ES2156011T3 - Derivados de ciclopeptidos. - Google Patents
Derivados de ciclopeptidos.Info
- Publication number
- ES2156011T3 ES2156011T3 ES97953826T ES97953826T ES2156011T3 ES 2156011 T3 ES2156011 T3 ES 2156011T3 ES 97953826 T ES97953826 T ES 97953826T ES 97953826 T ES97953826 T ES 97953826T ES 2156011 T3 ES2156011 T3 ES 2156011T3
- Authority
- ES
- Spain
- Prior art keywords
- disease
- cyclopeptides
- derivatives
- formula
- reivindication
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000001189 Cyclic Peptides Human genes 0.000 title 1
- 108010069514 Cyclic Peptides Proteins 0.000 title 1
- 201000010099 disease Diseases 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 208000037273 Pathologic Processes Diseases 0.000 abstract 1
- 208000007536 Thrombosis Diseases 0.000 abstract 1
- 230000033115 angiogenesis Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Diabetes (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
COMPUESTOS DE FORMULA (I): CICLO - (ARG - X - ASP R 1), EN DONDE X ES GLY, ALA O NH - NH - CO, R 1 ES UN RADI CAL DE FORMULA (II), Y R 2 , R 3 Y R 4 TIENEN LOS SIGNIFICADOS INDICADOS EN LA REIVINDICACION 1, ASI COMO SUS SALES, SE PUEDEN UTILIZAR COMO INHIBIDORES DE LA INTEGRINA, EN PARTICULAR PARA PREVENCION Y TRATAMIENTO DE ENFERMEDADES DE LA CIRCULACION, EN TROMBOSIS, INFARTO DE MIOCARDIO, ENFERMEDADES CORONARIAS, ARTERIOESCLEROSIS, EN PROCESOS PATOLOGICOS QUE SON FAVORECIDOS O PROPAGADOS POR LA ANGIOGENESIS, Y EN LA TERAPIA TUMORAL.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19653036A DE19653036A1 (de) | 1996-12-19 | 1996-12-19 | Cyclopeptidderivate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2156011T3 true ES2156011T3 (es) | 2001-06-01 |
Family
ID=7815374
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES97953826T Expired - Lifetime ES2156011T3 (es) | 1996-12-19 | 1997-12-15 | Derivados de ciclopeptidos. |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US6333308B1 (es) |
| EP (1) | EP0948525B1 (es) |
| CN (1) | CN1247543A (es) |
| AR (1) | AR008717A1 (es) |
| AT (1) | ATE199256T1 (es) |
| AU (1) | AU722817B2 (es) |
| CA (1) | CA2280233A1 (es) |
| CZ (1) | CZ223299A3 (es) |
| DE (2) | DE19653036A1 (es) |
| DK (1) | DK0948525T3 (es) |
| ES (1) | ES2156011T3 (es) |
| GR (1) | GR3035848T3 (es) |
| HU (1) | HUP0000490A3 (es) |
| NO (1) | NO993010L (es) |
| PL (1) | PL334186A1 (es) |
| PT (1) | PT948525E (es) |
| RU (1) | RU2202557C2 (es) |
| SK (1) | SK82099A3 (es) |
| TW (1) | TW494105B (es) |
| UA (1) | UA55439C2 (es) |
| WO (1) | WO1998027112A1 (es) |
| ZA (1) | ZA9711392B (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19728524A1 (de) * | 1997-07-04 | 1999-01-07 | Merck Patent Gmbh | Cyclische Azapeptide |
| US6235877B1 (en) * | 1999-08-04 | 2001-05-22 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Peptido-mimetic compounds containing RGD sequence useful as integrin inhibitors |
| DE10041402A1 (de) * | 2000-08-23 | 2002-03-14 | Morphochem Ag | Neue Verbindungen, die Faktor Xa-Aktivität inhibieren |
| ATE440094T1 (de) * | 2001-09-27 | 2009-09-15 | Equispharm Co Ltd | Fumagillolderivate und verfahren zu deren herstellung |
| ITMI20031476A1 (it) * | 2003-07-18 | 2005-01-19 | Univ Degli Studi Milano | Composti peptido-mimetici a struttura azabicicloalcanica comprendenti la sequenza rgd |
| PL1934248T3 (pl) * | 2005-10-12 | 2013-09-30 | Advanced Accelerator Applications | Selektywne peptydowe związki antagonistyczne receptora alfavbeta3 do zastosowań leczniczych i diagnostycznych |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2124060B1 (es) * | 1971-02-02 | 1974-04-12 | Rhone Poulenc Sa | |
| ES2121088T3 (es) * | 1992-06-04 | 1998-11-16 | Merrell Pharma Inc | Analogos de peptidos limitados conformacionalmente como agentes antiplaquetarios. |
| DE4237456A1 (de) * | 1992-11-06 | 1994-05-11 | Merck Patent Gmbh | Cyclopeptide |
| GB9524630D0 (en) * | 1994-12-24 | 1996-01-31 | Zeneca Ltd | Chemical compounds |
| JPH09278669A (ja) * | 1996-04-17 | 1997-10-28 | Asahi Glass Co Ltd | 腎炎治療薬 |
-
1996
- 1996-12-19 DE DE19653036A patent/DE19653036A1/de not_active Withdrawn
-
1997
- 1997-12-15 EP EP97953826A patent/EP0948525B1/de not_active Expired - Lifetime
- 1997-12-15 US US09/341,552 patent/US6333308B1/en not_active Expired - Fee Related
- 1997-12-15 PT PT97953826T patent/PT948525E/pt unknown
- 1997-12-15 CA CA002280233A patent/CA2280233A1/en not_active Abandoned
- 1997-12-15 ES ES97953826T patent/ES2156011T3/es not_active Expired - Lifetime
- 1997-12-15 AT AT97953826T patent/ATE199256T1/de not_active IP Right Cessation
- 1997-12-15 SK SK820-99A patent/SK82099A3/sk unknown
- 1997-12-15 CN CN97181862A patent/CN1247543A/zh active Pending
- 1997-12-15 DE DE59703023T patent/DE59703023D1/de not_active Expired - Fee Related
- 1997-12-15 CZ CZ992232A patent/CZ223299A3/cs unknown
- 1997-12-15 UA UA99074097A patent/UA55439C2/uk unknown
- 1997-12-15 WO PCT/EP1997/007048 patent/WO1998027112A1/de not_active Ceased
- 1997-12-15 AU AU57584/98A patent/AU722817B2/en not_active Ceased
- 1997-12-15 RU RU99115767/04A patent/RU2202557C2/ru not_active IP Right Cessation
- 1997-12-15 HU HU0000490A patent/HUP0000490A3/hu unknown
- 1997-12-15 PL PL97334186A patent/PL334186A1/xx unknown
- 1997-12-15 DK DK97953826T patent/DK0948525T3/da active
- 1997-12-18 TW TW086119172A patent/TW494105B/zh active
- 1997-12-18 ZA ZA9711392A patent/ZA9711392B/xx unknown
- 1997-12-19 AR ARP970106015A patent/AR008717A1/es not_active Application Discontinuation
-
1999
- 1999-06-18 NO NO993010A patent/NO993010L/no not_active Application Discontinuation
-
2001
- 2001-05-11 GR GR20010400698T patent/GR3035848T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| TW494105B (en) | 2002-07-11 |
| PL334186A1 (en) | 2000-02-14 |
| EP0948525B1 (de) | 2001-02-21 |
| CN1247543A (zh) | 2000-03-15 |
| CA2280233A1 (en) | 1998-06-25 |
| WO1998027112A1 (de) | 1998-06-25 |
| PT948525E (pt) | 2001-07-31 |
| DE59703023D1 (en) | 2001-03-29 |
| AU5758498A (en) | 1998-07-15 |
| US6333308B1 (en) | 2001-12-25 |
| HUP0000490A2 (hu) | 2000-08-28 |
| AR008717A1 (es) | 2000-02-09 |
| DK0948525T3 (da) | 2001-06-11 |
| ZA9711392B (en) | 1999-06-18 |
| ATE199256T1 (de) | 2001-03-15 |
| NO993010L (no) | 1999-08-18 |
| AU722817B2 (en) | 2000-08-10 |
| NO993010D0 (no) | 1999-06-18 |
| DE19653036A1 (de) | 1998-06-25 |
| CZ223299A3 (cs) | 1999-09-15 |
| GR3035848T3 (en) | 2001-08-31 |
| SK82099A3 (en) | 2000-06-12 |
| HUP0000490A3 (en) | 2000-10-30 |
| RU2202557C2 (ru) | 2003-04-20 |
| EP0948525A1 (de) | 1999-10-13 |
| UA55439C2 (uk) | 2003-04-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR9710686A (pt) | Método de tratamento de tumores malignos com tiroxinas análogas não possuindo atividade hormonal siginificativa. | |
| AR007640A1 (es) | DERIVADOS DE FENILALANINA, PROCEDIMIENTO PARA PREPARARLOS, PREPARACIONES FARMACEUTICAS QUE LOS CONTIENEN Y EMPLEO DE LOS MISMOS PARA PREPARAR UNMEDICAMENTO QUE ACTUA COMO INHIBIDOR DE LA INTEGRINA ALFA(v) | |
| ES2162942T3 (es) | Nuevos derivados de acidos carboxilicos, su obtencion y empleo. | |
| GB9903762D0 (en) | Organic compounds | |
| LV12253A (lv) | Veza arstesanas panemiens pielietojot naaladazes inhibitorus | |
| DE69921156D1 (de) | Verwendung von 5ht-6 antagonisten zur behandlung adhd | |
| ATE242632T1 (de) | Verwendung von betulinsäure-derivaten zur behandlung und vorbeugung von melanomen | |
| BR9715022A (pt) | Método para tratar de doenças prostáticas usando formulações de vitamina d por liberação sistemática e/ou prolongada | |
| EA200000723A1 (ru) | Производные 2-(пурин-9-ил)-тетрагидрофуран-3,4-диола | |
| ATE339957T1 (de) | Verwendung von egfr tyrosine kinase hemmern zur behandlung von brustkrebs | |
| ES2038609T3 (es) | 4,5-dihidroisoxazol, 3,5 disustituido como inhibidores de transglutaminasa. | |
| PT946166E (pt) | Utilizacao de inibidores das metaloproteinases da matriz para tratar disturbios neurologicos e promover a cicatrizacao de feridas | |
| BR9916879A (pt) | Composição e método para tratamento do câncer utilizando óleos essenciais vegetais naturais | |
| ES2183332T3 (es) | Aminoacidos biciclicos aromaticos. | |
| ES518261A0 (es) | Un procedimiento para la preparacion de derivados de tetrahidronaftaleno y de indano. | |
| ATE260282T1 (de) | Aromatische ester von camptothecinen und verfahren zur behandlung von krebserkrankungen | |
| ATE142499T1 (de) | Verwendung von kreatinphosphat oder phosphoenolbrenztraubensäure zur behandlung von tumoren | |
| ATE345790T1 (de) | Kombination von einem aromatasehemmer mit einem bisphosphonat | |
| ATE192923T1 (de) | Verwendung von boswelliasäure zur behandlung von hirntumoren | |
| BR9808263A (pt) | Processos para tratar câncer em um humano em necessidade de tratamento e para manufaturar um medicamento para inibir o crescimento em um humano de um tumor sólido, e, uso de um composto. | |
| DE69818823D1 (de) | Dipohosphonsäuresalze für die behandlung von osteoporose | |
| DE60111620D1 (de) | Aktiviertes protein c zur behandlung von pankreatitis | |
| ATE386029T1 (de) | Urokinase-inhibitoren | |
| ES2165233T3 (es) | Empleo de 1-fosfato de esfingosina, derivados de 1-fosfato de esfingosina y/o sus mezclas para el tratamiento de enfermedades cutaneas inflamatorias. | |
| BR0015121A (pt) | Composição farmacêutica utilizável para o tratamento de inflamação em humanos, e, método de tratamento de inflamação |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
Ref document number: 948525 Country of ref document: ES |