ES2159643T3 - Vitamina a estable. - Google Patents

Vitamina a estable.

Info

Publication number
ES2159643T3
ES2159643T3 ES95923812T ES95923812T ES2159643T3 ES 2159643 T3 ES2159643 T3 ES 2159643T3 ES 95923812 T ES95923812 T ES 95923812T ES 95923812 T ES95923812 T ES 95923812T ES 2159643 T3 ES2159643 T3 ES 2159643T3
Authority
ES
Spain
Prior art keywords
vitamin
tocopherol
encapsulated
heating
stable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95923812T
Other languages
English (en)
Inventor
Robert Joseph Sarama
Thomas Joseph Wehmeier
Michael Robert Sevenants
Robert Alan Sanders
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Procter and Gamble Co
Original Assignee
Procter and Gamble Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/285,242 external-priority patent/US5426248A/en
Application filed by Procter and Gamble Co filed Critical Procter and Gamble Co
Application granted granted Critical
Publication of ES2159643T3 publication Critical patent/ES2159643T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/07—Retinol compounds, e.g. vitamin A
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/06—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms
    • C07C403/08—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms by hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/06—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms
    • C07C403/12—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms by esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/09—Geometrical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE DESCRIBE UN PROCEDIMIENTO DE PURIFICACION DE VITAMINA A, CONSISTENTE EN CALENTAR UNA PREPARACION DE VITAMINA A EN UNA ATMOSFERA INERTE, A UNA TEMPERATURA INFERIOR A 170 C, Y UNA PRESION NO INFERIIOR A 4MM DE MERCURIO, LLEVANDOSE A CABO DICHO CALENTAMIENTO EN UN RECIPIENTE PROTEGIDO DE LA LUZ. LA VITAMINA A OBTENIDA A PARTIR DE DICHO PROCEDIMIENTO, Y UNA MEZCLA DE TOCOFEROL, SE PUEDEN ENCAPSULAR EN GOMA DE ACACIA, ALMIDON, PECTINAS, U OTROS MATERIALES ADECUADOS. CUANDO LA VITAMINA A SE ENCAPSULA, EN NIVEL DE TOCOFEROL REQUERIDO ES MENOR, PREFERIBLEMENTE DESDE 0''05:1 HASTA APROX. 1:1 PARTES DE TOCOFEROL A VITAMINA A SON UTILIZADAS EN UNA COMPOSICION ENCAPSULADA DE VITAMINA A. SE PUEDEN AÑADIR OTROS ANTIOXIDANTES.
ES95923812T 1994-08-03 1995-06-09 Vitamina a estable. Expired - Lifetime ES2159643T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/285,242 US5426248A (en) 1994-08-03 1994-08-03 Stable vitamin A
US08/438,869 US5648091A (en) 1994-08-03 1995-05-23 Stable vitamin A encapsulated

Publications (1)

Publication Number Publication Date
ES2159643T3 true ES2159643T3 (es) 2001-10-16

Family

ID=26963088

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95923812T Expired - Lifetime ES2159643T3 (es) 1994-08-03 1995-06-09 Vitamina a estable.

Country Status (18)

Country Link
US (1) US5648091A (es)
EP (1) EP0775111B1 (es)
JP (1) JP2960547B2 (es)
KR (1) KR100244067B1 (es)
CN (1) CN1072646C (es)
AT (1) ATE204858T1 (es)
AU (1) AU704286B2 (es)
BR (1) BR9508508A (es)
CA (1) CA2196295C (es)
CZ (1) CZ293262B6 (es)
DE (1) DE69522456T2 (es)
ES (1) ES2159643T3 (es)
FI (1) FI970425L (es)
HU (1) HUT76799A (es)
MX (1) MX9700841A (es)
NO (1) NO970429L (es)
NZ (1) NZ288880A (es)
WO (1) WO1996004243A1 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030008919A1 (en) * 1999-06-03 2003-01-09 Jean-Baptiste Roullet Use of retinoids to treat high blood pressure and other cardiovascular disease
CO5011072A1 (es) * 1997-12-05 2001-02-28 Lilly Co Eli Etanolaminas pirazinil substituidas como agfonistas de los receptores
US7604807B2 (en) * 2000-12-01 2009-10-20 Auburn University Use of pullulan to isolate and preserve biological material
WO2002043779A2 (en) * 2000-12-01 2002-06-06 Auburn University Use of acacia gum (arabic gum) to isolate and preserve biological material
KR20030070798A (ko) * 2002-02-26 2003-09-02 주식회사 국순당 다당류 및 단백질 물질로 미세캡슐화된 지용성 항산화제및 그의 제조 방법
US20030232091A1 (en) * 2002-06-17 2003-12-18 Adi Shefer Stabilized retinol for cosmetic dermatological, and pharmaceutical compositions, and use thereof
US9186640B2 (en) * 2007-08-28 2015-11-17 Pepsico, Inc. Delivery and controlled release of encapsulated lipophilic nutrients
JP5728152B2 (ja) * 2008-07-07 2015-06-03 株式会社ファンケル 乾燥リポソーム製剤
WO2012129765A1 (zh) * 2011-03-25 2012-10-04 浙江新和成股份有限公司 一种连续化稳定维生素a微胶囊的制备方法
WO2015023926A1 (en) 2013-08-15 2015-02-19 Mary Kay Inc. Topical skin compositions for treating wrinkles
EP4057835A1 (en) * 2019-11-15 2022-09-21 Basf Se Food additives and methods for preparing the same
CN112841319B (zh) * 2021-02-09 2021-11-19 赣州市全标生物科技有限公司 一种全程氮气介导下的婴幼儿辅食营养包与其制备方法
CN113016875B (zh) * 2021-02-09 2021-11-19 赣州市全标生物科技有限公司 一种氮气介导三级稳态保护的婴幼儿辅食营养包与其制备方法
WO2023161201A1 (en) * 2022-02-22 2023-08-31 Dsm Ip Assets B.V. Retinol formulation (vi)
KR20240152900A (ko) * 2022-02-22 2024-10-22 디에스엠 아이피 어셋츠 비.브이. 레티놀 제형(v)
WO2023161203A1 (en) * 2022-02-22 2023-08-31 Dsm Ip Assets B.V. Retinol formulation (iv)
US20250302710A1 (en) * 2024-03-27 2025-10-02 The Procter & Gamble Company Skin care compositions containing a retinoid with reduced malodor

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2777797A (en) * 1952-06-04 1957-01-15 Nopco Chem Co Vitamin products
US2828206A (en) * 1954-02-24 1958-03-25 Roseuberg Adolf Stabilized fat-soluble vitamins and methods of making same
FR1425252A (fr) * 1956-09-26 1966-01-24 Eastman Kodak Co Compositions stables à base de vitamines a ou de ses dérivés et stabilisant pour cette composition
GB887813A (en) * 1958-03-12 1962-01-24 Commercial Solvents Corp Vitamin containing compositions and methods of producing them
US3067104A (en) * 1958-09-17 1962-12-04 Nopco Chem Co Stable fat-soluble vitamin compositions
US3067105A (en) * 1959-09-22 1962-12-04 Nopco Chem Co Vitamin compositions and processes for producing same
US3949006A (en) * 1972-04-24 1976-04-06 Scm Corporation Synthesis of vitamin A, intermediates and conversion thereof to vitamin A
DE3578169D1 (de) * 1985-01-10 1990-07-19 Kuraray Co Verfahren zur herstellung von vitamin a oder seinen carbonsaeureestern und zwischenprodukte und ihre verwendung in diesem verfahren.
FR2623805B1 (fr) * 1987-12-01 1990-04-13 Rhone Poulenc Sante Procede de preparation de la vitamine a
WO1992010941A1 (en) * 1990-12-19 1992-07-09 Unilever N.V. Edible fat-containing products containing vitamin e
US5521221A (en) * 1991-04-09 1996-05-28 Sloan-Kettering Institute For Cancer Research Retro-α-retinol (4,14-retro-retinol) derivatives and uses of retro-α-retinol
US5426248A (en) * 1994-08-03 1995-06-20 The Procter & Gamble Company Stable vitamin A

Also Published As

Publication number Publication date
CA2196295A1 (en) 1996-02-15
NZ288880A (en) 1999-03-29
DE69522456D1 (de) 2001-10-04
NO970429L (no) 1997-04-03
CZ293262B6 (cs) 2004-03-17
AU2824495A (en) 1996-03-04
FI970425A7 (fi) 1997-03-21
KR100244067B1 (ko) 2000-03-02
HUT76799A (en) 1997-11-28
WO1996004243A1 (en) 1996-02-15
CZ31897A3 (en) 1997-07-16
DE69522456T2 (de) 2002-05-02
CN1072646C (zh) 2001-10-10
CA2196295C (en) 2003-01-28
MX9700841A (es) 1997-04-30
EP0775111A1 (en) 1997-05-28
AU704286B2 (en) 1999-04-15
JPH10504546A (ja) 1998-05-06
JP2960547B2 (ja) 1999-10-06
KR970704683A (ko) 1997-09-06
US5648091A (en) 1997-07-15
EP0775111B1 (en) 2001-08-29
NO970429D0 (no) 1997-01-31
CN1157608A (zh) 1997-08-20
FI970425L (fi) 1997-03-21
ATE204858T1 (de) 2001-09-15
BR9508508A (pt) 1998-06-02
FI970425A0 (fi) 1997-01-31

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