ES2159568T3 - Procedimiento de preparacion de benzo-indoles sustituidos de elevada pureza y sus sales alcalinas. - Google Patents

Procedimiento de preparacion de benzo-indoles sustituidos de elevada pureza y sus sales alcalinas.

Info

Publication number
ES2159568T3
ES2159568T3 ES94926984T ES94926984T ES2159568T3 ES 2159568 T3 ES2159568 T3 ES 2159568T3 ES 94926984 T ES94926984 T ES 94926984T ES 94926984 T ES94926984 T ES 94926984T ES 2159568 T3 ES2159568 T3 ES 2159568T3
Authority
ES
Spain
Prior art keywords
pct
elevada
benzo
purity
preparation procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94926984T
Other languages
English (en)
Inventor
Anh Hoa Huynh
Joanne Tran
Francois Scherninski
Jean-Paul Guette
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Etudes et de Recherches Biologiques Ste
Original Assignee
Etudes et de Recherches Biologiques Ste
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Etudes et de Recherches Biologiques Ste filed Critical Etudes et de Recherches Biologiques Ste
Application granted granted Critical
Publication of ES2159568T3 publication Critical patent/ES2159568T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

PROCEDIMIENTO DE PREPARACION DE BENZ[E]INDOLES SUSTITUIDOS DE PUREZA ELEVADA QUE RESPONDE A LA FORMULA GENERAL (I) QUE COMPRENDE LA PREPARACION DE UNA ARILHIDRACINA QUE ES SOMETIDA A UNA SINTESIS INDOLICA DE FISCHER CON UNA CETONA APROPIADA, SIENDO EL BENZ[E]INDOL ASI OBTENIDO PUESTO A REACCIONAR CON UN RADICAL R{SUB,6}, Y A CONTINUACION SOMETIDO A UNA ETAPA DE PURIFICACION. ESTE PROCEDIMIENTO PUEDE APLICARSE PARTICULARMENTE EN LA SINTESIS DEL VERDE DE INDOCIANINA.
ES94926984T 1993-09-17 1994-09-14 Procedimiento de preparacion de benzo-indoles sustituidos de elevada pureza y sus sales alcalinas. Expired - Lifetime ES2159568T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9311121A FR2710060B1 (fr) 1993-09-17 1993-09-17 Procédé de préparation de benz[e]indoles substitués de pureté élevée et leurs sels alcalins.

Publications (1)

Publication Number Publication Date
ES2159568T3 true ES2159568T3 (es) 2001-10-16

Family

ID=9450993

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94926984T Expired - Lifetime ES2159568T3 (es) 1993-09-17 1994-09-14 Procedimiento de preparacion de benzo-indoles sustituidos de elevada pureza y sus sales alcalinas.

Country Status (10)

Country Link
US (1) US5750722A (es)
EP (1) EP0719254B1 (es)
JP (1) JP4000194B2 (es)
AT (1) ATE201668T1 (es)
AU (1) AU7660594A (es)
CA (1) CA2171954C (es)
DE (1) DE69427362T2 (es)
ES (1) ES2159568T3 (es)
FR (1) FR2710060B1 (es)
WO (1) WO1995007888A1 (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09227485A (ja) 1996-02-16 1997-09-02 Fuji Photo Film Co Ltd ２−ヒドラジノナフタレン化合物の製造方法
JP3912758B2 (ja) * 1996-02-16 2007-05-09 富士フイルム株式会社 １，１−ジ置換−１Ｈ−ベンゾ〔ｅ〕インドール化合物の製造方法及び４〜９位ヒドロキシ基置換の該化合物
CN1063170C (zh) * 1997-09-23 2001-03-14 华东理工大学 一步法制备2－萘肼的方法
DE69921151T2 (de) * 1998-08-12 2005-06-02 Daiichi Pure Chemicals Co. Ltd. Fluorszierende marker
US6944493B2 (en) * 1999-09-10 2005-09-13 Akora, Inc. Indocyanine green (ICG) compositions and related methods of use
US6351663B1 (en) 1999-09-10 2002-02-26 Akorn, Inc. Methods for diagnosing and treating conditions associated with abnormal vasculature using fluorescent dye angiography and dye-enhanced photocoagulation
US6443976B1 (en) 1999-11-30 2002-09-03 Akorn, Inc. Methods for treating conditions and illnesses associated with abnormal vasculature
US6669926B1 (en) * 2000-10-16 2003-12-30 Mallinckrodt, Inc. Hydrophilic light absorbing indole compounds for determination of physiological function in critically ill patients
US20040180809A1 (en) * 2000-10-16 2004-09-16 Mallinckrodt Inc. Tissue-specific exogenous optical agents
DE102005025560A1 (de) * 2005-06-01 2006-12-07 Pulsion Medical Systems Ag Verfahren zur Aufreinigung von Betainen
FR2889700B1 (fr) 2005-08-11 2012-11-23 Synthinnove Lab Marqueurs, leur procede de fabrication et leurs applications
WO2008000298A1 (de) * 2006-06-28 2008-01-03 Pulsion Medical Systems Ag Verfahren zur aufreinigung von betainen
US9302018B2 (en) 2010-05-31 2016-04-05 Eisai R&D Management Co., Ltd. Fluorescent probe for imaging lymph nodes
JP5979385B2 (ja) 2011-10-07 2016-08-24 国立大学法人鳥取大学 リポソーム複合体
CN104130178A (zh) * 2014-06-30 2014-11-05 辽宁天医生物制药股份有限公司 一种药用吲哚菁绿的工业化合成方法
CA3007062A1 (en) 2015-12-01 2017-06-08 Dishman Pharmaceuticals And Chemicals Limited An improved process for the preparation of indocyanine green
US20190337896A1 (en) * 2018-05-02 2019-11-07 Biophore India Pharmaceuticals Pvt. Ltd. PROCESS FOR THE PREPARATION OF SODIUM 4-(2-((1E,3E,5E,7Z)-7-(1,1-DIMETHYL-3-(4-SULFONATOBUTYL)-1H-BENZO[e]INDOL-2(3H)-YLIDENE) HEPTA-1,3,5-TRIENYL)-1,1-DIMETHYL-1H-BENZO[e]INDOLIUM-3-YL) BUTANE-1-SULFONATE (INDOCYANINE GREEN)
ES3042376T3 (en) 2021-03-17 2025-11-20 Provepharm Life Solutions Stable formulations of indocyanine green
JP7842776B2 (ja) 2021-03-17 2026-04-08 プルーヴファーム・ライフ・ソリューションズ インドシアニングリーンの安定な処方物
BR112023018955A2 (pt) 2021-03-17 2023-10-17 Provepharm Life Solutions Formulações estáveis de indocianina verde
CN114436938B (zh) * 2022-01-26 2023-10-27 南京诺源医疗器械有限公司 一种吲哚菁绿药物中的杂质及其制备方法和应用
KR20250008084A (ko) 2022-05-06 2025-01-14 프로베팜 라이프 솔루션즈 결정질 인도시아닌 그린 및 그의 생산 방법

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2251286A (en) * 1937-12-30 1941-08-05 Eastman Kodak Co Process of preparing oxatricarbocyanine dyes
BE580869A (es) * 1957-06-05
DE2046141A1 (en) * 1970-09-18 1972-03-23 Merck Patent Gmbh, 6100 Darmstadt Tricarbocyanine dyestuff mfr - using alkali alcoholate instead of sodium iodide to obtain iodine-free products
GB1356431A (en) * 1971-06-03 1974-06-12 Wyeth John & Brother Ltd Substituted benz-g-indoles
US4370341A (en) * 1980-12-11 1983-01-25 Ayerst, Mckenna & Harrison, Ltd. 6,7,8,9-Tetrahydro-3H-benz[E]indol-8-amine derivatives
JP3028520B2 (ja) * 1988-12-19 2000-04-04 ソニー株式会社 光学情報記録媒体
JPH03272890A (ja) * 1990-03-22 1991-12-04 Sony Corp 光記録媒体

Also Published As

Publication number Publication date
US5750722A (en) 1998-05-12
EP0719254A1 (fr) 1996-07-03
FR2710060A1 (fr) 1995-03-24
DE69427362T2 (de) 2002-04-11
JPH09505558A (ja) 1997-06-03
CA2171954A1 (en) 1995-03-23
AU7660594A (en) 1995-04-03
FR2710060B1 (fr) 1995-11-17
JP4000194B2 (ja) 2007-10-31
WO1995007888A1 (fr) 1995-03-23
CA2171954C (en) 2006-01-24
EP0719254B1 (fr) 2001-05-30
ATE201668T1 (de) 2001-06-15
DE69427362D1 (de) 2001-07-05

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