAR FISIOLOGICAMENTE TOLERABLE (COMO SE DEFINE EN LAS ESPECIFICACION 1). EL COMPLEJO MULTINUCLEAR CONTIENE AL MENOS DOS, PERO PREFERENTEMENTE TRES O MAS ATOMOS AUMENTADORES DE CONTRASTE. PARA TECNICAS DE FORMACION DE IMAGENES POR ULTRASONIDOS O POR RAYOS X SE UTILIZAN ATOMO DE METALES PESADOS PARA INCREMENTAR EL CONTRASTE, EN TANTO QUE EN LA FORMACION DE IMAGENES POR RESONANCIA MAGNETICA LOS ATOMOS DE METAL PARAMAGNETICO AUMENTA EL CONTRASTE. EL MOLIBDENO Y EL TUNGSTENO SON LOS ATOMOS AUMENTADORES DE CONTRASTE PREFERIDOS. EL MEDIO PUEDE TAMBIEN SER USADO TERAPEUTICAMENTE.
ES92907484T 1991-03-27 1992-03-27 Medios de contraste. Expired - Lifetime ES2138970T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB919106579A GB9106579D0 (en) 1991-03-27 1991-03-27 Contrast media
GB919120507A GB9120507D0 (en) 1991-03-27 1991-09-26 Contrast media

Publications (1)

Publication Number Publication Date
ES2138970T3 true ES2138970T3 (es) 2000-02-01

Family

ID=26298647

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92907484T Expired - Lifetime ES2138970T3 (es) 1991-03-27 1992-03-27 Medios de contraste.

Country Status (15)

Country Link
US (2) US5482699A (es)
EP (1) EP0577675B1 (es)
JP (1) JPH06506449A (es)
AT (1) ATE187340T1 (es)
AU (1) AU660013B2 (es)
CA (1) CA2106976A1 (es)
DE (1) DE69230400T2 (es)
ES (1) ES2138970T3 (es)
FI (1) FI934194A7 (es)
HU (1) HUT65240A (es)
IE (1) IE920996A1 (es)
NO (1) NO933421L (es)
NZ (1) NZ242156A (es)
PH (1) PH29904A (es)
SG (1) SG43930A1 (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996019487A1 (en) * 1994-12-22 1996-06-27 Nissan Chemical Industries, Ltd. Organobismuth derivatives and process for producing the same
GB9501560D0 (en) * 1995-01-26 1995-03-15 Nycomed Imaging As Contrast agents
DE19507820A1 (de) * 1995-02-21 1996-08-22 Schering Ag Neuartig substituierte DTPA-Derivate, deren Metallkomplexe, diese Komplexe enthaltende pharmazeutische Mittel, deren Verwendung in der Diagnostik, sowie Verfahren zur Herstellung der Komplexe und Mittel
US5801228A (en) * 1995-06-07 1998-09-01 Nycomed Imaging As Polymeric contrast agents for medical imaging
US7745142B2 (en) * 1997-09-15 2010-06-29 Molecular Devices Corporation Molecular modification assays
US7070921B2 (en) 2000-04-28 2006-07-04 Molecular Devices Corporation Molecular modification assays
US7632651B2 (en) * 1997-09-15 2009-12-15 Mds Analytical Technologies (Us) Inc. Molecular modification assays
US20050227294A1 (en) * 1997-09-15 2005-10-13 Molecular Devices Corporation Molecular modification assays involving lipids
US7807137B1 (en) 1998-12-22 2010-10-05 University Of Puerto Rico Iron-based contrast agent
US6596259B1 (en) 1998-12-22 2003-07-22 University Of Puerto Rico Metal based cubane structure contained in an octanuclear complex stable over several oxidation states and a method of producing the same
US20030215391A1 (en) * 2001-07-19 2003-11-20 Carlos Rabito Fluorescent agents for real-time measurement of organ function
US20050106100A1 (en) * 2003-09-03 2005-05-19 Harris Thomas D. Compounds containing matrix metalloproteinase substrates and methods of their use
WO2006039505A2 (en) * 2004-09-30 2006-04-13 Molecular Devices Corporation Luminescent lanthanide complexes
US7888297B2 (en) * 2005-01-06 2011-02-15 Halliburton Energy Services, Inc. Compositions for reducing the viscosity of treatment fluids
WO2006084382A1 (en) * 2005-02-11 2006-08-17 University Health Network Compositions and methods for multimodal imaging
WO2007005491A1 (en) * 2005-06-30 2007-01-11 Bristol-Myers Squibb Pharma Company Hydrazide conjugates as imaging agents
US20120148501A1 (en) * 2010-12-08 2012-06-14 Fred Geisler Radiological image enhancement with tantalum clusters
JP6032729B2 (ja) * 2012-05-08 2016-11-30 国立研究開発法人理化学研究所 イメージングマーカーおよびその利用
CN104981475B (zh) * 2013-02-06 2018-10-26 Pom专利管理公司 杂多金属氧酸盐
CN114573609B (zh) * 2022-03-07 2024-02-06 桂林理工大学 一种基于不对称双核镝配合物的单分子磁体及其制备方法

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE130934C (es) *
DE263059C (es) *
DE361960C (de) * 1920-06-01 1922-10-20 Georg Spiess Rundstapelbogenanleger
US3860611A (en) * 1972-01-19 1975-01-14 Du Pont Macrocyclic polyether polyols and condensation polymers derived therefrom
US3763188A (en) * 1972-01-19 1973-10-02 Du Pont Spiro(1,1-polyethylenedi(oxymethyl))-3-oxetanes
US3952015A (en) * 1973-11-12 1976-04-20 Carl George Krespan Macrocyclic compounds having oxa and aza linkages in the ring and containing spirooxetane groups
US4079124A (en) * 1976-04-21 1978-03-14 Medi-Physics, Inc. Method of preparing X-ray contrast media containing ores of hafnium, tantalum and tungsten
US4176173A (en) * 1977-07-18 1979-11-27 Medi-Physics, Inc. Radiographic compositions
US4647447A (en) * 1981-07-24 1987-03-03 Schering Aktiengesellschaft Diagnostic media
DE3324235A1 (de) * 1983-07-01 1985-01-10 Schering AG, 1000 Berlin und 4709 Bergkamen Neue komplexbildner, komplexe und komplexsalze
US4639365A (en) * 1984-10-18 1987-01-27 The Board Of Regents, The University Of Texas System Gadolinium chelates as NMR contrast agents
US4826673A (en) * 1985-01-09 1989-05-02 Mallinckrodt, Inc. Methods and compositions for enhancing magnetic resonance imaging
US4795698A (en) * 1985-10-04 1989-01-03 Immunicon Corporation Magnetic-polymer particles
IL83966A (en) * 1986-09-26 1992-03-29 Schering Ag Amides of aminopolycarboxylic acids and pharmaceutical compositions containing them
JP2833766B2 (ja) * 1987-07-16 1998-12-09 ニユコメド・アクシエセルカペト アミノポリカルボン酸およびその誘導体
FR2630547A1 (fr) * 1988-04-22 1989-10-27 Centre Nat Rech Scient Marquage froid de molecules de nature peptidique ou proteique
US5260050A (en) * 1988-09-29 1993-11-09 Ranney David F Methods and compositions for magnetic resonance imaging comprising superparamagnetic ferromagnetically coupled chromium complexes
US5213788A (en) * 1988-09-29 1993-05-25 Ranney David F Physically and chemically stabilized polyatomic clusters for magnetic resonance image and spectral enhancement
EP0361960A3 (en) * 1988-09-29 1992-01-02 RANNEY, David F. Methods and compositions for magnetic resonance imaging
GB9006977D0 (en) * 1990-03-28 1990-05-23 Nycomed As Compositions
GB9007967D0 (en) * 1990-04-09 1990-06-06 Nycomed As Compounds

Also Published As

Publication number Publication date
SG43930A1 (en) 1997-11-14
HUT65240A (en) 1994-05-02
NO933421D0 (no) 1993-09-24
DE69230400D1 (de) 2000-01-13
ATE187340T1 (de) 1999-12-15
IE920996A1 (en) 1992-10-07
FI934194L (fi) 1993-11-23
NO933421L (no) 1993-11-24
AU660013B2 (en) 1995-06-08
AU1433892A (en) 1992-11-02
CA2106976A1 (en) 1992-09-28
FI934194A7 (fi) 1993-11-23
NZ242156A (en) 1994-07-26
JPH06506449A (ja) 1994-07-21
EP0577675A1 (en) 1994-01-12
US5932190A (en) 1999-08-03
PH29904A (en) 1996-09-16
US5482699A (en) 1996-01-09
DE69230400T2 (de) 2000-08-03
HU9302735D0 (en) 1993-12-28
FI934194A0 (fi) 1993-09-24
EP0577675B1 (en) 1999-12-08

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