ES2157225T3 - Celulas hepaticas de reserva. - Google Patents

Celulas hepaticas de reserva.

Info

Publication number
ES2157225T3
ES2157225T3 ES93923823T ES93923823T ES2157225T3 ES 2157225 T3 ES2157225 T3 ES 2157225T3 ES 93923823 T ES93923823 T ES 93923823T ES 93923823 T ES93923823 T ES 93923823T ES 2157225 T3 ES2157225 T3 ES 2157225T3
Authority
ES
Spain
Prior art keywords
liver
cells
reserve
differentiate
isolated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93923823T
Other languages
English (en)
Inventor
Brian A Naughton
Benson Sibanda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Advanced Tissue Sciences Inc
Original Assignee
Advanced Tissue Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Advanced Tissue Sciences Inc filed Critical Advanced Tissue Sciences Inc
Application granted granted Critical
Publication of ES2157225T3 publication Critical patent/ES2157225T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas
    • C12N5/16—Animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/407—Liver; Hepatocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • C12N5/0672—Stem cells; Progenitor cells; Precursor cells; Oval cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nutrition Science (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Physiology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A CELULAS DE RESERVA U ORIGINARIAS DEL HIGADO. EN PARTICULAR, SE REFIERE AL AISLAMIENTO, CARACTERIZACION, CULTIVO Y USOS DE LAS CELULAS DE RESERVA DEL HIGADO. LAS CELULAS DE RESERVA DEL HIGADO AISLADAS MEDIANTE CENTRIFUGACION DESCENDIENTE DE LA DENSIDAD PUEDEN DISTINGUIRSE DE OTRAS CELULAS PARENQUIMALES DEL HIGADO POR SU MORFOLOGIA, CARACTERISTICAS DE DECOLORACION, ALTA ACTIVIDAD PROLIFERATIVA Y CAPACIDAD DE DIFERENCIARSE IN VITRO. EN CULTIVOS A LARGO PLAZO DESCRITOS AQUI, ESTAS CELULAS SE EXPANDEN Y SE DIFERENCIAN EN CELULAS PARENQUIALES DEL HIGADO MORFOLOGICAMENTE ADULTO, CAPACES DE INTERVENIR EN FUNCIONES ESPECIFICAS DEL HIGADO. POR TANTO, LAS CELULAS DE RESERVA DEL HIGADO AISLADAS PUEDEN TENER UN AMPLIO RANGO DE APLICACIONES, INCLUYENDO PERO NO LIMITADAS A, SUS USOS COMO VEHICULOS DE GENES EXOGENOS EN TERAPIA DE GENES, Y/O PARA REEMPLAZAR Y RECONSTITUIR UN HIGADO DE MAMIFERO DESTROZADO, INFECTADO O GENETICAMENTE DEFICIENTE MEDIANTE EL TRASPLANTE.
ES93923823T 1992-10-09 1993-10-08 Celulas hepaticas de reserva. Expired - Lifetime ES2157225T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US95862192A 1992-10-09 1992-10-09

Publications (1)

Publication Number Publication Date
ES2157225T3 true ES2157225T3 (es) 2001-08-16

Family

ID=25501114

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93923823T Expired - Lifetime ES2157225T3 (es) 1992-10-09 1993-10-08 Celulas hepaticas de reserva.

Country Status (13)

Country Link
US (1) US5559022A (es)
EP (1) EP0671923B1 (es)
JP (1) JP3789930B2 (es)
KR (1) KR950703640A (es)
AT (1) ATE200625T1 (es)
AU (1) AU689758B2 (es)
CA (1) CA2146747C (es)
DE (1) DE69330167T2 (es)
DK (1) DK0671923T3 (es)
ES (1) ES2157225T3 (es)
GR (1) GR3036216T3 (es)
PT (1) PT671923E (es)
WO (1) WO1994008598A1 (es)

Families Citing this family (167)

* Cited by examiner, † Cited by third party
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