ES2157257T3 - Nuevos derivados liso-gangliosidos sulfatados. - Google Patents

Nuevos derivados liso-gangliosidos sulfatados.

Info

Publication number
ES2157257T3
ES2157257T3 ES94911404T ES94911404T ES2157257T3 ES 2157257 T3 ES2157257 T3 ES 2157257T3 ES 94911404 T ES94911404 T ES 94911404T ES 94911404 T ES94911404 T ES 94911404T ES 2157257 T3 ES2157257 T3 ES 2157257T3
Authority
ES
Spain
Prior art keywords
derivatives
sulfonil
liso
poly
gangliosid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94911404T
Other languages
English (en)
Inventor
Aurelio Romeo
Gunter Kirschner
Carlo Chizzolini
Hari Manev
Laura Facci
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fidia SpA
Original Assignee
Fidia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fidia SpA filed Critical Fidia SpA
Application granted granted Critical
Publication of ES2157257T3 publication Critical patent/ES2157257T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C07H15/10—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical containing unsaturated carbon-to-carbon bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Vascular Medicine (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

ANALOGOS SEMISINTETICOS DE GANGIOSIDOS ELEGIDOS ENTRE EL GRUPOS QUE CONSISTE EN N-SULFO-, N-HIDROCARBIL-SULFONIL- Y NHIDROCARBILOXI-SULFONIL-N-N''-DILISO-GANGLIOSIDOS Y SUS DERIVADOS N''-ACILO, N''-SULFO-, N''-HIDROCARBIL-SULFONIL- Y N''HIDROCARBILOXI-SULFONIL-N, N''-DILISO-GANGLIOSIDOS Y SUS DERIVADOS N-ACILO, N,N''-DI O POLISULFO-N.N''-DI O POLI-LISO-GLANGLIOSIDOS, N,N''-DI O POLIHIDROCARBILSULFONILO-N,N''-DI O POLI-LISOGANGLIOSIDOS Y N,N''-DI O POLIHIDROCARBILOXI-N,N''-DI O POLI-LISOGANGLIOSIDOS, Y SUS DERIVADOS FUNCIONALES Y SALES DE ESTOS COMPUESTOS, TIENEN ACTIVIDAD PROTECTORA CONTRA LA NEUROTOXICIDAD INDUCIDA POR AMINOACIDOS DE EXCITACION Y YA SE HAN VISTO EN TERAPIA DEL SISTEMA NERVIOSO Y EN LA MODULACION DE A EXPRESION DE DETERMINANTES TALES COMO CD{SUB,4} SOBRE LA SUPERFICIE DE CELULAS HUMANAS EN EL SISTEMA INUMNOLOGICO.
ES94911404T 1993-03-04 1994-03-04 Nuevos derivados liso-gangliosidos sulfatados. Expired - Lifetime ES2157257T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT93PD000044A IT1267955B1 (it) 1993-03-04 1993-03-04 Derivati solfatati dei lisogangliosidi

Publications (1)

Publication Number Publication Date
ES2157257T3 true ES2157257T3 (es) 2001-08-16

Family

ID=11390208

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94911404T Expired - Lifetime ES2157257T3 (es) 1993-03-04 1994-03-04 Nuevos derivados liso-gangliosidos sulfatados.

Country Status (9)

Country Link
EP (1) EP0688331B1 (es)
JP (1) JPH08507308A (es)
AT (1) ATE202112T1 (es)
AU (1) AU685787B2 (es)
CA (1) CA2157357A1 (es)
DE (1) DE69427468T2 (es)
ES (1) ES2157257T3 (es)
IT (1) IT1267955B1 (es)
WO (1) WO1994020516A1 (es)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1238346B (it) * 1989-11-14 1993-07-13 Gangliosidi modificati e loro derivati funzionali.
JPH03246297A (ja) * 1990-02-22 1991-11-01 Nippon Koutai Kenkyusho:Kk ガングリオシド誘導体及びこれを含有する抗ｈｉｖ剤
IT1253832B (it) * 1991-08-01 1995-08-29 Fidia Spa Derivati di gangliosidi
IT1267956B1 (it) * 1993-03-04 1997-02-18 Fidia S P A In Amministrazione Derivati o-solfatati di gangliosidi e lisogangliosidi

Also Published As

Publication number Publication date
WO1994020516A1 (en) 1994-09-15
JPH08507308A (ja) 1996-08-06
DE69427468T2 (de) 2002-04-18
EP0688331A1 (en) 1995-12-27
IT1267955B1 (it) 1997-02-18
ATE202112T1 (de) 2001-06-15
DE69427468D1 (de) 2001-07-19
AU685787B2 (en) 1998-01-29
AU6393594A (en) 1994-09-26
ITPD930044A1 (it) 1994-09-04
EP0688331B1 (en) 2001-06-13
CA2157357A1 (en) 1994-09-15
ITPD930044A0 (it) 1993-03-04

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