ES2151665T3 - Procedimiento y equipo para predecir la respuesta terapeutica de un farmaco contra un tumor maligno. - Google Patents
Procedimiento y equipo para predecir la respuesta terapeutica de un farmaco contra un tumor maligno.Info
- Publication number
- ES2151665T3 ES2151665T3 ES96919762T ES96919762T ES2151665T3 ES 2151665 T3 ES2151665 T3 ES 2151665T3 ES 96919762 T ES96919762 T ES 96919762T ES 96919762 T ES96919762 T ES 96919762T ES 2151665 T3 ES2151665 T3 ES 2151665T3
- Authority
- ES
- Spain
- Prior art keywords
- tumour
- cells
- therapeutic response
- sample
- pct
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 5
- 230000004797 therapeutic response Effects 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- 210000004027 cell Anatomy 0.000 abstract 4
- 239000003814 drug Substances 0.000 abstract 3
- 229940079593 drug Drugs 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 3
- 239000000427 antigen Substances 0.000 abstract 2
- 102000036639 antigens Human genes 0.000 abstract 2
- 108091007433 antigens Proteins 0.000 abstract 2
- 239000006285 cell suspension Substances 0.000 abstract 2
- 238000009007 Diagnostic Kit Methods 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 238000004458 analytical method Methods 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 210000004698 lymphocyte Anatomy 0.000 abstract 1
- 238000009877 rendering Methods 0.000 abstract 1
- 210000004881 tumor cell Anatomy 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56966—Animal cells
- G01N33/56972—White blood cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Cell Biology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Virology (AREA)
- Physiology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
LA PRESENTE INVENCION TRATA DE UN PROCEDIMIENTO PARA PREDECIR LA RESPUESTA TERAPEUTICA DE UN FARMACO CONTRA UN TUMOR MALIGNO EN UN PACIENTE HUMANO UTILIZANDO UNA MUESTRA DE UN ASPIRADO REALIZADO CON UNA AGUJA FINA DEL TUMOR DE UN PACIENTE. EL PROCEDIMIENTO INCLUYE LAS ETAPAS DE IDENTIFICAR Y ESTIMAR EN UNA MUESTRA EL NUMERO DE CELULAS QUE PERTENECEN A UNA CLASE DE CELULAS EN RELACION CON OTRAS CELULAS EN LA MUESTRA, Y COMPARAR LA ESTIMACION CON UN ANALISIS REALIZADO PREVIAMENTE PARA DEMOSTRAR LA CORRELACION ENTRE EL NUMERO DE CELULAS Y LOS PARAMETROS DE LA RESPUESTA TERAPEUTICA DEL FARMACO DIRIGIDO CONTRA EL TUMOR EN PACIENTES HUMANOS, SIENDO LOS RESULTADOS DE LA COMPARACION INDICATIVOS DE LA RESPUESTA TERAPEUTICA DEL FARMACO EN UN PACIENTE HUMANO. UN ESTUCHE DE ENSAYO DE DIAGNOSTICO INCLUYE UNA MEZCLA DE ENZIMAS QUE TRANSFORMA LA MUESTRA DEL TUMOR EN UNA SUSPENSION DE UNA SOLA CELULA, UNA PRIMERA MEZCLA DE ANTICUERPOS MONOCLONALES DIRIGIDOS CONTRA ANTIGENOS ASOCIADOS AL TUMOR QUE SE ENCUENTRAN SOBRE LAS CELULAS TUMORALES EN LA SUSPENSION DE UNA SOLA CELULA, TENIENDO DICHOS ANTICUERPOS UN PRIMER MARCADOR, Y UNA SEGUNDA MEZCLA DE DOS TIPOS DE ANTICUERPOS MONOCLONALES DIRIGIDOS CONTRA DOS ANTIGENOS ESPECIFICOS QUE SE ENCUENTRAN SOBRE LINFOCITOS, TENIENDO DICHOS ANTICUERPOS UN SEGUNDO Y UN TERCER MARCADOR, RESPECTIVAMENTE.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9501782A SE9501782D0 (sv) | 1995-05-12 | 1995-05-12 | Method of predicting the therapeutic response of a drug against a malignant tumour |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2151665T3 true ES2151665T3 (es) | 2001-01-01 |
Family
ID=20398299
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES96919762T Expired - Lifetime ES2151665T3 (es) | 1995-05-12 | 1996-05-10 | Procedimiento y equipo para predecir la respuesta terapeutica de un farmaco contra un tumor maligno. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6114128A (es) |
| EP (1) | EP0824696B1 (es) |
| JP (1) | JPH11504715A (es) |
| AT (1) | ATE196688T1 (es) |
| CA (1) | CA2215627A1 (es) |
| DE (1) | DE69610496T2 (es) |
| DK (1) | DK0824696T3 (es) |
| ES (1) | ES2151665T3 (es) |
| GR (1) | GR3034891T3 (es) |
| PT (1) | PT824696E (es) |
| SE (1) | SE9501782D0 (es) |
| WO (1) | WO1996035949A1 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5824467A (en) * | 1997-02-25 | 1998-10-20 | Celtrix Pharmaceuticals | Methods for predicting drug response |
| US6087090A (en) * | 1997-02-25 | 2000-07-11 | Celtrix Pharmaceuticals, Inc. | Methods for predicting drug response |
| US20030096237A1 (en) * | 2000-08-28 | 2003-05-22 | Ulrich Certa | Determination of the ability of patients to respond to a tumor treatment |
| SE0402536D0 (sv) | 2004-10-20 | 2004-10-20 | Therim Diagnostica Ab | Immunoregulation in cancer, chronic inflammatory and autoimmune diseases |
| WO2011048033A2 (en) | 2009-10-19 | 2011-04-28 | Rostaquo S.P.A. | Methods and systems for pharmacogenomic treatment of cardiovascular conditions |
| US20130216557A1 (en) * | 2010-08-14 | 2013-08-22 | Biogen Idec Ma Inc. | Ltbr blockade: methods for optimizing therapeutic responsiveness of patients |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5426029A (en) * | 1986-03-31 | 1995-06-20 | T Cell Diagnostics, Inc. | Therapeutic and diagnostic methods using leukocyte surface antigens |
| CA1296622C (en) * | 1986-08-12 | 1992-03-03 | Jeffrey E. Anderson | Method and apparatus for automated assessment of the immunoregulatory status of the mononuclear leukocyte immune system |
-
1995
- 1995-05-12 SE SE9501782A patent/SE9501782D0/xx unknown
-
1996
- 1996-05-10 ES ES96919762T patent/ES2151665T3/es not_active Expired - Lifetime
- 1996-05-10 DK DK96919762T patent/DK0824696T3/da active
- 1996-05-10 EP EP96919762A patent/EP0824696B1/en not_active Expired - Lifetime
- 1996-05-10 JP JP8533784A patent/JPH11504715A/ja not_active Ceased
- 1996-05-10 PT PT96919762T patent/PT824696E/pt unknown
- 1996-05-10 CA CA002215627A patent/CA2215627A1/en not_active Abandoned
- 1996-05-10 WO PCT/EP1996/002007 patent/WO1996035949A1/en not_active Ceased
- 1996-05-10 US US08/952,140 patent/US6114128A/en not_active Expired - Fee Related
- 1996-05-10 AT AT96919762T patent/ATE196688T1/de not_active IP Right Cessation
- 1996-05-10 DE DE69610496T patent/DE69610496T2/de not_active Expired - Fee Related
-
2000
- 2000-11-22 GR GR20000402580T patent/GR3034891T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| WO1996035949A1 (en) | 1996-11-14 |
| EP0824696A1 (en) | 1998-02-25 |
| SE9501782D0 (sv) | 1995-05-12 |
| PT824696E (pt) | 2001-03-30 |
| DK0824696T3 (da) | 2001-01-02 |
| DE69610496T2 (de) | 2001-05-10 |
| ATE196688T1 (de) | 2000-10-15 |
| JPH11504715A (ja) | 1999-04-27 |
| CA2215627A1 (en) | 1996-11-14 |
| DE69610496D1 (de) | 2000-11-02 |
| EP0824696B1 (en) | 2000-09-27 |
| US6114128A (en) | 2000-09-05 |
| GR3034891T3 (en) | 2001-02-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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