ES2160595T3 - Tratamiento de hepatomas con analogos de somatostatina. - Google Patents
Tratamiento de hepatomas con analogos de somatostatina.Info
- Publication number
- ES2160595T3 ES2160595T3 ES93907029T ES93907029T ES2160595T3 ES 2160595 T3 ES2160595 T3 ES 2160595T3 ES 93907029 T ES93907029 T ES 93907029T ES 93907029 T ES93907029 T ES 93907029T ES 2160595 T3 ES2160595 T3 ES 2160595T3
- Authority
- ES
- Spain
- Prior art keywords
- phe
- somatostatine
- hepatomas
- analogs
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 206010073071 hepatocellular carcinoma Diseases 0.000 title 1
- NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical class C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 title 1
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
- COLNVLDHVKWLRT-MRVPVSSYSA-N D-phenylalanine Chemical compound OC(=O)[C@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-MRVPVSSYSA-N 0.000 abstract 1
- 229940124277 aminobutyric acid Drugs 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 201000007270 liver cancer Diseases 0.000 abstract 1
- 208000014018 liver neoplasm Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/31—Somatostatins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
- C07K14/6555—Somatostatins at least 1 amino acid in D-form
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Endocrinology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
UN METODO DE TRATAMIENTO DE CANCER DE HIGADO EN UN SUJETO MAMIFERO. EL METODO COMPRENDE LA ADMINISTRACION AL SUJETO DE UNA COMPOSICION QUE CONTIENE UNA CANTIDAD TERAPEUTICAMENTE EFECTIVA DE UN OCTAPEPTIDO DE LA SIGUIENTE FORMULA: H-A1-CYS-AGAMMA-D-TRP-LYS-A3-CYS-A4-Y, EN LA QUE A1 ES D-BETA-NAL O D-PHE; A2 ES PHE, PENTAFLUOR-PHE O X-PHE P-SUSTITUIDO CONDE X ES UN HALOGENO; NH2, NO2, OH O C1-3ALKILO; A3 ES THR, SER, PHE, VAL, ACIDO ALFA-AMINOBUTIRICO O ILE; A4 ES THR, BETA-NAL O TRP; EY ES NH2 O OH; O UN SAL FARMACEUTICAMENTE ACEPTABLE O UN COMPLEJO DE ESTA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/840,881 US5411943A (en) | 1992-02-25 | 1992-02-25 | Hepatoma treatment with somatostatin analogs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2160595T3 true ES2160595T3 (es) | 2001-11-16 |
Family
ID=25283467
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES93907029T Expired - Lifetime ES2160595T3 (es) | 1992-02-25 | 1993-02-25 | Tratamiento de hepatomas con analogos de somatostatina. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5411943A (es) |
| EP (1) | EP0585444B1 (es) |
| JP (1) | JPH06507423A (es) |
| AT (1) | ATE203410T1 (es) |
| CA (1) | CA2107773A1 (es) |
| DE (1) | DE69330483T2 (es) |
| DK (1) | DK0585444T3 (es) |
| ES (1) | ES2160595T3 (es) |
| WO (1) | WO1993016718A1 (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5760000A (en) * | 1994-05-13 | 1998-06-02 | University Technologies International,Inc. | Inhibition of liver cancer by the use of GnRH and GnRH analogs |
| US5830431A (en) * | 1995-06-07 | 1998-11-03 | Mallinckrodt Medical, Inc. | Radiolabeled peptide compositions for site-specific targeting |
| US6080728A (en) * | 1996-07-16 | 2000-06-27 | Mixson; A. James | Carrier: DNA complexes containing DNA encoding anti-angiogenic peptides and their use in gene therapy |
| US6355613B1 (en) * | 1996-07-31 | 2002-03-12 | Peptor Limited | Conformationally constrained backbone cyclized somatostatin analogs |
| US6150333A (en) * | 1998-07-30 | 2000-11-21 | Biomeasure, Inc. | Methods of using a somatostatin analogue |
| US6465613B1 (en) | 1998-11-19 | 2002-10-15 | Tulane University | Hydrophilic somatostatin analogs |
| CN1589151A (zh) | 2001-09-21 | 2005-03-02 | 图兰恩教育基金管理人 | 诊断或治疗性促生长素抑制素或铃蟾肽类似物的连接物及其用途 |
| US7771727B2 (en) * | 2002-03-01 | 2010-08-10 | The Administrators Of The Tulane Educational Fund | Conjugates of therapeutic or cytotoxic agents and biologically active peptides |
| CA2518406A1 (en) * | 2003-03-10 | 2004-09-23 | Biogen Idec Ma Inc. | Thiol-mediated drug attachment to targeting peptides |
| EP2190453A2 (en) * | 2007-09-11 | 2010-06-02 | Mondobiotech Laboratories AG | Use of trp6-triptorelin and d-leu6-leuprolide as therapeutic agents |
| WO2009033739A2 (en) * | 2007-09-11 | 2009-03-19 | Mondobiotech Laboratories Ag | Use of a peptide as a therapeutic agent |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5073541A (en) * | 1987-11-18 | 1991-12-17 | Administrators Of The Tulane Educational Fund | Treatment of small cell lung cancer with somatostatin analogs |
| WO1991009056A1 (en) * | 1989-12-08 | 1991-06-27 | The Administrators Of The Tulane Educational Fund | Octapeptide analogs of somatostatin having threonine at the sixth position |
-
1992
- 1992-02-25 US US07/840,881 patent/US5411943A/en not_active Expired - Lifetime
-
1993
- 1993-02-25 EP EP93907029A patent/EP0585444B1/en not_active Expired - Lifetime
- 1993-02-25 CA CA002107773A patent/CA2107773A1/en not_active Abandoned
- 1993-02-25 ES ES93907029T patent/ES2160595T3/es not_active Expired - Lifetime
- 1993-02-25 AT AT93907029T patent/ATE203410T1/de not_active IP Right Cessation
- 1993-02-25 DE DE69330483T patent/DE69330483T2/de not_active Expired - Fee Related
- 1993-02-25 JP JP5515069A patent/JPH06507423A/ja active Pending
- 1993-02-25 DK DK93907029T patent/DK0585444T3/da active
- 1993-02-25 WO PCT/US1993/001679 patent/WO1993016718A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| HK1015123A1 (en) | 1999-10-08 |
| ATE203410T1 (de) | 2001-08-15 |
| EP0585444B1 (en) | 2001-07-25 |
| EP0585444A4 (en) | 1996-01-10 |
| DE69330483D1 (de) | 2001-08-30 |
| JPH06507423A (ja) | 1994-08-25 |
| CA2107773A1 (en) | 1993-08-26 |
| WO1993016718A1 (en) | 1993-09-02 |
| DK0585444T3 (da) | 2001-09-24 |
| DE69330483T2 (de) | 2002-06-13 |
| EP0585444A1 (en) | 1994-03-09 |
| US5411943A (en) | 1995-05-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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