ES2155474T3 - Preparacion y uso de ratones transgenicos que carecen de la expresion de cd28. - Google Patents

Preparacion y uso de ratones transgenicos que carecen de la expresion de cd28.

Info

Publication number
ES2155474T3
ES2155474T3 ES94917481T ES94917481T ES2155474T3 ES 2155474 T3 ES2155474 T3 ES 2155474T3 ES 94917481 T ES94917481 T ES 94917481T ES 94917481 T ES94917481 T ES 94917481T ES 2155474 T3 ES2155474 T3 ES 2155474T3
Authority
ES
Spain
Prior art keywords
expression
lack
preparation
mouses
transgenic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94917481T
Other languages
English (en)
Inventor
Craig Bernie Thompson
Tak Wah Mak
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ontario Cancer Institute
University of Michigan System
University of Michigan Ann Arbor
Original Assignee
Ontario Cancer Institute
University of Michigan System
University of Michigan Ann Arbor
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ontario Cancer Institute, University of Michigan System, University of Michigan Ann Arbor filed Critical Ontario Cancer Institute
Application granted granted Critical
Publication of ES2155474T3 publication Critical patent/ES2155474T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knock-out vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70521—CD28, CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70589—CD45
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0306—Animal model for genetic diseases
    • A01K2267/0325—Animal model for autoimmune diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A01K2267/0381—Animal model for diseases of the hematopoietic system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Environmental Sciences (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Animal Husbandry (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Packaging For Recording Disks (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

LOS MAMIFEROS QUE NO TIENEN EXPRESION DE CD28 O ISOFORMAS DETERMINADAS CD45 EN CIERTAS CELULAS DEL SISTEMA INMUNE. TAMBIEN SE PROPORCIONAN METODOS PARA LA UTILIZACION DE ESTOS ANIMALES.
ES94917481T 1993-05-26 1994-05-25 Preparacion y uso de ratones transgenicos que carecen de la expresion de cd28. Expired - Lifetime ES2155474T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US6776793A 1993-05-26 1993-05-26

Publications (1)

Publication Number Publication Date
ES2155474T3 true ES2155474T3 (es) 2001-05-16

Family

ID=22078279

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94917481T Expired - Lifetime ES2155474T3 (es) 1993-05-26 1994-05-25 Preparacion y uso de ratones transgenicos que carecen de la expresion de cd28.

Country Status (9)

Country Link
US (3) US6664107B1 (es)
EP (1) EP0701607B1 (es)
AT (1) ATE198621T1 (es)
AU (1) AU685811B2 (es)
DE (1) DE69426564T2 (es)
ES (1) ES2155474T3 (es)
GR (1) GR3035603T3 (es)
PT (1) PT701607E (es)
WO (1) WO1994028123A1 (es)

Families Citing this family (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6264915B1 (en) 1992-09-13 2001-07-24 The President And Fellows Of Harvard College Process for detecting potential carcinogens
US6025183A (en) * 1994-02-28 2000-02-15 Yissum Research Development Company Of The Hebrew University Of Jerusalem Transgenic animal assay system for anti-cholinesterase substances
WO1995034640A1 (en) * 1994-06-13 1995-12-21 Henry Ford Health System A novel neuronal-neonatal gene: neuronatin
PL321711A1 (en) * 1995-02-09 1997-12-22 Icn Pharmaceuticals Methods of and compositions for controlling the cd28 expression
US5858661A (en) 1995-05-16 1999-01-12 Ramot-University Authority For Applied Research And Industrial Development Ataxia-telangiectasia gene and its genomic organization
US5777093A (en) * 1995-05-16 1998-07-07 Ramot-University Authority For Applied Research & Industrial Development Ltd. cDNAs associated with ataxia-telangiectasia
US5728807A (en) * 1995-05-16 1998-03-17 Ramot-University Authority For Applied Research And Industrial Development, Ltd. Mutated proteins associated with ataxia-telangiectasia
US6140309A (en) * 1996-03-12 2000-10-31 University Of South Florida Vasoactive effects and free radical generation by β-amyloid peptides
US20060021070A1 (en) * 1996-04-01 2006-01-26 University of Massachusetts, a Public Institution of Higher Education of the Commonwealth of MA Production of chimeric bovine or porcine animals using cultured inner cell mass
CA2259123C (en) 1996-07-01 2003-10-21 Lorus Therapeutics Inc. Oligonucleotides from the untranslated regions of ribonucleotide reductase and their use to modulate cell growth
US7390891B1 (en) 1996-11-15 2008-06-24 Amgen Inc. Polynucleotides encoding a telomerase component TP2
AU4964097A (en) * 1996-11-15 1998-06-10 Sumitomo Pharmaceuticals Company, Limited Novel semaphorin genes (i)
US5919656A (en) * 1996-11-15 1999-07-06 Amgen Canada Inc. Genes encoding telomerase protein 1
US6046158A (en) * 1996-12-20 2000-04-04 Board Of Regents The University Of Texas Systems Unique dendritic cell-associated C-type lectins, dectin-1 and dectin-2; compositions and uses thereof
US7071171B1 (en) 1996-12-20 2006-07-04 Board Of Regents The University Of Texas System Unique dendritic cell-associated c-type lectins, dectin-1 and dectin-2 compositions and uses thereof
US5817912A (en) * 1997-01-16 1998-10-06 B.M.R.A. Corporation B.V. Transgenic mice with disrupted NPY Y1 receptor genes
IL134298A0 (en) 1997-08-21 2001-04-30 Quark Biotech Inc Hypoxia-regulating genes
US7973156B2 (en) 1997-08-21 2011-07-05 Quark Pharmaceuticals Inc. Hypoxia-regulated genes
JP4652566B2 (ja) 1998-01-12 2011-03-16 ロビン・エイ・フェルダー 本態性高血圧症におけるｇタンパク質関連変異体
US6893838B1 (en) 1998-04-07 2005-05-17 Genetics Institute Llc DADD, death activator death domain protein
US6492138B1 (en) * 1998-05-21 2002-12-10 Amgen Canada Inc. Polynucleotides encoding a novel SHC-binding protein
US5973119A (en) * 1998-06-05 1999-10-26 Amgen Inc. Cyclin E genes and proteins
US6344541B1 (en) * 1998-09-25 2002-02-05 Amgen Inc. DKR polypeptides
WO2000058479A1 (en) 1999-03-26 2000-10-05 Amgen Inc. Beta secretase genes and polypeptides
ATE377077T1 (de) 1999-04-28 2007-11-15 Genetics Inst Llc Humane gil-19/ae289 proteine und dafür kodierende polynukleotide
US6787318B1 (en) 1999-06-01 2004-09-07 Roskamp Research Institute, Llc Assay for evaluating the therapeutic effectiveness of agents in reducing Alzheimer's disease pathology
US6875582B1 (en) 1999-08-19 2005-04-05 Omniscience Pharmaceuticals, Inc. Methods and targets of antibiotic resistance
US7459540B1 (en) * 1999-09-07 2008-12-02 Amgen Inc. Fibroblast growth factor-like polypeptides
US7408047B1 (en) * 1999-09-07 2008-08-05 Amgen Inc. Fibroblast growth factor-like polypeptides
US6900043B1 (en) * 1999-09-21 2005-05-31 Amgen Inc. Phosphatases which activate map kinase pathways
US7638324B2 (en) 2000-04-06 2009-12-29 Burnham Institute For Medical Research Bcl-G polypeptides, encoding nucleic acids and methods of use
AU2404001A (en) * 2000-01-06 2001-07-16 Protegene Inc. Human proteins having hydrophobic domains and dnas encoding these proteins
EP1252292A4 (en) 2000-01-24 2004-11-17 Univ Ramot TOLERANT PLANTS AGAINST ENVIRONMENTAL STRESS CONDITIONS, METHOD FOR THE PRODUCTION THEREOF AND NEW NOVEL POLYNUCLEOTID SEQUENCES USED FOR THEM
TW201006846A (en) 2000-03-07 2010-02-16 Senomyx Inc T1R taste receptor and genes encidung same
ATE511856T1 (de) 2000-03-13 2011-06-15 Cornell Res Foundation Inc Blockieren der leukozytenemigration und entzündung durch störung mit cd99/hec2
AR030554A1 (es) 2000-03-16 2003-08-27 Amgen Inc Moleculas similares a receptores il-17 y usos de las mismas
US7514239B2 (en) 2000-03-28 2009-04-07 Amgen Inc. Nucleic acid molecules encoding beta-like glycoprotein hormone polypeptides and heterodimers thereof
US6686180B2 (en) * 2000-04-04 2004-02-03 Baxter International Inc. Method for the production of bacterial toxins
US7045314B2 (en) * 2000-04-04 2006-05-16 Baxter International Inc. Method for the production of bacterial toxins
US6503712B1 (en) * 2000-05-10 2003-01-07 Amgen Inc. Methods and compositions for preparing a genomic library for knockout targeting vectors
WO2002000724A2 (en) 2000-06-28 2002-01-03 Amgen, Inc. Thymic stromal lymphopoietin receptor molecules and uses thereof
HUP0300810A2 (hu) 2000-07-20 2003-08-28 M.G.V.S. Ltd. Mesterséges értranszplantátum, valamint ennek létrehozása és alkalmazása
US20040037828A1 (en) 2002-07-09 2004-02-26 Bar-Ilan University Methods and pharmaceutical compositions for healing wounds
US20050239125A1 (en) * 2000-09-06 2005-10-27 Hodge Timothy A Methods for genotype screening
TW201022287A (en) 2001-01-03 2010-06-16 Senomyx Inc T1R taste receptors and genes encoding same
US7883856B2 (en) 2001-04-05 2011-02-08 Senomyx Inc. Identification of bitter ligands that specifically activate human T2R receptors and related assays for identifying human bitter taste modulators
EP2003451B1 (en) 2001-06-26 2012-05-30 Senomyx, Inc. T1r1-t1r3 hetero-oligomeric umami taste receptors and cell lines that express said receptors and use thereof for identification of umami taste compounds
JP4551656B2 (ja) 2001-07-10 2010-09-29 セノミックス インコーポレイテッド 苦味を阻止する化合物を同定するための特異的ｔ２ｒ味覚受容体の使用
AU2002358921A1 (en) * 2001-07-10 2003-04-28 Omnio Ab Novel drug targets for arthritis
US7195916B2 (en) * 2001-09-13 2007-03-27 California Institute Of Technology Method for expression of small antiviral RNA molecules within a cell
US7737124B2 (en) 2001-09-13 2010-06-15 California Institute Of Technology Method for expression of small antiviral RNA molecules with reduced cytotoxicity within a cell
AU2002326906C1 (en) 2001-09-13 2009-01-29 California Institute Of Technology Method for expression of small antiviral RNA molecules within a cell
US20040023910A1 (en) * 2001-09-28 2004-02-05 Zhiming Zhang Use of cyr61 in the treatment and diagnosis of human uterine leiomyomas
AU2002358947A1 (en) 2001-12-05 2003-06-17 Yissum Research Development Company Of The Hebrew University Of Jerusalem Nanoparticles containing polymeric nucleic acid homologs, pharmaceutical compositions and articles of manufacture containing same and methods of use thereof
EP1329506A1 (en) * 2002-01-18 2003-07-23 Cypro S.A. Method to quantify in vivo RNA levels
US6992176B2 (en) 2002-02-13 2006-01-31 Technion Research & Development Foundation Ltd. Antibody having a T-cell receptor-like specificity, yet higher affinity, and the use of same in the detection and treatment of cancer, viral infection and autoimmune disease
US7662924B2 (en) * 2002-02-22 2010-02-16 The Board Of Trustees Of The University Of Illinois Beta chain-associated regulator of apoptosis
US20040025194A1 (en) * 2002-02-22 2004-02-05 Board Of Trustees Of The University Of Illinois Beta chain-associated regulator of apoptosis
JP2007512227A (ja) 2003-08-06 2007-05-17 セノミックス、インコーポレイテッド Ｔ１ｒヘテロオリゴマー味覚受容体、この受容体を発現する細胞株、および味覚化合物
US7415011B2 (en) * 2003-08-29 2008-08-19 Sun Microsystems, Inc. Distributed switch
EP1735435A1 (en) * 2004-03-18 2006-12-27 Fred Hutchinson Cancer Research Center Methods and compositions involving s-ship promoter regions
EP1789437A4 (en) * 2004-07-30 2008-11-05 Sinai School Medicine INHIBITORS OF NPC1L1 AND NPC1L1 AND METHODS OF USE THEREOF
WO2007005898A2 (en) * 2005-07-05 2007-01-11 Cornell Research Foundation, Inc. Blocking leukocyte emigration and inflammation by interfering with cd99l2
MX2007015931A (es) 2005-10-20 2008-04-22 Senomyx Inc Receptores de sabor dulce-umami y umami-dulce humanos quimericos.
EP1984040A1 (en) 2006-01-31 2008-10-29 Multi Gene Vascular Systems, Inc. Drug-eluting intravascular prostheses and methods of use
US8129334B2 (en) 2006-03-31 2012-03-06 The Regents Of The University Of California Methods and compositions for treating neurodegenerative disorders and Alzheimer'S disease and improving normal memory
EP3235811B1 (en) 2006-04-21 2018-07-25 Senomyx, Inc. Process of preparing oxalamides
US8153116B2 (en) 2006-07-11 2012-04-10 University Of Connecticut Use of conditional plasmodium strains lacking an essential gene in malaria vaccination
US8128921B2 (en) * 2006-07-11 2012-03-06 University Of Connecticut Use of conditional plasmodium strains lacking nutrient transporters in malaria vaccination
WO2008033375A2 (en) 2006-09-14 2008-03-20 Medgenics Ltd. Long lasting drug formulations
US8454948B2 (en) 2006-09-14 2013-06-04 Medgenics Medical Israel Ltd. Long lasting drug formulations
US7943590B2 (en) 2007-03-16 2011-05-17 Multi-Gene Vascular Systems Ltd. Compositions and methods for treating ophthalmic disorders
EP2144935A2 (en) 2007-03-29 2010-01-20 Technion Research & Development Foundation Ltd. Antibodies, methods and kits for diagnosing and treating melanoma
ES2545121T3 (es) 2007-08-21 2015-09-08 Senomyx, Inc. Compuestos que inhiben (bloquean) el sabor amargo en composiciones, y uso de los mismos
MX2010013333A (es) 2008-06-04 2011-04-05 Amgen Inc Mutantes fgf21 y usos de los mismos.
US8093043B2 (en) * 2008-06-04 2012-01-10 New York University β-TrCP1, β-TrCP2 and RSK1 or RSK2 inhibitors and methods for sensitizing target cells to apoptosis
WO2010017248A2 (en) 2008-08-04 2010-02-11 University Of Miami Sting (stimulator of interferon genes), a regulator of innate immune responses
EA032727B1 (ru) 2008-10-10 2019-07-31 Амген Инк. Мутантный резистентный к протеолизу полипептид fgf21 и его применение
TWI560197B (en) 2009-05-05 2016-12-01 Amgen Inc Fgf21 mutants and uses thereof
US20120052069A1 (en) 2009-05-05 2012-03-01 Amgen Inc Fgf21 mutants and uses thereof
WO2010148142A1 (en) * 2009-06-17 2010-12-23 Amgen Inc. Chimeric fgf19 polypeptides and uses thereof
JP2013512672A (ja) * 2009-12-02 2013-04-18 アムジエン・インコーポレーテツド ヒトＦＧＦＲ１ｃ、ヒトβ−クロト−、ならびにヒトＦＧＦＲ１ｃおよびヒトβ−クロト−の両方に結合する結合タンパク質
UA109888C2 (uk) 2009-12-07 2015-10-26 ІЗОЛЬОВАНЕ АНТИТІЛО АБО ЙОГО ФРАГМЕНТ, ЩО ЗВ'ЯЗУЄТЬСЯ З β-КЛОТО, РЕЦЕПТОРАМИ FGF І ЇХНІМИ КОМПЛЕКСАМИ
JP2013523184A (ja) 2010-04-15 2013-06-17 アムジエン・インコーポレーテツド ヒトＦＧＦ受容体およびβ−ＫＬＯＴＨＯ結合性タンパク質
JP2013532152A (ja) 2010-06-15 2013-08-15 メドジェニクス・メディカル・イスラエル・リミテッド 長期持続性の医薬製剤
WO2013091130A1 (zh) * 2011-12-19 2013-06-27 中国农业大学 猪cd28受体，编码其的基因及其应用
WO2015059701A1 (en) 2013-10-24 2015-04-30 Medgenics Medical Israel Ltd. Micro-organs providing sustained delivery of a therapeutic polypeptide and methods of use thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992022645A1 (en) 1991-06-14 1992-12-23 Genpharm International, Inc. Transgenic immunodeficient non-human animals
AU2661692A (en) 1991-09-19 1993-04-27 President And Fellows Of Harvard College Transgenic mhc class i and class ii antigen-deficient mammals

Also Published As

Publication number Publication date
DE69426564T2 (de) 2001-05-31
DE69426564D1 (de) 2001-02-15
AU6918794A (en) 1994-12-20
US5616491A (en) 1997-04-01
WO1994028123A1 (en) 1994-12-08
ATE198621T1 (de) 2001-01-15
AU685811B2 (en) 1998-01-29
EP0701607A1 (en) 1996-03-20
EP0701607B1 (en) 2001-01-10
US6664107B1 (en) 2003-12-16
PT701607E (pt) 2001-05-31
GR3035603T3 (en) 2001-06-29
US5557032A (en) 1996-09-17

Similar Documents

Publication Publication Date Title
ES2184769T3 (es) Metodos y composiciones para microencapsulacion de antigenos para utilizar como vacunas.
MX9405383A (es) Imidazo(4,5-c) piridin-4-aminas.
NO177374C (no) Stabile preparater av fettlöselige substanser og anvendelse av fiskegelatin ved fremstilling derav
IT1146776B (it) Schienale per sedia e sedia o poltroncina dotata del detto schienale
ES2161279T3 (es) Nucleosidos y nucleotidos que contienen racimos de boro.
ES8203375A1 (es) Procedimiento de preparar triazoloquinoxalin-4-onas substi- tuidas antihipertensoras
ATE63804T1 (de) Feindisperse fluessige pflanzenschutzmittel.
ES8403623A1 (es) Procedimiento para la determinacion de bilirrubina directa y total en liquidos corporales.
ES520950A0 (es) Perfeccionamientos en la construccion de sistemas abrasivos.
MX158383A (es) Mejoras en sistema de anuncios en el punto de compra
ES493034A0 (es) Mejoras introducidas en el objeto de la patente principal n.459766:sobre sistema para herrar caballos.
ES516522A0 (es) "perfeccionamientos en los sistemas de cultivo y metodo para su utilizacion".
ES492824A0 (es) Perfeccionamientos en los sistemas para la regulacion en al-tura y en inclinacion de butacas
MX9202643A (es) Peptidos utiles en la regulacion de los sistemas inmunologico y nervioso.
ES503036A0 (es) Sistema para la construccion y montaje de una isla artifi- cial en el mar y aparato para dicha construccion
IT1207135B (it) Sistema di sostegno del piede e del la gamba
DK0438358T3 (da) Fast og porøs enhedsform indeholdende partikler i form af perler samt dens fremstilling
BR8600328A (pt) Composicao inseticida que libera seletivamente os compostos ativos nela presentes
IT8219078A0 (it) Sistema di collegamento per parti di mobili e relativi dispositivi.
ES254408Y (es) Dispositivo para la prolongacion de asientos de sillones y similares
ES268365Y (es) Dispositivo para tapizado de sillas y similares.
MX151630A (es) Mejoras en sistema de extension para mesas de servicio o similares
IT8701212A0 (it) Sedile e sistema di assemblaggio nella sedia.
IT1142477B (it) Perfezionamento nei dispositivi di rilivazione presenza e di istradamento di personale
IT8205210A0 (it) Dispositivo di ritorno per piani girevoli di sedie e poltrone pesanti o fisse al pavimento.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 701607

Country of ref document: ES