ES2147223T3 - Derivados de indol como agonistas de tipo 5-ht1. - Google Patents

Derivados de indol como agonistas de tipo 5-ht1.

Info

Publication number
ES2147223T3
ES2147223T3 ES94400215T ES94400215T ES2147223T3 ES 2147223 T3 ES2147223 T3 ES 2147223T3 ES 94400215 T ES94400215 T ES 94400215T ES 94400215 T ES94400215 T ES 94400215T ES 2147223 T3 ES2147223 T3 ES 2147223T3
Authority
ES
Spain
Prior art keywords
image
alkyl
group
hydrogen atom
indol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94400215T
Other languages
English (en)
Inventor
Gilbert Lavielle
Philippe Maillos
Olivier Muller
Michel Laubie
Tony Verbeuren
Jean-Jacques Descombes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ADIR SARL
Original Assignee
ADIR SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ADIR SARL filed Critical ADIR SARL
Application granted granted Critical
Publication of ES2147223T3 publication Critical patent/ES2147223T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D419/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms
    • C07D419/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

LA INVENCION CONCIERNE A COMPUESTOS DE FORMULA (I), EN LA CUAL: R1 REPRESENTA UN ATOMO DE HIDROGENO, DE HALOGENO, UNA AGRUPACION ALQUILO, ALCOXI, CIANO, AMINOCARBONILO, O UNA CUALQUIERA DE LAS AGRUPACIONES SIGUIENTES: -------M ES IGUAL A 1, 2 O 3; N ES IGUAL A 0, 1 O 2, T REPRESENTA UN CO O SO2, R4 O R5, IDENTICOS O DIFERENTES, REPRESENTAN UN ATOMO DE HIDROGENO, UNA AGRUPACION ALQUILO O FENILO, R2, REPRESENTA UN ATOMO DE HIDROGENO, UNA AGRUPACION ALQUILO, FENILO O ACILO, R3 REPRESENTA UN ATOMO DE HIDROGENO, UNA AGRUPACION ALQUILO (EVENTUALMENTE SUSTITUIDO POR UNA AGRUPACION HIDROXI O FENILO) O ALCOXICARBONILO, -X-Y= REPRESENTA -NC=, -N-N= O BIEN -X(R2)-Y= REPRESENTA -O-N=, SUS ENANTIOMEROS, DIASTEROISOMEROS Y EPIMEROS ASI COMO SUS SALES DE ADICION A UN ACIDO FARMACEUTICAMENTE ACEPTABLE. MEDICAMENTOS.
ES94400215T 1993-02-02 1994-02-02 Derivados de indol como agonistas de tipo 5-ht1. Expired - Lifetime ES2147223T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9301054A FR2701026B1 (fr) 1993-02-02 1993-02-02 Nouveaux dérivés de l'indole, de l'indazole et du benzisoxazole, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.

Publications (1)

Publication Number Publication Date
ES2147223T3 true ES2147223T3 (es) 2000-09-01

Family

ID=9443592

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94400215T Expired - Lifetime ES2147223T3 (es) 1993-02-02 1994-02-02 Derivados de indol como agonistas de tipo 5-ht1.

Country Status (14)

Country Link
US (1) US5348968A (es)
EP (1) EP0610134B1 (es)
JP (1) JP2614981B2 (es)
AT (1) ATE191481T1 (es)
AU (1) AU669032B2 (es)
CA (1) CA2114593C (es)
DE (1) DE69423802T2 (es)
DK (1) DK0610134T3 (es)
ES (1) ES2147223T3 (es)
FR (1) FR2701026B1 (es)
GR (1) GR3033505T3 (es)
NZ (1) NZ250800A (es)
PT (1) PT610134E (es)
ZA (1) ZA94709B (es)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5578612A (en) * 1990-10-15 1996-11-26 Pfizer Inc. Indole derivatives
US5607951A (en) * 1990-10-15 1997-03-04 Pfizer Inc Indole derivatives
US5559129A (en) * 1990-10-15 1996-09-24 Pfizer Inc Indole derivatives
US5559246A (en) * 1990-10-15 1996-09-24 Pfizer Inc. Indole derivatives
US5545644A (en) * 1990-10-15 1996-08-13 Pfizer Inc. Indole derivatives
DE69230803T2 (de) * 1991-11-25 2000-12-07 Pfizer Inc., New York 5-(hetero- oder carbocyclylamino)-indol derivate, deren herstellung und deren verwendung als 5-ht1 agonisten
CA2169179C (en) * 1993-08-31 2000-02-29 John E. Macor 5-arylindole derivatives
DK139593D0 (da) * 1993-12-16 1993-12-16 Lundbeck & Co As H Compounds
US6423731B2 (en) * 1994-01-06 2002-07-23 Zeneca Limited Indole derivatives as prodrugs of 5-HT1-like receptor agonists
JP3262800B2 (ja) * 1994-06-01 2002-03-04 ゼネカ・リミテッド 療用複素環化合物
GB9417310D0 (en) * 1994-08-27 1994-10-19 Pfizer Ltd Therapeutic agents
AU726560B2 (en) * 1994-10-12 2000-11-09 Pfizer Research And Development Company, N.V./S.A. Use of indole derivatives for the treatment of various diseases
GB9420529D0 (en) * 1994-10-12 1994-11-30 Pfizer Ltd Indoles
FR2735129B1 (fr) * 1995-06-07 1997-07-11 Adir Nouveaux derives de l'indole, de l'indazole et du benzisoxazole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US5856510A (en) * 1996-12-16 1999-01-05 Allelix Biopharmaceuticals Inc. 5-alkenyl and 5-alkynyl indole compounds
US5998462A (en) * 1996-12-16 1999-12-07 Allelix Biopharmaceuticals Inc. 5-alkyl indole compounds
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
US5994352A (en) * 1998-11-13 1999-11-30 Pfizer Inc. 5-arylindole derivatives
FR2799463B1 (fr) * 1999-10-12 2004-04-16 Adir Nouveaux composes cyano-indoles inhibiteurs de recapture de serotonine, leur procede de preparation et ces compositions pharmaceutiques qui les contiennent
MXPA03005433A (es) 2000-12-22 2003-09-10 Wyeth Corp Compuestos de heterociclilalquilindol o-azaindol como ligandos de 5-hidroxitriptamina-6.
US20060154897A1 (en) * 2002-11-08 2006-07-13 Doherty James B Ophthalmic compositions for treating ocular hypertension
US7196082B2 (en) * 2002-11-08 2007-03-27 Merck & Co. Inc. Ophthalmic compositions for treating ocular hypertension
MXPA05005794A (es) * 2002-12-02 2005-08-16 Hoffmann La Roche Derivados de indazol como antagonistas del factor de liberacion de corticotropina.
GB0317229D0 (en) * 2003-07-23 2003-08-27 Pfizer Ltd Improved process
EP1653968A4 (en) * 2003-07-23 2006-09-06 Synta Pharmaceuticals Corp METHOD FOR MODULATING CALCIUMION RELIEF ACTIVATED CALCIUMION CHANNELS
AR050253A1 (es) 2004-06-24 2006-10-11 Smithkline Beecham Corp Compuesto derivado de indazol carboxamida, composicion que lo comprende y su uso para la preparacion de un medicamento
TW200626142A (en) 2004-09-21 2006-08-01 Glaxo Group Ltd Chemical compounds
ATE460415T1 (de) * 2004-11-29 2010-03-15 Warner Lambert Co Therapeutische pyrazoloä3,4-büpyridine und - indazole
DE102005026194A1 (de) * 2005-06-06 2006-12-07 Grünenthal GmbH Substituierte N-Benzo[d]isoxazol-3-yl-amin-Derivate und deren Verwendung zur Herstellung von Arzneimitteln
US8063071B2 (en) 2007-10-31 2011-11-22 GlaxoSmithKline, LLC Chemical compounds
CA2669311C (en) * 2006-11-13 2011-09-20 Pfizer Products Inc. Diaryl, dipyridinyl and aryl-pyridinyl derivatives and uses thereof
PE20081889A1 (es) 2007-03-23 2009-03-05 Smithkline Beecham Corp Indol carboxamidas como inhibidores de ikk2
WO2010102968A1 (en) 2009-03-10 2010-09-16 Glaxo Group Limited Indole derivatives as ikk2 inhibitors

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ197996A (en) * 1980-08-12 1985-08-16 Glaxo Group Ltd 1-(3-(omega-aminoalkyl)-1h-indol-5-yl)alkanamides
GB8903036D0 (en) * 1989-02-10 1989-03-30 Glaxo Group Ltd Chemical compounds
KR100215627B1 (ko) * 1990-06-07 1999-08-16 레슬리 제인 에드워즈 치료용 헤테로사이클 화합물
CA2091562C (en) * 1990-10-15 2001-03-27 John Eugene Macor Indole derivatives useful in psychotherapeutics
EP0494774A1 (en) * 1991-01-11 1992-07-15 MERCK SHARP & DOHME LTD. Indazole-substituted fivemembered heteroaromatic compounds
SK278998B6 (sk) * 1991-02-01 1998-05-06 Merck Sharp & Dohme Limited Deriváty imidazolu, triazolu a tetrazolu, spôsob i
CA2110574A1 (en) * 1991-06-21 1993-01-07 Lawrence I. Kruse Tryptamine analogues, their synthesis and their use as 5-ht1-like or 5-ht2 receptor agonists

Also Published As

Publication number Publication date
DK0610134T3 (da) 2000-08-21
EP0610134B1 (fr) 2000-04-05
JPH06271571A (ja) 1994-09-27
NZ250800A (en) 1995-03-28
CA2114593A1 (fr) 1994-08-03
AU5481794A (en) 1994-08-04
PT610134E (pt) 2000-07-31
AU669032B2 (en) 1996-05-23
ATE191481T1 (de) 2000-04-15
EP0610134A1 (fr) 1994-08-10
DE69423802D1 (de) 2000-05-11
FR2701026B1 (fr) 1995-03-31
JP2614981B2 (ja) 1997-05-28
US5348968A (en) 1994-09-20
ZA94709B (en) 1994-09-06
DE69423802T2 (de) 2000-11-09
GR3033505T3 (en) 2000-09-29
FR2701026A1 (fr) 1994-08-05
CA2114593C (fr) 2002-04-16

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