ES2153097T3 - Procedimiento de inmovilizacion fotoquimica de ligandos usando quinonas. - Google Patents
Procedimiento de inmovilizacion fotoquimica de ligandos usando quinonas.Info
- Publication number
- ES2153097T3 ES2153097T3 ES96909990T ES96909990T ES2153097T3 ES 2153097 T3 ES2153097 T3 ES 2153097T3 ES 96909990 T ES96909990 T ES 96909990T ES 96909990 T ES96909990 T ES 96909990T ES 2153097 T3 ES2153097 T3 ES 2153097T3
- Authority
- ES
- Spain
- Prior art keywords
- pct
- date oct
- photochemically reactive
- quinonas
- ligands
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000003446 ligand Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 239000000463 material Substances 0.000 abstract 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 230000005670 electromagnetic radiation Effects 0.000 abstract 1
- 230000003100 immobilizing effect Effects 0.000 abstract 1
- AZQWKYJCGOJGHM-UHFFFAOYSA-N para-benzoquinone Natural products O=C1C=CC(=O)C=C1 AZQWKYJCGOJGHM-UHFFFAOYSA-N 0.000 abstract 1
- -1 quinone compound Chemical class 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
- C07K1/042—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers characterised by the nature of the carrier
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J7/00—Chemical treatment or coating of shaped articles made of macromolecular substances
- C08J7/12—Chemical modification
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/31504—Composite [nonstructural laminate]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/31504—Composite [nonstructural laminate]
- Y10T428/31511—Of epoxy ether
- Y10T428/31515—As intermediate layer
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/31504—Composite [nonstructural laminate]
- Y10T428/31511—Of epoxy ether
- Y10T428/31515—As intermediate layer
- Y10T428/31518—Next to glass or quartz
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Treatments Of Macromolecular Shaped Articles (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Carbon And Carbon Compounds (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
UN METODO PARA LA INMOVILIZACION DE UN LIGANDO (L) SOBRE UNA SUPERFICIE (P) DE UN MATERIAL SUBSTRATO QUE CONTIENE CARBONO, COMPRENDIENDO DICHO METODO: UNA ETAPA FOTOQUIMICA DE UNION DE UNO O MAS COMPUESTOS FOTOQUIMICAMENTE REACTIVOS (Q) A UNA SUPERFICIE DE UN MATERIAL QUE CONTIENE CARBONO (P); EN EL QUE EL COMPUESTO FOTOQUIMICAMENTE REACTIVO (Q) ES UN COMPUESTO QUINONA QUE CONTIENE UN HIDROCARBURO CICLICO O ENTRE 2 Y 10 HIDROCARBUROS CONDENSADOS, CON AL MENOS DOS GRUPOS CARBONILO CONJUGADOS Y EN EL QUE EL PASO FOTOQUIMICO COMPRENDE LA IRRADIACION DEL COMPUESTO FOTOQUIMICAMENTE REACTIVO (Q) CON RADIACION ELECTROMAGNETICA NO IONIZANTE QUE TIENE UNA LONGITUD DE ONDA EN EL INTERVALO ENTRE LA LUZ UV Y LA LUZ VISIBLE.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK42595 | 1995-04-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2153097T3 true ES2153097T3 (es) | 2001-02-16 |
Family
ID=8093384
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES96909990T Expired - Lifetime ES2153097T3 (es) | 1995-04-07 | 1996-04-03 | Procedimiento de inmovilizacion fotoquimica de ligandos usando quinonas. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6033784A (es) |
| EP (1) | EP0820483B1 (es) |
| JP (1) | JP3124037B2 (es) |
| AT (1) | ATE198079T1 (es) |
| AU (1) | AU699321B2 (es) |
| CA (1) | CA2217053C (es) |
| DE (1) | DE69611235T2 (es) |
| DK (1) | DK0820483T3 (es) |
| ES (1) | ES2153097T3 (es) |
| GR (1) | GR3035079T3 (es) |
| PT (1) | PT820483E (es) |
| WO (1) | WO1996031557A1 (es) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1015469B2 (en) | 1997-09-12 | 2015-11-18 | Exiqon A/S | Bi- and tri-cyclic nucleoside, nucleotide and oligonucleoide analogues |
| US6762019B2 (en) * | 1997-09-30 | 2004-07-13 | Surmodics, Inc. | Epoxide polymer surfaces |
| US6465178B2 (en) * | 1997-09-30 | 2002-10-15 | Surmodics, Inc. | Target molecule attachment to surfaces |
| US6132561A (en) * | 1997-10-13 | 2000-10-17 | Mincher; Bruce J. | Process for the solvent extraction for the radiolysis and dehalogenation of halogenated organic compounds in soils, sludges, sediments and slurries |
| DE19818360C2 (de) * | 1998-04-24 | 2000-05-31 | Suisse Electronique Microtech | Dextranbeschichtete Oberfläche |
| EP1141718B1 (en) * | 1998-12-15 | 2005-07-20 | Exiqon A/S | Coupling of lipopolysaccharide-derived carbohydrates onto solid surfaces |
| US6436653B1 (en) | 1998-12-15 | 2002-08-20 | Exiqon A/S | Method for introduction of reporter groups into bacterial lipopolysaccharide-derived carbohydrates and the subsequent coupling of such derivatives onto solid surfaces |
| AUPP856399A0 (en) * | 1999-02-08 | 1999-03-04 | Australian Membrane And Biotechnology Research Institute | Improved compounds for protein binding |
| BRPI0008131B8 (pt) | 1999-02-12 | 2021-05-25 | Daiichi Sankyo Co Ltd | composto ou um sal deste, análogo de oligonucleotídeo, composição farmacêutica, sonda para um gene,iniciador para começar a amplificação, uso de um análogo de oligonucleotídeo ou de um sal deste farmacologicamente aceitável, agente antisentido, e, agente antígeno |
| DE60045706D1 (de) | 1999-03-18 | 2011-04-21 | Exiqon As | Detektion von genmutationen mittels lna primer |
| US6780980B1 (en) * | 1999-06-30 | 2004-08-24 | Centre Suisse D'electronique Et De Microtechnique S.A. | Process for the modification of surface |
| US6531591B1 (en) | 1999-07-07 | 2003-03-11 | Exiqon A/S | Synthesis of stable quinone and photoreactive ketone phosphoramidite reagents for solid phase synthesis of photoreactive-oligomer conjugates |
| JP4151751B2 (ja) | 1999-07-22 | 2008-09-17 | 第一三共株式会社 | 新規ビシクロヌクレオシド類縁体 |
| AU2001277635A1 (en) * | 2000-03-14 | 2001-10-08 | Exiqon A/S | New methods for separation and isolation of subpopulations of cells in biological samples |
| DE10041809A1 (de) * | 2000-08-25 | 2002-03-07 | Giesing Michael | Arrays immobilisierter Biomoleküle, deren Herstellung und Verwendung |
| DE10105079A1 (de) * | 2001-02-05 | 2002-08-08 | Febit Ferrarius Biotech Gmbh | Fotolabile Schutzgruppen für die Synthese von Biopolymeren |
| US20020187178A1 (en) * | 2001-05-04 | 2002-12-12 | Roe R. Michael | Polymer conjugates of insecticidal peptides or nucleic acids and methods of use thereof |
| US20030108585A1 (en) * | 2001-05-04 | 2003-06-12 | Roe R. Michael | Polymer conjugates of insecticidal peptides or nucleic acids or insecticides and methods of use thereof |
| US7060809B2 (en) | 2001-09-04 | 2006-06-13 | Exiqon A/S | LNA compositions and uses thereof |
| AU2002351164A1 (en) * | 2001-11-26 | 2003-06-10 | Molecular Reflections, Inc. | Microscale immobilization of molecules using a hydrogel and methods of use thereof |
| JP3888947B2 (ja) * | 2002-02-01 | 2007-03-07 | 日清紡績株式会社 | 生体分子の担体への固定法 |
| US20030198967A1 (en) * | 2002-04-23 | 2003-10-23 | Matson Robert S. | Multi-functional microarrays and methods |
| CA2489077A1 (en) * | 2002-06-07 | 2003-12-18 | Picosep A/S | Method and system for multi-stage isoelectric focussing |
| US7629016B2 (en) * | 2002-06-10 | 2009-12-08 | Council of Industrial and Scientific Research | Process for photochemical activation of polymer surface and immobilization of biomolecules onto the activated surface |
| EP1546404A2 (en) * | 2002-09-11 | 2005-06-29 | Exiqon A/S | A population of nucleic acids including a subpopulation of lna oligomers |
| US20040219565A1 (en) * | 2002-10-21 | 2004-11-04 | Sakari Kauppinen | Oligonucleotides useful for detecting and analyzing nucleic acids of interest |
| EP2143482A1 (en) * | 2003-02-19 | 2010-01-13 | Natrix Separations Inc. | Composite materials comprising supported porous gels |
| DE10323685A1 (de) * | 2003-05-22 | 2004-12-09 | Rühe, Jürgen, Prof. Dr. | Verfahren zur kovalenten Immobilisierung von Sonden-Biomolekülen an organischen Oberflächen |
| EP1722228A1 (en) * | 2004-03-05 | 2006-11-15 | Nisshinbo Industries, Inc. | Immobilized biomolecule and method of detecting substance capable of interacting with biomolecule |
| EP1758671B9 (en) | 2004-04-08 | 2014-02-19 | Natrix Separations Inc. | Membrane stacks |
| US7026851B2 (en) * | 2004-05-12 | 2006-04-11 | System General Corp. | PWM controller having frequency jitter for power supplies |
| JP4806401B2 (ja) * | 2004-06-07 | 2011-11-02 | ナトリックス セパレイションズ インコーポレーテッド | 支持型多孔質ゲルを含む安定な複合材料 |
| WO2006083328A2 (en) * | 2004-09-15 | 2006-08-10 | Massachusetts Institute Of Technology | Biologically active surfaces and methods of their use |
| GB0424560D0 (en) | 2004-11-08 | 2004-12-08 | Leuven K U Res & Dev | Heart valve tissue engineering |
| US20060199207A1 (en) * | 2005-02-24 | 2006-09-07 | Matysiak Stefan M | Self-assembly of molecules using combinatorial hybridization |
| JP5217973B2 (ja) * | 2007-12-05 | 2013-06-19 | 大日本印刷株式会社 | 物質固定化用担体の製造方法 |
| KR102178191B1 (ko) | 2008-09-02 | 2020-11-13 | 머크 밀리포어 리미티드 | 크로마토그래피 막, 이를 포함하는 장치 및 이의 이용방법 |
| CA2780095C (en) * | 2009-11-13 | 2018-12-11 | Merck Millipore Ltd. | Hydrophobic interaction chromatography membranes, and methods of use thereof |
| EP2575897A4 (en) | 2010-06-01 | 2016-06-01 | Advanced Proteome Therapeutics Inc | CROSSLINKING OF PROTEINS AND OTHER ENTITIES THROUGH ALPHA-HALO-ACETOPHENONES CONJUGATES, BENZYL HALIDES, QUINONES |
| US9873088B2 (en) | 2011-05-17 | 2018-01-23 | Natrix Separations Inc. | Layered tubular membranes for chromatography, and methods of use thereof |
| KR102392089B1 (ko) | 2012-09-26 | 2022-04-28 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 소형 유기 분자를 이용한 플로우 전지 |
| CN106063017B (zh) | 2013-09-26 | 2020-05-19 | 哈佛大学校长及研究员协会 | 基于醌和氢醌的液流电池 |
| US11923581B2 (en) | 2016-08-12 | 2024-03-05 | President And Fellows Of Harvard College | Aqueous redox flow battery electrolytes with high chemical and electrochemical stability, high water solubility, low membrane permeability |
| US10840532B2 (en) | 2017-01-27 | 2020-11-17 | President And Fellows Of Harvard College | Flow battery with electrolyte rebalancing system |
| WO2019157437A1 (en) | 2018-02-09 | 2019-08-15 | President And Fellows Of Harvard College | Quinones having high capacity retention for use as electrolytes in aqueous redox flow batteries |
| WO2020072406A2 (en) | 2018-10-01 | 2020-04-09 | President And Fellows Of Harvard College | Extending the lifetime of organic flow batteries via redox state management |
| AU2020233571B2 (en) | 2019-03-04 | 2025-05-22 | Immunolight, Llc | Energy augmentation structures for use with energy emitters and collectors |
| CN112390739B (zh) * | 2020-11-06 | 2022-06-17 | 南京航空航天大学 | 一种用于电催化制备过氧化氢的催化剂及其制备方法 |
| EP4305193B1 (en) | 2021-03-09 | 2025-09-17 | Illumina, Inc. | Polymers, methods of making polymers, and methods of coupling oligonucleotides to polymers |
| CN117813118A (zh) * | 2021-07-30 | 2024-04-02 | 因美纳有限公司 | 光活化的寡核苷酸与聚合物的偶联 |
| CN114716289B (zh) * | 2022-03-30 | 2024-03-01 | 华中师范大学 | 一种手性苄醇类衍生物的制备方法 |
| JP7765423B2 (ja) * | 2023-02-14 | 2025-11-06 | ノリタケ株式会社 | 添加剤および金属の製造方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US32991A (en) * | 1861-08-06 | Improvement in locomotives and steam-carriages for common roads | ||
| US31712A (en) * | 1861-03-19 | Improvement in plows | ||
| US3891327A (en) * | 1973-11-01 | 1975-06-24 | Grace W R & Co | Mounted slides and method of securing a cover glass to a glass slide having a specimen thereon |
| US4016306A (en) * | 1974-07-15 | 1977-04-05 | Mitsubishi Rayon Co., Ltd. | Process for forming a coated film in water |
| USRE31712E (en) | 1980-01-24 | 1984-10-23 | Biochemical avidin-biotin multiple-layer system | |
| US4737544A (en) * | 1982-08-12 | 1988-04-12 | Biospecific Technologies, Inc. | Biospecific polymers |
| US4722906A (en) * | 1982-09-29 | 1988-02-02 | Bio-Metric Systems, Inc. | Binding reagents and methods |
| US4973493A (en) | 1982-09-29 | 1990-11-27 | Bio-Metric Systems, Inc. | Method of improving the biocompatibility of solid surfaces |
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| SE8401437D0 (sv) * | 1984-03-14 | 1984-03-14 | Sven Gothe | Ytmodifierade plastytor och dess tillempningar for immunoassays (ia) |
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| DK641487A (da) * | 1987-12-07 | 1989-06-08 | Gluetech Aps | Fremgangsmaade til modificering af polymeroverflader |
| JPH01153776A (ja) * | 1987-12-10 | 1989-06-15 | Fuji Kagakushi Kogyo Co Ltd | 印字用液状インク |
| CA1335721C (en) * | 1987-12-24 | 1995-05-30 | Patrick E. Guire | Biomolecule attached to a solid surface by means of a spacer and methods of attaching biomolecules to surfaces |
| DE69031655T2 (de) * | 1989-08-21 | 1998-05-14 | Mag Georg Mayrhofer & Co Ohg | Immobilisierung von molekülen durch verwendung von radioderivatisierten polymeren |
| US5252743A (en) * | 1989-11-13 | 1993-10-12 | Affymax Technologies N.V. | Spatially-addressable immobilization of anti-ligands on surfaces |
| US5292873A (en) * | 1989-11-29 | 1994-03-08 | The Research Foundation Of State University Of New York | Nucleic acids labeled with naphthoquinone probe |
| IT1251576B (it) * | 1991-10-02 | 1995-05-17 | Donegani Guido Ist | Procedimento per aggraffare a corpi formati aventi superfici polimeriche monomeri idrofili contenti doppi legami. |
| US5378502A (en) * | 1992-09-09 | 1995-01-03 | U.S. Philips Corporation | Method of chemically modifying a surface in accordance with a pattern |
| US5288514A (en) * | 1992-09-14 | 1994-02-22 | The Regents Of The University Of California | Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support |
| US5409731A (en) * | 1992-10-08 | 1995-04-25 | Tomei Sangyo Kabushiki Kaisha | Method for imparting a hydrophilic nature to a contact lens |
| DE4331086A1 (de) * | 1993-09-11 | 1995-03-16 | Herberts Gmbh | Verfahren zur Fixierung von Wickelgütern mit radikalisch polymerisierbaren Massen |
| US5391438A (en) * | 1993-10-01 | 1995-02-21 | Texaco Inc. | Polymer treating process |
-
1996
- 1996-04-03 ES ES96909990T patent/ES2153097T3/es not_active Expired - Lifetime
- 1996-04-03 DE DE69611235T patent/DE69611235T2/de not_active Expired - Lifetime
- 1996-04-03 PT PT96909990T patent/PT820483E/pt unknown
- 1996-04-03 CA CA2217053A patent/CA2217053C/en not_active Expired - Lifetime
- 1996-04-03 AT AT96909990T patent/ATE198079T1/de active
- 1996-04-03 WO PCT/DK1996/000167 patent/WO1996031557A1/en not_active Ceased
- 1996-04-03 JP JP08529895A patent/JP3124037B2/ja not_active Expired - Lifetime
- 1996-04-03 DK DK96909990T patent/DK0820483T3/da active
- 1996-04-03 US US08/930,623 patent/US6033784A/en not_active Expired - Lifetime
- 1996-04-03 EP EP96909990A patent/EP0820483B1/en not_active Expired - Lifetime
- 1996-04-03 AU AU53329/96A patent/AU699321B2/en not_active Expired
-
2000
- 2000-12-14 GR GR20000402602T patent/GR3035079T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GR3035079T3 (en) | 2001-03-30 |
| ATE198079T1 (de) | 2000-12-15 |
| DK0820483T3 (da) | 2001-01-02 |
| AU5332996A (en) | 1996-10-23 |
| JP3124037B2 (ja) | 2001-01-15 |
| WO1996031557A1 (en) | 1996-10-10 |
| US6033784A (en) | 2000-03-07 |
| EP0820483A1 (en) | 1998-01-28 |
| DE69611235T2 (de) | 2001-04-05 |
| EP0820483B1 (en) | 2000-12-13 |
| CA2217053C (en) | 2010-11-30 |
| AU699321B2 (en) | 1998-12-03 |
| CA2217053A1 (en) | 1996-10-10 |
| DE69611235D1 (de) | 2001-01-18 |
| PT820483E (pt) | 2001-03-30 |
| JPH11505554A (ja) | 1999-05-21 |
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