ES2149737T3 - Procedimiento para la preparacion de 10,11-dihidro-5h-dibenzo(a,d)ciclohept-5-enos y sus derivados. - Google Patents

Procedimiento para la preparacion de 10,11-dihidro-5h-dibenzo(a,d)ciclohept-5-enos y sus derivados.

Info

Publication number
ES2149737T3
ES2149737T3 ES98907067T ES98907067T ES2149737T3 ES 2149737 T3 ES2149737 T3 ES 2149737T3 ES 98907067 T ES98907067 T ES 98907067T ES 98907067 T ES98907067 T ES 98907067T ES 2149737 T3 ES2149737 T3 ES 2149737T3
Authority
ES
Spain
Prior art keywords
dibenzo
preparation
ciclohept
dihidro
enso
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98907067T
Other languages
English (en)
Other versions
ES2149737T5 (es
ES2149737T1 (es
Inventor
William Paul Jackson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rolabo SL
Original Assignee
Rolabo SL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10808344&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2149737(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Rolabo SL filed Critical Rolabo SL
Publication of ES2149737T1 publication Critical patent/ES2149737T1/es
Publication of ES2149737T3 publication Critical patent/ES2149737T3/es
Application granted granted Critical
Publication of ES2149737T5 publication Critical patent/ES2149737T5/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Glass Compositions (AREA)
  • Iron Core Of Rotating Electric Machines (AREA)

Abstract

Un procedimiento para la preparación de 10,11-dihidro-5H- dibenzo{[}a,d{]}ciclohept-5-enos (por ejemplo loratadina) mediante la reacción de una dibenzozuberona con una cetona alif tica en presencia de titanio de valencia baja.
ES98907067T 1997-02-26 1998-02-26 Procedimiento para la preparacion de 5,6-dihidro-11h-dibenzo(a,d)ciclohept-11-enos. Expired - Lifetime ES2149737T5 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9703992 1997-02-26
GBGB9703992.9A GB9703992D0 (en) 1997-02-26 1997-02-26 Process

Publications (3)

Publication Number Publication Date
ES2149737T1 ES2149737T1 (es) 2000-11-16
ES2149737T3 true ES2149737T3 (es) 2001-12-16
ES2149737T5 ES2149737T5 (es) 2009-12-14

Family

ID=10808344

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98907067T Expired - Lifetime ES2149737T5 (es) 1997-02-26 1998-02-26 Procedimiento para la preparacion de 5,6-dihidro-11h-dibenzo(a,d)ciclohept-11-enos.

Country Status (10)

Country Link
US (2) US6093827A (es)
EP (1) EP0970050B2 (es)
AT (1) ATE207466T1 (es)
AU (1) AU6304798A (es)
CA (1) CA2282480C (es)
DE (1) DE69802171T3 (es)
DK (1) DK0970050T4 (es)
ES (1) ES2149737T5 (es)
GB (1) GB9703992D0 (es)
WO (1) WO1998038166A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9703992D0 (en) * 1997-02-26 1997-04-16 Rolabo Sl Process
BR112014003567A2 (pt) 2011-08-16 2018-08-14 Mt Sinai School Of Medicine composto, uso de um composto, e, composição farmacêutica
CN112552230B (zh) * 2020-12-11 2022-08-26 佛山普正医药科技有限公司 一种盐酸赛庚啶的合成方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3905972A (en) * 1970-10-09 1975-09-16 Hoffmann La Roche Tricyclic imines
FR2266676B1 (es) * 1974-04-05 1980-04-04 Univ California
DE2641075C2 (de) * 1975-09-29 1985-11-14 The Regents Of The University Of California, Berkeley, Calif. Verfahren zur Herstellung von symmetrischen Olefinen
DE3477661D1 (en) † 1983-05-19 1989-05-18 Bristol Myers Co Process for the preparation of tamoxifen
GB9703992D0 (en) † 1997-02-26 1997-04-16 Rolabo Sl Process
CH688412A5 (de) † 1997-03-11 1997-09-15 Cilag Ag Verfahren zur Herstellung von 1,4-disubstituierten Piperidinverbindungen.
US6084100A (en) † 1997-05-30 2000-07-04 Medichem, S.A. Process for the preparation of loratadine

Also Published As

Publication number Publication date
DE69802171T2 (de) 2002-07-04
DE69802171T3 (de) 2010-07-08
US6093827A (en) 2000-07-25
CA2282480C (en) 2002-04-23
AU6304798A (en) 1998-09-18
US7282587B1 (en) 2007-10-16
EP0970050B2 (en) 2009-10-14
EP0970050B1 (en) 2001-10-24
ES2149737T5 (es) 2009-12-14
CA2282480A1 (en) 1998-09-03
ES2149737T1 (es) 2000-11-16
DK0970050T3 (da) 2002-02-11
DE69802171T8 (de) 2009-10-08
ATE207466T1 (de) 2001-11-15
DE69802171D1 (de) 2001-11-29
GB9703992D0 (en) 1997-04-16
EP0970050A1 (en) 2000-01-12
WO1998038166A1 (en) 1998-09-03
DK0970050T4 (da) 2010-03-01

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