ES2153648T3 - Polimeros con estado fisico y bioerosionabilidad controlados. - Google Patents

Polimeros con estado fisico y bioerosionabilidad controlados.

Info

Publication number
ES2153648T3
ES2153648T3 ES97901352T ES97901352T ES2153648T3 ES 2153648 T3 ES2153648 T3 ES 2153648T3 ES 97901352 T ES97901352 T ES 97901352T ES 97901352 T ES97901352 T ES 97901352T ES 2153648 T3 ES2153648 T3 ES 2153648T3
Authority
ES
Spain
Prior art keywords
polymers
esters
bioerosionability
physical state
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97901352T
Other languages
English (en)
Inventor
Jorge Heller
Steve Y Ng
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Heron Therapeutics LLC
Original Assignee
Advanced Polymer Systems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Advanced Polymer Systems Inc filed Critical Advanced Polymer Systems Inc
Application granted granted Critical
Publication of ES2153648T3 publication Critical patent/ES2153648T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/85—Polyesters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/86—Polyethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A61K9/204—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/66—Polyesters containing oxygen in the form of ether groups
    • C08G63/664—Polyesters containing oxygen in the form of ether groups derived from hydroxy carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/002—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from unsaturated compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/34—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from hydroxy compounds or their metallic derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/91—Injection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Birds (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Preparation (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Materials For Medical Uses (AREA)
  • Polyethers (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)

Abstract

LA PRESENTE INVENCION ESTA RELACIONADA CON UNOS POLIMEROS UTILES COMO IMPLANTES ORTOPEDICOS O VEHICULOS PARA LA LIBERACION SOSTENIDA DE AGENTES FARMACEUTICOS, COSMETICOS O AGRICOLAS. ESTOS POLIMEROS SE PREPARAN DE TAL MANERA QUE PUEDE CONTROLARSE LA VELOCIDAD Y EL GRADO CON QUE SE HIDROLIZAN SIN TENER QUE AÑADIR UN ACIDO EXOGENO. ESTE DESCUBRIMIENTO SE BASA EN LA INCORPORACION DE ESTERES DE AL HIDROXIACIDOS DE CADENA CORTA, CO MO POR EJEMPLO ESTERES DE ACIDO GLICOLICO, ACIDO LACTICO O COPOLIMERO DE ACIDO LACTICO Y GLICOLICO, DENTRO DE LA CADENA POLIMERICA Y LA VARIACION DE LA CANTIDAD DE ESTOS ESTERES CON RELACION AL POLIMERO EN SU TOTALIDAD.
ES97901352T 1996-01-05 1997-01-03 Polimeros con estado fisico y bioerosionabilidad controlados. Expired - Lifetime ES2153648T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58358596A 1996-01-05 1996-01-05
US58364996A 1996-01-05 1996-01-05

Publications (1)

Publication Number Publication Date
ES2153648T3 true ES2153648T3 (es) 2001-03-01

Family

ID=27078846

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97901352T Expired - Lifetime ES2153648T3 (es) 1996-01-05 1997-01-03 Polimeros con estado fisico y bioerosionabilidad controlados.

Country Status (11)

Country Link
EP (1) EP0869986B1 (es)
JP (1) JP4015194B2 (es)
AT (1) ATE197310T1 (es)
AU (1) AU1527097A (es)
BR (1) BR9706960A (es)
CA (1) CA2242631C (es)
DE (1) DE69703430T2 (es)
ES (1) ES2153648T3 (es)
GR (1) GR3034753T3 (es)
PT (1) PT869986E (es)
WO (1) WO1997025366A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA978537B (en) 1996-09-23 1998-05-12 Focal Inc Polymerizable biodegradable polymers including carbonate or dioxanone linkages.
DE19726412A1 (de) * 1997-06-21 1998-12-24 Merck Patent Gmbh Implantatmaterial mit einer Träger-Wirkstoff-Kombination
US5939453A (en) * 1998-06-04 1999-08-17 Advanced Polymer Systems, Inc. PEG-POE, PEG-POE-PEG, and POE-PEG-POE block copolymers
US20050042194A1 (en) * 2000-05-11 2005-02-24 A.P. Pharma, Inc. Semi-solid delivery vehicle and pharmaceutical compositions
WO2002020663A2 (en) 2000-09-06 2002-03-14 Ap Pharma, Inc. Degradable polyacetal polymers
US6524606B1 (en) * 2001-11-16 2003-02-25 Ap Pharma, Inc. Bioerodible polyorthoesters containing amine groups
US7045589B2 (en) * 2002-11-15 2006-05-16 A.P. Pharma, Inc. Bioerodible poly(ortho esters) from dioxane-based di(ketene acetals), and block copolymers containing them
US7875697B2 (en) 2006-06-29 2011-01-25 Medtronic, Inc. Poly(orthoester) polymers, and methods of making and using same
US8956642B2 (en) 2008-04-18 2015-02-17 Medtronic, Inc. Bupivacaine formulation in a polyorthoester carrier
US8475823B2 (en) * 2008-04-18 2013-07-02 Medtronic, Inc. Baclofen formulation in a polyorthoester carrier
CN106535886A (zh) * 2014-04-21 2017-03-22 赫伦治疗有限公司 长效聚合物输送系统

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0489843A4 (en) * 1989-08-28 1992-08-12 Pharmaceutical Delivery Systems, Inc. Bioerodible polymers useful for the controlled release of therapeutic agents
US5047464A (en) * 1989-09-20 1991-09-10 Merck & Co., Inc. Bioerodible thermoset elastomers

Also Published As

Publication number Publication date
JP2000512322A (ja) 2000-09-19
DE69703430D1 (de) 2000-12-07
GR3034753T3 (en) 2001-02-28
PT869986E (pt) 2001-04-30
DE69703430T2 (de) 2001-05-03
AU1527097A (en) 1997-08-01
EP0869986B1 (en) 2000-11-02
CA2242631A1 (en) 1997-07-17
CA2242631C (en) 2008-09-09
ATE197310T1 (de) 2000-11-15
JP4015194B2 (ja) 2007-11-28
BR9706960A (pt) 1999-12-28
WO1997025366A1 (en) 1997-07-17
EP0869986A1 (en) 1998-10-14

Similar Documents

Publication Publication Date Title
Song et al. Current development of biodegradable polymeric materials for biomedical applications
Chen et al. Hydrogels in dental medicine
AU697005B2 (en) Implantable molded articles for the administration of active substances to plants
IE872618L (en) Cross-linked esters of hyaluronic acid
SE9504495D0 (sv) Linjär blockpolymer innefattande urea- och uretangrupper, förfarande för framställning av linjära blockpolymerer samt användning av blockpolymererna som implantat
BR9808933A (pt) Composição sob forma de microcápsulas ou de implantes, processo de preparação de uma substância hidrossolúvel, substância ativa, acetato de triptorelina, acetato de lanreotìdeo, ou acetato de octreotìdeo, e rna de filamento duplo
BR9706960A (pt) Polìmeros com estado fìsico e condição de bioerosão controlados
DK0981381T3 (da) Polyhydroxyalkanoater ti anvendelser in vivo
WO1997013502A3 (en) Prolonged release of gm-csf
WO2003007782A3 (en) Biodegradable injectable implants and related methods of manufacture and use
WO2006036202A3 (en) Stabilized biodegradable neurotoxin implants
EP1125577A3 (en) Liquid drug delivery compositions
AU1278000A (en) Particles based on polyamino-acid(s) and methods for preparing same
BR9916053A (pt) Composições contendo um peptìdio e um ácido glicólico poliláctico, adequadas para preparação de implantes subcutâneos com perìodo de liberação prolongado
WO2004013206A3 (fr) Polyaminoacides fonctionnalises par au moins un groupement hydrophobe et leurs applications notamment therapeutiques
Francis et al. Synthesis, structure, and properties of biopolymers (natural and synthetic)
WO2005033181A3 (fr) Homopolyaminoacides telecheliques fonctionnalises par des groupements hydrophobes et leurs applications notamment therapeutiques
EP0635531A3 (en) Liquid copolymers of epsilon-caprolactone and lactide
CA2556426A1 (en) Wound dressings comprising a protein polymer and a polyfunctional spacer
DK0825848T3 (da) Translucente collagenformuleringer
Indalkar et al. A comprehensive review on biodegradable polymers
WO2007051923A3 (fr) Acides polyglutamiques fonctionnalises par des derives de l'histidine et des groupements hydrophobes et leurs applications notamment therapeutiques
Ahmed et al. Handbook of Biodegradable Polymers: Applications in Biomedical Sciences, Industry, and the Environment
Ben Abdeladhim et al. Polyhydroxyalkanoates: Medical Applications and Potential for Use in Dentistry. Materials 2024, 17, 5415
IL128329A0 (en) Pharmaceutical composition of hedgehog proteins and use thereof

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 869986

Country of ref document: ES