ES2143154T3 - Compuestos alcoxi-arilos con afinidad para los receptores melatoninergicos, sus procedimientos de preparacion, y las composiciones farmaceuticas que los contienen. - Google Patents

Compuestos alcoxi-arilos con afinidad para los receptores melatoninergicos, sus procedimientos de preparacion, y las composiciones farmaceuticas que los contienen.

Info

Publication number
ES2143154T3
ES2143154T3 ES96401158T ES96401158T ES2143154T3 ES 2143154 T3 ES2143154 T3 ES 2143154T3 ES 96401158 T ES96401158 T ES 96401158T ES 96401158 T ES96401158 T ES 96401158T ES 2143154 T3 ES2143154 T3 ES 2143154T3
Authority
ES
Spain
Prior art keywords
substd
opt
alkyl
alkynyl
cycloalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96401158T
Other languages
English (en)
Inventor
Daniel Lesieur
Patrick Depreux
Veronique Leclerc
Philippe Delagrance
Pierre Renard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ADIR SARL
Original Assignee
ADIR SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ADIR SARL filed Critical ADIR SARL
Application granted granted Critical
Publication of ES2143154T3 publication Critical patent/ES2143154T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/60—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/58—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)

Abstract

COMPUESTOS DE FORMULA (I) EN LA QUE : R 1 REPRESENTA UNA CADENA (C{SUB,1-4}ALQUILENO NO SUSTITUIDA O SUSTITUIDA POR UN RADICAL ELEGIDO ENTRE ALQUILO, HIDROXI, ALCOXICARBONILO Y CARBOXILO; R{SUP,2} REPRESENTA UN ATOMO DE HIDROGENO O UN ALQUILO, R{SUB,3} REPRESENTA: - BIEN UN GRUPO DE FORMULA R{SUP,31} EN EL QUE N REPRESENTA CERO O UN NUMERO ENTERO DE 1 A 3, X REPRESENTA UN AZUFRE O UN OXIGENO Y R{SUP,5} REPRESENTA UN ATOMO DE HIDROGENO, UN ALQUILO NO SUSTITUIDO O SUSTITUIDO, UN ALCENILO, UN ALCINILO, UN CICLOALQUILO NO SUSTITUIDO O SUSTITUIDO, UN DICICLOALQUILO NO SUSTITUIDO O SUSTITUIDO, - BIEN UN GRUPO DE FORMULA R{SUP,32} EN EL QUE X'' REPRESENTA UN ATOMO DE OXIGENO O DE AZUFRE, M REPRESENTA CERO O UN NUMERO ENTERO DE 1 A 3 Y R{SUP,6} REPRESENTA UN ATOMO DE HIDROGENO, UN ALQUILO NO SUSTITUIDO O SUSTITUIDO, UN ALCENILO O UN ALCINILO, ENTENDIENDOSE QUE R{SUP,6} TAMBIEN PUEDE REPRESENTAR UN CICLOALQUILO NO SUSTITUIDO O SUSTITUIDO O UN DICICLOALQUILO NO SUSTITUIDO O SUSTITUIDO CUANDO X'' ES UNOXIGENO. - A REPRESENTA UN RADICAL ELEGIDO ENTRE UN ALQUILO Y UN GRUPO A'' ELEGIDO ENTRE UN ALQUILO SUSTITUIDO, UN ALCENILO O UN ALCINILO, - R REPRESENTA UN GRUPO ELEGIDO ENTRE UN ALQUILO NO SUSTITUIDO O SUSTITUIDO, UN ALCENILO, UN ALCINILO, UN CICLOALQUILO NO SUSTITUIDO O SUSTITUIDO, UN CICLOALQUILO NO SUSTITUIDO O SUSTITUIDO, UN ARILO NO SUSTITUIDO O SUSTITUIDO, UN ARILALQUILO NO SUSTITUIDO O SUSTITUIDO, UN DIARILALQUILO NO SUSTITUIDO O SUSTITUIDO, UN CICLOALCENILO Y CICLOALCENILALQUILO, Y FORMA CON EL NUCLEO BENZO AL QUE ESTA ENLAZADO UN GRUPO Y{SUP,1} QUE - BIEN REPRESENTA UN GRUPO ELEGIDO ENTRE NAFTENO, BENZOFURANO, BENZOTIOFENO E INDOL EN EL CASO EN QUE A REPRESENTA UN GRUPO A'', - BIEN REPRESENTA UN GRUPO NAFTALENO, EN EL CASO EN QUE A REPRESENTA UN RADICAL ALQUILO, ESTANDO Y{SUP,1} EVENTUALMENTE HIDROGENADO, SUS ENANTIOMEROS Y DIASTEREOISOMEROS, Y SUS SALES DE ADICION A UNA BASE FARMACEUTICAMENTE ACEPTABLE. UNOS COMPUESTOS QUE PERMITEN ACTUAR SOBRE EL SISTEMA MELATONINERGICO SON POR CONSIGUIENTE PARA EL CLINICO EXCELENTES MEDICAMENTOS PARA EL TRATAMIENTO DE LAS PATOLOGIAS UNIDAS AL SISTEMA MELATONINERGICO.
ES96401158T 1995-05-31 1996-05-30 Compuestos alcoxi-arilos con afinidad para los receptores melatoninergicos, sus procedimientos de preparacion, y las composiciones farmaceuticas que los contienen. Expired - Lifetime ES2143154T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9506434A FR2734814B1 (fr) 1995-05-31 1995-05-31 Nouveaux composes alkoxy-aryles, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
ES2143154T3 true ES2143154T3 (es) 2000-05-01

Family

ID=9479524

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96401158T Expired - Lifetime ES2143154T3 (es) 1995-05-31 1996-05-30 Compuestos alcoxi-arilos con afinidad para los receptores melatoninergicos, sus procedimientos de preparacion, y las composiciones farmaceuticas que los contienen.

Country Status (16)

Country Link
US (1) US5668180A (es)
EP (1) EP0745583B1 (es)
JP (1) JPH08325217A (es)
CN (1) CN1064674C (es)
AT (1) ATE188207T1 (es)
AU (1) AU704023B2 (es)
CA (1) CA2177743C (es)
DE (1) DE69605856T2 (es)
DK (1) DK0745583T3 (es)
ES (1) ES2143154T3 (es)
FR (1) FR2734814B1 (es)
GR (1) GR3032289T3 (es)
NO (1) NO310652B1 (es)
NZ (1) NZ286695A (es)
PT (1) PT745583E (es)
ZA (1) ZA964484B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE193700T1 (de) * 1994-09-12 2000-06-15 Takeda Chemical Industries Ltd Benzozykloalkenverbindungen, deren herstellung und verwendung
EP0751126A4 (en) 1995-01-06 1998-05-13 Toray Industries BENZOCONDENSE HETEROCYCLIC DERIVATIVE AND ITS USE
FR2734816B1 (fr) * 1995-05-31 1997-07-04 Adir Nouveaux aryl (alkyl) propylamides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP0848699B1 (en) * 1995-07-26 2001-10-24 Takeda Chemical Industries, Ltd. Benzocycloalkene compounds with melatonine receptor binding affinity, their production and use
FR2752839B1 (fr) * 1996-08-29 1998-10-09 Synthelabo Derives de benzofurane, leur preparation et leur application en therapeutique
FR2763335B1 (fr) * 1997-05-16 2000-11-24 Adir Nouveaux composes heterocycliques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
ES2267190T3 (es) * 1997-08-07 2007-03-01 Fujimoto Brothers Co., Ltd. Derivados de etilamina novedosos.
FR2771739B1 (fr) * 1997-11-28 2001-04-20 Adir Nouveaux composes naphtaleniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2772766B1 (fr) * 1997-12-24 2000-06-30 Adir Nouveaux composes heterocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2778662B1 (fr) * 1998-05-12 2000-06-16 Adir Nouveaux composes cycliques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2784375B1 (fr) * 1998-10-12 2000-11-24 Adir Nouveaux derives cycliques a chaine cycloalkylenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CA2477604A1 (en) 2002-03-13 2003-09-25 Signum Biosciences, Inc. Modulation of protein methylation and phosphoprotein phosphate
WO2006019497A2 (en) * 2004-06-17 2006-02-23 Neurocrine Biosciences, Inc. Sleep-inducing compounds and methods related thereto
US7923041B2 (en) 2005-02-03 2011-04-12 Signum Biosciences, Inc. Compositions and methods for enhancing cognitive function
WO2006084033A1 (en) 2005-02-03 2006-08-10 Signum Biosciences, Inc. Compositions and methods for enhancing cognitive function
CN102014897B (zh) 2008-04-21 2015-08-05 西格纳姆生物科学公司 化合物、组合物和其制备方法
WO2014064706A1 (en) * 2012-10-22 2014-05-01 Symed Labs Limited Processes for the preparation of agomelatine using novel intermediates
CN115151540A (zh) 2019-12-02 2022-10-04 风暴治疗有限公司 作为mettl3抑制剂的多杂环化合物
CR20230576A (es) 2021-06-14 2024-04-05 Scorpion Therapeutics Inc Derivados de la urea que pueden ser utilizados para tratar el cáncer

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5071875A (en) * 1989-09-25 1991-12-10 Northwestern University Substituted 2-amidotetralins as melatonin agonists and antagonists
FR2658818B1 (fr) * 1990-02-27 1993-12-31 Adir Cie Nouveaux derives a structure naphtalenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
US5571810A (en) * 1990-06-11 1996-11-05 Fujisawa Pharmaceutical Co., Ltd. Thiophene derivatives
FR2680366B1 (fr) * 1991-08-13 1995-01-20 Adir Nouveaux derives d'arylethylamines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
FR2680507B1 (fr) * 1991-08-23 1993-10-08 Adir Cie Nouvelles naphtylethylurees et naphtylethylthiourees, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
FR2696453B1 (fr) * 1992-10-02 1994-12-23 Adir Nouveaux arylalkyl(thio)amides, leur procédé de préparation, et les compositions pharmaceutiques qui les contiennent.
FR2713636B1 (fr) * 1993-12-07 1996-01-05 Adir Nouveaux dérivés naphtaléniques, leur procédé de préparation, et les compositions pharmaceutiques qui les contiennent.

Also Published As

Publication number Publication date
ZA964484B (en) 1996-12-12
AU5455996A (en) 1996-12-12
EP0745583A1 (fr) 1996-12-04
JPH08325217A (ja) 1996-12-10
CN1064674C (zh) 2001-04-18
EP0745583B1 (fr) 1999-12-29
GR3032289T3 (en) 2000-04-27
FR2734814B1 (fr) 1997-07-04
DE69605856D1 (de) 2000-02-03
AU704023B2 (en) 1999-04-15
ATE188207T1 (de) 2000-01-15
DE69605856T2 (de) 2000-07-20
US5668180A (en) 1997-09-16
NO310652B1 (no) 2001-08-06
CA2177743A1 (fr) 1996-12-01
DK0745583T3 (da) 2000-05-29
NZ286695A (en) 1997-05-26
NO962207L (no) 1996-12-02
CN1145896A (zh) 1997-03-26
CA2177743C (fr) 2000-08-08
NO962207D0 (no) 1996-05-30
FR2734814A1 (fr) 1996-12-06
PT745583E (pt) 2000-04-28

Similar Documents

Publication Publication Date Title
GR3032289T3 (en) Alkoxy aryl compounds with affinity to the melatonine receptors, process for their preparation and pharmaceutical compositions containing them
ES2146365T3 (es) Nuevas aril-(alquil)-propil-amidas, su procedimiento de preparacion y las composiciones farmaceuticas que las contienen.
OA09311A (fr) "Dérivés de 4-benzoylisoxazole, compositions les contenant et leur utilisation comme herbicides".
MX9102621A (es) Nuevos compuestos de hidantoina, procedimiento para su preparacion y composiciones herbicidas que los contienen.
DE69207194D1 (de) Verfahren zur Herstellung von Bacchatin III und von Desacetyl-10-Bacchatin III Derivate
ATE209641T1 (de) Tricyclische amidverbindungen, verfahren zu deren herstellung und sie enthaltende pharmazeutische zusammensetzungen
ES2036852T3 (es) Procedimiento para la obtencion de trifluormetilfenil-azolilmetiloxiranos y su empleo como agentes protectores de las plantas.
MX9306227A (es) Nuevos derivados de taxano, procedimiento para su preparacion y composiciones farmaceuticas que los contienen.
ES2105549T3 (es) Nuevos derivados fenoxi-isobutiricos sustituidos, su procedimiento de preparacion y composiciones farmaceuticas que los contienen.
ATE199715T1 (de) Alkyl(hetero)cyclische derivate, verfahren zu deren herstellung und sie enthaltende pharmazeutische zusammensetzungen
PT83725B (pt) Processo para preparacao de novos derivados da 3-oxadiol-beta-carbolina e 3-carboxilato-beta-carbolina e de composicoes farmaceuticas que os contem
BR9802212A (pt) Compostos cromeno um processo para sua preparação e composições farmacêuticas contendo os mesmos
ES2062845T3 (es) Derivados eter de 2,5-dimercapto-1,3,4-tiadiazoles.
ES2136947T3 (es) Amidas triciclicas, sus procedimientos de preparacion y las composiciones farmaceuticas que las contienen.
DE69605975D1 (de) Arylalkyl(thio)carboxamidverbindungen mit Affinität für Melatoninrezeptoren, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
PT873993E (pt) Novos compostos heterociclicos processo para a sua preparacao e as composicoes farmaceuticas que os contem
TR25443A (tr) Zararli bitki öldürücü herbisit maddeler.
DK0507318T3 (da) Benzothiazolderivater
ES524524A0 (es) Procedimiento para la preparacion de un aducto de un diisocianato
DK226280A (da) N-arylthiolcarbamater med herbicid virkning
MX9203929A (es) Derivados de 1,2,4-tiadiazino[3,4-b]benzotiazol, procedimiento para su preparacion y medicamentos que los contienen.
ATE266402T1 (de) Okulares hypotonikum
FI950818A0 (fi) Uudet substituoidut sulfoniamidit, menetelmä niiden valmistamiseksi ja niitä sisältävät farmaseuttiset koostumukset
ES8507525A1 (es) Procedimiento para preparar 3-acil-2-nitrometilentetrahidro-2h-1, 3-tiazinas
ATE148462T1 (de) Isoxazole derivate als lichtschutzmittel

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 745583

Country of ref document: ES