ES2143058T3 - Procedimiento de preparacion de un 2,5-diamino-3-hidroxihexano sustituido. - Google Patents

Procedimiento de preparacion de un 2,5-diamino-3-hidroxihexano sustituido.

Info

Publication number
ES2143058T3
ES2143058T3 ES95926318T ES95926318T ES2143058T3 ES 2143058 T3 ES2143058 T3 ES 2143058T3 ES 95926318 T ES95926318 T ES 95926318T ES 95926318 T ES95926318 T ES 95926318T ES 2143058 T3 ES2143058 T3 ES 2143058T3
Authority
ES
Spain
Prior art keywords
independently selected
loweralkyl
image
preparation
trifluoromethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95926318T
Other languages
English (en)
Inventor
Anthony R Haight
Owen J Goodmonson
Shyamal I Parekh
Timothy A Robbins
Louis S Seif
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Application granted granted Critical
Publication of ES2143058T3 publication Critical patent/ES2143058T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C07C215/30—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings containing hydroxy groups and carbon atoms of six-membered aromatic rings bound to the same carbon atom of the carbon skeleton
    • C07C215/32—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings containing hydroxy groups and carbon atoms of six-membered aromatic rings bound to the same carbon atom of the carbon skeleton containing hydroxy groups and carbon atoms of two six-membered aromatic rings bound to the same carbon atom of the carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)

Abstract

SE DESCRIBE UN PROCEDIMIENTO PARA LA PREPARACION DEL COMPUESTO SUSTANCIALMENTE PURO DE FORMULA (I) QUE COMPRENDE LA HIDROGENACION CATALITICA DE UN COMPUESTO DE FORMULA (II) EN DONDE R{SUB,6} Y R{SUB,7} SE SELECCIONAN INDEPENDIENTEMENTE DE (I) EN DONDE R{SUB,A} Y R{SUB,B} SE SELECCIONAN INDEPENDIENTEMENTE DE HIDROGENO, ALQUILO BAJO Y FENILO Y R{SUB,C}, R{SUB,D} Y R{SUB,E} SE SELECCIONAN INDEPENDIENTEMENTE DE HIDROGENO, ALQUILO BAJO, TRIFLUOMETILO, ALCOXI, HALO Y FENILO; Y (I) EN DONDE EL ANILLO DE NAFTILO ES INSUSTITUIDO O SUSTITUIDO CON UNO, DOS O TRES SUSTITUYENTES INDEPENDIENTEMENTE SELECCIONADOS DE ALQUILO BAJO, TRIFLUOMETILO, ALCOXI Y HALO; O R{SUB,6} Y R{SUB,7} TOMADOS JUNTO AL ATOMO DE NITROGENO AL QUE ESTAN UNIDOS SON (A) O (B) EN DONDE R{SUB,F}, R{SUB,G}, R{SUB,H} Y R{SUB,I} SE SELECCIONAN INDEPENDIENTEMENTE DE HIDROGENO, ALQUILO BAJO, ALCOXI, HALOGENO Y TRIFLUOMETILO; O UNA SAL DE ADICION ACIDA DE LOS MISMOS.
ES95926318T 1994-07-29 1995-07-17 Procedimiento de preparacion de un 2,5-diamino-3-hidroxihexano sustituido. Expired - Lifetime ES2143058T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US28310994A 1994-07-29 1994-07-29

Publications (1)

Publication Number Publication Date
ES2143058T3 true ES2143058T3 (es) 2000-05-01

Family

ID=23084563

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95926318T Expired - Lifetime ES2143058T3 (es) 1994-07-29 1995-07-17 Procedimiento de preparacion de un 2,5-diamino-3-hidroxihexano sustituido.

Country Status (11)

Country Link
US (1) US5672706A (es)
EP (1) EP0773921B1 (es)
JP (1) JPH10503772A (es)
AT (1) ATE187160T1 (es)
CA (1) CA2192836A1 (es)
DE (1) DE69513667T2 (es)
DK (1) DK0773921T3 (es)
ES (1) ES2143058T3 (es)
GR (1) GR3032553T3 (es)
PT (1) PT773921E (es)
WO (1) WO1996004232A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2492500A (en) 1999-01-06 2000-07-24 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Aspartic protease inhibitors, compositions, and associated therapeutic methods
IT1313624B1 (it) * 1999-09-21 2002-09-09 Archimica Spa Ora Clariant Lif Procedimento per la sintesi del ritonavir
EP1411045B1 (en) * 2002-10-18 2008-01-16 Tohru Yokozawa Process for production of optically active amino alcohols
JP2004346008A (ja) * 2003-05-22 2004-12-09 Sumitomo Chem Co Ltd Ｎ−モノアルキル−３−ヒドロキシ−３−アリールプロピルアミン類の製造方法および中間体
AU2005294123C1 (en) 2004-10-07 2010-01-21 Vitae Pharmaceuticals, Inc. Diaminoalkane aspartic protease inhibitors
JP2006248978A (ja) 2005-03-10 2006-09-21 Mebiopharm Co Ltd 新規なリポソーム製剤
TWI411607B (zh) 2005-11-14 2013-10-11 Vitae Pharmaceuticals Inc 天門冬胺酸蛋白酶抑制劑
CL2007002689A1 (es) 2006-09-18 2008-04-18 Vitae Pharmaceuticals Inc Compuestos derivados de piperidin-1-carboxamida, inhibidores de la renina; compuestos intermediarios; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como hipertension, insuficiencia cardiaca, fibrosis cardiaca, entre otras.
AR077692A1 (es) 2009-08-06 2011-09-14 Vitae Pharmaceuticals Inc Sales de 2-((r)-(3-clorofenil) ((r)-1-((s) -2-(metilamino)-3-((r)-tetrahidro-2h-piran-3-il) propilcarbamoil) piperidin -3-il) metoxi) etilcarbamato de metilo
CN111393329A (zh) * 2020-04-16 2020-07-10 安徽一帆香料有限公司 一种利托那韦和洛匹那韦中间体的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4360684A (en) * 1981-04-08 1982-11-23 Merck & Co., Inc. Process for the preparation of (2S)-tetrahydro-2α-methyl-6-oxo-4βα-carboxylic acid
IE913840A1 (en) * 1990-11-20 1992-05-20 Abbott Lab Retroviral protease inhibiting compounds
EP1302468B1 (en) * 1992-12-29 2008-12-17 Abbott Laboratories Processes and intermediates for manufacturing retroviral protease inhibiting compounds

Also Published As

Publication number Publication date
MX9700720A (es) 1997-09-30
WO1996004232A1 (en) 1996-02-15
GR3032553T3 (en) 2000-05-31
ATE187160T1 (de) 1999-12-15
EP0773921B1 (en) 1999-12-01
JPH10503772A (ja) 1998-04-07
US5672706A (en) 1997-09-30
PT773921E (pt) 2000-05-31
EP0773921A1 (en) 1997-05-21
DE69513667T2 (de) 2000-07-06
DE69513667D1 (de) 2000-01-05
DK0773921T3 (da) 2000-05-08
CA2192836A1 (en) 1996-02-15

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