ES2152976T3 - Proteina crp mutante, procedimientos y medios para su fabricacion y su utilizacion. - Google Patents
Proteina crp mutante, procedimientos y medios para su fabricacion y su utilizacion.Info
- Publication number
- ES2152976T3 ES2152976T3 ES94909837T ES94909837T ES2152976T3 ES 2152976 T3 ES2152976 T3 ES 2152976T3 ES 94909837 T ES94909837 T ES 94909837T ES 94909837 T ES94909837 T ES 94909837T ES 2152976 T3 ES2152976 T3 ES 2152976T3
- Authority
- ES
- Spain
- Prior art keywords
- unmutated
- amino acid
- crp
- precrp
- subunit
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 102000008300 Mutant Proteins Human genes 0.000 abstract 8
- 108010021466 Mutant Proteins Proteins 0.000 abstract 8
- 108010074051 C-Reactive Protein Proteins 0.000 abstract 6
- 102100032752 C-reactive protein Human genes 0.000 abstract 6
- 150000001413 amino acids Chemical class 0.000 abstract 5
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
- 238000012258 culturing Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4737—C-reactive protein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
LA INVENCION SE REFIERE A UNA PROTEINA MUTANTE QUE TIENE LA MISMA SECUENCIA AMINOACIDA QUE UNA SUBUNIDAD DE PROTEINA CREACTIVA NO MUTADA (CRP) O PRECPR NO MUTADA, SALVO QUE AL MENOS UN AMINOACIDO DE LA SUBUNIDAD CRP NO MUTADA O PRECRP NO MUTADA HA SIDO ELIMINADO, AL MENOS UN AMINOACIDO DE LA SUBUNIDAD CRP NO MUTADA O PRECRP NO MUTADA HA SIDO SUSTITUIDO POR OTRO AMINOACIDO, AL MENOS UN AMINOACIDO HA SIDO AÑADIDO A LA SUBUNIDAD CRP NO MUTADA O PRECRP , O UNA COMBINACION DE TALES CAMBIOS HA SIDO REALIZADA. LOS AMINOACIDOS AÑADIDOS, ELIMINADO Y/O SUSTITUIDOS SON ELEGIDOS DE MANERA QUE LA PROTEINA MUTANTE ES MENOS APROPIADA PARA FORMAR AGREGADOS COVALENTEMENTE RETICULADOS QUE LA SUBUNIDAD CRP NO MUTADA O PRECRP NO MUTADA. LA PROTEINA MUTANTE TAMBIEN EXHIBE AL MENOS UNA DE LAS ACTIVIDADES BIOLOGICAS DE CRP MODIFICADA. LA INVENCION TAMBIEN PREVE MOLECULAS DE ADN QUE CODIFICAN LAS PROTEINAS MUTANTES DE LA INVENCION, VECTORES PARA EXPRESAR LAS PROTEINAS MUTANTES, CELULAS HUESPEDES QUE HAN SIDO TRANSFORMADAS DE MANERA QUE PUEDAN EXPRESAR LA PROTEINAS MUTANTES, Y UN METODO PARA PRODUCIR LAS PROTEINAS MUTANTES DE LA INVENCION QUE CONSISTE EN CULTIVAR LA CELULAS HUESPEDES TRANSFORMADAS. FINALMENTE LA INVENCION SE REFIERE A LOS METODOS Y MATERIALES PARA USAR LAS PROTEINAS MUTANTES.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2395293A | 1993-02-26 | 1993-02-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2152976T3 true ES2152976T3 (es) | 2001-02-16 |
Family
ID=21818104
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES94909837T Expired - Lifetime ES2152976T3 (es) | 1993-02-26 | 1994-02-24 | Proteina crp mutante, procedimientos y medios para su fabricacion y su utilizacion. |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0688224B1 (es) |
| JP (1) | JPH08507212A (es) |
| AT (1) | ATE196649T1 (es) |
| AU (1) | AU6252294A (es) |
| DE (1) | DE69426018T2 (es) |
| ES (1) | ES2152976T3 (es) |
| WO (1) | WO1994018999A1 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2675100A1 (en) * | 2007-01-20 | 2008-07-24 | Boehringer Ingelheim International Gmbh | C-reactive protein (crp) knockout mouse |
| MX2016012840A (es) | 2014-03-31 | 2017-05-09 | Boehringer Ingelheim Vetmedica Gmbh | Moléculas para transporte de antígeno modular mejoradas y sus usos. |
| KR20180061338A (ko) | 2015-09-30 | 2018-06-07 | 베링거잉겔하임베트메디카게엠베하 | 동물에서의 개선된 모듈러 항원 수송 분자 및 이의 용도 |
| CN115785193B (zh) * | 2022-11-25 | 2023-11-21 | 天津鸿宇泰生物科技有限公司 | 一种用于包涵体蛋白复性的复性缓冲液以及方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1989009628A1 (en) * | 1988-04-04 | 1989-10-19 | Potempa Lawrence A | Binding of immune complexes by modified forms of c-reactive protein |
-
1994
- 1994-02-24 JP JP6519333A patent/JPH08507212A/ja active Pending
- 1994-02-24 ES ES94909837T patent/ES2152976T3/es not_active Expired - Lifetime
- 1994-02-24 AT AT94909837T patent/ATE196649T1/de not_active IP Right Cessation
- 1994-02-24 EP EP94909837A patent/EP0688224B1/en not_active Expired - Lifetime
- 1994-02-24 WO PCT/US1994/002181 patent/WO1994018999A1/en not_active Ceased
- 1994-02-24 AU AU62522/94A patent/AU6252294A/en not_active Abandoned
- 1994-02-24 DE DE69426018T patent/DE69426018T2/de not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JPH08507212A (ja) | 1996-08-06 |
| AU6252294A (en) | 1994-09-14 |
| DE69426018T2 (de) | 2001-02-22 |
| WO1994018999A1 (en) | 1994-09-01 |
| DE69426018D1 (de) | 2000-11-02 |
| EP0688224A4 (en) | 1997-09-10 |
| EP0688224A1 (en) | 1995-12-27 |
| ATE196649T1 (de) | 2000-10-15 |
| EP0688224B1 (en) | 2000-09-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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