ES2158809B1 - NEW SULFONATED DERIVATIVES AS INHIBITORS OF CYCLLOXYGENASA II. - Google Patents
NEW SULFONATED DERIVATIVES AS INHIBITORS OF CYCLLOXYGENASA II.Info
- Publication number
- ES2158809B1 ES2158809B1 ES9902286A ES9902286A ES2158809B1 ES 2158809 B1 ES2158809 B1 ES 2158809B1 ES 9902286 A ES9902286 A ES 9902286A ES 9902286 A ES9902286 A ES 9902286A ES 2158809 B1 ES2158809 B1 ES 2158809B1
- Authority
- ES
- Spain
- Prior art keywords
- sup
- sub
- inhibitors
- cyclooxygenase
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 102000010907 Cyclooxygenase 2 Human genes 0.000 abstract 3
- 108010037462 Cyclooxygenase 2 Proteins 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 206010009944 Colon cancer Diseases 0.000 abstract 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 abstract 1
- 102000004005 Prostaglandin-endoperoxide synthases Human genes 0.000 abstract 1
- 108090000459 Prostaglandin-endoperoxide synthases Proteins 0.000 abstract 1
- 206010037660 Pyrexia Diseases 0.000 abstract 1
- 229940124639 Selective inhibitor Drugs 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Nuevos derivados sulfonados como inhibidores de la ciclooxigenasa II. La presente invención se refiere a compuestos de fórmula general I, **FORMULA** inhibidores selectivos de la ciclooxigenasa-II en los que D es un grupo -C(R{sup,2}) (R{sup,3}) -C(R{sup,4}) (R{sup,5})-, -C(R{sup,2})=C(R{sup,4})- ó -C=C-; A es un birradical -CO-, -O-, -S-, ó -NH- y E es halógeno, (C{sub,1}-C{sub,6})-alquilo, (C{sub,2}-C{sub,6})-alquenilo, (C{sub,2}-C{sub,6})-alquinilo, etc, a sus sales y solvatos farmacéuticamente aceptables, y a las composiciones farmacéuticas que las contienen. Los compuestos de la presente invención son útiles en el tratamiento de la inflamación, dolor y fiebre, así como de aquellas otras afecciones que recientemente se han asociado con las ciclooxigenasas, especialmente con la ciclooxigenasa-II, como, por ejemplo, el cáncer colorectal y la enfermedad de Alzheimer. De igual modo, la presente invención se refiere a un procedimiento para la preparación de los compuestos, así como a su utilización terapéutica.New sulphonated derivatives as inhibitors of cyclooxygenase II. The present invention relates to compounds of general formula I, ** FORMULA ** selective inhibitors of cyclooxygenase-II in which D is a group -C (R {sup, 2}) (R {sup, 3}) - C (R {sup, 4}) (R {sup, 5}) -, -C (R {sup, 2}) = C (R {sup, 4}) - or -C = C-; A is a biradical -CO-, -O-, -S-, or -NH- and E is halogen, (C {sub, 1} -C {sub, 6}) -alkyl, (C {sub, 2} -C {sub, 6}) - alkenyl, (C {sub, 2} -C {sub, 6}) - alkynyl, etc., to their pharmaceutically acceptable salts and solvates, and to the pharmaceutical compositions containing them. The compounds of the present invention are useful in the treatment of inflammation, pain and fever, as well as those other conditions that have recently been associated with cyclooxygenases, especially with cyclooxygenase-II, such as, for example, colorectal cancer and Alzheimer's disease. Similarly, the present invention relates to a process for the preparation of the compounds, as well as to their therapeutic use.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES9902286A ES2158809B1 (en) | 1999-10-18 | 1999-10-18 | NEW SULFONATED DERIVATIVES AS INHIBITORS OF CYCLLOXYGENASA II. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES9902286A ES2158809B1 (en) | 1999-10-18 | 1999-10-18 | NEW SULFONATED DERIVATIVES AS INHIBITORS OF CYCLLOXYGENASA II. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2158809A1 ES2158809A1 (en) | 2001-09-01 |
| ES2158809B1 true ES2158809B1 (en) | 2002-03-16 |
Family
ID=8310282
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES9902286A Expired - Fee Related ES2158809B1 (en) | 1999-10-18 | 1999-10-18 | NEW SULFONATED DERIVATIVES AS INHIBITORS OF CYCLLOXYGENASA II. |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES2158809B1 (en) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4192873A (en) * | 1976-11-25 | 1980-03-11 | Ciba-Geigy Corporation | Anti-inflammatory 2-sulphonyl- (or -sulphinyl)-2'-aminoacetophenones |
| PT86407B (en) * | 1986-12-31 | 1990-11-20 | Fujisawa Pharmaceutical Co | METHOD FOR PREPARING NEW ALCANO-SULFONANILIDA DERIVATIVES, AND OF PHARMACEUTICAL COMPOSITIONS UNDERSTANDING THE SAME |
| JP3802581B2 (en) * | 1995-03-01 | 2006-07-26 | 富山化学工業株式会社 | Novel biphenyl derivatives or salts thereof and anti-inflammatory agents containing them |
-
1999
- 1999-10-18 ES ES9902286A patent/ES2158809B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ES2158809A1 (en) | 2001-09-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69912606D1 (en) | 2- (purin-9-yl) -tetrahydro-3,4-DIOL DERIVATIVES | |
| ECSP055609A (en) | "Use of IkB-kinase inhibitors for the treatment of pain" | |
| ES2037013T3 (en) | PROCEDURE FOR PREPARING TIENO-1,4-DIAZEPINES. | |
| CY1106784T1 (en) | SUBSTITUTED phenylpropionic acid derivatives as competitors of human peroxisome proliferator-activated receptor alpha (PPAR) | |
| TR200100410T2 (en) | 2- (purin-9-yl) -tetrahydrofuran-3,4-diol derivatives. | |
| AR026052A1 (en) | PURINA DERIVATIVES | |
| PA8442001A1 (en) | DERIVATIVES OF CONDENSED BICYCLIC PIRIMIDINE | |
| SV1999000016A (en) | DERIVATIVES OF 2- (PURIN-9-IL-TETRAHIDROFURAN-3,4-DIOL REF. PG3443 / SV | |
| ES2161290T3 (en) | DERIVATIVES OF QUINAZOLINA. | |
| ES2148229T3 (en) | ATERES AND THIOETERES IN POSITION 17 OF 4-AZA-STEROIDS. | |
| ES467828A1 (en) | A PROCEDURE FOR PREPARING NEW CEFEM AND CEFAM COMPOUNDS | |
| ES2167377T3 (en) | DERIVATIVES OF PIRIDINA PHARMACOLOGICALLY ACTIVE AND PROCEDURES FOR THE PREPARATION OF THE SAME. | |
| PA8503501A1 (en) | PURINA DERIVATIVES | |
| AR037484A1 (en) | A COMPOUND DERIVED FROM AMINO-TRIAZOLOPIRIDINE, A MEDICINAL PRODUCT CONTAINING ONE OR MORE OF THE COMPOUNDS, A PROCESS FOR THE PREPARATION OF THE COMPOUND AND THE USE OF THE COMPOUND | |
| TR200100411T2 (en) | 2- (Purin-9-yl) -tetrahydrofuran-3,4-diol derivatives. | |
| CR7743A (en) | NEW OXAZOL AND TIAZOL COMPOUNDS AS INHIBITOR OF THE TRANSFORMING GROWTH FACTOR (TGF) | |
| ES2153820T3 (en) | DERIVATIVES OF BENZIMIDAZOL, PROCEDURE FOR PREPARATION AND APPLICATIONS. | |
| AR035963A1 (en) | COMPOUNDS DERIVED FROM TRIFLUORMETHYLBENENE USEFUL AS INTERMEDIATES OF THE INHIBITORS OF THE PROTEIN OF TRANSFER OF THE ESTER OF CHOLESTERILE AND PROCEDURES FOR THEIR PREPARATION | |
| AR003427A1 (en) | PEPTIDES RELATED TO DOLASTATIN, PROCEDURE FOR PREPARING THEM, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THE USE OF THE SAME FOR THE PREPARATION OF SUCH PHARMACEUTICAL COMPOSITIONS. | |
| MX9303145A (en) | 7- (2-AMINOETIL) BENZOTIAZOLONAS. | |
| ES2009723A4 (en) | DERIVATIVES OF BILIAR ACIDS, PROCEDURES FOR THE PREPARATION OF THE SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. | |
| AR021843A1 (en) | DERIVATIVES OF PROPANOLAMINE SUBSTITUTED WITH HETEROCICLES, PROCEDURE FOR THEIR PREPARATION, AND ITS USE. | |
| ES2041705T3 (en) | PROCEDURE FOR THE PREPARATION OF 1- (4-HYDROXY-3,5-DI-TERC-BUTYL-BENZOIL) -HOMOPIPERAZINE AND ITS DERIVATIVES. | |
| SE8701406D0 (en) | AROMATIC COMPOUNDS, THEIR PRODUCTION PROCEDURES AND THEIR USE IN HUMAN AND VETERINARY MEDICINES AND IN COSMETICS | |
| AR018162A1 (en) | SUBSTITUTED PIRROLS, PHARMACEUTICAL COMPOSITION AND THE USE OF THEM FOR THE PREPARATION OF SUCH PHARMACEUTICAL COMPOSITION |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EC2A | Search report published |
Date of ref document: 20010120 Kind code of ref document: A1 Effective date: 20010120 |
|
| FD1A | Patent lapsed |
Effective date: 20100312 |