ES2148166T3 - Receptor de ka-2 humano, un receptor de alta afinidad de cainato de la familia eaa2 (aminoacidos excitaddores). - Google Patents
Receptor de ka-2 humano, un receptor de alta afinidad de cainato de la familia eaa2 (aminoacidos excitaddores).Info
- Publication number
- ES2148166T3 ES2148166T3 ES92307724T ES92307724T ES2148166T3 ES 2148166 T3 ES2148166 T3 ES 2148166T3 ES 92307724 T ES92307724 T ES 92307724T ES 92307724 T ES92307724 T ES 92307724T ES 2148166 T3 ES2148166 T3 ES 2148166T3
- Authority
- ES
- Spain
- Prior art keywords
- receiver
- family
- amino acids
- cainate
- eaa2
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102100022761 Glutamate receptor ionotropic, kainate 5 Human genes 0.000 title 1
- 101000903313 Homo sapiens Glutamate receptor ionotropic, kainate 5 Proteins 0.000 title 1
- 150000001413 amino acids Chemical class 0.000 title 1
- 102000005962 receptors Human genes 0.000 abstract 6
- 108020003175 receptors Proteins 0.000 abstract 6
- 239000003257 excitatory amino acid Substances 0.000 abstract 2
- 230000002461 excitatory amino acid Effects 0.000 abstract 2
- 239000012528 membrane Substances 0.000 abstract 2
- VLSMHEGGTFMBBZ-OOZYFLPDSA-M Kainate Chemical compound CC(=C)[C@H]1C[NH2+][C@H](C([O-])=O)[C@H]1CC([O-])=O VLSMHEGGTFMBBZ-OOZYFLPDSA-M 0.000 abstract 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229930195712 glutamate Natural products 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 230000000638 stimulation Effects 0.000 abstract 1
- 230000005062 synaptic transmission Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/839—Nerves; brain
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
LA NEUROTRANSMISION POR AMINOACIDOS EXCITADORES (EAAS) COMO EL GLUTAMATO ES TRANSMITIDO VIA RECEPTORES DE SUPERFICIE VINCULADOS A LA MEMBRANA. LA CODIFICACION DEL ADN PARA UNA FAMILIA DE ESTOS RECEPTORES, DEL TIPO VINCULADO AL KAINATO DE RECEPTORES EAA, HA SIDO AHORA AISLADO Y LA PROTEINA RECEPTORA CARACTERIZADA. LO QUE AQUI SE DESCRIBE SON LINEAS DE CELULA RECOMBINANTES QUE PRODUCEN EL RECEPTOR EAA COMO UN PRODUCTO VINCULADO A LA MEMBRANA HETEROLOGO. TAMBIEN SE DESCRIBEN ASPECTOS DE LA INVENCION, QUE SON DE SIGNIFICANCIA COMERCIAL. SE INCLUYE EL USO DE LAS LINEAS DE CELULA COMO UNA HERRAMIENTA PARA EL DESCUBRIMIENTO DE COMPUESTOS QUE MODULAN LA ESTIMULACION DEL RECEPTOR EAA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75008191A | 1991-08-27 | 1991-08-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2148166T3 true ES2148166T3 (es) | 2000-10-16 |
Family
ID=25016407
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES92307724T Expired - Lifetime ES2148166T3 (es) | 1991-08-27 | 1992-08-25 | Receptor de ka-2 humano, un receptor de alta afinidad de cainato de la familia eaa2 (aminoacidos excitaddores). |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US5494792A (es) |
| EP (1) | EP0529995B1 (es) |
| JP (1) | JP3361554B2 (es) |
| AT (1) | ATE191500T1 (es) |
| CA (1) | CA2076901C (es) |
| DE (1) | DE69230872T2 (es) |
| DK (1) | DK0529995T3 (es) |
| ES (1) | ES2148166T3 (es) |
| GR (1) | GR3033880T3 (es) |
| PT (1) | PT529995E (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5574144A (en) * | 1992-06-24 | 1996-11-12 | Allelix Biopharmaceuticals, Inc. | Kainate-binding, human CNS receptors of the EAA4 family |
| CA2105804C (en) * | 1992-09-17 | 2003-04-29 | Rajender Kamboj | Kainate-binding, human cns receptors of the eaa5 family |
| CA2110933C (en) * | 1992-12-11 | 2005-02-08 | Rajender Kamboj | Kainate-binding, human cns receptors of the eaa3 family |
| DE10125258A1 (de) * | 2001-05-23 | 2003-01-09 | November Ag Molekulare Medizin | Verfahren zur Bestimmung des Bindeverhaltens von an Ziel-Molekülen spezifisch bindenden Liganden |
| WO2003002606A2 (en) * | 2001-06-29 | 2003-01-09 | Decode Genetics Ehf. | Nucleic acids encoding ion channels |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1991006648A1 (en) * | 1989-10-27 | 1991-05-16 | The Salk Institute For Biological Studies | Glutamate receptor compositions and methods |
-
1992
- 1992-08-25 DE DE69230872T patent/DE69230872T2/de not_active Expired - Fee Related
- 1992-08-25 AT AT92307724T patent/ATE191500T1/de not_active IP Right Cessation
- 1992-08-25 ES ES92307724T patent/ES2148166T3/es not_active Expired - Lifetime
- 1992-08-25 DK DK92307724T patent/DK0529995T3/da active
- 1992-08-25 EP EP92307724A patent/EP0529995B1/en not_active Expired - Lifetime
- 1992-08-25 PT PT92307724T patent/PT529995E/pt unknown
- 1992-08-26 JP JP25056092A patent/JP3361554B2/ja not_active Expired - Fee Related
- 1992-08-26 CA CA002076901A patent/CA2076901C/en not_active Expired - Fee Related
-
1993
- 1993-07-15 US US08/091,569 patent/US5494792A/en not_active Expired - Fee Related
-
1994
- 1994-02-28 US US08/203,676 patent/US5614406A/en not_active Expired - Lifetime
-
1997
- 1997-03-20 US US08/822,238 patent/US5981704A/en not_active Expired - Fee Related
-
2000
- 2000-07-05 GR GR20000401565T patent/GR3033880T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| US5614406A (en) | 1997-03-25 |
| EP0529995A1 (en) | 1993-03-03 |
| PT529995E (pt) | 2000-09-29 |
| US5981704A (en) | 1999-11-09 |
| CA2076901C (en) | 2001-04-10 |
| DK0529995T3 (da) | 2000-07-03 |
| DE69230872T2 (de) | 2000-10-26 |
| EP0529995B1 (en) | 2000-04-05 |
| US5494792A (en) | 1996-02-27 |
| CA2076901A1 (en) | 1993-02-28 |
| ATE191500T1 (de) | 2000-04-15 |
| JPH07196696A (ja) | 1995-08-01 |
| DE69230872D1 (de) | 2000-05-11 |
| JP3361554B2 (ja) | 2003-01-07 |
| GR3033880T3 (en) | 2000-11-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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