ES2155190T3 - Determinacion de un analito en un medio liquido. - Google Patents

Determinacion de un analito en un medio liquido.

Info

Publication number
ES2155190T3
ES2155190T3 ES96922207T ES96922207T ES2155190T3 ES 2155190 T3 ES2155190 T3 ES 2155190T3 ES 96922207 T ES96922207 T ES 96922207T ES 96922207 T ES96922207 T ES 96922207T ES 2155190 T3 ES2155190 T3 ES 2155190T3
Authority
ES
Spain
Prior art keywords
immobilized
probe
members
recognition pair
metal plates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96922207T
Other languages
English (en)
Inventor
Itamar Willner
Shlomo Levi
Yael Cohen
Eugenii Katz
Arie Dagan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yissum Research Development Co of Hebrew University of Jerusalem
Original Assignee
Yissum Research Development Co of Hebrew University of Jerusalem
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yissum Research Development Co of Hebrew University of Jerusalem filed Critical Yissum Research Development Co of Hebrew University of Jerusalem
Application granted granted Critical
Publication of ES2155190T3 publication Critical patent/ES2155190T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)

Abstract

SE DETERMINA LA UNION ENTRE DOS MIEMBROS DE UNA PAREJA DE RECONOCIMIENTO, POR EJ., UNA PAREJA ANTIGENO-ANTICUERPO, POR EL USO DE UNA SONDA QUE COMPRENDE UN CRISTAL PIEZOELECTRICO CON ELECTRODOS SOBRE DOS CARAS OPUESTAS DEL CRISTAL. EL CRISTAL LLEVA UNA O MAS PLACAS DE METAL QUE PUEDEN SER IGUALES O DIFERENTES QUE DICHOS ELECTRODOS, CUYAS PLACAS METALICAS HAN INMOVILIZADO ENTRE ELLAS UN PRIMER MIEMBRO DE LA PAREJA DE RECONOCIMIENTO. LA UNION DE UN SEGUNDO MIEMBRO DE LA PAREJA DE RECONOCIMIENTO AL PRIMER MIEMBRO, O LA DISOCIACION ENTRE LOS DOS MIEMBROS Y LA LIBERACION DEL SEGUNDO MIEMBRO DE LA SONDA, PRODUCE UN CAMBIO DE LA MASA INMOVILIZADA QUE PROVOCA UN CAMBIO EN LA FRECUENCIA DE RESONANCIA DE LA SONDA. DICHOS MIEMBROS INMOVILIZADOS PUEDEN INMOVILIZARSE SOBRE LA SUPERFICIE DE LAS MENCIONADAS PLACAS METALICAS POR MEDIO DE UN GRUPO DE UNION, CON LA SIGUIENTE ESTRUCTURA GENERAL (I): Z NTA UN NUCLEO DE CONTENIDO SULFURO CAPAZ DE ASOCIACION QUIMICA, DE UNION O DE QUIMIOABSORCION CON DICHO METAL, R SUP,1} REPRESENTA UN GRUPO DE CONEXION; Q ES UN GRUPO FUNCIONAL CAPAZ DE FORMAR UN ENLACE COVALENTE CON UN NUCLEO DEL MENCIONADO PRIMER MIEMBRO DE LA PAREJA DE RECONOCIMIENTO. EL MIEMBRO INMOVILIZADO PUEDE ESTAR O HABERSE UNIDO A UN GRUPO ISOMERIZABLE QUE CAMBIA SU ESTADO DE ISOMERIZACION COMO CONSECUENCIA DE LA EXPOSICION AL CAMPO DE ENERGIA.
ES96922207T 1995-07-21 1996-07-16 Determinacion de un analito en un medio liquido. Expired - Lifetime ES2155190T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL11469295A IL114692A (en) 1995-07-21 1995-07-21 Determination of an analyte in a liquid medium

Publications (1)

Publication Number Publication Date
ES2155190T3 true ES2155190T3 (es) 2001-05-01

Family

ID=11067798

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96922207T Expired - Lifetime ES2155190T3 (es) 1995-07-21 1996-07-16 Determinacion de un analito en un medio liquido.

Country Status (11)

Country Link
US (1) US6630309B2 (es)
EP (1) EP0843816B1 (es)
JP (1) JP3895379B2 (es)
AT (1) ATE198376T1 (es)
AU (1) AU6317896A (es)
CA (1) CA2227281C (es)
DE (1) DE69611373T2 (es)
DK (1) DK0843816T3 (es)
ES (1) ES2155190T3 (es)
IL (1) IL114692A (es)
WO (1) WO1997004314A2 (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000503773A (ja) * 1996-05-23 2000-03-28 ユニリーバー・ナームローゼ・ベンノートシヤープ 特異的結合アッセイの改良
SE9604575D0 (sv) * 1996-12-12 1996-12-12 Biacore Ab Method and system for analyte determination
IL120445A0 (en) * 1997-03-13 1997-07-13 Yissum Res Dev Co Biosensor for cells
SG81232A1 (en) * 1998-06-05 2001-06-19 Inst Materials Research & Eng Piezoelectric immunosensor
SE512994C2 (sv) * 1998-09-24 2000-06-12 Biosensor Applic Sweden Ab Biosensorcellanordning och dess användning
IL128212A (en) * 1999-01-25 2004-06-20 Biosensor Applic Sweden Ab Detection of small molecules by use of a piezoelectric sensor
GB9909308D0 (en) * 1999-04-22 1999-06-16 Univ Cambridge Tech Measurement and use of molecular interactions
US7763475B2 (en) * 1999-04-22 2010-07-27 Inverness Medical Switzerland Gmbh Measurement and use of molecular interactions
SG93209A1 (en) * 1999-07-05 2002-12-17 Inst Of Molecular Agrobiology A novel immuno-diagnostic test method for veterinary disease
JP2004309416A (ja) * 2003-04-10 2004-11-04 Sony Corp センサ装置、センシング方法、生体物質のセンサ装置、生体物質のセンシング方法、分泌物のセンサ装置、分泌物のセンシング方法、感情センサ装置および感情センシング方法
US20050148065A1 (en) 2003-12-30 2005-07-07 Intel Corporation Biosensor utilizing a resonator having a functionalized surface
US8354066B2 (en) * 2004-03-24 2013-01-15 Technion Research & Development Foundation Ltd. Artificial receptors
WO2005090981A2 (en) * 2004-03-24 2005-09-29 Technion Research & Development Foundation Ltd. Electrode
US7695681B2 (en) * 2005-03-31 2010-04-13 Intel Corporation Miniature chemical analysis system
US20080261323A1 (en) * 2005-09-06 2008-10-23 Dermot Diamond Photo-Swichable Surfaces with Controllable Physico-Chemical Properties
KR100722844B1 (ko) * 2006-05-30 2007-05-31 이화여자대학교 산학협력단 단일 측정 시스템에서 효소의 활성 및 양을 인 시투측정하기 위한 방법 및 키트
US8512947B2 (en) 2007-02-16 2013-08-20 Drexel University Detection of nucleic acids using a cantilever sensor
WO2008101199A1 (en) * 2007-02-16 2008-08-21 Drexel University Enhanced sensitivity of a cantilever sensor via specific bindings
JP5276655B2 (ja) * 2007-06-01 2013-08-28 アトノミックス アクティーゼルスカブ 標的検体の検出用のナノ粒子を用いた生体表面弾性波（ｓａｗ）共振器増幅
WO2010055959A1 (en) * 2008-11-11 2010-05-20 Korea Institute Of Science And Technology System for detecting biomolecule wi th high sensitivity using micro-cant i lever
WO2010096439A1 (en) * 2009-02-17 2010-08-26 Leversense, Llc Resonant sensors and methods of use thereof for the determination of analytes
EP2630479B1 (en) 2010-10-20 2020-04-08 Qorvo US, Inc. Apparatus and method for measuring binding kinetics and concentration with a resonating sensor
JP6582046B2 (ja) * 2015-05-29 2019-09-25 京セラ株式会社 検出方法、および検出装置
US9464487B1 (en) 2015-07-22 2016-10-11 William Harrison Zurn Drill bit and cylinder body device, assemblies, systems and methods
IT201900007725A1 (it) * 2019-05-31 2020-12-01 Eye Pharma Spa Metodo per la diagnosi precoce del glaucoma

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4242096A (en) 1977-11-14 1980-12-30 Minnesota Mining And Manufacturing Company Immunoassay for antigens
US4314821A (en) 1979-04-09 1982-02-09 Minnesota Mining And Manufacturing Company Sandwich immunoassay using piezoelectric oscillator
US4236893A (en) 1979-04-09 1980-12-02 Minnesota Mining And Manufacturing Company Method for the assay of classes of antigen-specific antibodies
US4735906A (en) 1984-11-28 1988-04-05 Texas A&M University Sensor having piezoelectric crystal for microgravimetric immunoassays
US5595908A (en) * 1985-09-26 1997-01-21 University Of Southern Mississipi Piezoelectric device for detection of polynucleotide hybridization
US5192507A (en) * 1987-06-05 1993-03-09 Arthur D. Little, Inc. Receptor-based biosensors
US4999284A (en) * 1988-04-06 1991-03-12 E. I. Du Pont De Nemours And Company Enzymatically amplified piezoelectric specific binding assay
SE462454B (sv) * 1988-11-10 1990-06-25 Pharmacia Ab Maetyta foer anvaendning i biosensorer
US5235238A (en) * 1989-08-10 1993-08-10 Dainabot Company, Limited Electrode-separated piezoelectric crystal oscillator and method for measurement using the electrode-separated piezoelectric crystal oscillator
DE69010506T2 (de) * 1989-10-04 1994-12-22 Du Pont Bestimmungsverfahren für biologische zielkomplexe auf der oberfläche eines biosensors.
DE69309468T2 (de) 1992-07-17 1997-09-04 Du Pont Nachweis eines Analyten mittels eines Analyt-sensitiven Polymers
EP0587408A1 (en) * 1992-09-07 1994-03-16 Terumo Kabushiki Kaisha Method for determination of DNA and sensor therefor
US5527711A (en) * 1993-12-13 1996-06-18 Hewlett Packard Company Method and reagents for binding chemical analytes to a substrate surface, and related analytical devices and diagnostic techniques
IL108726A (en) * 1994-02-22 1999-12-31 Yissum Res Dev Co Electrobiochemical method and system for the determination of an analyte which is a member of a recognition pair in a liquid medium and electrodes therefor
US5583432A (en) * 1994-04-11 1996-12-10 Sci-Nostics Limited Electrical method and apparatus for non-contact determination of physical and/or chemical properties of a sample, particularly of blood
US5705399A (en) * 1994-05-20 1998-01-06 The Cooper Union For Advancement Of Science And Art Sensor and method for detecting predetermined chemical species in solution
US5514501A (en) * 1994-06-07 1996-05-07 The United States Of America As Represented By The Secretary Of Commerce Process for UV-photopatterning of thiolate monolayers self-assembled on gold, silver and other substrates
US5852229A (en) * 1996-05-29 1998-12-22 Kimberly-Clark Worldwide, Inc. Piezoelectric resonator chemical sensing device

Also Published As

Publication number Publication date
WO1997004314A3 (en) 1997-05-22
CA2227281C (en) 2008-09-23
IL114692A0 (en) 1995-11-27
EP0843816A2 (en) 1998-05-27
WO1997004314A2 (en) 1997-02-06
DK0843816T3 (da) 2001-03-26
JPH11510247A (ja) 1999-09-07
US6630309B2 (en) 2003-10-07
AU6317896A (en) 1997-02-18
IL114692A (en) 1999-10-28
ATE198376T1 (de) 2001-01-15
EP0843816B1 (en) 2000-12-27
DE69611373T2 (de) 2001-08-16
US20020028440A1 (en) 2002-03-07
CA2227281A1 (en) 1997-02-06
JP3895379B2 (ja) 2007-03-22
DE69611373D1 (de) 2001-02-01

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