ES2143990T3 - Utilizacion de factores de crecimiento de hepatocitos para la fabricacion de un multiplicador de celulas cepa hematopoyeticas. - Google Patents

Utilizacion de factores de crecimiento de hepatocitos para la fabricacion de un multiplicador de celulas cepa hematopoyeticas.

Info

Publication number
ES2143990T3
ES2143990T3 ES92916220T ES92916220T ES2143990T3 ES 2143990 T3 ES2143990 T3 ES 2143990T3 ES 92916220 T ES92916220 T ES 92916220T ES 92916220 T ES92916220 T ES 92916220T ES 2143990 T3 ES2143990 T3 ES 2143990T3
Authority
ES
Spain
Prior art keywords
proliferating
cell multiplier
hematopoietic stem
hepatocyte
hepatocitos
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92916220T
Other languages
English (en)
Inventor
Atsushi Komiyama
Tatsutoshi Nakahata
Tetsuo Kubo
Ryuhei Tanaka
Genji Kawano
Tetsuo Sudo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toray Industries Inc
Original Assignee
Toray Industries Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toray Industries Inc filed Critical Toray Industries Inc
Application granted granted Critical
Publication of ES2143990T3 publication Critical patent/ES2143990T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/4753—Hepatocyte growth factor; Scatter factor; Tumor cytotoxic factor II
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SE PRESENTA UN MULTIPLICADOR DE CELULAS MADRE HEMATOPOIETICOS QUE COMPRENDE AL MENOS UN FACTOR PROLIFERATIVO DE HEPATOCITOS COMO INGREDIENTE ACTIVO. A CAUSA DE QUE LOS FACTORES PROLIFERATIVOS DE HEPATOCITOS TIENEN UNA ACTIVIDAD PROLIFERATIVA DE CELULAS MADRE, INDEFERENCIADAS PLURIPOTENCIALES, HEMATOPOIETICOS SON UTILES COMO MULTIPLICADORES DE CELULAS DE TRONCO HEMATOPOIETICO NO SOLAMENTE EN EL TRATAMIENTO DE LA INHIBICION E INSUFICIENCIA DE LA MEDULA OSEA SINO QUE TAMBIEN SON UTILES PARA EFECTUAR EL CRECIMIENTO IN VITRO DE CELULAS MADRE DE SANGRE PERIFERICA Y CELULAS MADRE DE MEDULA OSEA. ADEMAS ES POSIBLE OBTENER POR DERIVACION UN FACTOR PROLIFERATIVO DE HEPATOCITOS A PARTIR DE FIBROBLASTOS HUMANOS NORMALES, ENTRE OTROS FACTORES PROLIFERATIVOS DE HEPATOCITOS, MEDIANTE TECNICAS DE RECOMBINACION DE GENES, Y EL FACTOR PROLIFERATIVO OBTENIDO ES TAMBIEN UTIL COMO MULTIPLICADOR DE CELULAS MADRE HEMATOPOIETICOS.
ES92916220T 1991-07-26 1992-07-24 Utilizacion de factores de crecimiento de hepatocitos para la fabricacion de un multiplicador de celulas cepa hematopoyeticas. Expired - Lifetime ES2143990T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP18748191 1991-07-26
JP18747091 1991-07-26

Publications (1)

Publication Number Publication Date
ES2143990T3 true ES2143990T3 (es) 2000-06-01

Family

ID=26504364

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92916220T Expired - Lifetime ES2143990T3 (es) 1991-07-26 1992-07-24 Utilizacion de factores de crecimiento de hepatocitos para la fabricacion de un multiplicador de celulas cepa hematopoyeticas.

Country Status (8)

Country Link
US (1) US6221359B1 (es)
EP (1) EP0550769B1 (es)
JP (1) JP3395181B2 (es)
AT (1) ATE191501T1 (es)
CA (1) CA2092542A1 (es)
DE (1) DE69230879T2 (es)
ES (1) ES2143990T3 (es)
WO (1) WO1993003061A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1271088B (it) * 1994-11-24 1997-05-26 Dompe Spa Uso di fattore di crescita degli epatociti per indurre la proliferazione e differenziazione di cellule emopoietiche
US5824789A (en) * 1995-06-07 1998-10-20 Systemix, Inc. Human growth factors, nucleotide sequence encoding growth factors, and method of use thereof
US5728581A (en) * 1995-06-07 1998-03-17 Systemix, Inc. Method of expanding hematopoietic stem cells, reagents and bioreactors for use therein
CN1222310C (zh) * 1998-08-05 2005-10-12 住友制药株式会社 肝实质细胞增殖因子药用制剂
WO2004085616A2 (en) * 2003-03-24 2004-10-07 The Uab Research Foundation Regulation of self-renewal in stem cells
EP1613742A2 (en) * 2003-04-08 2006-01-11 YEDA RESEARCH AND DEVELOPMENT Co. LTD. Stem cells having increased sensitivity to a chemoattractant and methods of generating and using same
FR2853551B1 (fr) 2003-04-09 2006-08-04 Lab Francais Du Fractionnement Formulation stabilisante pour compositions d'immunoglobulines g sous forme liquide et sous forme lyophilisee
CA2537246A1 (en) * 2003-09-03 2005-03-17 Kringle Pharma Inc. Skin ulcer preventive or curative agent containing human recombinant hgf
JP4716875B2 (ja) 2003-12-16 2011-07-06 敏一 中村 糖鎖欠損型肝細胞増殖因子
JP5093783B2 (ja) 2006-04-20 2012-12-12 クリングルファーマ株式会社 Ｈｇｆ前駆体蛋白質改変体及びその活性型蛋白質
CN103743906B (zh) * 2013-07-24 2015-05-20 北京大学人民医院 用于测定造血干细胞移植后患者骨髓微环境的试剂盒、系统及方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2564486B2 (ja) * 1986-07-14 1996-12-18 修治 橋本 肝細胞増殖因子
US5362716A (en) * 1989-12-27 1994-11-08 The United States Of America As Represented By The Department Of Health And Human Services Methods for stimulating hematopoietic progenitors using hepatocyte growth factor and lymphokines
DE69131069T2 (de) * 1990-07-13 1999-07-15 Snow Brand Milk Products Co., Ltd., Sapporo, Hokkaido Plasmid das für die aminosäuresequenz von tcf-ii kodierende dns enthalt, transformierte zelle und produktion einer physiologisch aktiven substanz mit ihrer verwendung

Also Published As

Publication number Publication date
DE69230879D1 (de) 2000-05-11
EP0550769A4 (es) 1994-04-27
JP3395181B2 (ja) 2003-04-07
CA2092542A1 (en) 1993-01-27
ATE191501T1 (de) 2000-04-15
WO1993003061A1 (fr) 1993-02-18
EP0550769B1 (en) 2000-04-05
DE69230879T2 (de) 2000-08-03
US6221359B1 (en) 2001-04-24
EP0550769A1 (en) 1993-07-14

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