ES2155472T3 - NEW POLYPEPTIDE WITH INHIBITING ACTIVITY OF FACTOR XA. - Google Patents
NEW POLYPEPTIDE WITH INHIBITING ACTIVITY OF FACTOR XA.Info
- Publication number
- ES2155472T3 ES2155472T3 ES94914087T ES94914087T ES2155472T3 ES 2155472 T3 ES2155472 T3 ES 2155472T3 ES 94914087 T ES94914087 T ES 94914087T ES 94914087 T ES94914087 T ES 94914087T ES 2155472 T3 ES2155472 T3 ES 2155472T3
- Authority
- ES
- Spain
- Prior art keywords
- polypeptide
- factor
- inhibiting activity
- new polypeptide
- deposited
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 229920001184 polypeptide Polymers 0.000 title abstract 5
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 5
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 5
- 108010074860 Factor Xa Proteins 0.000 title abstract 2
- 230000002401 inhibitory effect Effects 0.000 title 1
- 230000023555 blood coagulation Effects 0.000 abstract 2
- 241000237902 Hirudo medicinalis Species 0.000 abstract 1
- 239000002299 complementary DNA Substances 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/57—Protease inhibitors from animals; from humans
- A61K38/58—Protease inhibitors from animals; from humans from leeches, e.g. hirudin, eglin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Public Health (AREA)
- Plant Pathology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
A novel polypeptide derived from the leech Hirudo medicinalis was found to be able to inhibit Factor Xa thereby reducing the extent of blood coagulation. The polypeptide is useful in treating conditions of excessive blood coagulation. A recombinant organism containing cDNA encoding the polypeptide has been deposited in the ATCC under Accession No. 69134. Recombinant microorganisms able to produce the polypeptide have been deposited in the ATCC under Accession Nos. 69135, 69137 and 69269.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4580593A | 1993-04-09 | 1993-04-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2155472T3 true ES2155472T3 (en) | 2001-05-16 |
Family
ID=21939985
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES94914087T Expired - Lifetime ES2155472T3 (en) | 1993-04-09 | 1994-04-08 | NEW POLYPEPTIDE WITH INHIBITING ACTIVITY OF FACTOR XA. |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0696198B1 (en) |
| JP (1) | JPH08511157A (en) |
| KR (1) | KR960701649A (en) |
| AT (1) | ATE198710T1 (en) |
| AU (1) | AU682361B2 (en) |
| CA (1) | CA2159218A1 (en) |
| DE (1) | DE69426598T2 (en) |
| DK (1) | DK0696198T3 (en) |
| ES (1) | ES2155472T3 (en) |
| GR (1) | GR3035722T3 (en) |
| IL (1) | IL109259A0 (en) |
| NZ (1) | NZ265507A (en) |
| PT (1) | PT696198E (en) |
| WO (1) | WO1994023735A1 (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE498409T1 (en) | 1998-08-06 | 2011-03-15 | Mountain View Pharmaceuticals | PEG-URICASE CONJUGATES AND USE THEREOF |
| MX2007012548A (en) | 2005-04-11 | 2008-03-11 | Savient Pharmaceuticals Inc | A variant form of urate oxidase and use thereof. |
| US8148123B2 (en) | 2005-04-11 | 2012-04-03 | Savient Pharmaceuticals, Inc. | Methods for lowering elevated uric acid levels using intravenous injections of PEG-uricase |
| SG161247A1 (en) | 2005-04-11 | 2010-05-27 | Savient Pharmaceuticals Inc | Variant forms of urate oxidase and use thereof |
| JP5033177B2 (en) | 2006-04-12 | 2012-09-26 | サビエント ファーマセウティカルズ インク． | Purification of proteins with cationic surfactants |
| US9377454B2 (en) | 2009-06-25 | 2016-06-28 | Crealta Pharmaceuticals Llc | Methods and kits for predicting infusion reaction risk and antibody-mediated loss of response by monitoring serum uric acid during pegylated uricase therapy |
| US8685462B1 (en) | 2012-09-17 | 2014-04-01 | Biopep Solutions, Inc. | Whole, leech saliva product and applications thereof |
| CN116637177A (en) | 2016-11-11 | 2023-08-25 | 好利恩治疗美国公司 | Combination therapy of prednisone and uricase molecule and uses thereof |
| WO2020160325A1 (en) | 2019-01-30 | 2020-08-06 | Horizon Pharma Rheumatology Llc | Reducing immunogenicity to pegloticase |
| US12269875B2 (en) | 2023-08-03 | 2025-04-08 | Jeff R. Peterson | Gout flare prevention methods using IL-1BETA blockers |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4588587A (en) * | 1983-03-01 | 1986-05-13 | Pennsylvania Hospital | Method of treatment to inhibit metastasis |
| ES2052062T3 (en) * | 1988-06-11 | 1994-07-01 | Ciba Geigy Ag | NEW POLYPEPTIDES WITH ANTICOAGULANT ACTIVITY. |
| US4832849A (en) * | 1988-06-16 | 1989-05-23 | Merrell Dow Pharmaceuticals Inc. | Extraction and purification of an anticoagulant principle from the south american leech, haementeria ghilianii |
| IL86856A0 (en) * | 1988-06-24 | 1988-11-30 | Yissum Res Dev Co | Bovine xa factor and pharmaceutical compositions containing the same |
-
1994
- 1994-04-08 DE DE69426598T patent/DE69426598T2/en not_active Expired - Fee Related
- 1994-04-08 PT PT94914087T patent/PT696198E/en unknown
- 1994-04-08 AU AU66291/94A patent/AU682361B2/en not_active Ceased
- 1994-04-08 EP EP94914087A patent/EP0696198B1/en not_active Expired - Lifetime
- 1994-04-08 JP JP6523326A patent/JPH08511157A/en not_active Ceased
- 1994-04-08 WO PCT/US1994/003871 patent/WO1994023735A1/en not_active Ceased
- 1994-04-08 CA CA002159218A patent/CA2159218A1/en not_active Abandoned
- 1994-04-08 DK DK94914087T patent/DK0696198T3/en active
- 1994-04-08 NZ NZ265507A patent/NZ265507A/en unknown
- 1994-04-08 KR KR1019950704404A patent/KR960701649A/en not_active Abandoned
- 1994-04-08 AT AT94914087T patent/ATE198710T1/en not_active IP Right Cessation
- 1994-04-08 ES ES94914087T patent/ES2155472T3/en not_active Expired - Lifetime
- 1994-04-08 IL IL10925994A patent/IL109259A0/en unknown
-
2001
- 2001-04-06 GR GR20010400573T patent/GR3035722T3/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| GR3035722T3 (en) | 2001-07-31 |
| DE69426598D1 (en) | 2001-02-22 |
| AU6629194A (en) | 1994-11-08 |
| KR960701649A (en) | 1996-03-28 |
| EP0696198A4 (en) | 1999-01-27 |
| AU682361B2 (en) | 1997-10-02 |
| CA2159218A1 (en) | 1994-10-27 |
| HK1013315A1 (en) | 1999-08-20 |
| PT696198E (en) | 2001-07-31 |
| EP0696198A1 (en) | 1996-02-14 |
| DE69426598T2 (en) | 2001-08-09 |
| EP0696198B1 (en) | 2001-01-17 |
| IL109259A0 (en) | 1994-07-31 |
| ATE198710T1 (en) | 2001-02-15 |
| DK0696198T3 (en) | 2001-08-06 |
| JPH08511157A (en) | 1996-11-26 |
| NZ265507A (en) | 1998-09-24 |
| WO1994023735A1 (en) | 1994-10-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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