ES2149687A1 - Procedimiento de obtencion de (+-)-trans-4-(4-fluorofenil)-3-hidroximetilpiperidinas e intermedios de sintesis para las mismas. - Google Patents

Procedimiento de obtencion de (+-)-trans-4-(4-fluorofenil)-3-hidroximetilpiperidinas e intermedios de sintesis para las mismas.

Info

Publication number
ES2149687A1
ES2149687A1 ES009800757A ES9800757A ES2149687A1 ES 2149687 A1 ES2149687 A1 ES 2149687A1 ES 009800757 A ES009800757 A ES 009800757A ES 9800757 A ES9800757 A ES 9800757A ES 2149687 A1 ES2149687 A1 ES 2149687A1
Authority
ES
Spain
Prior art keywords
production
reduction
hydroxy methyl
piperidine
antidepressant drugs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES009800757A
Other languages
English (en)
Other versions
ES2149687B1 (es
Inventor
Diez Del Corral Alberto Stampa
Garcia Pelayo Camps
Llado Jordi Bosch
Lascorz Juan Contreras
Miguel M-Carmen Onrubia
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medichem SA
Original Assignee
Medichem SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medichem SA filed Critical Medichem SA
Priority to ES9800757A priority Critical patent/ES2149687B1/es
Publication of ES2149687A1 publication Critical patent/ES2149687A1/es
Application granted granted Critical
Publication of ES2149687B1 publication Critical patent/ES2149687B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Procedimiento de obtención de (+) -trans-4-(4-fluorofenil)-3-hidroximetilpiperidinas e intermedios de síntesis para las mismas; los productos son de fórmula (I) (R es H o CH3 ) y el procedimiento se basa en la reducción de compuestos de fórmula (II) (R1 es H o CH3 y R2 un alquilo C1-C4 ). Estos productos de fórmula (I) son importantes intermedios para la obtención del antidepresivo paroxetina.
ES9800757A 1998-04-08 1998-04-08 Procedimiento de obtencion de (+-)-trans-4-(4-fluorofenil)-3-hidroximetilpiperidinas e intermedios de sintesis para las mismas. Expired - Fee Related ES2149687B1 (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9800757A ES2149687B1 (es) 1998-04-08 1998-04-08 Procedimiento de obtencion de (+-)-trans-4-(4-fluorofenil)-3-hidroximetilpiperidinas e intermedios de sintesis para las mismas.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9800757A ES2149687B1 (es) 1998-04-08 1998-04-08 Procedimiento de obtencion de (+-)-trans-4-(4-fluorofenil)-3-hidroximetilpiperidinas e intermedios de sintesis para las mismas.

Publications (2)

Publication Number Publication Date
ES2149687A1 true ES2149687A1 (es) 2000-11-01
ES2149687B1 ES2149687B1 (es) 2001-05-16

Family

ID=8303411

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9800757A Expired - Fee Related ES2149687B1 (es) 1998-04-08 1998-04-08 Procedimiento de obtencion de (+-)-trans-4-(4-fluorofenil)-3-hidroximetilpiperidinas e intermedios de sintesis para las mismas.

Country Status (1)

Country Link
ES (1) ES2149687B1 (es)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4188396A (en) * 1977-01-17 1980-02-12 Ciba-Geigy Corporation New phenylazacycloalkanes
EP0190496A2 (en) * 1984-12-13 1986-08-13 Beecham Group Plc Piperidine derivatives having a gastro-intestinal activity
WO1994003428A1 (en) * 1992-08-06 1994-02-17 Sepracor, Inc. Method of preparing optically pure precursors of paroxetine
WO1994021609A1 (en) * 1993-03-13 1994-09-29 Smithkline Beecham P.L.C. Process for preparing acryl-piperidine carbinols
EP0802185A1 (en) * 1996-04-15 1997-10-22 Asahi Glass Company Ltd. Process for producing piperidinecarbinols

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4188396A (en) * 1977-01-17 1980-02-12 Ciba-Geigy Corporation New phenylazacycloalkanes
EP0190496A2 (en) * 1984-12-13 1986-08-13 Beecham Group Plc Piperidine derivatives having a gastro-intestinal activity
WO1994003428A1 (en) * 1992-08-06 1994-02-17 Sepracor, Inc. Method of preparing optically pure precursors of paroxetine
WO1994021609A1 (en) * 1993-03-13 1994-09-29 Smithkline Beecham P.L.C. Process for preparing acryl-piperidine carbinols
EP0802185A1 (en) * 1996-04-15 1997-10-22 Asahi Glass Company Ltd. Process for producing piperidinecarbinols

Also Published As

Publication number Publication date
ES2149687B1 (es) 2001-05-16

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