ES2153034T3 - Sistema de suministro en microparticulas. - Google Patents

Sistema de suministro en microparticulas.

Info

Publication number
ES2153034T3
ES2153034T3 ES95918482T ES95918482T ES2153034T3 ES 2153034 T3 ES2153034 T3 ES 2153034T3 ES 95918482 T ES95918482 T ES 95918482T ES 95918482 T ES95918482 T ES 95918482T ES 2153034 T3 ES2153034 T3 ES 2153034T3
Authority
ES
Spain
Prior art keywords
nucleus
particulated
organometal
agent
polymer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95918482T
Other languages
English (en)
Inventor
Mark R Mcdermott
Michael A Brook
Philippa L Heritage
Brian J Underdown
Lesley M Loomes
Jianxiong Jiang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
McMaster University
Original Assignee
McMaster University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by McMaster University filed Critical McMaster University
Application granted granted Critical
Publication of ES2153034T3 publication Critical patent/ES2153034T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/10—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a carbohydrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • C07K17/02—Peptides being immobilised on, or in, an organic carrier
    • C07K17/10—Peptides being immobilised on, or in, an organic carrier the carrier being a carbohydrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SE FACILIGA UN VEHICULO PARTICULADO PARA UN AGENTE QUE INCLUYE UN NUCLEO SOLIDO DE UN POLISACARIDO Y UN MATERIAL PROTEINACEO ASI COMO UN POLIMERO ORGANOMETALICO UNIDOS AL NUCLEO. EL AGENTE TIENE UNA ACTIVIDAD BIOLOGICA, COMO LA REFERIDA A LA INMUNOGENICIDAD, Y PUEDE INCLUIR EL MATERIAL PROTEINACEO O ESTAR SEPARADO DEL NUCLEO. LOS NUCLEOS DE POLISACARIDOS INCLUYEN DEXTRANO, ALMIDON, CELULOSA Y DERIVADOS DE LO ANTERIOR INCLUYENDO EL POLIMERO ORGANOMETALICO SILICONAS Y SUSTITUTIVOS DE SILICONAS. LOS VEHICULOS PARTICULADOS TIENEN UTILIDAD PARA ENVIAR AGENTES AL SISTEMA INMUNOLOGICO DE UN SUJETO MEDIANTE ADMINISTRACION MUCOSA O PARENTERAL PARA PRODUCIR RESPUESTAS INMUNES, INCLUYENDO RESPUESTAS DE ANTICUERPOS.
ES95918482T 1994-05-18 1995-05-18 Sistema de suministro en microparticulas. Expired - Lifetime ES2153034T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/245,646 US5571531A (en) 1994-05-18 1994-05-18 Microparticle delivery system with a functionalized silicone bonded to the matrix

Publications (1)

Publication Number Publication Date
ES2153034T3 true ES2153034T3 (es) 2001-02-16

Family

ID=22927514

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95918482T Expired - Lifetime ES2153034T3 (es) 1994-05-18 1995-05-18 Sistema de suministro en microparticulas.

Country Status (11)

Country Link
US (1) US5571531A (es)
EP (1) EP0762875B1 (es)
AT (1) ATE198153T1 (es)
AU (1) AU2441995A (es)
CA (1) CA2190591C (es)
DE (1) DE69519670T2 (es)
DK (1) DK0762875T3 (es)
ES (1) ES2153034T3 (es)
GR (1) GR3035544T3 (es)
PT (1) PT762875E (es)
WO (1) WO1995031187A1 (es)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0732936T3 (da) * 1993-12-09 2000-09-04 Heinrich Exner Adjuvans til antigener, fremgangsmåde til fremstilling og anvendelse
US5583162A (en) * 1994-06-06 1996-12-10 Biopore Corporation Polymeric microbeads and method of preparation
US6465253B1 (en) 1994-09-08 2002-10-15 Genvec, Inc. Vectors and methods for gene transfer to cells
US5846782A (en) * 1995-11-28 1998-12-08 Genvec, Inc. Targeting adenovirus with use of constrained peptide motifs
US5770442A (en) * 1995-02-21 1998-06-23 Cornell Research Foundation, Inc. Chimeric adenoviral fiber protein and methods of using same
US6127525A (en) * 1995-02-21 2000-10-03 Cornell Research Foundation, Inc. Chimeric adenoviral coat protein and methods of using same
US6783980B2 (en) 1995-06-15 2004-08-31 Crucell Holland B.V. Packaging systems for human recombinant adenovirus to be used in gene therapy
GB9709900D0 (en) 1997-05-15 1997-07-09 Microbiological Res Authority Microencapsulated DNA for vaccination and gene therapy
US6270795B1 (en) 1995-11-09 2001-08-07 Microbiological Research Authority Method of making microencapsulated DNA for vaccination and gene therapy
WO1997017063A1 (en) 1995-11-09 1997-05-15 Microbiological Research Authority Microencapsulated dna for vaccination and gene therapy
EP0888124A4 (en) * 1996-03-22 2001-04-11 Univ Georgia Res Found Immunogenic assemblies of Porphyromonas Gingivalis peptides and their methods
US6077662A (en) * 1996-11-27 2000-06-20 Emory University Virus-like particles, methods and immunogenic compositions
AU7563798A (en) * 1997-04-30 1998-11-24 Emory University Methods and compositions for administering dna to mucosal surfaces
TW586934B (en) * 1997-05-19 2004-05-11 Sumitomo Pharma Immunopotentiating composition
US6048908A (en) * 1997-06-27 2000-04-11 Biopore Corporation Hydrophilic polymeric material
US7022683B1 (en) 1998-05-13 2006-04-04 Carrington Laboratories, Inc. Pharmacological compositions comprising pectins having high molecular weights and low degrees of methoxylation
US6406719B1 (en) 1998-05-13 2002-06-18 Microbiological Research Authority Encapsulation of bioactive agents
GB9810236D0 (en) 1998-05-13 1998-07-08 Microbiological Res Authority Improvements relating to encapsulation of bioactive agents
US20030017138A1 (en) 1998-07-08 2003-01-23 Menzo Havenga Chimeric adenoviruses
WO2000014547A1 (en) * 1998-09-04 2000-03-16 Powderject Research Limited Immunodiagnostics using particle delivery methods
US6929946B1 (en) 1998-11-20 2005-08-16 Crucell Holland B.V. Gene delivery vectors provided with a tissue tropism for smooth muscle cells, and/or endothelial cells
US6492169B1 (en) 1999-05-18 2002-12-10 Crucell Holland, B.V. Complementing cell lines
US6913922B1 (en) 1999-05-18 2005-07-05 Crucell Holland B.V. Serotype of adenovirus and uses thereof
US20020006412A1 (en) * 2000-04-28 2002-01-17 Roberts Bruce L. Preparation and use of particulates composed of adenovirus particles
DE60138403D1 (de) 2000-09-26 2009-05-28 Crucell Holland Bv Adenovirale vektoren für die übertragung von genen in zellen der skelettmuskulatur oder myoblasten
WO2002032396A2 (en) * 2000-10-16 2002-04-25 Massachusetts Institute Of Technology Lipid-protein-sugar particles for delivery of nucleic acids
US20020150621A1 (en) * 2000-10-16 2002-10-17 Kohane Daniel S. Lipid-protein-sugar particles for drug delivery
US6596262B2 (en) * 2001-02-15 2003-07-22 Aeropharm Technology Incorporated Modulated release particles for aerosol delivery
US7494669B2 (en) 2001-02-28 2009-02-24 Carrington Laboratories, Inc. Delivery of physiological agents with in-situ gels comprising anionic polysaccharides
US6777000B2 (en) 2001-02-28 2004-08-17 Carrington Laboratories, Inc. In-situ gel formation of pectin
AU2002367976B2 (en) * 2001-06-05 2007-06-21 The Regents Of The University Of Michigan Nanoemulsion vaccines
EP1434571B1 (en) * 2001-10-05 2005-05-11 SurModics, Inc. Particle immobilized coatings and uses thereof
PL215165B1 (pl) 2002-04-25 2013-10-31 Crucell Holland Bv Rekombinowany wektor adenowirusowy oraz sposób wytwarzania rekombinowanego wektora adenowirusowego
JP4060167B2 (ja) * 2002-11-14 2008-03-12 花王株式会社 化粧料組成物
US7943179B2 (en) 2003-09-23 2011-05-17 Massachusetts Institute Of Technology pH triggerable polymeric particles
US20080038295A1 (en) * 2006-04-13 2008-02-14 Regents Of The University Of Michigan Compositions and methods for orthopox virus vaccination
US10138279B2 (en) 2006-04-13 2018-11-27 Regents Of The University Of Michigan Compositions and methods for Bacillus anthracis vaccination
US9839685B2 (en) * 2006-04-13 2017-12-12 The Regents Of The University Of Michigan Methods of inducing human immunodeficiency virus-specific immune responses in a host comprising nasally administering compositions comprising a naonemulsion and recombinant GP120 immunogen
US7638344B2 (en) * 2006-06-28 2009-12-29 Surmodics, Inc. Active agent eluting matrices with particulates
FR2931360B1 (fr) * 2008-05-20 2012-05-18 Centre Nat Rech Scient Nanoparticules contenant un peptide, vecteurs les contenant et utilisations pharmaceutiques desdits nanoparticules et vecteurs
WO2009143524A2 (en) * 2008-05-23 2009-11-26 The Regents Of The University Of Michigan Nanoemulsion vaccines
BR112014018732A8 (pt) 2012-02-01 2017-07-11 Univ Arizona Composições imunogênicas contra campylobacter e usos das mesmas

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH453269A4 (es) * 1968-03-29 1973-01-31
US4251387A (en) * 1979-04-17 1981-02-17 Damon Corporation Process for preparing semipermeable microcapsules
US4389330A (en) * 1980-10-06 1983-06-21 Stolle Research And Development Corporation Microencapsulation process
US4798786A (en) * 1982-05-06 1989-01-17 Stolle Research And Development Corporation Living cells encapsulated in crosslinked protein
FR2602423B1 (fr) * 1986-08-08 1989-05-05 Ethypharm Sa Procede de preparation d'un medicament a base de fenofibrate, medicament obtenu par ce procede
US5075109A (en) * 1986-10-24 1991-12-24 Southern Research Institute Method of potentiating an immune response
CA1301109C (en) * 1986-12-17 1992-05-19 Peter Y.K. Lo Process for preparing silicone microparticles
FR2631826B1 (fr) * 1988-05-27 1992-06-19 Centre Nat Rech Scient Vecteur particulaire utile notamment pour le transport de molecules a activite biologique et procede pour sa preparation
FR2652820B1 (fr) * 1989-10-09 1993-12-24 Rhone Poulenc Chimie Suspensions stables de zeolites comprenant un succinoglycane.
GB2237510B (en) * 1989-11-04 1993-09-15 Danbiosyst Uk Small particle drug compositions for nasal administration
WO1991009678A1 (en) * 1989-12-22 1991-07-11 Omni Quest Corporation Organo-metallic coated particles for use in separations
BE1003677A3 (nl) * 1990-01-29 1992-05-19 Schacht Etienne Werkwijze voor het bereiden van azobevattende polymeren en het gebruik ervan als geneesmiddelafgiftesystemen.

Also Published As

Publication number Publication date
ATE198153T1 (de) 2001-01-15
GR3035544T3 (en) 2001-06-29
DK0762875T3 (da) 2001-01-08
AU2441995A (en) 1995-12-05
EP0762875A1 (en) 1997-03-19
WO1995031187A1 (en) 1995-11-23
EP0762875B1 (en) 2000-12-20
US5571531A (en) 1996-11-05
DE69519670T2 (de) 2001-05-31
DE69519670D1 (de) 2001-01-25
CA2190591A1 (en) 1995-11-23
CA2190591C (en) 2001-08-28
PT762875E (pt) 2001-05-31

Similar Documents

Publication Publication Date Title
PT850046E (pt) Microemulsoes para utilizacao como veiculos para administracao de compostos activos
OA08481A (fr) Dérivés d'indolizine, leur procédé de préparation ainsi que les compositions les contenant.
BR9809791A (pt) Compostos de fosfato de aminoalquil glucosamina e seu uso como auxiliares e imuno efetores
FI934227A0 (fi) Foerbaettringar i eller relaterande till kontrastmedel
DE3686953D1 (de) Lyophilisierter schaum.
DE69839251D1 (de) Alpha interferon-polymer konjugate mit erhöhter biologischer wirksamkeit sowie verfahren zu deren herstellung
ES2188652T3 (es) Sistema de direccionado de farmacos, metodos de fabricacion y uso del mismo.
ES551371A0 (es) Procedimiento para preparar una dispersion acuosa estable, congelada, de un copolimero y una droga insoluble en agua. (como desglose y con prioridad de la patente espanola no. 544.580, presentada el 26 de junio de 1985).
ITRM920590A0 (it) Sistema per la realizzazione distrutture in fibra di carbonio, e procedimento per detto, particolarmente idoneo per applicazioni aeronautiche.
ES2159564T3 (es) Preparados farmaceuticos para principios activos dificilmente solubles.
ATE501T1 (de) Kolloide waessrige zusammensetzung fuer pharmazeutische zwecke, und deren herstellung.
KR890011609A (ko) 구충 분열체를 사용한 포자충증에 대한 생백신
IL112667A0 (en) 6-substituted derivatives of mycophenolic acid, their preparation and pharmaceutical compositions containing them
DE69812343D1 (de) Feste pharmazeutische formulierungen enthaltend eine physische mischung aus sulphoalkylethercyclodextrin und einem therapeutischen wirkstoff
ES8303702A1 (es) "un procedimiento para preparar un vehiculo artificial util para el material de un reactivo de diagnostico".
IE871203L (en) Formulations containing unsaturated fatty acids
IL123642A (en) Pharmaceutical compositions comprising mononuclear phagocytes to promote axonal regeneration
ES522637A0 (es) Procedimiento para la preparacion de nuevas sustancias ws 6049.
KR900007424A (ko) 세포보호성 약제로서의 n-아세틸글루코사민의 사용방법 및 그 조성물
ATE56139T1 (de) Verfahren zur herstellung einer waessrigen pharmazeutischen loesung einer organischen saeure als wirkstoff.
ATE168695T1 (de) Glycosyl-etoposid-prodrugs, verfahren zu ihrer herstellung und ihre anwendung in kombination mit funktionalisierten tumorspezifischen enzym- konjugaten
ATE226065T1 (de) Feste instant-release-darreichungsformen und verfahren zu ihrer herstellung
SE8803935D0 (sv) Laekemedelskomposition
KR860003825A (ko) 안정한 현탁액 제조용 고체 약물제형의 제조방법
EP0547102A4 (es)

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 762875

Country of ref document: ES