ES2157463T3 - Derivados de pirimidina. - Google Patents

Derivados de pirimidina.

Info

Publication number
ES2157463T3
ES2157463T3 ES96934545T ES96934545T ES2157463T3 ES 2157463 T3 ES2157463 T3 ES 2157463T3 ES 96934545 T ES96934545 T ES 96934545T ES 96934545 T ES96934545 T ES 96934545T ES 2157463 T3 ES2157463 T3 ES 2157463T3
Authority
ES
Spain
Prior art keywords
image
alkyl
alkoxy
hydrogen
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96934545T
Other languages
English (en)
Inventor
Thierry Godel
Claus Riemer
Albrecht Edenhofer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of ES2157463T3 publication Critical patent/ES2157463T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

LA INVENCION SE REFIERE A COMPUESTOS DE FORMULA GENERAL (I), DONDE R 1 Y R 2 , CADA UNO INDIVIDUALMENTE, REPRE SENTAN AMINO O ALQUILO INFERIOR, A REPRESENTA A 1 , A 2 , A 3 , A 4 , A 5 , A 6 O A 7 ; B REPRE SENTA HIDROGENO EN A 4 , A 5 Y A 6 ; (I) EN A SUP,1 A 6 ; ALCOXI INFERIOR EN A 4 - A 6 ; Y ALQUILO INFERIOR, ESTIRILO, FENILETINILO O BENZOILOXI - ALQUILO INFERIOR EN A 1 Y A 2 ; N REPRESENTA 0-2; M, P REPRESENTAN 0, 1 Y R 3 , R 4 , R 5 Y R 6 , CADA UNO INDEPENDIENTEMENTE, REPRESENTAN HIDROGENO, HALOGENO, ALQUILO INFERIOR, TRIFLUOROMETILO, NITRO O ALCOXI INFERIOR. ASIMISMO, LA INVENCION SE REFIERE A LAS SALES DE ADICION FARMACEUTICAMENTE ACEPTABLES DE DICHOS COMPUESTOS. LOS CITADOS COMPUESTOS SE PUEDEN UTILIZAR EN EL CONTROL Y LA PREVENCION DE ENFERMEDADES PRODUCIDAS POR ALTERACIONES DEL SISTEMA DE LA DOPAMINA, A CUYO TIPO PERTENECEN LAS ENFERMEDADES PSICOTICAS, COMO LA ESQUIZOFRENIA.
ES96934545T 1995-10-10 1996-10-04 Derivados de pirimidina. Expired - Lifetime ES2157463T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH285595 1995-10-10
CH162596 1996-06-28

Publications (1)

Publication Number Publication Date
ES2157463T3 true ES2157463T3 (es) 2001-08-16

Family

ID=25688204

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96934545T Expired - Lifetime ES2157463T3 (es) 1995-10-10 1996-10-04 Derivados de pirimidina.

Country Status (14)

Country Link
US (1) US5688798A (es)
EP (1) EP0873317B1 (es)
JP (1) JP3013940B2 (es)
CN (1) CN1199397A (es)
AT (1) ATE200486T1 (es)
BR (1) BR9611037A (es)
CA (1) CA2233502A1 (es)
DE (1) DE69612512T2 (es)
DK (1) DK0873317T3 (es)
ES (1) ES2157463T3 (es)
GR (1) GR3036177T3 (es)
PT (1) PT873317E (es)
TR (1) TR199800636T1 (es)
WO (1) WO1997013759A1 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6232326B1 (en) 1998-07-14 2001-05-15 Jodi A. Nelson Treatment for schizophrenia and other dopamine system dysfunctions
CA2448080A1 (en) 2001-05-22 2002-11-28 Neurogen Corporation Melanin concentrating hormone receptor ligands: substituted 1-benzyl-4-aryl piperazine analogues
MY150088A (en) 2003-05-19 2013-11-29 Irm Llc Immunosuppressant compounds and compositions
EP1644367B1 (en) * 2003-05-19 2015-10-14 Novartis AG Immunosuppressant compounds and compositions
WO2005110982A2 (en) * 2004-04-07 2005-11-24 Neurogen Corporation Substituted 1-benzyl-4-substituted piperazine analogues
WO2005110989A1 (en) * 2004-04-07 2005-11-24 Neurogen Corporation Substituted 1-heteroaryl-4-substituted piperazine and piperidine analogues
TW200609219A (en) * 2004-06-17 2006-03-16 Neurogen Corp Aryl-substituted piperazine derivatives
GB0503646D0 (en) * 2005-02-22 2005-03-30 Novartis Ag Organic compounds
GB0508319D0 (en) * 2005-04-25 2005-06-01 Novartis Ag Organic compounds
GB0508318D0 (en) * 2005-04-25 2005-06-01 Novartis Ag Organic compounds
GB0508314D0 (en) * 2005-04-25 2005-06-01 Novartis Ag Organic compounds
US8258139B2 (en) 2010-11-08 2012-09-04 Dainippon Sumitomo Pharma Co., Ltd. Method of treatment for mental disorders
ITFI20110040A1 (it) 2011-03-18 2012-09-19 Paolino Bacci Srl "testa porta-utensili per macchine utensili o centri di lavoro, e macchina comprendente detta testa"
WO2014192868A1 (ja) * 2013-05-30 2014-12-04 大日本住友製薬株式会社 環状アミノメチルピリミジン誘導体
ES3029867T3 (en) * 2019-12-18 2025-06-25 Chdi Foundation Inc Compounds and probes for imaging huntingtin protein

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3155572A (en) * 1959-04-13 1964-11-03 Merck & Co Inc Compositions and methods for treating coccidiosis
US3060184A (en) * 1960-11-30 1962-10-23 Merck & Co Inc 1-(4-amino-2-perfluoroalkyl-5-pyrimidinylmethyl)piperazines
DK190983A (da) * 1982-05-01 1983-11-02 Wellcome Found 2,4-diamino-5-(substituerede)pyrimidiner, fremgangsmaade til deres fremstilling og mellemprodukter derfor
US5116846A (en) * 1990-03-28 1992-05-26 Du Pont Merck Pharmaceutical Company N-aralkyl piperidine derivatives as psychotropic drugs
US5169855A (en) * 1990-03-28 1992-12-08 Du Pont Merck Pharmaceutical Company Piperidine ether derivatives as psychotropic drugs or plant fungicides
DE9117064U1 (de) * 1991-02-14 1995-07-06 Sirona Dental Systems GmbH, 64625 Bensheim Ventilanordnung in einer zahnärztlichen Absauganlage
WO1994020459A2 (en) * 1993-03-01 1994-09-15 Merck Sharp & Dohme Limited Pyrrolo-pyridine derivatives as dopamine receptor ligands

Also Published As

Publication number Publication date
CA2233502A1 (en) 1997-04-17
CN1199397A (zh) 1998-11-18
US5688798A (en) 1997-11-18
ATE200486T1 (de) 2001-04-15
TR199800636T1 (xx) 1998-06-22
EP0873317A1 (en) 1998-10-28
PT873317E (pt) 2001-09-28
GR3036177T3 (en) 2001-10-31
DK0873317T3 (da) 2001-08-06
EP0873317B1 (en) 2001-04-11
WO1997013759A1 (en) 1997-04-17
DE69612512D1 (de) 2001-05-17
MX9802816A (es) 1998-09-30
BR9611037A (pt) 1999-07-06
JP3013940B2 (ja) 2000-02-28
DE69612512T2 (de) 2002-03-28
JPH11500745A (ja) 1999-01-19

Similar Documents

Publication Publication Date Title
ES2157463T3 (es) Derivados de pirimidina.
ATE185792T1 (de) Stilbenderivate und diese enthaltende pharmazeutische zusammensetzungen
NO308848B1 (no) Kromanforbindelse og farmasøytisk preparat som inneholder den
NO942953D0 (no) 11-benzaldoksimestradienderivater, fremgangsmåte for deres fremstilling smat legemddel inneholdende slike
CA2216796A1 (en) Quinazoline derivatives
DK0734383T3 (da) Cykliske amidderivater som neurokinin-A-antagonister
ATE18902T1 (de) Aminosaeurederivate und ihre therapeutischen verwendungen.
DK0865281T3 (da) Naphthylsubstituerede benzimidazolderivater som antikoagulerende midler
DK1021456T3 (da) Makrocykliske derivater af erythromysin A og B med 13-leddet ring
DK0894084T3 (da) Kanelsyrederivater og deres anvendelse som integrinantagonister
ATE202337T1 (de) Cyclopropylalkansäurederivate
CA2234319A1 (en) Fluoro-substituted adamantane derivatives
NO942952D0 (no) 11-benzaldoksin-17 ater, fremgangsmåte for deres fremstilling samt legemiddel inneholdende slike
CA2297486A1 (en) 2-(4-aryl or heteroaryl-piperazin-1-ylmethyl)-1h-indole derivatives interacting with the dopamine d4 receptor
CA2254117A1 (en) 2,4-diaminopyrimidine derivatives
MX9708595A (es) Derivados de bencil piperidina como agentes farmaceuticos.
PT781126E (pt) Derivados de 2-amino-1,2,3,4-tetra-hidro naftalino activos no sistema cardiovascular
DE69402935D1 (de) Substituierte arylalkylaminobenzyl-aminopropanamide, ihre herstellung und verwendung als antiepileptische, neuroprotektive und antidepressive mittel
DE69627519D1 (de) Sesquiterpen-derivate mit antiviraler aktivität
NO961719D0 (no) 3-aryl-4-alkyl og 4,5-dialkyl-4H-1,2,4-triazoler som er anvendbare som hukommelsesforsterkere
DE69412794D1 (de) 2'-desoxy-5-fluoruridin, pharmazeutisch anwendbare salze davon, verfahren zu ihrer herstellung und antitumormedikament
DK0573360T3 (da) Pyrrolothienopyrazinforbindelser som 5-HT3-receptorantagonister
DK0514267T3 (da) Hidtil ukendte amidderivater af 1-aminooctahydropyrido(2,1-c)(1,4)oxazin, fremgangsmåder til fremstilling heraf og farmaceutiske midler, som indeholder dem

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 873317

Country of ref document: ES