ES2159626T3 - Procedimiento para la preparacion de una sal del acido clavulanico. - Google Patents

Procedimiento para la preparacion de una sal del acido clavulanico.

Info

Publication number
ES2159626T3
ES2159626T3 ES95907075T ES95907075T ES2159626T3 ES 2159626 T3 ES2159626 T3 ES 2159626T3 ES 95907075 T ES95907075 T ES 95907075T ES 95907075 T ES95907075 T ES 95907075T ES 2159626 T3 ES2159626 T3 ES 2159626T3
Authority
ES
Spain
Prior art keywords
clavulanic acid
acid salt
preparation
dissolution
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95907075T
Other languages
English (en)
Inventor
Michael Alan Cook
Geoffrey Clive Webb
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
SmithKline Beecham Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Ltd filed Critical SmithKline Beecham Ltd
Application granted granted Critical
Publication of ES2159626T3 publication Critical patent/ES2159626T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

UN PROCESO PARA LA PREPARACION DE UNA SAL DE ACIDO CLAVULANICO, EN DONDE AL ACIDO CLAVULANICO EN DISOLUCION EN UN DISOLVENTE ORGANICO TOTAL O PARCIALMENTE HIDROINMISCIBLE ES PUESTO EN CONTACTO EN UNA REGION DE ALTA TURBULENCIA Y/O ESFUERZO CORTANTE , CON UN COMPUESTO PRECURSOR DE SAL PARA FORMAR UNA DISOLUCION DE LA SAL DE ACIDO CLAVULANICO EN UNA FASE ACUOSA, ENTONCES EL DISOLVENTE ORGANICO Y LAS FASES ACUOSAS SON SEPARADAS FISICAMENTE DURANTE UN PASO DE SEPARACION, SEGUIDO POR UN PASO DE TRATAMIENTO ADICIONAL EN EL CUAL DICHA SAL DE ACIDO CLAVULANICO ES AISLADA DE LA DISOLUCION COMO UN SOLIDO.
ES95907075T 1994-02-02 1995-01-31 Procedimiento para la preparacion de una sal del acido clavulanico. Expired - Lifetime ES2159626T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB9401969A GB9401969D0 (en) 1994-02-02 1994-02-02 Process

Publications (1)

Publication Number Publication Date
ES2159626T3 true ES2159626T3 (es) 2001-10-16

Family

ID=10749727

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95907075T Expired - Lifetime ES2159626T3 (es) 1994-02-02 1995-01-31 Procedimiento para la preparacion de una sal del acido clavulanico.

Country Status (31)

Country Link
US (1) US5965728A (es)
EP (1) EP0741732B1 (es)
JP (1) JP4074336B2 (es)
KR (1) KR100388769B1 (es)
CN (1) CN1065246C (es)
AP (1) AP610A (es)
AT (1) ATE202358T1 (es)
AU (1) AU688849B2 (es)
BG (1) BG63307B1 (es)
BR (1) BR9506919A (es)
CA (1) CA2182504C (es)
CZ (1) CZ294005B6 (es)
DE (1) DE69521415T2 (es)
DK (1) DK0741732T3 (es)
ES (1) ES2159626T3 (es)
FI (1) FI111949B (es)
GB (1) GB9401969D0 (es)
GR (1) GR3036602T3 (es)
HU (1) HU226597B1 (es)
MX (1) MX9603204A (es)
NO (1) NO314505B1 (es)
NZ (1) NZ278927A (es)
OA (1) OA10587A (es)
PL (1) PL181451B1 (es)
PT (1) PT741732E (es)
RO (1) RO115730B1 (es)
RU (1) RU2140418C1 (es)
SI (1) SI0741732T1 (es)
SK (1) SK282544B6 (es)
UA (1) UA48944C2 (es)
WO (1) WO1995021173A1 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT400033B (de) 1992-03-10 1995-09-25 Biochemie Gmbh Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben
SI9400107A (en) 1994-03-02 1995-10-31 Lek Tovarna Farmacevtskih New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804.
GB9500977D0 (en) 1995-01-19 1995-03-08 Smithkline Beecham Plc Novel process
SI9500134B (sl) * 1995-04-20 2004-04-30 Lek, Postopek za pripravo čistih alkalijskih soli klavulanske kisline
GB9515809D0 (en) * 1995-08-02 1995-10-04 Smithkline Beecham Plc Process
AT403375B (de) * 1995-11-15 1998-01-26 Biochemie Gmbh Verfahren zur fällung von alkalisalzen der clavulansäure
US6414142B1 (en) * 1996-06-13 2002-07-02 Smithkline Beecham Corporation Process for preparing potassium clavulanate
ATE187498T1 (de) 1997-03-24 1999-12-15 Cipan Comp Ind Prod Verfahren zur isolierung eines pharmazeutisch verträglichen alkalimetallsalzes der clavulansäure
WO1998042858A1 (en) * 1997-03-24 1998-10-01 Cipan-Companhia Industrial Produtora De Antibióticos, S.A. Process for the isolation of a pharmaceutically acceptable alkali metal salt of clavulanic acid
DZ2456A1 (fr) * 1997-04-04 2003-01-18 Smithkline Beecham Plc Procédé de préparation de sels de l'acide clavulanique.
PT1412078E (pt) 2001-08-02 2009-01-08 Lg Life Sciences Ltd Processos para a produção de derivados amino-protegidos da 4- aminometileno-pirrolidin-3-ona, gemifloxacina ou um seu sal
KR20190039137A (ko) 2016-07-14 2019-04-10 아카오젠, 인코포레이티드 박테리아 감염 치료에서 사용하기 위한 세프티부텐과 클라불란산의 조합
CN108822134B (zh) * 2018-04-25 2021-06-25 国药集团威奇达药业有限公司 克拉维酸叔丁胺盐的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1508977A (en) * 1974-04-20 1978-04-26 Beecham Group Ltd Beta-lactam antibiotic from streptomyces clavuligerus
ES444195A1 (es) * 1974-10-09 1977-08-01 Beecham Group Ltd Un procedimiento para la preparacion de acido clavulanico.
GB1543563A (en) * 1975-02-07 1979-04-04 Glaxo Lab Ltd Beta-lactam antibiotic in purified form
GB1563103A (en) * 1975-10-13 1980-03-19 Beecham Group Ltd Process for the preparation of clavulanic acid
GB1578739A (en) * 1976-07-23 1980-11-05 Beecham Group Ltd Amine salts of clavulanic acid methods for their preparation and compositions containing them
DE3063683D1 (en) * 1979-08-24 1983-07-14 Beecham Group Plc Amine salt of clavulanic acid, its preparation and use
GB8404749D0 (en) * 1984-02-23 1984-03-28 Atomic Energy Authority Uk Fluidic contactor
ES2010143A6 (es) * 1989-03-01 1989-10-16 Pharma Mar S A Pharmar Un nuevo procedimiento de obtencion del acido z(2r,5r)-3-(2-hiadroxietiliden)-7- oxo-4-oxa-1-azabiciclo(3,2,0) -heptano-2-carboxilico y de sales estares farmaceutiacamente aceptables del mismo,a partir de caldos de fermentacion de streptomyces, sp.

Also Published As

Publication number Publication date
RO115730B1 (ro) 2000-05-30
JPH09508411A (ja) 1997-08-26
US5965728A (en) 1999-10-12
HK1012373A1 (en) 1999-07-30
RU2140418C1 (ru) 1999-10-27
DE69521415D1 (de) 2001-07-26
PL181451B1 (en) 2001-07-31
DE69521415T2 (de) 2002-05-29
SI0741732T1 (es) 2001-10-31
SK100396A3 (en) 1996-12-04
WO1995021173A1 (en) 1995-08-10
GR3036602T3 (en) 2001-12-31
HU9602128D0 (en) 1996-09-30
EP0741732A1 (en) 1996-11-13
CN1065246C (zh) 2001-05-02
NZ278927A (en) 1998-02-26
CA2182504A1 (en) 1995-08-10
NO963217D0 (no) 1996-08-01
JP4074336B2 (ja) 2008-04-09
BG100765A (en) 1997-09-30
CA2182504C (en) 2008-04-08
HU226597B1 (en) 2009-04-28
CZ229496A3 (en) 1997-01-15
CN1144528A (zh) 1997-03-05
AP610A (en) 1997-09-04
NO963217L (no) 1996-10-01
OA10587A (en) 2002-07-10
BR9506919A (pt) 1997-09-30
HUT74885A (en) 1997-02-28
NO314505B1 (no) 2003-03-31
SK282544B6 (sk) 2002-10-08
AP9600838A0 (en) 1996-07-31
BG63307B1 (bg) 2001-09-28
EP0741732B1 (en) 2001-06-20
GB9401969D0 (en) 1994-03-30
FI963050L (fi) 1996-10-01
AU688849B2 (en) 1998-03-19
CZ294005B6 (cs) 2004-09-15
PT741732E (pt) 2001-11-30
DK0741732T3 (da) 2001-10-15
UA48944C2 (uk) 2002-09-16
ATE202358T1 (de) 2001-07-15
MX9603204A (es) 1997-03-29
PL315782A1 (en) 1996-12-09
FI111949B (fi) 2003-10-15
KR100388769B1 (ko) 2003-09-02
AU1541295A (en) 1995-08-21
FI963050A0 (fi) 1996-08-01

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