ES2167326T3 - N-acetilglucosaminil-transferasa, gen que la codifica, vectores y huespedes transformados correspondientes y procedimientos para su produccion. - Google Patents

N-acetilglucosaminil-transferasa, gen que la codifica, vectores y huespedes transformados correspondientes y procedimientos para su produccion.

Info

Publication number
ES2167326T3
ES2167326T3 ES93306718T ES93306718T ES2167326T3 ES 2167326 T3 ES2167326 T3 ES 2167326T3 ES 93306718 T ES93306718 T ES 93306718T ES 93306718 T ES93306718 T ES 93306718T ES 2167326 T3 ES2167326 T3 ES 2167326T3
Authority
ES
Spain
Prior art keywords
production
activity
acetilglucosaminil
transferasa
codifies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93306718T
Other languages
English (en)
Inventor
Naoyuki Taniguchi
Atsushi Nishikawa
Nozomi Yamaguchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Suntory Ltd
Original Assignee
Suntory Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Suntory Ltd filed Critical Suntory Ltd
Application granted granted Critical
Publication of ES2167326T3 publication Critical patent/ES2167326T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

UNA TRANSFERASA (BETA) 1,6 TIENE LAS SIGUIENTES PROPIEDADES: (1) ACCION: TRANSFIERE N CETILGLUCOSAMINA DESDE UDP 6 ACTIVIDAD DE UN 79% PARA GNGNF CTIVIDAD PARA GNGN ''3; (4) INHIBICION, ACTIVACION Y ESTABILIDAD: MN2 NO ES NECESARIO PARA EXPRESION DE ACTIVIDAD, Y LA ACTIVIDAD NO SE INHIBE EN PRESENCIA DE 20 MM EDTA; (5) PESO MOLECULAR: 73.000, DETERMINADO POR SDS 60.000 SEGUN LO DETERMINADO EN PRESENCIA DE UN AGENTE REDUCTOR; (6) VALOR KM: 133 (MU)M Y 3''5 MM PARA ACEPTOR GNGN Y DONADOR UDP GLCNAC, RESPECTIVAMENTE; Y (7) INCLUYE LOS SIGUIENTES FRAGMENTOS PEPTIDOS: (1) THR ASN ASN PARA LA CITADA ENZIMA, Y UN PROCESO PARA LA PRODUCCION DE LA ENZIMA.
ES93306718T 1992-08-24 1993-08-24 N-acetilglucosaminil-transferasa, gen que la codifica, vectores y huespedes transformados correspondientes y procedimientos para su produccion. Expired - Lifetime ES2167326T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP24595092 1992-08-24
JP23711893A JP3979678B2 (ja) 1992-08-24 1993-08-06 新規糖転移酵素及びそれをコードする遺伝子並びに該酵素の製造方法

Publications (1)

Publication Number Publication Date
ES2167326T3 true ES2167326T3 (es) 2002-05-16

Family

ID=26533055

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93306718T Expired - Lifetime ES2167326T3 (es) 1992-08-24 1993-08-24 N-acetilglucosaminil-transferasa, gen que la codifica, vectores y huespedes transformados correspondientes y procedimientos para su produccion.

Country Status (6)

Country Link
US (2) US5707846A (es)
EP (1) EP0585109B1 (es)
JP (1) JP3979678B2 (es)
DE (1) DE69331484T2 (es)
DK (1) DK0585109T3 (es)
ES (1) ES2167326T3 (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5602003A (en) * 1992-06-29 1997-02-11 University Of Georgia Research Foundation N-acetylglucosaminyltransferase V gene
US5545553A (en) * 1994-09-26 1996-08-13 The Rockefeller University Glycosyltransferases for biosynthesis of oligosaccharides, and genes encoding them
US8178090B2 (en) * 1995-06-07 2012-05-15 Danisco A/S Recombinant hexose oxidase
US6897052B1 (en) * 1998-08-07 2005-05-24 Glycodesign Holdings Ltd. N-acetylglycosaminyl transferase genes
US7173003B2 (en) 2001-10-10 2007-02-06 Neose Technologies, Inc. Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
US7696163B2 (en) 2001-10-10 2010-04-13 Novo Nordisk A/S Erythropoietin: remodeling and glycoconjugation of erythropoietin
US7214660B2 (en) 2001-10-10 2007-05-08 Neose Technologies, Inc. Erythropoietin: remodeling and glycoconjugation of erythropoietin
WO2003060131A1 (en) 2002-01-09 2003-07-24 Suntory Limited SUGAR TRANSFERASE GnT-V HAVING ANGIOGENIC EFFECT
WO2003091402A2 (en) 2002-04-23 2003-11-06 University Of Georgia Research Foundation, Inc. N-ACETYLGLUCOSAMINYLTRANSFERASE Vb CODING SEQUENCE, RECOMBINANT CELLS AND METHODS
MXPA04012496A (es) 2002-06-21 2005-09-12 Novo Nordisk Healthcare Ag Glicoformos del factor vii pegilados.
JP2006523211A (ja) 2003-03-14 2006-10-12 ネオス テクノロジーズ インコーポレイテッド 分岐水溶性ポリマーとその複合物
EP1613261A4 (en) 2003-04-09 2011-01-26 Novo Nordisk As INTRA-CELLULAR FORMATION OF PEPTIDE CONJUGATES
NZ542586A (en) 2003-04-09 2009-11-27 Biogenerix Ag Method of forming a covalent conjugate between a G-CSF peptide and PEG
US9005625B2 (en) 2003-07-25 2015-04-14 Novo Nordisk A/S Antibody toxin conjugates
US20080305992A1 (en) 2003-11-24 2008-12-11 Neose Technologies, Inc. Glycopegylated erythropoietin
US7338933B2 (en) 2004-01-08 2008-03-04 Neose Technologies, Inc. O-linked glycosylation of peptides
WO2006010143A2 (en) 2004-07-13 2006-01-26 Neose Technologies, Inc. Branched peg remodeling and glycosylation of glucagon-like peptide-1 [glp-1]
EP1799249A2 (en) 2004-09-10 2007-06-27 Neose Technologies, Inc. Glycopegylated interferon alpha
EP3061461A1 (en) 2004-10-29 2016-08-31 ratiopharm GmbH Remodeling and glycopegylation of fibroblast growth factor (fgf)
US20070105755A1 (en) 2005-10-26 2007-05-10 Neose Technologies, Inc. One pot desialylation and glycopegylation of therapeutic peptides
WO2007056191A2 (en) 2005-11-03 2007-05-18 Neose Technologies, Inc. Nucleotide sugar purification using membranes
CN101796063B (zh) 2007-04-03 2017-03-22 拉蒂奥法姆有限责任公司 使用糖聚乙二醇化g‑csf的治疗方法
US9493499B2 (en) 2007-06-12 2016-11-15 Novo Nordisk A/S Process for the production of purified cytidinemonophosphate-sialic acid-polyalkylene oxide (CMP-SA-PEG) as modified nucleotide sugars via anion exchange chromatography
DK2257311T3 (da) 2008-02-27 2014-06-30 Novo Nordisk As Konjugerede Faktor VIII-Molekyler

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0515536B1 (en) * 1990-02-14 2000-01-19 The Regents Of The University Of Michigan Methods and products for the synthesis of oligosaccharide structures on glycoproteins, glycolipids, or as free molecules
AU8941191A (en) * 1990-11-30 1992-06-25 Hsc Research And Development Limited Partnership Cloning of udp-n-acetylglucosamine:alpha-3-d-mannoside beta -1,2-n-acetylglucosaminyltransferase i
US5602003A (en) * 1992-06-29 1997-02-11 University Of Georgia Research Foundation N-acetylglucosaminyltransferase V gene

Also Published As

Publication number Publication date
US5707846A (en) 1998-01-13
JPH06197756A (ja) 1994-07-19
DE69331484T2 (de) 2002-08-29
DE69331484D1 (de) 2002-03-14
EP0585109A3 (en) 1994-07-06
DK0585109T3 (da) 2002-03-11
JP3979678B2 (ja) 2007-09-19
EP0585109B1 (en) 2002-01-23
US5834284A (en) 1998-11-10
EP0585109A2 (en) 1994-03-02

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