ES2140449T3 - Reductor del nivel de colesterol. - Google Patents

Reductor del nivel de colesterol.

Info

Publication number
ES2140449T3
ES2140449T3 ES93901534T ES93901534T ES2140449T3 ES 2140449 T3 ES2140449 T3 ES 2140449T3 ES 93901534 T ES93901534 T ES 93901534T ES 93901534 T ES93901534 T ES 93901534T ES 2140449 T3 ES2140449 T3 ES 2140449T3
Authority
ES
Spain
Prior art keywords
alkyl group
carbon atoms
exchange resin
anion exchange
cholesterol level
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93901534T
Other languages
English (en)
Inventor
Minenobu Okayama
Shuji Sato
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hisamitsu Pharmaceutical Co Inc
Original Assignee
Hisamitsu Pharmaceutical Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hisamitsu Pharmaceutical Co Inc filed Critical Hisamitsu Pharmaceutical Co Inc
Application granted granted Critical
Publication of ES2140449T3 publication Critical patent/ES2140449T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F20/00—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride, ester, amide, imide or nitrile thereof
    • C08F20/02—Monocarboxylic acids having less than ten carbon atoms, Derivatives thereof
    • C08F20/10—Esters
    • C08F20/34—Esters containing nitrogen, e.g. N,N-dimethylaminoethyl (meth)acrylate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

UN DEPRESIVO DE NIVEL DE COLESTEROL, CONTENIENDO UNA RESINA DE INTERCAMBIO DE ANIONES NO RETICULAR, TENIENDO UNA UNIDAD ESTRUCTURAL REPRESENTADA POR LA FORMULA GENERAL (I) COMO EL INGREDIENTE PRINCIPAL, DONDE R1 REPRESENTA BENCILO O ALQUILO DE C1 TRO, Y CADA UNO REPRESENTA ALQUILO DE C1 IDROGENO O ALQUILO INFERIOR; X REPRESENTA UN CONTRAION SE ASOCIA A SI MISMO CON ION DE OPUESTA CARGA; N ES 1 A 3; Y P REPRESENTA UN GRADO PROMEDIO DE POLIMERIZACION DE 10 A 10.000.
ES93901534T 1992-01-14 1993-01-11 Reductor del nivel de colesterol. Expired - Lifetime ES2140449T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2453192 1992-01-14

Publications (1)

Publication Number Publication Date
ES2140449T3 true ES2140449T3 (es) 2000-03-01

Family

ID=12140740

Family Applications (2)

Application Number Title Priority Date Filing Date
ES93901534T Expired - Lifetime ES2140449T3 (es) 1992-01-14 1993-01-11 Reductor del nivel de colesterol.
ES97119915T Expired - Lifetime ES2149537T3 (es) 1992-01-14 1993-01-11 Resina intercambiadora de aniones no reticulados y composicion farmaceutica que contiene la misma.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES97119915T Expired - Lifetime ES2149537T3 (es) 1992-01-14 1993-01-11 Resina intercambiadora de aniones no reticulados y composicion farmaceutica que contiene la misma.

Country Status (13)

Country Link
US (1) US5665348A (es)
EP (2) EP0622078B1 (es)
JP (1) JP2712056B2 (es)
KR (1) KR0179675B1 (es)
AT (2) ATE193307T1 (es)
AU (1) AU658713B2 (es)
CA (1) CA2117371C (es)
DE (2) DE69328741T2 (es)
DK (2) DK0835888T3 (es)
ES (2) ES2140449T3 (es)
GR (2) GR3031583T3 (es)
PT (1) PT835888E (es)
WO (1) WO1993013781A1 (es)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5800809A (en) * 1992-01-14 1998-09-01 Hisamitsu Pharmaceutical Co, Inc Non-crosslinked acrylic polymers and non-crosslinked anion exchange resins
US5624963A (en) * 1993-06-02 1997-04-29 Geltex Pharmaceuticals, Inc. Process for removing bile salts from a patient and compositions therefor
US5703188A (en) * 1993-06-02 1997-12-30 Geltex Pharmaceuticals, Inc. Process for removing bile salts from a patient and compositions therefor
TW438608B (en) * 1995-08-02 2001-06-07 Hisamitsu Pharmaceutical Co A tablet containing anion exchange resin
AUPO104496A0 (en) * 1996-07-17 1996-08-08 Biomolecular Research Institute Limited Angiogenic inhibitory compounds
AUPO104396A0 (en) * 1996-07-17 1996-08-08 Biomolecular Research Institute Limited Antiviral linear polymers
JP4010585B2 (ja) * 1996-10-15 2007-11-21 久光製薬株式会社 陰イオン交換樹脂を含有する錠剤
RU2164921C2 (ru) * 1997-05-06 2001-04-10 Институт высокомолекулярных соединений РАН Способ получения полимеров на основе солей n,n,n,n-триметилметакрилоилоксиэтиламмония
EP1051977A1 (en) * 1997-11-10 2000-11-15 Hisamitsu Pharmaceutical Co., Inc. Release-sustaining agent for drugs and sustained-release pharmaceutical composition
US7048917B1 (en) 1998-01-09 2006-05-23 Genzyme Corporation Fat-binding polymers
US6299868B1 (en) 1999-07-14 2001-10-09 Geltex Pharmaceuticals, Inc. Fat-binding polymers
US6264937B1 (en) * 1998-01-09 2001-07-24 Geltex Pharmaceuticals, Inc. Fat-binding polymers
US6267952B1 (en) 1998-01-09 2001-07-31 Geltex Pharmaceuticals, Inc. Lipase inhibiting polymers
WO2000008063A1 (fr) 1998-08-05 2000-02-17 Hisamitsu Pharmaceutical Co., Inc. Procede de production d'un polymere cationique
EP1090634A1 (en) * 1999-10-01 2001-04-11 Helmut Hauser Agents for reducing cholesterol and lipid uptake
WO2002081528A1 (en) * 2001-04-05 2002-10-17 Sekisui Chemical Co., Ltd. Polymer specifically recognizing bile acid, process for producing the same, bile acid-absorbing polymer and cholesterol-lowering agents
US7041280B2 (en) * 2001-06-29 2006-05-09 Genzyme Corporation Aryl boronate functionalized polymers for treating obesity
US7049345B2 (en) * 2001-06-29 2006-05-23 Genzyme Corporation Fat-binding polymers
US6669955B2 (en) 2001-08-28 2003-12-30 Longwood Pharmaceutical Research, Inc. Combination dosage form containing individual dosage units of a cholesterol-lowering agent, an inhibitor of the renin-angiotensin system, and aspirin
US6576256B2 (en) 2001-08-28 2003-06-10 The Brigham And Women's Hospital, Inc. Treatment of patients at elevated cardiovascular risk with a combination of a cholesterol-lowering agent, an inhibitor of the renin-angiotensin system, and aspirin
JP4272841B2 (ja) 2001-10-26 2009-06-03 富士フイルム株式会社 インクジェット記録用シート
JP2006052236A (ja) * 2002-07-30 2006-02-23 Yukio Nagasaki コレステロール低下作用を有する新規化合物
JP4048101B2 (ja) 2002-11-19 2008-02-13 富士フイルム株式会社 インクジェット記録用シート
FR2850389B1 (fr) * 2003-01-24 2005-04-15 Virsol Nouveaux copolymeres cationiques, leur utilisation pour la vectorisation de biomolecules, leurs intermediaires de synthese
FR2850388B1 (fr) * 2003-01-24 2005-04-15 Virsol Nouveaux polymeres et copolymeres cationiques, leur utilisation pour la vectorisation de biomolecules, leurs intermediaires de synthese
EP1527774A1 (en) * 2003-11-03 2005-05-04 Basilea Pharmaceutica AG New formulation for retinoid-containing soft gelatin capsules
EP1721604A4 (en) * 2004-03-04 2008-04-30 Takeda Pharmaceutical STABLE CAPSULE PREPARATION
TW200639190A (en) * 2005-02-04 2006-11-16 Showa Denko Kk Packing material for ion chromatography
EP1894571A1 (en) * 2006-08-29 2008-03-05 Protaffin Biotechnologie AG Use of modified interleukin-8 proteins for treating reperfusion injury or transplant rejection

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2843573A (en) * 1955-03-21 1958-07-15 Rohm & Haas New quaternary ammonium compounds in which the nitrogen atom carries an alkoxymethyl group
IL35162A0 (en) * 1969-09-12 1970-10-30 Inveresk Res Int Linear anion exchange polymers,their production and pharmaceutical compositions containing them
BE756035A (fr) * 1969-09-12 1971-03-11 Inveresk Res Int Polymeres pontes
US4759923A (en) * 1987-06-25 1988-07-26 Hercules Incorporated Process for lowering serum cholesterol using poly(diallylmethylamine) derivatives
GB8829088D0 (en) * 1988-12-13 1989-01-25 Smith Kline French Lab Compounds
DE3901527A1 (de) * 1989-01-20 1990-07-26 Hoechst Ag Alkylierte polyethyleniminderivate, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel sowie pharmazeutische praeparate
JP2909500B2 (ja) * 1989-03-23 1999-06-23 ベルレックス、ラボラトリーズ、レンコーポレイテッド 水溶性抗高脂質血症剤として有用な官能化側鎖を有するポリアミド
US5236701A (en) * 1989-07-19 1993-08-17 Lowchol Scientific Inc. Ingestible hydrophilic polymeric amines useful for lowering blood cholesterol
GB9011332D0 (en) * 1990-05-21 1990-07-11 Smith Kline French Lab Compounds

Also Published As

Publication number Publication date
DK0622078T3 (da) 2000-02-28
GR3031583T3 (en) 2000-01-31
DE69326231D1 (de) 1999-10-07
ES2149537T3 (es) 2000-11-01
AU3266793A (en) 1993-08-03
US5665348A (en) 1997-09-09
GR3034214T3 (en) 2000-12-29
EP0622078A4 (en) 1995-08-09
EP0622078A1 (en) 1994-11-02
EP0835888B1 (en) 2000-05-24
PT835888E (pt) 2000-09-29
DK0835888T3 (da) 2000-09-25
WO1993013781A1 (fr) 1993-07-22
ATE183924T1 (de) 1999-09-15
EP0622078B1 (en) 1999-09-01
EP0835888A2 (en) 1998-04-15
CA2117371C (en) 2000-10-10
KR940703678A (ko) 1994-12-12
DE69328741D1 (de) 2000-06-29
CA2117371A1 (en) 1993-07-22
EP0835888A3 (de) 1998-05-27
KR0179675B1 (ko) 1999-03-20
ATE193307T1 (de) 2000-06-15
DE69326231T2 (de) 1999-12-30
DE69328741T2 (de) 2000-09-07
AU658713B2 (en) 1995-04-27
JP2712056B2 (ja) 1998-02-10

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