ES2166031T3 - Nuevos inhibidores de beta-glucuronidasa. - Google Patents

Nuevos inhibidores de beta-glucuronidasa.

Info

Publication number
ES2166031T3
ES2166031T3 ES97112940T ES97112940T ES2166031T3 ES 2166031 T3 ES2166031 T3 ES 2166031T3 ES 97112940 T ES97112940 T ES 97112940T ES 97112940 T ES97112940 T ES 97112940T ES 2166031 T3 ES2166031 T3 ES 2166031T3
Authority
ES
Spain
Prior art keywords
glucuronidasa
inhibitors
new beta
new
po3h2
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97112940T
Other languages
English (en)
Inventor
Klaus Bosslet
Joerg Czech
Andrea Vasella
Roland Hoos
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Application granted granted Critical
Publication of ES2166031T3 publication Critical patent/ES2166031T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/78—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/02—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/59—Hydrogenated pyridine rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/6552—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

LAS COMPOSICIONES DE LAS FORMULAS I Y II SON APTAS PARA FRENAR EL CRECIMIENTO DE TUMORES, ASI COMO LA METASTASIS TUMORAL.
ES97112940T 1996-08-02 1997-07-28 Nuevos inhibidores de beta-glucuronidasa. Expired - Lifetime ES2166031T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19631288A DE19631288A1 (de) 1996-08-02 1996-08-02 Neue Inhibitoren der ß-Glucuronidase

Publications (1)

Publication Number Publication Date
ES2166031T3 true ES2166031T3 (es) 2002-04-01

Family

ID=7801634

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97112940T Expired - Lifetime ES2166031T3 (es) 1996-08-02 1997-07-28 Nuevos inhibidores de beta-glucuronidasa.

Country Status (11)

Country Link
US (1) US5817800A (es)
EP (1) EP0822192B1 (es)
JP (1) JP4203133B2 (es)
AT (1) ATE207067T1 (es)
AU (1) AU717219B2 (es)
CA (1) CA2212200C (es)
DE (2) DE19631288A1 (es)
DK (1) DK0822192T3 (es)
ES (1) ES2166031T3 (es)
MX (1) MX9705893A (es)
PT (1) PT822192E (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19925810A1 (de) * 1999-06-07 2000-12-14 Paz Arzneimittelentwicklung Anwendung von Verapamil und Verapamilderivaten zur Herstellung von Arzneimitteln mit Glucuronidase hemmender Wirkung
CA2792613C (en) * 2010-03-10 2016-06-28 North Carolina Central University Phenoxy thiophene sulfonamides and their use as inhibitors of glucuronidase
CN103613619B (zh) * 2013-12-13 2016-02-17 沈阳药科大学 N-4-苯磺酰胺基-N’-1-脱氧-β-D-吡喃葡萄糖醛酸基-硫脲化合物的制备方法及医药用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3903289A (en) * 1971-10-06 1975-09-02 Diamond Shamrock Corp 4-Methyl-3-methylcarbamyloximinotetra-hydrothiapyran used to control insects and acarids
US5231185A (en) * 1985-11-19 1993-07-27 Cornell Research Foundation, Inc. Monosaccharide analog-based glycosidase inhibitors
ES2056801T3 (es) * 1986-08-13 1994-10-16 Hoechst Ag Oxirano-seudooligosacaridos, procedimiento para su preparacion, su utilizacion y preparados farmaceuticos.
CA2037767A1 (en) * 1990-03-23 1991-09-24 Mark D. Wittman Conversion of amines to hydroxylamines
EP0647450A1 (en) * 1993-09-09 1995-04-12 BEHRINGWERKE Aktiengesellschaft Improved prodrugs for enzyme mediated activation

Also Published As

Publication number Publication date
CA2212200C (en) 2007-05-22
PT822192E (pt) 2002-03-28
AU717219B2 (en) 2000-03-23
EP0822192B1 (de) 2001-10-17
AU3241997A (en) 1998-02-12
CA2212200A1 (en) 1998-02-02
ATE207067T1 (de) 2001-11-15
US5817800A (en) 1998-10-06
EP0822192A3 (en) 1998-03-18
JP4203133B2 (ja) 2008-12-24
MX9705893A (es) 1998-02-28
EP0822192A2 (de) 1998-02-04
DE19631288A1 (de) 1998-02-05
JPH1077279A (ja) 1998-03-24
DE59704940D1 (de) 2001-11-22
DK0822192T3 (da) 2002-02-11

Similar Documents

Publication Publication Date Title
BR9810459A (pt) sais nìtricos dos inibidores de ace
GB9801690D0 (en) Therapeutic agents
TR199700844T1 (xx) Pirazolil-Benzoil T�revleri.
ES2176402T3 (es) Compuestos sulfatos de 2,2-difluoro-3-carbomoil-ribosa y procedimientopara la preparacion de beta-nucleosidos.
TW335396B (en) Benzofurans
TR199701654T1 (xx) 4-Fenilaminotiyazol t�revleri.
MY129409A (en) Arylpiperazines and their use as metalloproteinase inhibiting agents (mmp)
PT1076663E (pt) Derivados funcionalizados de alquilo e alcenilo de cadeia lateral de glicinamidas como inibidores de farnesil transferase
GR3004018T3 (es)
NO20014925D0 (no) Farmasöytiske forbindelser
ATE211139T1 (de) Tetrahydroimidazopyridoindoldione als cgmp spezifische pde hemmer
TR199900186T2 (xx) H�cre proliferasyonunun engellenmesine y�nelik ikameli/katk�l� bisindolilmaleimidler
GB9715030D0 (en) Metalloproteinase inhibitors
DE69931051D1 (de) Neue vinylbenzolderivate
TR200003859T2 (tr) Amidino ve guanidino azetidinon triptaz önleyicileri
ATE166342T1 (de) Desferrioxamine-b salze und ihre verwendung als oral wirksame eisen- chelatbildner
DK0822192T3 (da) Nye inhibitorer af beta-blucuronidase
MX9804828A (es) Benzotiazolona etanaminas biologicamente activas.
TW333533B (en) Novel indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase
EP0978277A4 (en) ANTI-RHUMATISMAL AGENTS
IL128280A0 (en) Method fro treating bipolar disorder
ATE165875T1 (de) Lactobionsäureamid enthaltende korrosionsschutzmittel
SE9800932D0 (sv) New compunds
ATE151742T1 (de) Alicyclische phospholipase a 2 inhibitoren
DE69514388D1 (de) Antiherpetische peptidomimetische verbindungen

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 822192

Country of ref document: ES