ES2157221T3 - Composiciones metaloporfirinicas. - Google Patents

Composiciones metaloporfirinicas.

Info

Publication number
ES2157221T3
ES2157221T3 ES93921333T ES93921333T ES2157221T3 ES 2157221 T3 ES2157221 T3 ES 2157221T3 ES 93921333 T ES93921333 T ES 93921333T ES 93921333 T ES93921333 T ES 93921333T ES 2157221 T3 ES2157221 T3 ES 2157221T3
Authority
ES
Spain
Prior art keywords
treatment
well
metaloporphirinic
compositions
metal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93921333T
Other languages
English (en)
Inventor
Stephen B Kahl
Charles S Craik
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California Berkeley
University of California San Diego UCSD
Original Assignee
University of California Berkeley
University of California San Diego UCSD
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California Berkeley, University of California San Diego UCSD filed Critical University of California Berkeley
Application granted granted Critical
Publication of ES2157221T3 publication Critical patent/ES2157221T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/027—Organoboranes and organoborohydrides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/05—Cyclic compounds having at least one ring containing boron but no carbon in the ring

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)

Abstract

COMPUESTOS DE PORFIRINA SUSTITUIDOS DE CARBORANO SELECTIVAMENTE INHIBEN PROTEASAS ASPARTILO VIRALES, Y SON UTILES EN EL TRATAMIENTO DE INFECCIONES TALES COMO AIDS (ENFERMEDAD DE SISTEMA INUNE), ASI COMO USOS EN EL TRATAMIENTO DE TUMORES SOLIDOS. TRATAMIENTOS PARTICULARMENTE PREFERENTES DE CONFORMIDAD CON LA INVENCION USAN LA SAL DIPOTASICA DE 2''4 - BIS [ ,(BETA) - (1''2 - DICARBACLOSODODECABORANO CARBOXI) ETIL] DEUTEROPORFIRINA COMPLEJO CON UN METAL O UN METAL DE TRANSICION, QUE SE SOLUBILIZA BIEN EN AGUA, Y ES ADECUADO PARA ADMINISTRACION ORAL.
ES93921333T 1992-09-03 1993-09-03 Composiciones metaloporfirinicas. Expired - Lifetime ES2157221T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US94009592A 1992-09-03 1992-09-03

Publications (1)

Publication Number Publication Date
ES2157221T3 true ES2157221T3 (es) 2001-08-16

Family

ID=25474216

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93921333T Expired - Lifetime ES2157221T3 (es) 1992-09-03 1993-09-03 Composiciones metaloporfirinicas.

Country Status (7)

Country Link
EP (1) EP0658109B1 (es)
JP (1) JPH08501103A (es)
AT (1) ATE201595T1 (es)
AU (1) AU4846193A (es)
DE (1) DE69330275T2 (es)
ES (1) ES2157221T3 (es)
WO (1) WO1994005285A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0626178A1 (de) * 1993-05-17 1994-11-30 Ciba-Geigy Ag Verwendung von Hemmstoffen von HIV-Aspartatproteasen zur Bekämpfung von Tumorerkrankungen
WO1995009856A1 (en) * 1993-10-01 1995-04-13 The Regents Of The University Of California Boronated metalloporphyrins and therapeutic methods
US6127356A (en) 1993-10-15 2000-10-03 Duke University Oxidant scavengers
DE19708461A1 (de) * 1997-02-18 1998-08-27 Meulen Volker Prof Dr Ter Verwendung aminerg wirkender Substanzen zur Herstellung eines Arzneimittels für die Behandlung viraler Infektionen des zentralen Nervensystems
JP2001521939A (ja) 1997-11-03 2001-11-13 デューク・ユニバーシティー 置換されたポルフィリン類
DE69928655T2 (de) * 1998-04-24 2006-08-24 Duke University Substituierte porphyrine
EP1155019B1 (en) 1999-01-25 2005-12-07 National Jewish Medical and Research Center Substituted porphyrins and their therapeutic use
JP2005508864A (ja) 2001-06-01 2005-04-07 ナショナル・ジュウィッシュ・メディカル・アンド・リサーチ・センター 糖尿病の治療、または移植術における使用、または免疫寛容の誘導のためのオキシダントスカベンジャー
EP1513537A4 (en) 2002-06-07 2006-09-06 Univ Duke Substituted porphyrins
CZ303046B6 (cs) * 2005-01-14 2012-03-14 Vysoká Škola Chemicko-Technologická II. Inhibitory HIV proteasy
US11382895B2 (en) 2008-05-23 2022-07-12 National Jewish Health Methods for treating injury associated with exposure to an alkylating species

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5128319A (en) * 1987-08-28 1992-07-07 Board Of Regents, The University Of Texas System Prophylaxis and therapy of acquired immunodeficiency syndrome
EP0337598A3 (en) * 1988-02-26 1991-07-03 Georgia State University Foundation, Inc. Use of porphyrins and metalloporphyrins in the treatment of diseases caused by human immunodeficiency viruses
US5109016A (en) * 1988-05-23 1992-04-28 Georgia State University Foundation, Inc. Method for inhibiting infection or replication of human immunodeficiency virus with porphyrin and phthalocyanine antiviral compositions
US4959356A (en) * 1989-05-26 1990-09-25 The United States Of America As Represented By The United States Department Of Energy Porphyrins for boron neutron capture therapy
EP0543902A4 (en) * 1990-07-31 1993-10-27 The Rockefeller University Use of metalloporphyrins to potentiate aids therapy
US5149801A (en) * 1990-11-21 1992-09-22 The Regents Of The University Of California Boronated porphyrin compounds

Also Published As

Publication number Publication date
ATE201595T1 (de) 2001-06-15
DE69330275T2 (de) 2001-10-31
EP0658109A4 (en) 1997-04-09
EP0658109B1 (en) 2001-05-30
DE69330275D1 (de) 2001-07-05
EP0658109A1 (en) 1995-06-21
AU4846193A (en) 1994-03-29
WO1994005285A1 (en) 1994-03-17
JPH08501103A (ja) 1996-02-06

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