ES2149777T3 - Derivados de triazol que tienen actividad antifungica. - Google Patents

Derivados de triazol que tienen actividad antifungica.

Info

Publication number
ES2149777T3
ES2149777T3 ES92920368T ES92920368T ES2149777T3 ES 2149777 T3 ES2149777 T3 ES 2149777T3 ES 92920368 T ES92920368 T ES 92920368T ES 92920368 T ES92920368 T ES 92920368T ES 2149777 T3 ES2149777 T3 ES 2149777T3
Authority
ES
Spain
Prior art keywords
triazole
derivatives
antifungal activity
alkyl
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92920368T
Other languages
English (en)
Inventor
Andrew Simon Bell
Kenneth Richardson
Peter John Whittle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PFIZER
Pfizer Inc
Original Assignee
PFIZER
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PFIZER, Pfizer Inc filed Critical PFIZER
Application granted granted Critical
Publication of ES2149777T3 publication Critical patent/ES2149777T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/70—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Cephalosporin Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

SE DESCRIBEN UNOS COMPUESTOS ANTIHONGOS DE FORMULA (I) Y SUS SALES FARMACEUTICAMENTE ACEPTABLES, DONDE R ES FENILO SUSTITUIDO POR MAS DE 3 SUSTITUYENTES CADA UNO DE ELLOS SELECCIONADOS INDEPENDIENTEMENTE DE HALO Y TRIFLUOROMETILO; R1 ES ALQUILO C1-4; R2 ES (ALFA), O ; R3 ES S(O)MR4; R4 ES ALQUILO C1-4; Y M ES 0, 1 O 2, JUNTO CON LAS COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN Y PROCESOS E INTERMEDIARIOS PARA PREPARAR DICHOS COMPUESTOS.
ES92920368T 1991-10-10 1992-10-01 Derivados de triazol que tienen actividad antifungica. Expired - Lifetime ES2149777T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB919121456A GB9121456D0 (en) 1991-10-10 1991-10-10 Triazole antifungal agents

Publications (1)

Publication Number Publication Date
ES2149777T3 true ES2149777T3 (es) 2000-11-16

Family

ID=10702663

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92920368T Expired - Lifetime ES2149777T3 (es) 1991-10-10 1992-10-01 Derivados de triazol que tienen actividad antifungica.

Country Status (13)

Country Link
US (1) US5541203A (es)
EP (1) EP0607193B1 (es)
JP (1) JPH07502022A (es)
AT (1) ATE196293T1 (es)
CA (1) CA2118937C (es)
DE (1) DE69231445T2 (es)
DK (1) DK0607193T3 (es)
ES (1) ES2149777T3 (es)
FI (1) FI108131B (es)
GB (1) GB9121456D0 (es)
GR (1) GR3034769T3 (es)
PT (1) PT100942B (es)
WO (1) WO1993007139A1 (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9317491D0 (en) * 1993-08-23 1993-10-06 Fujisawa Pharmaceutical Co New compound and a process for preparation thereof
NZ270418A (en) * 1994-02-07 1997-09-22 Eisai Co Ltd Polycyclic triazole & imidazole derivatives, antifungal compositions
GB9512961D0 (en) * 1995-06-26 1995-08-30 Pfizer Ltd Antifungal agents
GB9605705D0 (en) * 1996-03-19 1996-05-22 Pfizer Ltd Therapeutic agents
KR100889937B1 (ko) 2007-08-06 2009-03-20 한미약품 주식회사 보리코나졸의 제조방법
GB2452049A (en) * 2007-08-21 2009-02-25 Alpharma Aps Process for the preparation of voriconazole
WO2012177635A1 (en) * 2011-06-19 2012-12-27 Viamet Pharmaceuticals, Inc. Metalloenzyme inhibitor compounds
KR20140040235A (ko) 2011-06-19 2014-04-02 비아멧 파마슈티컬즈, 인코포레이티드 금속효소 억제제 화합물
IN2014DN06792A (es) * 2012-01-20 2015-05-22 Viamet Pharmaceuticals Inc
TWI561515B (en) * 2012-03-16 2016-12-11 Viamet Pharmaceuticals Inc Metalloenzyme inhibitor compounds
CA2986041C (en) 2015-05-18 2021-06-29 Viamet Pharmaceuticals, Inc. 4-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1h-1,2,4-triazol-1-yl)propyl)pyridin-3-yl)oxy)benzonitrile and 4-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(5-thioxo-4,5-dihydro-1h-1,2,4-triazol-1-yl)propyl)pyridin-3-yl)oxy)benzonitrile compounds as antifungal agents
CA3044386A1 (en) * 2016-11-22 2018-05-31 Dow Agrosciences Llc Use of a difluoro-(2-hydroxypropyl)pyridine compound as a fungicide for control of phytopathogenic fungi of corn
US20190274303A1 (en) * 2016-11-22 2019-09-12 Dow Agrosciences Llc Use of a difluoro-(2-hydroxypropyl)pyridine compound as a fungicide for control of phytopathogenic fungi of barley
JP7084398B2 (ja) * 2016-11-22 2022-06-14 コルテバ アグリサイエンス エルエルシー 殺真菌組成物および穀類における真菌防除のための混合物
WO2018098237A1 (en) * 2016-11-22 2018-05-31 Vps-3, Inc. Use of a difluoro-(2-hydroxypropyl)pyridine compound as a fungicide for control of leaf spot of sugar beets
US20210282401A1 (en) * 2016-11-22 2021-09-16 Dow Agrosciences Llc Fungicidal compounds and mixtures for fungal control in cereals
JP2019535748A (ja) * 2016-11-22 2019-12-12 ダウ アグロサイエンシィズ エルエルシー 殺真菌組成物および穀類における真菌防除のための混合物
US20210298305A1 (en) * 2016-11-22 2021-09-30 Dow Agrosciences Llc Use of a difluoro-(2-hydroxypropyl)pyridine compound as a fungicide for control of phytopathogenic fungi of wheat
RU2759947C2 (ru) 2016-11-22 2021-11-19 ДАУ АГРОСАЙЕНСИЗ ЭлЭлСи Фунгицидные соединения и смеси для борьбы с грибковыми заболеваниями зерновых культур
EP3544431A4 (en) * 2016-11-22 2020-04-22 Dow AgroSciences LLC USE OF A DIFLUOR (2-HYDROXYPROPYL) PYRIDINE COMPOUND AS A FUNGICIDE FOR CONTROLLING PHYTOPATHOGENIC MUSHROOMS OF RICE
MA46076B1 (fr) * 2016-11-22 2022-01-31 Dow Agrosciences Llc Composés fongicides et mélanges de régulation des champignons dans les céréales

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE322526C (de) * 1918-08-31 1920-07-01 Hermann Meyer Sicherheitskettenverschluss fuer Korridortueren u. dgl.
EP0158741A3 (en) * 1980-11-19 1986-02-12 Imperial Chemical Industries Plc Intermediates for fungicidal triazole and imidazole compounds
ES523184A0 (es) * 1982-06-17 1985-04-01 Pfizer Un procedimiento para la preparacion de un compuesto dotado de propiedades fungicidas
DE3245504A1 (de) * 1982-12-09 1984-06-14 Bayer Ag, 5090 Leverkusen Fungizide mittel, deren herstellung und verwendung
US4952232A (en) * 1987-04-29 1990-08-28 E. I. Du Pont De Nemours And Company Antifungal carbinols
DE3813841A1 (de) * 1987-06-03 1988-12-15 Bayer Ag Heterocyclische hydroxyethylazole
DE3732385A1 (de) * 1987-09-25 1989-04-06 Bayer Ag Hydroxyalkylcyclopropyl1-1,2,4-triazolyl- oder -imidazolyl-derivate und ihre verwendung als antimykotische mittel
EP0321211A1 (en) * 1987-12-17 1989-06-21 E.I. Du Pont De Nemours And Company Antifungal carbinols
NO171272C (no) * 1988-03-04 1993-02-17 Sankyo Co Analogifremgangsmaate til fremstilling av terapeutisk aktive 1,2,4-triazolforbindelser
GB8819308D0 (en) * 1988-08-13 1988-09-14 Pfizer Ltd Triazole antifungal agents
GB9002375D0 (en) * 1990-02-02 1990-04-04 Pfizer Ltd Triazole antifungal agents

Also Published As

Publication number Publication date
EP0607193A1 (en) 1994-07-27
FI108131B (fi) 2001-11-30
PT100942A (pt) 1993-10-29
JPH07502022A (ja) 1995-03-02
EP0607193B1 (en) 2000-09-13
WO1993007139A1 (en) 1993-04-15
CA2118937A1 (en) 1993-04-15
FI941644L (fi) 1994-04-08
FI941644A0 (fi) 1994-04-08
DK0607193T3 (da) 2000-10-09
GR3034769T3 (en) 2001-02-28
PT100942B (pt) 1999-07-30
ATE196293T1 (de) 2000-09-15
CA2118937C (en) 1998-04-28
GB9121456D0 (en) 1991-11-27
US5541203A (en) 1996-07-30
DE69231445D1 (de) 2000-10-19
DE69231445T2 (de) 2001-01-11

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