ES2160410T3 - Preparados de complejos de protrombina inmunotolerantes. - Google Patents

Preparados de complejos de protrombina inmunotolerantes.

Info

Publication number
ES2160410T3
ES2160410T3 ES98913425T ES98913425T ES2160410T3 ES 2160410 T3 ES2160410 T3 ES 2160410T3 ES 98913425 T ES98913425 T ES 98913425T ES 98913425 T ES98913425 T ES 98913425T ES 2160410 T3 ES2160410 T3 ES 2160410T3
Authority
ES
Spain
Prior art keywords
immunotolerant
protrombine
complex preparations
factor viii
antigen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98913425T
Other languages
English (en)
Inventor
Hans-Peter Schwarz
Peter Turecek
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baxter AG
Original Assignee
Baxter AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AT0059497A external-priority patent/AT405608B/de
Priority claimed from AT159297A external-priority patent/AT406824B/de
Application filed by Baxter AG filed Critical Baxter AG
Application granted granted Critical
Publication of ES2160410T3 publication Critical patent/ES2160410T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4833—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
    • A61L2/02—Disinfection or sterilisation of materials or objects, in general; Accessories therefor using physical processes
    • A61L2/022—Filtration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
    • A61L2/02—Disinfection or sterilisation of materials or objects, in general; Accessories therefor using physical processes
    • A61L2/04—Heat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
    • A61L2/16—Disinfection or sterilisation of materials or objects, in general; Accessories therefor using chemical substances
    • A61L2/18—Liquid substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2103/00—Materials or objects being the target of disinfection or sterilisation
    • A61L2103/05—Living organisms or biological materials

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)

Abstract

Un preparado de complejo farmacéutico de protrombina inmunotolerante que contiene los factores II, IX, X y, en caso dado, VII, caracterizado porque tiene un contenido de antígeno del factor VIII inferior al 0,1 Factor VIII:C-antígeno/E FEIBA.
ES98913425T 1997-04-08 1998-04-06 Preparados de complejos de protrombina inmunotolerantes. Expired - Lifetime ES2160410T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT0059497A AT405608B (de) 1997-04-08 1997-04-08 Verfahren zur inaktivierung von pathogenen, insbesondere von viren, in einem biologischen material
AT159297A AT406824B (de) 1997-09-19 1997-09-19 Immuntolerante prothrombinkomplex-präparation

Publications (1)

Publication Number Publication Date
ES2160410T3 true ES2160410T3 (es) 2001-11-01

Family

ID=25593261

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98913425T Expired - Lifetime ES2160410T3 (es) 1997-04-08 1998-04-06 Preparados de complejos de protrombina inmunotolerantes.

Country Status (14)

Country Link
US (1) US6358534B1 (es)
EP (1) EP0973544B1 (es)
JP (1) JP3976351B2 (es)
AT (1) ATE202483T1 (es)
AU (1) AU737566B2 (es)
BR (1) BR9807936A (es)
CA (1) CA2285935C (es)
DE (1) DE59800935D1 (es)
DK (1) DK0973544T3 (es)
ES (1) ES2160410T3 (es)
NO (1) NO994822L (es)
PT (1) PT973544E (es)
SK (1) SK139099A3 (es)
WO (1) WO1998044942A1 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATA159597A (de) * 1997-09-19 2000-09-15 Immuno Ag Präparat zur behandlung von blutgerinnungsstörungen
AT407484B (de) * 1997-11-12 2001-03-26 Bio Prod & Bio Eng Ag Arzneimittel zur förderung der wundheilung
DE10012732A1 (de) * 2000-03-18 2001-09-20 Aventis Behring Gmbh Thrombin-Zubereitungen und Verfahren zu ihrer Herstellung
AU2001291653A1 (en) * 2000-10-02 2002-04-15 Novo-Nordisk A/S Industrial-scale serum-free production of recombinant factor vii in mammalian cells
US20040185535A1 (en) * 2003-03-21 2004-09-23 Giles Wilson Industrial-scale serum-free production of recombinant FVII in mammalian cells
US20040185534A1 (en) * 2000-10-02 2004-09-23 Knudsen Ida Molgaard Industrial-scale serum-free production of recombinant proteins in mammalian cells
EP1434857B1 (en) * 2001-10-02 2007-08-01 Novo Nordisk Health Care AG Method for production of recombinant proteins in eukaryote cells
US6989891B2 (en) 2001-11-08 2006-01-24 Optiscan Biomedical Corporation Device and method for in vitro determination of analyte concentrations within body fluids
EP1523327A1 (de) * 2002-07-23 2005-04-20 Bio-Products & Bio-Engineering Aktiengesellschaft Thrombingenerierfahige und thrombinhaltige pharmazeutische wirkstoffzubereitungen und arzneimittel
EP1528930B1 (de) * 2002-07-23 2009-04-15 Bio & Bio Licensing SA Thrombingenerierfähige und thrombinhaltige pharmazeutische wirkstoffzubereitungen und arzneimittel
US7364562B2 (en) * 2005-10-06 2008-04-29 Optiscan Biomedical Corp. Anti-clotting apparatus and methods for fluid handling system
WO2007120746A2 (en) * 2006-04-11 2007-10-25 Optiscan Biomedical Corporation Anti-clotting apparatus and methods for fluid handling system
WO2008144575A2 (en) 2007-05-18 2008-11-27 Optiscan Biomedical Corporation Fluid injection and safety system
EP2568043A1 (en) * 2007-12-27 2013-03-13 Baxter International Inc. Chemically modified factor IX
EP2652491B1 (en) 2010-12-15 2017-11-29 Baxalta GmbH Eluate collection using conductivity gradient
JP6182210B2 (ja) 2012-06-29 2017-08-16 イー・エム・デイー・ミリポア・コーポレイシヨン タンパク質精製プロセス中のウイルスの不活性化方法
IL230150A0 (en) * 2013-12-24 2014-09-30 Omrix Biopharmaceuticals Ltd One-component fibrin glue containing zymogens
RU2559576C1 (ru) * 2014-06-09 2015-08-10 Федеральное государственное бюджетное учреждение Гематологический научный центр Министерства здравоохранения РФ Способ получения вирусбезопасного полного протромбинового комплекса
EP3205665A1 (en) * 2016-02-11 2017-08-16 Octapharma AG Method of separating factor viii from blood products

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4286056A (en) * 1980-01-28 1981-08-25 Baxter Travenol Laboratories, Inc. Method for making therapeutic enzyme compositions
DE3165600D1 (en) 1980-01-28 1984-09-27 Baxter Travenol Lab Prothrombin-containing therapeutic compositions and methods of producing enzymatically active blood clotting factors from prothrombin-containing blood fractions
AT368883B (de) 1980-07-22 1982-11-25 Immuno Ag Verfahren zur herstellung einer neuen blutgerinnungsfoerdernden praeparation auf basis von humanproteinen
US4412985A (en) 1980-10-06 1983-11-01 Edward Shanbrom Depyrogenation process
US4382083A (en) 1981-06-25 1983-05-03 Baxter Travenol Laboratories, Inc. Therapeutic method for treating blood-clotting defects with factor VIIa
US4540573A (en) 1983-07-14 1985-09-10 New York Blood Center, Inc. Undenatured virus-free biologically active protein derivatives
US4673733A (en) 1985-04-11 1987-06-16 Sudhish Chandra Treatment of biological and pharmaceutical products adsorbed on a solid phase with virus and pyrogen inactivating agents
US5156973A (en) 1988-11-23 1992-10-20 Edward Shanbrom Antiviral blood sampling process and apparatus
JP3145696B2 (ja) 1990-10-05 2001-03-12 日本ケミカルリサーチ株式会社 分泌型免疫グロブリンａ製剤の製造法
ZA93587B (en) 1992-01-27 1994-07-07 Cryopharm Corp Method of freezing cells and cell like material
FI952196A0 (fi) 1995-05-08 1995-05-08 Suomen Punainen Risti Veripalv Framstaellning av immunoglobulin
DE19531637A1 (de) 1995-08-28 1997-03-06 Immuno Ag Pharmazeutische Zusammensetzung zur Behandlung von Blutgerinnungsstörugnen, Verfahren zur Herstellung derselben und deren Verwendung
US6686191B1 (en) 1995-09-22 2004-02-03 Bayer Healthcare Llc Preparation of virally inactivated intravenously injectable immune serum globulin

Also Published As

Publication number Publication date
CA2285935A1 (en) 1998-10-15
EP0973544B1 (de) 2001-06-27
ATE202483T1 (de) 2001-07-15
BR9807936A (pt) 2000-02-22
NO994822L (no) 1999-12-02
EP0973544A1 (de) 2000-01-26
PT973544E (pt) 2001-12-28
AU737566B2 (en) 2001-08-23
DE59800935D1 (en) 2001-08-02
JP3976351B2 (ja) 2007-09-19
CA2285935C (en) 2011-01-18
WO1998044942A1 (de) 1998-10-15
DK0973544T3 (da) 2001-10-15
AU6812198A (en) 1998-10-30
SK139099A3 (en) 2000-06-12
US6358534B1 (en) 2002-03-19
JP2001524953A (ja) 2001-12-04
NO994822D0 (no) 1999-10-04

Similar Documents

Publication Publication Date Title
MX9306499A (es) Composiciones farmaceuticas que contienen una anfetamina.
DE69808130D1 (de) Adamantan-derivate
EA199800946A1 (ru) Концентрированный препарат антител
ES2182906T3 (es) Grapa quirurgica helicoidal.
NO20002785D0 (no) Adamantanderivater
SE9704546D0 (sv) Novel compounds
EP0727438A3 (en) Addition products PEG and GM-CSF
NO944377L (no) Kjölemiddelblandinger
ATE278779T1 (de) Alphavirus rna replikon-systeme
NO954694D0 (no) Doseringsform for antidepressiva
DE69726015D1 (de) Pharmazeutische zusammensetzung enthaltend koenzym q-10
TR200100922T2 (tr) Aktif maddelerin akciğerler yolu ile tatbik edilmesi.
ES2130420T3 (es) Preparado transdermico de sustancia activa.
DK0460062T3 (da) Huperzin A-analoger
ES2148512T3 (es) Complejos de inclusion multicomponentes de alta solubilidad que constan de una sustancia farmaceutica acidica, una ciclodextrina y una base.
NO994822L (no) Immunotolerant protrombinkomplekspreparat
TR199801298T2 (xx) ACE-engelleyicinin dispeptik semptomlar�n tedavisinde yeni t�bbi kullan�m�.
ES2176805T3 (es) Empleo de mezclas de productos activos para la obtencion de agentes hipocolesterinemicos.
ES2105605T3 (es) Antagonistas de taquiquinina, su preparacion y utilizacion en formulaciones farmaceuticas.
ES2172682T3 (es) Preparaciones desodorantes con contenido en quitosano, clorohidrato de aluminio e inhibidores de esterasa.
AR019331A2 (es) Composicion farmaceutica que contiene un sensibilizador a insulina y un secretagogo de insulina.
EA200000112A1 (ru) Новая композиция
DE69726602D1 (en) Hepatitis b inhibitoren
ES2167956T3 (es) Zeolita itq-5.
IT1290910B1 (it) 2-amminotetralina otticamente attiva, procedimento per la sua preparazione e composizioni farmaceutiche che la contengono, attive

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 973544

Country of ref document: ES