ES2158684T3 - Procedimiento para la preparacion de acido 3,4-epoxibutirico quiral y sus sales. - Google Patents
Procedimiento para la preparacion de acido 3,4-epoxibutirico quiral y sus sales.Info
- Publication number
- ES2158684T3 ES2158684T3 ES98929880T ES98929880T ES2158684T3 ES 2158684 T3 ES2158684 T3 ES 2158684T3 ES 98929880 T ES98929880 T ES 98929880T ES 98929880 T ES98929880 T ES 98929880T ES 2158684 T3 ES2158684 T3 ES 2158684T3
- Authority
- ES
- Spain
- Prior art keywords
- acid
- preparation
- epoxibutric
- salts
- procedure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract 2
- 239000002253 acid Substances 0.000 title 2
- ZVNYKZKUBKIIAH-UHFFFAOYSA-N 2-(oxiran-2-yl)acetic acid Chemical compound OC(=O)CC1CO1 ZVNYKZKUBKIIAH-UHFFFAOYSA-N 0.000 abstract 1
- 238000006735 epoxidation reaction Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 239000002994 raw material Substances 0.000 abstract 1
- 238000007142 ring opening reaction Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/38—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D301/00—Preparation of oxiranes
- C07D301/02—Synthesis of the oxirane ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Epoxy Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
La invención se refiere al procedimiento para la preparación del ácido quiral 3,4-epoxibutírico representado por la fórmula (1) y la sal de éste, en el que se emplea como materia prima la hidroxibutirolactona-(S)-3-activada u otro material barato para realizar una reacción eficaz de apertura de anillo y una epoxidación con una inversión del centro quiral.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR19970033208 | 1997-07-16 | ||
| KR1019970057812A KR100247563B1 (ko) | 1997-07-16 | 1997-11-03 | 키랄3,4-에폭시부티르산및이의염의제조방법 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2158684T3 true ES2158684T3 (es) | 2001-09-01 |
Family
ID=26632933
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES98929880T Expired - Lifetime ES2158684T3 (es) | 1997-07-16 | 1998-06-17 | Procedimiento para la preparacion de acido 3,4-epoxibutirico quiral y sus sales. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6232478B1 (es) |
| EP (1) | EP1000049B1 (es) |
| JP (1) | JP3306549B2 (es) |
| KR (1) | KR100247563B1 (es) |
| CN (1) | CN1264372A (es) |
| CA (1) | CA2296316A1 (es) |
| DE (1) | DE69800805T2 (es) |
| ES (1) | ES2158684T3 (es) |
| WO (1) | WO1999003850A1 (es) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100255039B1 (ko) * | 1997-07-28 | 2000-05-01 | 박영구 | L-카르니틴의제조방법 |
| US20100108118A1 (en) * | 2008-06-02 | 2010-05-06 | Daniel Luch | Photovoltaic power farm structure and installation |
| US20090293941A1 (en) * | 2008-06-02 | 2009-12-03 | Daniel Luch | Photovoltaic power farm structure and installation |
| KR20000065995A (ko) * | 1999-04-12 | 2000-11-15 | 박영구 | 키랄 3-히드록시-γ-부티로락톤의 제조방법 |
| WO2004019943A1 (en) | 2002-08-30 | 2004-03-11 | Memory Pharmaceuticals Corporation | Anabaseine derivatives useful in the treatment of neurodegenerative diseases |
| AU2003276919B2 (en) | 2002-09-25 | 2013-05-16 | Memory Pharmaceuticals Corporation | Indazoles, benzothiazoles, and benzoisothiazoles, and preparation and uses thereof |
| US7317109B2 (en) | 2003-11-12 | 2008-01-08 | Phenomix Corporation | Pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV |
| US7767828B2 (en) | 2003-11-12 | 2010-08-03 | Phenomix Corporation | Methyl and ethyl substituted pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV |
| US7576121B2 (en) | 2003-11-12 | 2009-08-18 | Phenomix Corporation | Pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV |
| EP1689757B1 (en) | 2003-11-12 | 2014-08-27 | Phenomix Corporation | Heterocyclic boronic acid compounds |
| RU2417225C2 (ru) | 2004-03-25 | 2011-04-27 | Мемори Фармасьютиклз Корпорейшн | Индазолы, бензотиазолы, бензоизотиазолы, бензизоксазолы и их получение и применение |
| US7825139B2 (en) | 2005-05-25 | 2010-11-02 | Forest Laboratories Holdings Limited (BM) | Compounds and methods for selective inhibition of dipeptidyl peptidase-IV |
| US9236512B2 (en) | 2006-04-13 | 2016-01-12 | Daniel Luch | Collector grid and interconnect structures for photovoltaic arrays and modules |
| US9865758B2 (en) | 2006-04-13 | 2018-01-09 | Daniel Luch | Collector grid and interconnect structures for photovoltaic arrays and modules |
| PT2099442E (pt) | 2006-12-26 | 2015-02-10 | Pharmacyclics Inc | Métodos de utilização de inibidores de histona desacetilase e monitorização de biomarcadores em terapia de combinação |
| TW200901974A (en) | 2007-01-16 | 2009-01-16 | Wyeth Corp | Compounds, compositions, and methods of making and using them |
| CN102374987A (zh) * | 2010-08-17 | 2012-03-14 | 上海新先锋药业有限公司 | 一种4-乙酰氧基氮杂环丁酮中间体的含量测定方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1189069B (it) * | 1986-03-14 | 1988-01-28 | Donegani Guido Ist | Processo per la preparazione biotecnologica della l(-)-carnitina cloruro |
| JP2834501B2 (ja) * | 1989-11-25 | 1998-12-09 | 鐘淵化学工業株式会社 | 3,4―エポキシ酪酸エステルの製法および中間体 |
| CA2049536C (en) | 1991-05-13 | 1999-07-06 | Rawle I. Hollingsworth | Process for the preparation of 3,4-dihydroxybutanoic acid and salts thereof |
-
1997
- 1997-11-03 KR KR1019970057812A patent/KR100247563B1/ko not_active Expired - Fee Related
-
1998
- 1998-06-17 WO PCT/KR1998/000166 patent/WO1999003850A1/en not_active Ceased
- 1998-06-17 CN CN98807288A patent/CN1264372A/zh active Pending
- 1998-06-17 CA CA002296316A patent/CA2296316A1/en not_active Abandoned
- 1998-06-17 EP EP98929880A patent/EP1000049B1/en not_active Expired - Lifetime
- 1998-06-17 JP JP50693299A patent/JP3306549B2/ja not_active Expired - Fee Related
- 1998-06-17 ES ES98929880T patent/ES2158684T3/es not_active Expired - Lifetime
- 1998-06-17 DE DE69800805T patent/DE69800805T2/de not_active Expired - Fee Related
- 1998-06-17 US US09/462,810 patent/US6232478B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| KR100247563B1 (ko) | 2000-04-01 |
| JP2001508082A (ja) | 2001-06-19 |
| CN1264372A (zh) | 2000-08-23 |
| CA2296316A1 (en) | 1999-01-28 |
| WO1999003850A1 (en) | 1999-01-28 |
| KR19990013236A (ko) | 1999-02-25 |
| EP1000049A1 (en) | 2000-05-17 |
| EP1000049B1 (en) | 2001-05-16 |
| US6232478B1 (en) | 2001-05-15 |
| DE69800805T2 (de) | 2001-11-15 |
| JP3306549B2 (ja) | 2002-07-24 |
| DE69800805D1 (de) | 2001-06-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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