ES2157569T3 - Procedimiento de deteccion y/o cuantificacion de un factor gliotoxico. - Google Patents

Procedimiento de deteccion y/o cuantificacion de un factor gliotoxico.

Info

Publication number
ES2157569T3
ES2157569T3 ES97919095T ES97919095T ES2157569T3 ES 2157569 T3 ES2157569 T3 ES 2157569T3 ES 97919095 T ES97919095 T ES 97919095T ES 97919095 T ES97919095 T ES 97919095T ES 2157569 T3 ES2157569 T3 ES 2157569T3
Authority
ES
Spain
Prior art keywords
factor
cells
initial
sample
adherent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97919095T
Other languages
English (en)
Inventor
Carine Malcus-Vocanson
Herve Perron
Bernard Mandrand
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biomerieux SA
Original Assignee
Biomerieux SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biomerieux SA filed Critical Biomerieux SA
Application granted granted Critical
Publication of ES2157569T3 publication Critical patent/ES2157569T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Rehabilitation Therapy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

LA INVENCION SE REFIERE A UN PROCEDIMIENTO PARA DETECTAR Y/O CUANTIFICAR, EN UNA MUESTRA BIOLOGICA, UN FACTOR CITOTOXICO, PARTICULARMENTE UN FACTOR GLIOTOXICO, RESPECTO A CELULAS ADHERENTES OBJETIVO, PARTICULARMENTE LAS CELULAS MACROGIALES, Y CUYA CITOTOXICIDAD INDUCE LA MUERTE POR APOPTOSIS DE DICHAS CELULAS, SEGUN EL CUAL SE DISPONE DE UNA FRACCION DE SALIDA DE DICHA MUESTRA OPCIONALMENTE ENRIQUECIDA CON DICHO FACTOR TOXICO POR UN TRATAMIENTO PREVIO, SE INCUBA DICHA FRACCION DE SALIDA CON UN MEDIO DE CULTIVO DE REFERENCIA QUE COMPRENDE CELULAS ADHERENTES OBJETIVO, Y SE DETECTAN Y/O CUANTIFICAN LAS CELULAS ADHERENTES MUERTAS POR APOPTOSIS, POR CITOMETRIA DE FLUJO, AL MENOS UNA CARACTERISTICA DIRECTA O INDIRECTA, ASOCIADA A LAS CELULAS ADHERENTES APOPTOTICAS DE TODO O PARTE DEL MEDIO INCUBADO QUE, SI EXISTE Y/O SE CUANTIFICA, CLASIFICA DICHA MUESTRA BIOLOGICA COMO POSITIVA, ES DECIR QUE CONTIENEN DICHO FACTOR TOXICO. LA MUESTRA BIOLOGICA DE SALIDA ES PREFERENTEMENTE UNA MUESTRA DE ORINA.
ES97919095T 1996-09-12 1997-09-12 Procedimiento de deteccion y/o cuantificacion de un factor gliotoxico. Expired - Lifetime ES2157569T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9611347 1996-09-12

Publications (1)

Publication Number Publication Date
ES2157569T3 true ES2157569T3 (es) 2001-08-16

Family

ID=9495830

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97919095T Expired - Lifetime ES2157569T3 (es) 1996-09-12 1997-09-12 Procedimiento de deteccion y/o cuantificacion de un factor gliotoxico.

Country Status (9)

Country Link
US (1) US6270953B1 (es)
EP (1) EP0925504B1 (es)
JP (1) JP2001504686A (es)
AT (1) ATE199782T1 (es)
CA (1) CA2266124A1 (es)
DE (1) DE69704279T2 (es)
DK (1) DK0925504T3 (es)
ES (1) ES2157569T3 (es)
WO (1) WO1998011439A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2797402B1 (fr) * 1999-07-15 2004-03-12 Biomerieux Stelhys Utilisation d'un polypeptide pour detecter, prevenir ou traiter un etat pathologique associe a une maladie degenerative, neurologique ou autoimmune
DE10053521B4 (de) * 2000-10-27 2004-07-08 november Aktiengesellschaft Gesellschaft für Molekulare Medizin Verfahren zum Nachweis apoptotischer und nekrotischer Zellen
ES2661168T3 (es) * 2003-07-12 2018-03-27 Accelerate Diagnostics, Inc. Biodetección sensible y rápida
US20120077206A1 (en) 2003-07-12 2012-03-29 Accelr8 Technology Corporation Rapid Microbial Detection and Antimicrobial Susceptibility Testing
US7341841B2 (en) * 2003-07-12 2008-03-11 Accelr8 Technology Corporation Rapid microbial detection and antimicrobial susceptibility testing
US10254204B2 (en) 2011-03-07 2019-04-09 Accelerate Diagnostics, Inc. Membrane-assisted purification
US9434937B2 (en) 2011-03-07 2016-09-06 Accelerate Diagnostics, Inc. Rapid cell purification systems
US9442092B2 (en) 2011-06-20 2016-09-13 Kerry Lane Methods for treatment of autism
US9677109B2 (en) 2013-03-15 2017-06-13 Accelerate Diagnostics, Inc. Rapid determination of microbial growth and antimicrobial susceptibility
US10023895B2 (en) 2015-03-30 2018-07-17 Accelerate Diagnostics, Inc. Instrument and system for rapid microogranism identification and antimicrobial agent susceptibility testing
US10253355B2 (en) 2015-03-30 2019-04-09 Accelerate Diagnostics, Inc. Instrument and system for rapid microorganism identification and antimicrobial agent susceptibility testing
CN110196219B (zh) * 2019-05-16 2022-06-03 扬州大学 一种基于流式细胞术检测鸡脾脏cd8+t细胞特异性杀伤作用的方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2716198B1 (fr) * 1994-02-15 1996-04-19 Bio Merieux Facteur cytotoxique tel qu'associé à la sclérose en plaques, sa détection et sa quantification.
IT1278044B1 (it) * 1995-03-09 1997-11-17 Salvatore Petraroli Metodologia per la realizzazione di un esame di laboratorio dell' integrita' in vitro delle cellule ematiche non fissate e/o

Also Published As

Publication number Publication date
CA2266124A1 (fr) 1998-03-19
EP0925504A1 (fr) 1999-06-30
DK0925504T3 (da) 2001-07-23
DE69704279T2 (de) 2001-10-31
WO1998011439A1 (fr) 1998-03-19
EP0925504B1 (fr) 2001-03-14
US6270953B1 (en) 2001-08-07
JP2001504686A (ja) 2001-04-10
DE69704279D1 (de) 2001-04-19
ATE199782T1 (de) 2001-03-15

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