ES2157399T3 - Complejos de platino. - Google Patents

Complejos de platino.

Info

Publication number
ES2157399T3
ES2157399T3 ES96300601T ES96300601T ES2157399T3 ES 2157399 T3 ES2157399 T3 ES 2157399T3 ES 96300601 T ES96300601 T ES 96300601T ES 96300601 T ES96300601 T ES 96300601T ES 2157399 T3 ES2157399 T3 ES 2157399T3
Authority
ES
Spain
Prior art keywords
carboxylate
halo
sub
replaced
equal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96300601T
Other languages
English (en)
Inventor
Barry A Murrer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Anormed Inc
Institute of Cancer Research Royal Cancer Hospital
Original Assignee
Anormed Inc
Institute of Cancer Research Royal Cancer Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Anormed Inc, Institute of Cancer Research Royal Cancer Hospital filed Critical Anormed Inc
Application granted granted Critical
Publication of ES2157399T3 publication Critical patent/ES2157399T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0086—Platinum compounds
    • C07F15/0093—Platinum compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Photolithography (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Studio Devices (AREA)

Abstract

SE PRESENTAN COMPLEJOS DE PLATINO DE LA FORMULA (IA) O (IB) EN DONDE CADA A, ES UN GRUPO SALIENTE Y PUEDE SER IGUAL O DIFERENTE, QUE ES ADECUADAMENTE HALO, ESPECIALMENTE CLORURO, HIDROXI, CARBOXILATO O JUNTAS FORMAN UN CARBOXILATO BIDENTADO O SULFATO, CADA B, QUE PUEDEN SER IGUALES O DIFERENTES, ES HALO, HIDROXIDO, CARBOXILATO, CARBAMATO O ESTER DE CARBONATO, Z ES UNA AMINA SUSTITUIDA EN DONDE EL SUSTITUYENTE ESTERICAMENTE IMPEDIDO ACCEDE DEL ATOMO DE PT A UN RAMAL DE ADN DE UNA CELULA TUMORAL, Y X ES NH{SUB,3} O NH{SUB,3} SUSTITUIDO CON MONO- O DI-ALQUILO. LOS COMPLEJOS SON ACTIVOS CONTRA LAS CELULAS CANCEROSAS, Y PARECEN MOSTRAR UNA UNICA FORMA DE ACCION QUIMICA Y BIOLOGICA.
ES96300601T 1995-02-14 1996-01-29 Complejos de platino. Expired - Lifetime ES2157399T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9502799.1A GB9502799D0 (en) 1995-02-14 1995-02-14 Improvements in platinum complexes

Publications (1)

Publication Number Publication Date
ES2157399T3 true ES2157399T3 (es) 2001-08-16

Family

ID=10769529

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96300601T Expired - Lifetime ES2157399T3 (es) 1995-02-14 1996-01-29 Complejos de platino.

Country Status (18)

Country Link
US (2) US5665771A (es)
EP (1) EP0727430B1 (es)
JP (1) JP3219235B2 (es)
KR (1) KR100339866B1 (es)
AT (1) ATE202111T1 (es)
AU (1) AU707814B2 (es)
CA (1) CA2169019C (es)
DE (1) DE69613254T2 (es)
DK (1) DK0727430T3 (es)
ES (1) ES2157399T3 (es)
FI (1) FI120493B (es)
GB (1) GB9502799D0 (es)
GR (1) GR3036513T3 (es)
NO (1) NO307569B1 (es)
NZ (1) NZ280946A (es)
PT (1) PT727430E (es)
TW (1) TW432068B (es)
ZA (1) ZA96885B (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6001872A (en) * 1999-03-05 1999-12-14 Virginia Commonwealth University Water soluble transplatinum complexes with anti-cancer activity and method of using same
CN1916009B (zh) * 1999-04-13 2010-12-15 阿诺麦德股份有限公司 制备胺铂配合物的方法
US6413953B1 (en) * 1999-04-13 2002-07-02 Anormed Inc. Pt(IV) antitumor agent
AU775373B2 (en) 1999-10-01 2004-07-29 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
RU2186068C2 (ru) * 1999-12-02 2002-07-27 Институт химии и химической технологии СО РАН Способ очистки цис-дихлороамминизопропиламинплатины (ii)
AUPQ641100A0 (en) * 2000-03-23 2000-04-15 Australia Nuclear Science & Technology Organisation Methods of synthesis and use of radiolabelled platinum chemotherapeutic ag ents
GB0011903D0 (en) * 2000-05-18 2000-07-05 Astrazeneca Ab Combination chemotherapy
US6894049B1 (en) 2000-10-04 2005-05-17 Anormed, Inc. Platinum complexes as antitumor agents
RU2284818C2 (ru) * 2001-05-10 2006-10-10 Анормед, Инк. Комбинированная химиотерапия
EP1420775B1 (en) * 2001-08-23 2010-02-17 Yissum Research Development Company Of The Hebrew University Of Jerusalem Platinum complexes and their uses in therapy
WO2007021852A2 (en) * 2005-08-11 2007-02-22 Virginia Commonwealth University Transplatinum complexes with n2o2 donor sets as cytotoxic and antitumor agents
US8168661B2 (en) * 2006-11-06 2012-05-01 Poniard Pharmaceuticals, Inc. Use of picoplatin to treat colorectal cancer
US8178564B2 (en) * 2006-11-06 2012-05-15 Poniard Pharmaceuticals, Inc. Use of picoplatin to treat colorectal cancer
US8168662B1 (en) 2006-11-06 2012-05-01 Poniard Pharmaceuticals, Inc. Use of picoplatin to treat colorectal cancer
US8173686B2 (en) * 2006-11-06 2012-05-08 Poniard Pharmaceuticals, Inc. Use of picoplatin to treat colorectal cancer
US20110033528A1 (en) * 2009-08-05 2011-02-10 Poniard Pharmaceuticals, Inc. Stabilized picoplatin oral dosage form
MX2009008487A (es) * 2007-02-09 2010-01-15 Poniard Pharmaceuticals Inc Picoplatino encapsulado.
CA2677640A1 (en) * 2007-02-09 2008-08-14 Poniard Pharmaceuticals, Inc. Stabilized picoplatin oral dosage form
US20100260832A1 (en) * 2007-06-27 2010-10-14 Poniard Pharmaceuticals, Inc. Combination therapy for ovarian cancer
TW200916094A (en) * 2007-06-27 2009-04-16 Poniard Pharmaceuticals Inc Stabilized picoplatin dosage form
US20100310661A1 (en) * 2007-07-16 2010-12-09 Poniard Pharmaceuticals, Inc. Oral formulations for picoplatin
CA2715348A1 (en) * 2008-02-08 2009-08-13 Poniard Pharmaceuticals, Inc. Use of picoplatin and bevacizumab to treat colorectal cancer
RU2383339C1 (ru) * 2008-07-04 2010-03-10 Федеральное государственное учреждение "Ростовский научно-исследовательский онкологический институт Росмедтехнологий" Способ прогнозирования эффективности неоадъювантной химиотерапии при местнораспространенном раке яичников
CN101775040B (zh) * 2009-12-31 2012-05-09 南京臣功制药有限公司 吡铂的制备方法
US9771387B2 (en) 2013-07-16 2017-09-26 Placon Therapeutics Platinum compounds having a heterocycle ligand, nanoparticles, and uses thereof
CN106943343B (zh) * 2016-01-06 2020-05-12 山东新时代药业有限公司 一种甲啶铂注射液及其制备方法
WO2017192290A1 (en) 2016-05-04 2017-11-09 The Wistar Institute Of Anatomy And Biology Methods of treating cancers overexpressing carm1 with ezh2 inhibitors and platinum-based antineoplastic drugs

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1432562A (en) 1972-04-10 1976-04-22 Rustenburg Platinum Mines Ltd Platinum co-ordination compounds
KR840007599A (ko) * 1983-01-21 1984-12-08 마쓰바라 이찌로오 백금 착화합 유기물의 제조방법
US4533502A (en) * 1983-02-22 1985-08-06 Rochon Fernande D Platinum (II) compounds and their preparation
EP0167310B1 (en) * 1984-06-27 1991-05-29 Johnson Matthey Public Limited Company Platinum co-ordination compounds
JPS61238795A (ja) * 1985-04-16 1986-10-24 エンゲルハード・コーポレーシヨン 白金トリアミン抗腫瘍剤
CA1327039C (en) * 1986-12-18 1994-02-15 Tetsushi Totani Ammine-alicyclic amine-platinum complexes and antitumor agents
US4812193A (en) * 1986-12-22 1989-03-14 Gauron Richard F Inset panel fastener and method of using
EP0328274B1 (en) * 1988-02-02 1994-10-19 Johnson Matthey, Inc., Pt (IV) complexes
GB8806044D0 (en) * 1988-03-14 1988-04-13 Johnson Matthey Plc Platinum coordination compounds
GB9105037D0 (en) * 1991-03-09 1991-04-24 Johnson Matthey Plc Improvements in chemical compounds
US5624919A (en) * 1993-09-14 1997-04-29 The University Of Vermont And State Agricultural College Trans platinum (IV) complexes
GB9408218D0 (en) * 1994-04-26 1994-06-15 Johnson Matthey Plc Improvements in platinum complexes
CN1916009B (zh) * 1999-04-13 2010-12-15 阿诺麦德股份有限公司 制备胺铂配合物的方法
EP1420775B1 (en) * 2001-08-23 2010-02-17 Yissum Research Development Company Of The Hebrew University Of Jerusalem Platinum complexes and their uses in therapy
DK1789427T3 (da) * 2004-09-01 2009-09-07 Platco Technologies Proprietar Fremstilling af platin(II)-komplekser
WO2007021852A2 (en) * 2005-08-11 2007-02-22 Virginia Commonwealth University Transplatinum complexes with n2o2 donor sets as cytotoxic and antitumor agents

Also Published As

Publication number Publication date
USRE41209E1 (en) 2010-04-06
JPH08259581A (ja) 1996-10-08
KR100339866B1 (ko) 2002-11-07
ZA96885B (en) 1996-08-14
NO960569L (no) 1996-08-15
PT727430E (pt) 2001-11-30
US5665771A (en) 1997-09-09
GR3036513T3 (en) 2001-12-31
ATE202111T1 (de) 2001-06-15
FI960660A0 (fi) 1996-02-14
FI960660L (fi) 1996-08-15
EP0727430B1 (en) 2001-06-13
AU4225896A (en) 1996-08-22
FI120493B (fi) 2009-11-13
EP0727430A1 (en) 1996-08-21
DE69613254T2 (de) 2001-09-20
CA2169019C (en) 2003-02-04
GB9502799D0 (en) 1995-04-05
DK0727430T3 (da) 2001-09-03
NZ280946A (en) 1997-05-26
DE69613254D1 (de) 2001-07-19
NO307569B1 (no) 2000-04-25
TW432068B (en) 2001-05-01
JP3219235B2 (ja) 2001-10-15
HK1011997A1 (en) 1999-07-23
AU707814B2 (en) 1999-07-22
NO960569D0 (no) 1996-02-13
CA2169019A1 (en) 1996-08-15
KR960030940A (ko) 1996-09-17

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