ES2157991T3 - Cadn que codifica una nueva proteina humana, la tirosin-fosfatasa. - Google Patents

Cadn que codifica una nueva proteina humana, la tirosin-fosfatasa.

Info

Publication number
ES2157991T3
ES2157991T3 ES94929163T ES94929163T ES2157991T3 ES 2157991 T3 ES2157991 T3 ES 2157991T3 ES 94929163 T ES94929163 T ES 94929163T ES 94929163 T ES94929163 T ES 94929163T ES 2157991 T3 ES2157991 T3 ES 2157991T3
Authority
ES
Spain
Prior art keywords
ptp
human protein
phosphatase
tirosin
cadn
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94929163T
Other languages
English (en)
Inventor
Gideon A Rodan
Su J Rutledge
Azriel Schmidt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of ES2157991T3 publication Critical patent/ES2157991T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/42—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving phosphatase

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

SE HA IDENTIFICADO UNA NUEVA FOSFATASA DE TIROSINA DE PROTEINA HUMANA (PTP) Y SE HA AISLADO SU ADNC. ESTA NUEVA PTP IDENTIFICADA COMO PTP-OB, TIENE UNA ESTRUCTURA TRIDIMENSIONAL SIMILAR AL RECEPTOR Y ESTA PRESENTE EN LOS OSTEOBLASTOS. LA PTB-OB ESTA INVOLUCRADA EN LA DIFERENCIACION DEL OSTEOBLASTO, Y LOS MODULADORES DE LA ACTIVIDAD DE LA PTP-OB MODULAN A SU VEZ LA DIFERENCIACION DEL OSTEOBLASTO, LA DIFERENCIACION DEL OSTEOCLASTO Y LA ACTIVIDAD DEL OSTEOCLASTO.
ES94929163T 1993-09-14 1994-09-09 Cadn que codifica una nueva proteina humana, la tirosin-fosfatasa. Expired - Lifetime ES2157991T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12203293A 1993-09-14 1993-09-14

Publications (1)

Publication Number Publication Date
ES2157991T3 true ES2157991T3 (es) 2001-09-01

Family

ID=22400183

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94929163T Expired - Lifetime ES2157991T3 (es) 1993-09-14 1994-09-09 Cadn que codifica una nueva proteina humana, la tirosin-fosfatasa.

Country Status (8)

Country Link
US (3) US5658756A (es)
EP (1) EP0725800B1 (es)
JP (1) JPH09502614A (es)
AT (1) ATE202571T1 (es)
CA (1) CA2171610A1 (es)
DE (1) DE69427588T2 (es)
ES (1) ES2157991T3 (es)
WO (1) WO1995007935A1 (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5821084A (en) * 1994-11-21 1998-10-13 The Regents Of The University Of Michigan Osteoblast-testicular protein tyrosine phosphatase
US6919434B1 (en) 1995-02-20 2005-07-19 Sankyo Co., Ltd. Monoclonal antibodies that bind OCIF
IL117175A (en) * 1995-02-20 2005-11-20 Sankyo Co Osteoclastogenesis inhibitory factor protein
US5719058A (en) * 1995-04-10 1998-02-17 Merck & Co., Inc. Method for producing a highly enriched population of osteoclast cells
AU709191B2 (en) * 1995-09-11 1999-08-26 Osteoarthritis Sciences, Inc. Protein tyrosine kinase inhibitors for treating osteoarthritis
US20050147611A1 (en) * 1995-12-22 2005-07-07 Amgen Inc. Combination therapy for conditions leading to bone loss
US7632922B1 (en) * 1995-12-22 2009-12-15 Amgen, Inc. Osteoprotegerin
DE69740107D1 (de) 1996-12-23 2011-03-10 Immunex Corp Rezeptor aktivator von nf-kappa b, rezeptor is mitglied der tnf rezeptor superfamilie
ES2263204T5 (es) * 1997-04-15 2013-10-14 Daiichi Sankyo Company, Limited Nueva proteína y proceso para producir la misma
US6316408B1 (en) * 1997-04-16 2001-11-13 Amgen Inc. Methods of use for osetoprotegerin binding protein receptors
ES2284203T5 (es) 1997-04-16 2016-03-11 Amgen Inc. Proteínas de unión a osteoprotegerina y sus receptores
WO1998054357A1 (en) * 1997-05-30 1998-12-03 David Jeston Baylink SCREENING METHODS TO IDENTIFY COMPOUNDS WHICH EFFECT OSTEOCLAST-SPECIFIC PHOSPHOTYROSYL PHOSPHATASE (PTP-oc) ACTIVITY
JP4268684B2 (ja) 1997-09-24 2009-05-27 第一三共株式会社 骨代謝異常症の診断方法
EP1037900A4 (en) 1997-10-24 2006-08-30 Univ Utah Res Found KNCQ2 AND KNCQ3, GENES OF THE POTASSIUM CHANNEL HAVING MUTATION IN BENIGN FAMILY NEONATAL CONVULSIONS (BFNC) AND OTHER EPILEPSIES
US6780596B2 (en) * 1998-09-17 2004-08-24 Ashni Naturaceuticals, Inc. Methods for determining the activity of complex mixtures
US6331533B1 (en) 1998-11-16 2001-12-18 Merck & Co., Inc. Method for inhibiting dental resorptive lesions
AU2900400A (en) 1999-03-08 2000-09-28 Merck Frosst Canada & Co. Intact cell assay for protein tyrosine phosphatases
US20030103978A1 (en) * 2000-02-23 2003-06-05 Amgen Inc. Selective binding agents of osteoprotegerin binding protein
DK1373215T3 (da) * 2001-03-30 2006-11-13 Us Health Gelanamycinderivater egnet til behandling af cancer
US7247618B2 (en) * 2001-04-30 2007-07-24 Tripathi Rajavashisth Methods for inhibiting macrophage colony stimulating factor and c-FMS-dependent cell signaling
US7718776B2 (en) 2002-04-05 2010-05-18 Amgen Inc. Human anti-OPGL neutralizing antibodies as selective OPGL pathway inhibitors
CA2514363A1 (en) * 2003-02-12 2004-08-26 Transtech Pharma, Inc. Substituted azole derivatives as therapeutic agents
WO2004071448A2 (en) * 2003-02-12 2004-08-26 Transtech Pharma Inc. Substituted azole derivatives as inhibitors of protein tyrosine phosphatases
CA2551909C (en) * 2004-02-12 2011-10-11 Transtech Pharma, Inc. Substituted azole derivatives, compositions, and methods of use
NZ569329A (en) 2006-01-30 2011-09-30 Transtech Pharma Inc Substituted imidazole derivatives and their use as PTPase inhibitors
JP6770750B2 (ja) * 2015-10-06 2020-10-21 国立大学法人東京工業大学 チロシンホスファターゼ及びチロシンキナーゼ活性の測定方法

Also Published As

Publication number Publication date
US6214564B1 (en) 2001-04-10
ATE202571T1 (de) 2001-07-15
CA2171610A1 (en) 1995-03-23
EP0725800A4 (en) 1997-09-10
DE69427588D1 (de) 2001-08-02
JPH09502614A (ja) 1997-03-18
EP0725800A1 (en) 1996-08-14
WO1995007935A1 (en) 1995-03-23
EP0725800B1 (en) 2001-06-27
DE69427588T2 (de) 2002-04-25
US5866397A (en) 1999-02-02
US5658756A (en) 1997-08-19

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