ES2147996T3 - Ciclitol que contiene carbohidratos a partir de tejido humano que regula la actividad lipogenica. - Google Patents

Ciclitol que contiene carbohidratos a partir de tejido humano que regula la actividad lipogenica.

Info

Publication number
ES2147996T3
ES2147996T3 ES97939087T ES97939087T ES2147996T3 ES 2147996 T3 ES2147996 T3 ES 2147996T3 ES 97939087 T ES97939087 T ES 97939087T ES 97939087 T ES97939087 T ES 97939087T ES 2147996 T3 ES2147996 T3 ES 2147996T3
Authority
ES
Spain
Prior art keywords
human tissue
containing carbohydrates
lipogenic activity
regulates
cyclitol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97939087T
Other languages
English (en)
Inventor
Thomas William Rademacher
Hugo Caro
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rademacher Group Ltd
Original Assignee
Rademacher Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rademacher Group Ltd filed Critical Rademacher Group Ltd
Application granted granted Critical
Publication of ES2147996T3 publication Critical patent/ES2147996T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/407—Liver; Hepatocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/50—Placenta; Placental stem cells; Amniotic fluid; Amnion; Amniotic stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07G—COMPOUNDS OF UNKNOWN CONSTITUTION
    • C07G3/00—Glycosides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Pregnancy & Childbirth (AREA)
  • Nutrition Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

LA INVENCION SE REFIERE A LA PURIFICACION Y CARACTERIZACION DE UNA FAMILIA DE INOSITOLFOSFOGLICANOS DE TIPO A (IPGS) DEL HIGADO Y DE LA PLACENTA HUMANOS. ESTAS SUBSTANCIAS HAN MOSTRADO QUE TIENEN ACTIVIDAD BIOLOGICA ASOCIADA CON FRACCIONES DE IPG DE TIPO A, REGULANDO NOMINALMENTE LA ACTIVIDAD LIPOGENICA E INHIBIENDO LA PROTEINA QUINASA DEPENDIENTE DE CAMP. LA CARACTERIZACION DE LOS COMPUESTOS DEMUESTRAN QUE CONTIENEN IONES DE METAL, EN PARTICULAR ZN 2+ , Y OPCIONALMENTE FOSFATO. LOS C OMPUESTOS Y SUS ANTAGONISTAS TIENEN UTILIZACION COMO PRODUCTOS FARMACEUTICOS, POR EJEMPLO PARA EL TRATAMIENTO DE LA DIABETES, Y EN LA SELECCION DE ANALOGOS SINTETICOS.
ES97939087T 1996-09-11 1997-09-11 Ciclitol que contiene carbohidratos a partir de tejido humano que regula la actividad lipogenica. Expired - Lifetime ES2147996T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9618930.3A GB9618930D0 (en) 1996-09-11 1996-09-11 Metal containing carbohydrates from human tissue which regulate lipogenic activity

Publications (1)

Publication Number Publication Date
ES2147996T3 true ES2147996T3 (es) 2000-10-01

Family

ID=10799738

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97939087T Expired - Lifetime ES2147996T3 (es) 1996-09-11 1997-09-11 Ciclitol que contiene carbohidratos a partir de tejido humano que regula la actividad lipogenica.

Country Status (10)

Country Link
US (2) US6303580B1 (es)
EP (1) EP0925305B1 (es)
JP (1) JP2001504450A (es)
AT (1) ATE192161T1 (es)
AU (1) AU713103B2 (es)
CA (1) CA2264938A1 (es)
DE (1) DE69701812T2 (es)
ES (1) ES2147996T3 (es)
GB (1) GB9618930D0 (es)
WO (1) WO1998011116A1 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9801899D0 (en) * 1998-01-29 1998-03-25 Univ London Neurotrophic properties of ipgs analogues
US20040192586A1 (en) * 1998-03-18 2004-09-30 Rodaris Pharmaceuticals Limited Materials and methods relating to anti-inositolphosphoglycan antibodies
GB9805771D0 (en) * 1998-03-18 1998-05-13 Hoeft Rademacher Limited Materials and methods relating to screening for inositolphosphoglycan mimetics
WO1999047565A1 (en) * 1998-03-18 1999-09-23 Rademacher Group Limited Anti-inositolphosphoglycan monoclonal antibodies
GB9806645D0 (en) * 1998-03-27 1998-05-27 Univ London Materials and methods relating to the treatment of conditions involving mast cells,basophils and eosinophils
GB9826099D0 (en) * 1998-11-27 1999-01-20 Hoeft Rademacher Limited Carbohydrates and methods for their synthesis
GB9828560D0 (en) * 1998-12-23 1999-02-17 Rademacher Group Limited Substances from porcine tissue
GB9828564D0 (en) * 1998-12-23 1999-02-17 Rademacher Group Limited Materials and methods for the treatment and diagnosis of cancer
GB9828559D0 (en) * 1998-12-23 1999-02-17 Rademacher Group Limited Insulin mimetics from honey
US6953781B2 (en) 2000-05-12 2005-10-11 Rodaris Pharmaceuticals Limited Compounds and their uses
US6759390B2 (en) 2000-05-12 2004-07-06 Manuel Martin-Lomas Compounds and their uses
US6716826B2 (en) 2000-05-12 2004-04-06 Rodaris Pharmaceuticals Limited Compounds and their uses
US6939857B2 (en) 2000-05-12 2005-09-06 Rodaris Pharmaceuticals Limited Compounds and their uses
GB0015623D0 (en) * 2000-06-26 2000-08-16 Rademacher Group Limited Phosphoglycan messengers and their medical uses

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4839466A (en) * 1986-04-11 1989-06-13 The Rockefeller University Insulin activity messengers
US4906468A (en) 1986-04-11 1990-03-06 The Rockefeller University Insulin activity messengers, their antibodies, and thereof
US5122603A (en) * 1989-03-08 1992-06-16 The University Of Virginia Alumni Patents Foundation Purified insulin mediators and purification process for same
US5750348A (en) * 1989-03-08 1998-05-12 The University Of Virginia Patents Foundation Method for detecting insulin resistance
YU66892A (sh) 1991-08-20 1995-10-24 Hoechst Ag. Fosfoinositolglikan - peptid sa delovanjem kao insulin
GB9505658D0 (en) * 1995-03-21 1995-05-10 Univ London Hormone and growth factor mimetics
GB9618931D0 (en) * 1996-09-11 1996-10-23 Univ London Inositol phosphoglycans for therapeutic use in pre-eclampsia and diabetes
GB9618934D0 (en) * 1996-09-11 1996-10-23 Univ London Inositol phosphoglycans for therapeutic use in the treatment of diabetes and obesity

Also Published As

Publication number Publication date
EP0925305B1 (en) 2000-04-26
GB9618930D0 (en) 1996-10-23
DE69701812T2 (de) 2000-10-12
US20010039027A1 (en) 2001-11-08
CA2264938A1 (en) 1998-03-19
DE69701812D1 (de) 2000-05-31
US6303580B1 (en) 2001-10-16
EP0925305A1 (en) 1999-06-30
AU713103B2 (en) 1999-11-25
JP2001504450A (ja) 2001-04-03
WO1998011116A1 (en) 1998-03-19
ATE192161T1 (de) 2000-05-15
AU4130797A (en) 1998-04-02

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