ES2162655T3 - Derivados de carboestirilo como agentes antitromboticos. - Google Patents
Derivados de carboestirilo como agentes antitromboticos.Info
- Publication number
- ES2162655T3 ES2162655T3 ES96932816T ES96932816T ES2162655T3 ES 2162655 T3 ES2162655 T3 ES 2162655T3 ES 96932816 T ES96932816 T ES 96932816T ES 96932816 T ES96932816 T ES 96932816T ES 2162655 T3 ES2162655 T3 ES 2162655T3
- Authority
- ES
- Spain
- Prior art keywords
- short chain
- sup
- rent
- replaced
- activity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
DERIVADOS DEL CARBOSTIRILO DE FORMULA (1), DONDE A ES UN ALQUILENO DE CADENA CORTA, R ES H, HALOGENO O ALCOXI, R{SUP,1} Y R{SUP,2} SON ALQUILOS DE CADENA CORTA QUE PUEDEN SUSTITUIRSE POR OH, ALCOXI DE CADENA CORTA, FENIL ALCOXI DE CADENA CORTA O ALCANOILOXI DE CADENA CORTA; CICLOALQUILO QUE PUEDE SUSTITUIRSE POR OH, HIDROXI ALCOXI DE CADENA CORTA O ALCANOILOXI DE CADENA CORTA; O AMINO QUE PUEDE SUSTITUIRSE POR ALQUILO DE CADENA CORTA O CICLOALQUILO, R{SUP,3} ES H, ALQUILO DE CADENA CORTA, ALQUENILO DE CADENA CORTA O HIDROXI ALQUILO DE CADENA CORTA. EL ENLACE ENTRE LAS POSICIONES 3 Y 4 DEL NUCLEO DEL CARBOSTIRILO PUEDE SER SENCILLO O DOBLE, SIEMPRE QUE CUANDO R Y R{SUP,3} SEAN H, R{SUP,1} Y R{SUP,2} NO SEAN SUSTITUIDOS NI POR ALQUILO DE CADENA CORTA NI POR CICLOAQUILO NI POR UNA SAL DE LOS MISMOS. ESTOS COMPUESTOS EXHIBEN ACTIVIDAD ANTITROMBOTICA, ACTIVIDAD INHIBIDORA DEL ENGROSAMIENTO DE LA INTIMA, ACTIVIDAD DE DISOCIACION PLAQUETARIA Y AUMENTO DE LA ACTIVIDAD DEL FLUJO SANGUINEO EN EL CEREBRO Y LOS VASOS PERIFERICOS, SIENDO POR TANTO UTILES COMO MEDICAMENTOS PARA LA PROFILAXIS O EL TRATAMIENTO DE DIVERSAS ENFERMEDADES ISQUEMICAS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP25870595 | 1995-10-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2162655T3 true ES2162655T3 (es) | 2002-01-01 |
Family
ID=17323960
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES96932816T Expired - Lifetime ES2162655T3 (es) | 1995-10-05 | 1996-10-04 | Derivados de carboestirilo como agentes antitromboticos. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US6143763A (es) |
| EP (1) | EP0796248B1 (es) |
| KR (1) | KR100230639B1 (es) |
| CN (1) | CN1131213C (es) |
| AR (1) | AR004686A1 (es) |
| AT (1) | ATE204255T1 (es) |
| AU (1) | AU690861B2 (es) |
| CA (1) | CA2207185C (es) |
| DE (1) | DE69614503T2 (es) |
| ES (1) | ES2162655T3 (es) |
| MX (1) | MX9704145A (es) |
| TW (1) | TW338037B (es) |
| WO (1) | WO1997012869A1 (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ505921A (en) | 1998-03-31 | 2003-08-29 | Warner Lambert Co | 1-[5-(2,6-Dimethylpiperidino)pentyl] substituted quinolone serine protease inhibitors and their use for treating thrombin related disorders |
| EP1714654A4 (en) * | 2004-02-09 | 2011-02-16 | Nissan Chemical Ind Ltd | MEDICAMENT FOR INHIBITING VASCULAR INTIMATE HYPERPLASIA |
| PL1894576T3 (pl) * | 2005-06-08 | 2011-10-31 | Kowa Co | Nowy środek do obniżania poziomu triglicerydów |
| TWI481601B (zh) | 2009-08-21 | 2015-04-21 | Otsuka Pharma Co Ltd | 含氮化合物及藥學組成物 |
| US8796447B2 (en) | 2009-08-21 | 2014-08-05 | Otsuka Pharmaceutical Co., Ltd. | Process for producing benzo[B][1,4]diazepine-2,4-dione compound |
| EP2801361A4 (en) | 2012-01-05 | 2015-11-18 | Kowa Co | CONVEYOR FOR THE DEVELOPMENT OF COLLATERAL BLOOD CIRCULATION |
| US11166948B2 (en) | 2017-09-13 | 2021-11-09 | National University Corporation Hamamatsu University School Of Medicine | Pharmaceutical composition for treatment of aortic aneurysm |
| US20220184058A1 (en) | 2019-03-13 | 2022-06-16 | National University Corporation Hamamatsu University School Of Medicine | Pharmaceutical composition for treating aortic aneurysm |
| GB202019475D0 (en) | 2020-12-10 | 2021-01-27 | Cancer Research Tech Ltd | Therapeutic compounds and their use |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR930702307A (ko) * | 1991-08-23 | 1993-09-08 | 오오쓰까 아끼히꼬 | 카르보스티릴 유도체 및 혈소판 응집 억제제 |
-
1996
- 1996-09-25 TW TW085111708A patent/TW338037B/zh not_active IP Right Cessation
- 1996-09-30 AR ARP960104540A patent/AR004686A1/es active IP Right Grant
- 1996-10-04 EP EP96932816A patent/EP0796248B1/en not_active Expired - Lifetime
- 1996-10-04 AT AT96932816T patent/ATE204255T1/de active
- 1996-10-04 CA CA002207185A patent/CA2207185C/en not_active Expired - Fee Related
- 1996-10-04 DE DE69614503T patent/DE69614503T2/de not_active Expired - Lifetime
- 1996-10-04 AU AU71457/96A patent/AU690861B2/en not_active Ceased
- 1996-10-04 MX MX9704145A patent/MX9704145A/es unknown
- 1996-10-04 WO PCT/JP1996/002892 patent/WO1997012869A1/en not_active Ceased
- 1996-10-04 CN CN96191700A patent/CN1131213C/zh not_active Expired - Fee Related
- 1996-10-04 ES ES96932816T patent/ES2162655T3/es not_active Expired - Lifetime
- 1996-10-04 KR KR1019970703738A patent/KR100230639B1/ko not_active Expired - Lifetime
- 1996-10-04 US US08/849,664 patent/US6143763A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0796248A1 (en) | 1997-09-24 |
| EP0796248B1 (en) | 2001-08-16 |
| AR004686A1 (es) | 1999-03-10 |
| KR100230639B1 (ko) | 1999-11-15 |
| TW338037B (en) | 1998-08-11 |
| US6143763A (en) | 2000-11-07 |
| DE69614503T2 (de) | 2002-04-11 |
| CA2207185A1 (en) | 1997-04-10 |
| CA2207185C (en) | 2008-08-19 |
| AU690861B2 (en) | 1998-04-30 |
| AU7145796A (en) | 1997-04-28 |
| WO1997012869A1 (en) | 1997-04-10 |
| CN1131213C (zh) | 2003-12-17 |
| HK1002194A1 (en) | 1998-08-07 |
| DE69614503D1 (en) | 2001-09-20 |
| MX9704145A (es) | 1997-09-30 |
| ATE204255T1 (de) | 2001-09-15 |
| CN1172478A (zh) | 1998-02-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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