ES2151599T3 - Acidos hidroxamicos substituidos con arilsulfonamido como inhibidores de matriz metaloproteinasas. - Google Patents

Acidos hidroxamicos substituidos con arilsulfonamido como inhibidores de matriz metaloproteinasas.

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Publication number
ES2151599T3
ES2151599T3 ES95919600T ES95919600T ES2151599T3 ES 2151599 T3 ES2151599 T3 ES 2151599T3 ES 95919600 T ES95919600 T ES 95919600T ES 95919600 T ES95919600 T ES 95919600T ES 2151599 T3 ES2151599 T3 ES 2151599T3
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Spain
Prior art keywords
arilsulfonamide
metaloproteinase
hydroxamic acids
acids substituted
matrix inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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ES95919600T
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English (en)
Inventor
Lawrence Joseph Roa Macpherson
David Thomas Parker
Arco Yingcheu Jeng
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Novartis AG
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Novartis AG
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/42—Radicals substituted by singly-bound nitrogen atoms having hetero atoms attached to the substituent nitrogen atom
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    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
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    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C07C311/38—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
    • C07C311/39—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/42—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
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Abstract

COMPOSICIONES DE FORMULA (I) EN DONDE R, R 1 , R 2} Y AR SON COMO SE DEFINE EN LA ESPECIFICACION, TIENEN PROPIEDADES FARMACEUTICAS VALIOSAS Y SON EFECTIVOS ESPECIALMENTE COMO INHIBIDORES DE METALOPROTEINASA MATRIZ, POR EJEMPLO PARA EL TRATAMIENTO DE ARTRITIS. SE PREPARAN DE UNA MANERA CONOCIDA PER SE.
ES95919600T 1994-06-24 1995-06-12 Acidos hidroxamicos substituidos con arilsulfonamido como inhibidores de matriz metaloproteinasas. Expired - Lifetime ES2151599T3 (es)

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US08/265,296 US5506242A (en) 1993-01-06 1994-06-24 Arylsufonamido-substituted hydroxamic acids

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AU692553B2 (en) 1998-06-11
US5506242A (en) 1996-04-09
GR3035181T3 (en) 2001-04-30
NZ285846A (en) 2000-01-28
PT766672E (pt) 2001-02-28
DE69519024D1 (de) 2000-11-09
FI965156A7 (fi) 1996-12-20
JP3875264B2 (ja) 2007-01-31
NO308130B1 (no) 2000-07-31
JPH11505502A (ja) 1999-05-21
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TW429244B (en) 2001-04-11
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ZA955206B (en) 1995-12-27
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AU2536995A (en) 1996-01-19
IL114171A (en) 2001-01-28
NO965568L (no) 1997-02-17
IL114171A0 (en) 1995-10-31
ATE196762T1 (de) 2000-10-15
HU226893B1 (en) 2010-01-28
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EP0766672A1 (en) 1997-04-09

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