ES2150890T3 - Sintesis de oligosacaridos. - Google Patents

Sintesis de oligosacaridos.

Info

Publication number
ES2150890T3
ES2150890T3 ES97935368T ES97935368T ES2150890T3 ES 2150890 T3 ES2150890 T3 ES 2150890T3 ES 97935368 T ES97935368 T ES 97935368T ES 97935368 T ES97935368 T ES 97935368T ES 2150890 T3 ES2150890 T3 ES 2150890T3
Authority
ES
Spain
Prior art keywords
oligosacarids
synthesis
glycoside
solid phase
provides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97935368T
Other languages
English (en)
Other versions
ES2150890T1 (es
Inventor
Istvan Toth
Gyula Dekany
Barry Kellam
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alchemia Pty Ltd
Original Assignee
Alchemia Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alchemia Pty Ltd filed Critical Alchemia Pty Ltd
Publication of ES2150890T1 publication Critical patent/ES2150890T1/es
Application granted granted Critical
Publication of ES2150890T3 publication Critical patent/ES2150890T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18—Acyclic radicals, substituted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Treatments Of Macromolecular Shaped Articles (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

LA INVENCION PROPORCIONA UN SISTEMA DE SINTESIS EN FASE SOLIDA DE OLIGOSACARIDOS, BASADO EN EL DESCUBRIMIENTO DE QUE SE PUEDE EMPLEAR UN GRUPO DE UNION DE 1,3 - DIOXOCICLOALQUILO SUSTITUIDO EN POSICION 2, DE FORMULA GENERAL (I), PARA ENLAZAR GRUPOS SACARIDOS, TANTO DE TIPO O - GLICOSIDO COMO N - GLICOSIDO, A UN SOPORTE POLIMERICO. LA INVENCION PROPORCIONA REACTIVOS, EQUIPAMIENTOS DE REACTIVOS Y PROCEDIMIENTOS DE SINTESIS DE OLIGOSACARIDOS EN FASE SOLIDA.
ES97935368T 1996-08-26 1997-08-26 Sintesis de oligosacaridos. Expired - Lifetime ES2150890T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AUPO1905A AUPO190596A0 (en) 1996-08-26 1996-08-26 Oligosaccharide synthesis

Publications (2)

Publication Number Publication Date
ES2150890T1 ES2150890T1 (es) 2000-12-16
ES2150890T3 true ES2150890T3 (es) 2003-07-01

Family

ID=3796218

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97935368T Expired - Lifetime ES2150890T3 (es) 1996-08-26 1997-08-26 Sintesis de oligosacaridos.

Country Status (12)

Country Link
US (2) US6573337B1 (es)
EP (1) EP0923528B1 (es)
JP (1) JP2001501174A (es)
CN (1) CN1121375C (es)
AT (1) ATE227258T1 (es)
AU (1) AUPO190596A0 (es)
CA (1) CA2264390A1 (es)
DE (2) DE69716931T2 (es)
DK (1) DK0923528T3 (es)
ES (1) ES2150890T3 (es)
HU (1) HUP0000069A3 (es)
WO (1) WO1998008799A1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPO190596A0 (en) * 1996-08-26 1996-09-19 Alchemia Pty Ltd Oligosaccharide synthesis
AUPO536797A0 (en) * 1997-02-28 1997-03-20 Alchemia Pty Ltd Protected aminosugars
AUPO937597A0 (en) 1997-09-24 1997-10-16 Alchemia Pty Ltd Protecting and linking groups for organic synthesis
AUPP823099A0 (en) 1999-01-18 1999-02-11 Alchemia Pty Ltd Protecting groups for carbohydrate synthesis
US6476191B1 (en) * 1999-02-05 2002-11-05 Mixture Sciences, Inc. Volatilizable solid phase supports for compound synthesis
US20010051349A1 (en) 2000-02-17 2001-12-13 Glycominds Ltd. Combinatorial complex carbohydrate libraries and methods for the manufacture and uses thereof
DE60044846D1 (de) 1999-03-05 2010-09-30 Massachusetts Inst Technology Linker zur synthese von oligosacchariden auf festträgern
DE60110094T2 (de) * 2000-08-18 2009-10-01 Massachusetts Institute Of Technology, Cambridge Vorrichtung und verfahren zur automatisierten synthese von oligosacchariden
US7723296B2 (en) 2001-01-18 2010-05-25 Genzyme Corporation Methods for introducing mannose-6-phosphate and other oligosaccharides onto glycoproteins and its application thereof
AUPS143402A0 (en) 2002-03-28 2002-05-09 Alchemia Pty Ltd Anomeric derivatives of monosaccharides
US8603530B2 (en) 2006-06-14 2013-12-10 Abbott Cardiovascular Systems Inc. Nanoshell therapy
CN102978185B (zh) 2007-01-18 2015-02-11 建新公司 包含氨基氧基基团的寡糖及其轭合物
CN102046781A (zh) * 2008-05-30 2011-05-04 动量制药公司 糖结构以及制造和使用此类结构的方法
EP3608330B1 (en) 2008-12-16 2022-11-09 Genzyme Corporation Synthetic intermediates for preparing oligosaccharide-protein conjugates
CN118459632B (zh) * 2024-04-12 2026-06-30 江南大学 一种用于聚糖固相合成的碱切除连接臂制备与应用
CN118459756A (zh) * 2024-05-07 2024-08-09 南京师范大学 一种温敏性材料和糖缀合物及其合成方法和在糖固相合成中的应用

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1339748A (en) 1970-07-02 1973-12-05 Ici Ltd Pyrimidine derivatives
US4062950A (en) 1973-09-22 1977-12-13 Bayer Aktiengesellschaft Amino sugar derivatives
JPS5829281B2 (ja) 1974-06-04 1983-06-22 日本曹達株式会社 バルビツ−ル酸系除草剤
PL103086B1 (pl) 1976-05-06 1979-05-31 Ciba Geigy Ag Srodek owadobojczy
DE2832698A1 (de) 1978-07-26 1980-02-07 Bayer Ag Substituierte 5-phenylcarbamoyl- barbitursaeuren, verfahren zu ihrer herstellung und ihre verwendung als insektizide
US4283444A (en) 1978-09-12 1981-08-11 Ciba-Geigy Corporation Method of protecting keratinous material from attack by insects that feed on keratin by treatment with 5-phenylcarbamoylbarbituric acid compounds
CH654720A5 (de) 1981-09-03 1986-03-14 Ciba Geigy Ag Lagerstabile mottenschutzformulierungen.
CH658770A5 (de) 1982-08-26 1986-12-15 Ciba Geigy Ag Motten- und kaeferschutzmittel.
GB2145087B (en) 1983-08-19 1987-02-04 Ciba Geigy Ag Barbituric acid derivatives
CH657015A5 (de) 1984-06-27 1986-08-15 Ciba Geigy Ag Motten- und kaeferschutzmittel.
GB2171099B (en) 1985-02-15 1988-10-19 Ciba Geigy Ag 5-(azolyloxphenylcarbamoyl)barbituric acid derivatives as anthelmintics
US4753940A (en) 1985-02-15 1988-06-28 Ciba-Geigy Corporation Barbituric acid derivatives
US4742128A (en) 1985-10-15 1988-05-03 Stamicarbon B.V. Process for preparing a polymer alloy, molded product, and reaction injection molded products
US4797147A (en) 1986-06-09 1989-01-10 Stauffer Chemical Company Herbicidal method and composition utilizing certain 5-(2-substituted benzoyl)-barbituric acids
US4938796A (en) 1987-07-06 1990-07-03 Ici Americas Inc. Herbicidal compositions of acylated 1,3-dicarbonyl herbicides and antidotes therefor
DE3903404A1 (de) 1989-02-06 1990-08-09 Hoechst Ag Pyrimidintrionderivate, verfahren zu ihrer herstellung, sie enthaltende mittel und ihre verwendung als schaedlingsbekaempfungsmittel
US5959109A (en) 1996-05-15 1999-09-28 Neurocrine Biosciences, Inc. Compounds and methods for increasing endogenous levels of corticotropin-releasing factor
AUPO190596A0 (en) * 1996-08-26 1996-09-19 Alchemia Pty Ltd Oligosaccharide synthesis
AUPO536797A0 (en) * 1997-02-28 1997-03-20 Alchemia Pty Ltd Protected aminosugars
EP0989982B1 (en) 1997-06-21 2005-08-17 Roche Diagnostics GmbH Barbituric acid derivatives with antimetastatic and antitumor activity
EP1017683A4 (en) 1997-09-24 2002-03-06 Alchemia Pty Ltd PROTECTIVE AND BINDING GROUPS FOR ORGANIC SYNTHESIS
AUPP823099A0 (en) 1999-01-18 1999-02-11 Alchemia Pty Ltd Protecting groups for carbohydrate synthesis

Also Published As

Publication number Publication date
US6573337B1 (en) 2003-06-03
DE923528T1 (de) 2001-03-01
HUP0000069A3 (en) 2002-04-29
CA2264390A1 (en) 1998-03-05
JP2001501174A (ja) 2001-01-30
CN1121375C (zh) 2003-09-17
US20030027925A1 (en) 2003-02-06
HUP0000069A2 (hu) 2000-05-28
ATE227258T1 (de) 2002-11-15
ES2150890T1 (es) 2000-12-16
AUPO190596A0 (en) 1996-09-19
DE69716931T2 (de) 2003-07-31
EP0923528B1 (en) 2002-11-06
DE69716931D1 (de) 2002-12-12
EP0923528A1 (en) 1999-06-23
EP0923528A4 (en) 2000-07-19
US6723843B2 (en) 2004-04-20
DK0923528T3 (da) 2003-03-10
CN1234790A (zh) 1999-11-10
WO1998008799A1 (en) 1998-03-05

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