ES2151671T3 - Procedimiento para sintetizar productos intermedios de cadena lateral de carbapenem. - Google Patents

Procedimiento para sintetizar productos intermedios de cadena lateral de carbapenem.

Info

Publication number
ES2151671T3
ES2151671T3 ES96926210T ES96926210T ES2151671T3 ES 2151671 T3 ES2151671 T3 ES 2151671T3 ES 96926210 T ES96926210 T ES 96926210T ES 96926210 T ES96926210 T ES 96926210T ES 2151671 T3 ES2151671 T3 ES 2151671T3
Authority
ES
Spain
Prior art keywords
procedure
synthetizing
side chain
intermediate products
chain intermediate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96926210T
Other languages
English (en)
Inventor
Karel M J Brands
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9602881.6A external-priority patent/GB9602881D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of ES2151671T3 publication Critical patent/ES2151671T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

SE DESCRIBE UN PROCEDIMIENTO PARA SINTETIZAR UN COMPUESTO DE FORMULA (I). SE HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON CLORURO DIFENILFOSFINICO PARA ACTIVAR EL GRUPO ACIDO CARBOXILICO, Y LUEGO SE HACE REACCIONAR CON CLORURO DE METANOSULFONILO PARA PRODUCIR UN COMPUESTO DE FORMULA (IV). ENTONCES EL COMPUESTO (IV) SE HACE REACCIONAR CON NA SUB,2}S EN AGUA PARA PRODUCIR UN COMPUESTO DE FORMULA (I).
ES96926210T 1995-08-04 1996-07-31 Procedimiento para sintetizar productos intermedios de cadena lateral de carbapenem. Expired - Lifetime ES2151671T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US189195P 1995-08-04 1995-08-04
GBGB9602881.6A GB9602881D0 (en) 1996-02-13 1996-02-13 Process for synthesizing carbapenem side chain intermediates

Publications (1)

Publication Number Publication Date
ES2151671T3 true ES2151671T3 (es) 2001-01-01

Family

ID=26308673

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96926210T Expired - Lifetime ES2151671T3 (es) 1995-08-04 1996-07-31 Procedimiento para sintetizar productos intermedios de cadena lateral de carbapenem.

Country Status (11)

Country Link
EP (1) EP0842166B1 (es)
JP (1) JP3112952B2 (es)
AT (1) ATE197456T1 (es)
AU (1) AU704304B2 (es)
CA (1) CA2227696C (es)
DE (1) DE69610924T2 (es)
DK (1) DK0842166T3 (es)
ES (1) ES2151671T3 (es)
GR (1) GR3034795T3 (es)
PT (1) PT842166E (es)
WO (1) WO1997006154A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999002531A1 (en) * 1997-07-09 1999-01-21 Merck & Co., Inc. Process for synthesizing carbapenem side chain intermediates
US6063931A (en) * 1997-07-09 2000-05-16 Merck & Co., Inc. Process for synthesizing carbapenem side chain intermediates
US5965747A (en) * 1997-07-10 1999-10-12 Merck & Co., Inc. Crystalline forms of antibiotic side chain intermediates
US6060607A (en) * 1998-06-29 2000-05-09 Merck & Co., Inc. Process for synthesizing carbapenem side chain intermediates
AU2001243331A1 (en) 2000-03-01 2001-09-12 Merck & Co., Inc. Crystalline forms of antibiotic side chain intermediates
CN102264744A (zh) * 2008-12-25 2011-11-30 株式会社钟化 碳青霉烯侧链中间体的改良制造方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4321383A (en) * 1980-11-24 1982-03-23 E. R. Squibb & Sons, Inc. Heterobicyclo intermediates
JP3091297B2 (ja) * 1992-01-10 2000-09-25 住友製薬株式会社 ピロリジン誘導体およびその製造方法

Also Published As

Publication number Publication date
JPH11510509A (ja) 1999-09-14
DK0842166T3 (da) 2000-11-27
PT842166E (pt) 2001-04-30
WO1997006154A1 (en) 1997-02-20
CA2227696C (en) 2003-09-23
DE69610924D1 (de) 2000-12-14
ATE197456T1 (de) 2000-11-11
JP3112952B2 (ja) 2000-11-27
AU704304B2 (en) 1999-04-22
CA2227696A1 (en) 1997-02-20
GR3034795T3 (en) 2001-02-28
EP0842166B1 (en) 2000-11-08
AU6643996A (en) 1997-03-05
DE69610924T2 (de) 2001-05-17
EP0842166A1 (en) 1998-05-20
EP0842166A4 (en) 1998-11-25

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