ES2148154T3 - Sensor de glucosa implantable. - Google Patents

Sensor de glucosa implantable.

Info

Publication number
ES2148154T3
ES2148154T3 ES91919026T ES91919026T ES2148154T3 ES 2148154 T3 ES2148154 T3 ES 2148154T3 ES 91919026 T ES91919026 T ES 91919026T ES 91919026 T ES91919026 T ES 91919026T ES 2148154 T3 ES2148154 T3 ES 2148154T3
Authority
ES
Spain
Prior art keywords
sensor
sensors
enzymatic
implantation
indicating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91919026T
Other languages
English (en)
Inventor
George S Wilson
Dilbir S Bindra
Brian S Hill
Daniel R Thevenot
Robert Sternberg
Gerard Reach Md
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut National de la Santé et de la Recherche Médicale
Université Paris-Est Créteil Val de Marne
Université de Marne-la-Vallée
University of Kansas
Original Assignee
Institut National de la Santé et de la Recherche Médicale
Université Paris-Est Créteil Val de Marne
Université de Marne-la-Vallée
University of Kansas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institut National de la Santé et de la Recherche Médicale, Université Paris-Est Créteil Val de Marne, Université de Marne-la-Vallée, University of Kansas filed Critical Institut National de la Santé et de la Recherche Médicale
Application granted granted Critical
Publication of ES2148154T3 publication Critical patent/ES2148154T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/005—Enzyme electrodes involving specific analytes or enzymes
    • C12Q1/006—Enzyme electrodes involving specific analytes or enzymes for glucose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
    • A61B5/1486—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase
    • A61B5/14865—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
    • A61B5/6848—Needles

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pathology (AREA)
  • Surgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Medical Informatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Optics & Photonics (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Liquid Crystal (AREA)
  • Electroluminescent Light Sources (AREA)
  • Metal-Oxide And Bipolar Metal-Oxide Semiconductor Integrated Circuits (AREA)
  • Thin Film Transistor (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

SE PRESENTAN SENSORES ENZIMATICOS IMPLANTABLES (25, 43, 44) PARA PRODUCTOS BIOQUIMICOS TALES COMO LA GLUCOSA QUE TIENEN GEOMETRIA Y TAMAÑO IDEALES PARA SU IMPLANTACION DURANTE LARGOS PERIODOS Y QUE SUMINISTRAN RESPUESTAS LINEALES SOBRE LA CONCENTRACION DEL PRODUCTO DE INTERES. LOS SENSORES INCLUYEN UN CUERPO ALARGADO (10, 26, 46) QUE SOPORTA UNA SECCION DE UN ELECTRODO INDICADOR QUE TIENE UNA ENZIMA APROPIADA INMOVILIZADA SOBRE EL MISMO PARA PRESENTAR UNA SUPERFICIE INDICADORA ENZIMATICA (21, 33, 54). UNA MEMBRANA DE UN POLIMERO SINTETICO PERMEABLE (24, 52, 56) SE APLICA SOBRE EL CUERPO DEL SENSOR (12, 26, 46) PARA PROTEGER LA ENZIMA Y REGULAR LA DIFUSION DEL SUJETO DE ANALISIS A TRAVES DE LA MISMA PARA ASEGURAR LA LINEALIDAD DE LA RESPUESTA DEL SENSOR. LOS SENSORES (25, 43) SON DE DISEÑO SENSIBLE Y PUEDEN SER IMPLANTADOS USANDO UN CATETER. ALTERNATIVAMENTE, EL SENSOR (44) INCLUYE UN CUERPO DE UN ELECTRODO INDICADOR INTERNO (46) ALOJADO EN EL INTERIOR DE UNA AGUJA HUECA (48). UNA PIEZA DE SOPORTE (66) FIJADA A LA AGUJA (48) PERMITE LA FACIL MANIPULACION E IMPLANTACION DEL SENSOR (44).
ES91919026T 1990-04-19 1991-04-17 Sensor de glucosa implantable. Expired - Lifetime ES2148154T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51104990A 1990-04-19 1990-04-19
US07/682,560 US5165407A (en) 1990-04-19 1991-04-09 Implantable glucose sensor

Publications (1)

Publication Number Publication Date
ES2148154T3 true ES2148154T3 (es) 2000-10-16

Family

ID=27057105

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91919026T Expired - Lifetime ES2148154T3 (es) 1990-04-19 1991-04-17 Sensor de glucosa implantable.

Country Status (11)

Country Link
US (1) US5165407A (es)
EP (1) EP0525127B1 (es)
JP (1) JP3194434B2 (es)
AT (1) ATE194062T1 (es)
AU (1) AU640785B2 (es)
CA (1) CA2080022C (es)
DE (1) DE69132270T2 (es)
DK (1) DK0525127T3 (es)
ES (1) ES2148154T3 (es)
GR (1) GR3034376T3 (es)
WO (1) WO1991015993A1 (es)

Families Citing this family (606)

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AU640785B2 (en) 1993-09-02
EP0525127A4 (en) 1996-07-10
CA2080022A1 (en) 1991-10-20
WO1991015993A1 (en) 1991-10-31
EP0525127B1 (en) 2000-06-28
DK0525127T3 (da) 2000-08-28
DE69132270D1 (de) 2000-08-03
EP0525127A1 (en) 1993-02-03
GR3034376T3 (en) 2000-12-29
ATE194062T1 (de) 2000-07-15
CA2080022C (en) 1997-12-23
AU7782891A (en) 1991-11-11
JP3194434B2 (ja) 2001-07-30
DE69132270T2 (de) 2000-10-26
US5165407A (en) 1992-11-24

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