ES2144409T3 - Composiciones para el tratamiento de las onicomicosis. - Google Patents

Composiciones para el tratamiento de las onicomicosis.

Info

Publication number
ES2144409T3
ES2144409T3 ES92400384T ES92400384T ES2144409T3 ES 2144409 T3 ES2144409 T3 ES 2144409T3 ES 92400384 T ES92400384 T ES 92400384T ES 92400384 T ES92400384 T ES 92400384T ES 2144409 T3 ES2144409 T3 ES 2144409T3
Authority
ES
Spain
Prior art keywords
penetration
glycol
antifungal agent
antifungal
chosen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92400384T
Other languages
English (en)
Inventor
Jean-Pierre Laugier
Marie-France Rude
Philippe Touzan
Francois Ringenbach
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG filed Critical Novartis AG
Application granted granted Critical
Publication of ES2144409T3 publication Critical patent/ES2144409T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q3/00—Manicure or pedicure preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/41—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Emergency Medicine (AREA)
  • Birds (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Cosmetics (AREA)

Abstract

LOS AGENTES DE PENETRACION HIDROFILOS HABITUALMENTE UTILIZADOS PARA LA PENETRACION TRANSCUTANEA DE AGENTES ACTIVOS MEJORAN, DE FORMA SORPRENDENTE, LA PENETRACION DE AGENTES ANTIFUNGICOS A TRAVES DE LA UÑA. UNA COMPOSICION DERMATOLOGICA CORRESPONDIENTE COMPRENDE, AL MENOS, UN AGENTE ANTIFUNGICO ELEGIDO, SOBRE TODO, ENTRE LOS DE LA FAMILIA DE LAS ALILAMINAS, COMO LA TERBINAFINA-HCI Y LA NAFTIFINA-HCI; AL MENOS, UN AGENTE DE PENETRACION HIDROFILO ELEGIDO, SOBRE TODO, ENTRE LOS GLICOLES, LOS MONOETERES DE GLICOLES, LOS DIETERES DE GLICOLES, EL DIMETILSULFOXIDO, LA COPRALACTAMA, EL DIMETILISOSORBIDO, EL ISOPROPILIDENO GLICEROL, LA DIMETILIMIDAZOLIDONA, EL LACTATO DE ETILO, LOS GLICERIDOS EN C8-C10 POLIOXIETILENOS, EL POLIETILENO GLICOL 20 GLICERIL LAURATO Y EL DIMETILACETAMIDA; Y UN MEDIO HIDROALCOHOLICO QUE SOLUBILIZA DICHO (O DICHOS) AGENTE(S) ANTIFUNGICO(S) Y CON EL QUE DICHO (O DICHOS) AGENTE(S) ANTIFUNGICO(S) ES (O SON) PARCIALMENTE MEZCLABLE(S).
ES92400384T 1991-03-08 1992-02-13 Composiciones para el tratamiento de las onicomicosis. Expired - Lifetime ES2144409T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9102838A FR2673537B1 (fr) 1991-03-08 1991-03-08 Utilisation d'agents de penetration hydrophiles dans les compositions dermatologiques pour le traitement des onychomycoses, et compositions correspondantes.

Publications (1)

Publication Number Publication Date
ES2144409T3 true ES2144409T3 (es) 2000-06-16

Family

ID=9410536

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92400384T Expired - Lifetime ES2144409T3 (es) 1991-03-08 1992-02-13 Composiciones para el tratamiento de las onicomicosis.

Country Status (17)

Country Link
US (3) US5814305A (es)
EP (1) EP0503988B1 (es)
JP (1) JP3559973B2 (es)
AT (1) ATE190485T1 (es)
AU (1) AU1147092A (es)
BR (1) BR9200786A (es)
CA (1) CA2062341C (es)
CY (1) CY2233B1 (es)
DE (1) DE69230772T2 (es)
DK (1) DK0503988T3 (es)
ES (1) ES2144409T3 (es)
FR (1) FR2673537B1 (es)
GR (1) GR3033297T3 (es)
MX (1) MX9200965A (es)
PT (1) PT503988E (es)
SG (1) SG46660A1 (es)
ZA (1) ZA921706B (es)

Families Citing this family (86)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2673537B1 (fr) * 1991-03-08 1993-06-11 Oreal Utilisation d'agents de penetration hydrophiles dans les compositions dermatologiques pour le traitement des onychomycoses, et compositions correspondantes.
HU223343B1 (hu) * 1991-05-20 2004-06-28 Novartis Ag. Allil-amin-származékot tartalmazó gyógyászati készítmények és eljárás azok előállítására
US6005001A (en) * 1991-05-20 1999-12-21 Novartis Ag (Formerly Sandoz Ag) Pharmaceutical composition
HU219480B (hu) * 1991-05-23 2001-04-28 Novartis Ag. Eljárás gombás körömmegbetegségek ellen helyileg alkalmazható, allil-amin-származékot tartalmazó gyógyászati készítmények előállítására
US5652256A (en) * 1995-06-06 1997-07-29 Knowles; W. Roy Topical composition for fungal treatment
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AU1147092A (en) 1992-09-10
BR9200786A (pt) 1992-11-17
MX9200965A (es) 1992-09-01
JPH0585929A (ja) 1993-04-06
DE69230772D1 (de) 2000-04-20
CY2233B1 (en) 2003-04-18
CA2062341C (fr) 2004-05-11
PT503988E (pt) 2000-06-30
DE69230772T2 (de) 2000-07-27
EP0503988A1 (fr) 1992-09-16
GR3033297T3 (en) 2000-09-29
CA2062341A1 (fr) 1992-09-09
DK0503988T3 (da) 2000-07-24
ZA921706B (en) 1992-11-25
SG46660A1 (en) 1998-02-20
US5814305A (en) 1998-09-29
FR2673537A1 (fr) 1992-09-11
EP0503988B1 (fr) 2000-03-15
FR2673537B1 (fr) 1993-06-11
US6455592B1 (en) 2002-09-24
JP3559973B2 (ja) 2004-09-02
US6143793A (en) 2000-11-07
ATE190485T1 (de) 2000-04-15

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