ES2148540T3 - METALLIC COMPLEXES WITH LOADED LINKER. - Google Patents

METALLIC COMPLEXES WITH LOADED LINKER.

Info

Publication number
ES2148540T3
ES2148540T3 ES95928451T ES95928451T ES2148540T3 ES 2148540 T3 ES2148540 T3 ES 2148540T3 ES 95928451 T ES95928451 T ES 95928451T ES 95928451 T ES95928451 T ES 95928451T ES 2148540 T3 ES2148540 T3 ES 2148540T3
Authority
ES
Spain
Prior art keywords
metallic complexes
linker
loaded
complexes
loaded linker
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95928451T
Other languages
Spanish (es)
Inventor
Hans-Peter Josel
Eva Hoss
Beatus Ofenloch-Hahnle
Christoph Seidel
Barbara Upmeier
Ursula-Henrike Wienhues
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Roche Diagnostics GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE4430998A external-priority patent/DE4430998A1/en
Application filed by Roche Diagnostics GmbH filed Critical Roche Diagnostics GmbH
Application granted granted Critical
Publication of ES2148540T3 publication Critical patent/ES2148540T3/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0046—Ruthenium compounds
    • C07F15/0053—Ruthenium compounds without a metal-carbon linkage
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6878—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids in epitope analysis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Electroluminescent Light Sources (AREA)
  • Luminescent Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)

Abstract

LA PRSENTE INVENCION TRATA DE NUEVOS COMPLEJOS METALICOS CON UN LIGANTE Y LA UTILIZACION DE TALES COMPLEJOS COMO GRUPOS MARCADORES LUMINISCENTES EN INMUNOENSAYOS.THE PRESENT INVENTION IS ABOUT NEW METALLIC COMPLEXES WITH A BINDER AND THE USE OF SUCH COMPLEXES AS LUMINISCENT MARKER GROUPS IN IMMUNO-ASSAYS.

ES95928451T 1994-07-25 1995-07-24 METALLIC COMPLEXES WITH LOADED LINKER. Expired - Lifetime ES2148540T3 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE4426276 1994-07-25
DE4430998A DE4430998A1 (en) 1994-07-25 1994-08-31 Metal chelated peptides
DE4439345A DE4439345A1 (en) 1994-07-25 1994-11-04 New conjugates comprising oligomeric carrier and attached hapten(s)
DE4439347A DE4439347A1 (en) 1994-07-25 1994-11-04 New rare earth or transition metal complexes contg. charged linker

Publications (1)

Publication Number Publication Date
ES2148540T3 true ES2148540T3 (en) 2000-10-16

Family

ID=27436023

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95928451T Expired - Lifetime ES2148540T3 (en) 1994-07-25 1995-07-24 METALLIC COMPLEXES WITH LOADED LINKER.

Country Status (13)

Country Link
US (1) US5958783A (en)
EP (1) EP0720614B1 (en)
JP (1) JP2771900B2 (en)
CN (1) CN1046531C (en)
AT (1) ATE193294T1 (en)
AU (1) AU690315B2 (en)
CA (1) CA2172145C (en)
DE (1) DE59508391D1 (en)
ES (1) ES2148540T3 (en)
FI (1) FI961349L (en)
NO (1) NO961161D0 (en)
NZ (1) NZ291154A (en)
WO (1) WO1996003409A1 (en)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2276462C (en) * 1996-12-31 2007-06-12 High Throughput Genomics, Inc. Multiplexed molecular analysis system apparatus and method
DE19811582A1 (en) * 1998-03-17 1999-09-23 Roche Diagnostics Gmbh Electrochemiluminescence assay, especially for biological substances, with long measurement period
DE19828441A1 (en) 1998-06-25 1999-12-30 Roche Diagnostics Gmbh Detection of analytes uses oxidation protected chemiluminescence or electro-chemiluminescence reagents
DE19828466A1 (en) 1998-06-26 1999-12-30 Roche Diagnostics Gmbh Suppressor peptides derived from antibodies for use in immunoassays
US20050112607A1 (en) * 1999-01-23 2005-05-26 Bamdad Cynthia C. Rapid and sensitive detection of protein aggregation
US6300143B1 (en) * 1999-03-01 2001-10-09 Idec Pharmaceuticals Corporation Electrochemiluminescent assays for eukaryotic cells
DE10048417A1 (en) * 2000-09-29 2002-04-11 Roche Diagnostics Gmbh Branched linker connections
EP1245956A1 (en) * 2001-03-29 2002-10-02 Roche Diagnostics GmbH Conjugates of defined stoichiometry
US7897404B2 (en) * 2000-09-29 2011-03-01 Roche Diagnostics Operations, Inc. Conjugates of defined stoichiometry
EP1343973B2 (en) 2000-11-16 2020-09-16 California Institute Of Technology Apparatus and methods for conducting assays and high throughput screening
US7135296B2 (en) 2000-12-28 2006-11-14 Mds Inc. Elemental analysis of tagged biologically active materials
US7700295B2 (en) * 2000-12-28 2010-04-20 Mds Sciex Elemental analysis of tagged biologically active materials
US6808939B2 (en) 2001-06-29 2004-10-26 Igen International, Inc. ECL labels having improved non-specific binding properties, methods of using and kits containing the same
DE60214709T2 (en) * 2001-07-02 2007-09-13 Arctic Diagnostics Oy Method for increasing the hydrophilicity of fluorescent marker compounds
RU2296333C2 (en) * 2001-07-02 2007-03-27 Арктик Диагностикс Ой Dyes based on dipyrromethene boron difluoride with biphotonic absorption and their use
US6989273B2 (en) * 2002-02-08 2006-01-24 Canon Kabushiki Kaisha Light emissive iridium (III) complexes
DE10227599B4 (en) * 2002-06-20 2005-04-28 Proteome Factory Ag Method and reagent for the specific identification and quantification of one or more proteins in a sample
DE10239098A1 (en) * 2002-08-26 2004-03-11 Roche Diagnostics Gmbh Detecting analyte using luminescent metal complex, useful for diagnosis, where chemiluminescence is induced by sequential oxidation and reduction of the complex
TW200508606A (en) * 2003-03-07 2005-03-01 Nard Kenkyusho Kk Method of finding molecular weight of phosphoric acid monoester compound, and additive for mass spectrometric measurement
ES2309785T3 (en) 2004-08-13 2008-12-16 F. Hoffmann-La Roche Ag MODIFICATION C-TERMINAL OF POLYPEPTIDES.
DE102005032332A1 (en) * 2005-07-08 2007-01-11 Merck Patent Gmbh metal complexes
US8101368B2 (en) * 2006-02-13 2012-01-24 Dvs Sciences Inc. Quantitation of cellular DNA and cell numbers using element labeling
DE112006003813T5 (en) * 2006-03-20 2009-01-22 Inverness Medical Switzerland Gmbh Water-soluble conjugates for electrochemical detection
WO2007118712A1 (en) * 2006-04-14 2007-10-25 Proteome Factory Ag Method and reagent for the specific identification and quantification of one or more proteins in a sample using inductively coupled plasma-mass spectrometry
GB0711849D0 (en) 2007-06-19 2007-07-25 Oxford Biosensors Ltd Redox Mediators
DE102007032799B4 (en) 2007-07-11 2018-08-23 Friedrich-Schiller-Universität Jena Sugary metal complexes and their use
US8637194B2 (en) 2008-09-02 2014-01-28 Bio-Nano Power, Llc Bio-nano power cells and their uses
CN101747381B (en) * 2008-12-19 2013-09-11 苏州纳凯科技有限公司 Cyclometalated iridium coordination compound used as biomarker
CA2784782C (en) 2009-12-18 2018-02-27 Hendrik A. Weeber Limited echelette lens, systems and methods
BR112013007614B1 (en) 2010-10-25 2020-12-29 F. Hoffmann-La Roche Ag method for measuring an analyte, reagent composition, reagent mixture, use of a reagent composition, use of a carbonic acid amide and kit
US10406227B2 (en) 2012-12-19 2019-09-10 California Institute Of Technology Photoactivated molecules for light-induced modulation of the activity of electrically excitable cells and methods of using same
US10232043B2 (en) 2015-08-19 2019-03-19 California Institute Of Technology Photoactivated molecules for light-induced modulation of the activity of electrically excitable cells and methods of using the same
WO2017153574A1 (en) 2016-03-11 2017-09-14 Roche Diagnostics Gmbh Branched-chain amines in electrochemiluminescence detection
CN107759799B (en) * 2017-09-21 2020-10-23 中山大学 A kind of solid-phase synthesis method of ruthenium terpyridine-lysine polymer
CA3169298A1 (en) * 2020-02-27 2021-09-02 The Trustees Of Princeton University Intercellular and intracellular proximity-based labeling compositions and systems

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK365785A (en) * 1984-09-17 1986-03-18 Hoffmann La Roche metal complex
US5075447A (en) * 1984-09-17 1991-12-24 Hoffmann-La Roche Inc. Ruthenium complexes useful as carriers for immunologically active materials
US5238808A (en) * 1984-10-31 1993-08-24 Igen, Inc. Luminescent metal chelate labels and means for detection

Also Published As

Publication number Publication date
FI961349A7 (en) 1996-03-25
DE59508391D1 (en) 2000-06-29
US5958783A (en) 1999-09-28
EP0720614B1 (en) 2000-05-24
NO961161L (en) 1996-03-21
ATE193294T1 (en) 2000-06-15
WO1996003409A1 (en) 1996-02-08
CA2172145A1 (en) 1996-02-08
CA2172145C (en) 2010-09-21
FI961349A0 (en) 1996-03-25
NZ291154A (en) 1997-11-24
EP0720614A1 (en) 1996-07-10
CN1046531C (en) 1999-11-17
JPH08509995A (en) 1996-10-22
NO961161D0 (en) 1996-03-21
FI961349L (en) 1996-03-25
CN1134154A (en) 1996-10-23
AU3220595A (en) 1996-02-22
AU690315B2 (en) 1998-04-23
JP2771900B2 (en) 1998-07-02

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