ES2168084A1 - Combinacion de aminas y compuestos de vanadio (iv) (v) para el tratatamiento y/o la prevencion de la diabetes mellitus. - Google Patents

Combinacion de aminas y compuestos de vanadio (iv) (v) para el tratatamiento y/o la prevencion de la diabetes mellitus.

Info

Publication number
ES2168084A1
ES2168084A1 ES200002745A ES200002745A ES2168084A1 ES 2168084 A1 ES2168084 A1 ES 2168084A1 ES 200002745 A ES200002745 A ES 200002745A ES 200002745 A ES200002745 A ES 200002745A ES 2168084 A1 ES2168084 A1 ES 2168084A1
Authority
ES
Spain
Prior art keywords
vanadium
compounds
combination
amines
prevention
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES200002745A
Other languages
English (en)
Other versions
ES2168084B1 (es
Inventor
Olarte Antonio Zorzano
Christian Marti Carpene
Delmas Gemma Enrique-Tarancon
Ymbert Xavier Testar
Luc Marti
Prieto Manuel Palacin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universitat de Barcelona UB
Original Assignee
Universitat de Barcelona UB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universitat de Barcelona UB filed Critical Universitat de Barcelona UB
Priority to ES200002745A priority Critical patent/ES2168084B1/es
Priority to PCT/ES2001/000424 priority patent/WO2002038152A1/es
Priority to AU2002215059A priority patent/AU2002215059A1/en
Priority to CA002425192A priority patent/CA2425192A1/en
Priority to EP01983613A priority patent/EP1338280A1/en
Publication of ES2168084A1 publication Critical patent/ES2168084A1/es
Priority to ZA200302730A priority patent/ZA200302730B/en
Application granted granted Critical
Publication of ES2168084B1 publication Critical patent/ES2168084B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Combinación de aminas y compuestos de vanadio (IV)/(V) para el tratamiento y/o la prevención de la Diabetes mellitus Las combinaciones que incluyen compuestos de vanadio (IV)/(V) y aminas farmacéuticamente aceptables seleccionadas del grupo de los sustratos de la amino oxidasa sensible a semicarbazida (en inglés "semicarbazide-sensitive amina oxidase", abreviado SSAO) son imitadores de la insulina. Los compuestos de vanadio (IV)/(V) preferidos son los complejos de peroxovanadio, las sales de vanadilo, los complejos de vanadilo y los vanadatos (p.ej., el ortovanadato sódico). Las aminas preferidas son la tiramina y la bencilamina. Una sinergia entre el compuesto de vanadio y la amina, descubierta aquí, hace que la concentración eficaz de vanadato en la combinación sea un orden de magnitud menor que la correspondiente al vanadato solo. Consecuentemente, la combinación tiene una toxicidad mucho menor que la del compuesto vanadio solo, ya conocido, lo cual representa una ventaja crucial de la primera para su uso en el tratamiento y/o la prevención de la Diabetes mellitus.
ES200002745A 2000-11-07 2000-11-07 Combinacion de aminas y compuestos de vanadio (iv) (v) para el tratatamiento y/o la prevencion de la diabetes mellitus. Expired - Fee Related ES2168084B1 (es)

Priority Applications (6)

Application Number Priority Date Filing Date Title
ES200002745A ES2168084B1 (es) 2000-11-07 2000-11-07 Combinacion de aminas y compuestos de vanadio (iv) (v) para el tratatamiento y/o la prevencion de la diabetes mellitus.
PCT/ES2001/000424 WO2002038152A1 (es) 2000-11-07 2001-11-06 Combinacion de aminas y compuestos de vanadio (iv)/(v) para el tratamiento y/o la prevencion de la diabetes mellitus
AU2002215059A AU2002215059A1 (en) 2000-11-07 2001-11-06 Combination of amines and vanadium (IV)/(V) compounds for the treatment and/or prevention of diabetes mellitus
CA002425192A CA2425192A1 (en) 2000-11-07 2001-11-06 Combination of amines and vanadium (iv)/(v) compounds for the treatment and/or prevention of diabetes mellitus
EP01983613A EP1338280A1 (en) 2000-11-07 2001-11-06 Combination of amines and vanadium (iv)/(v) compounds for the treatment and/or prevention of diabetes mellitus
ZA200302730A ZA200302730B (en) 2000-11-07 2003-04-08 Combination of amines and vanadium (IV)/(V) compounds for the treatment and/or prevention of diabetes mellitus.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200002745A ES2168084B1 (es) 2000-11-07 2000-11-07 Combinacion de aminas y compuestos de vanadio (iv) (v) para el tratatamiento y/o la prevencion de la diabetes mellitus.

Publications (2)

Publication Number Publication Date
ES2168084A1 true ES2168084A1 (es) 2002-05-16
ES2168084B1 ES2168084B1 (es) 2003-11-16

Family

ID=8495654

Family Applications (1)

Application Number Title Priority Date Filing Date
ES200002745A Expired - Fee Related ES2168084B1 (es) 2000-11-07 2000-11-07 Combinacion de aminas y compuestos de vanadio (iv) (v) para el tratatamiento y/o la prevencion de la diabetes mellitus.

Country Status (6)

Country Link
EP (1) EP1338280A1 (es)
AU (1) AU2002215059A1 (es)
CA (1) CA2425192A1 (es)
ES (1) ES2168084B1 (es)
WO (1) WO2002038152A1 (es)
ZA (1) ZA200302730B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR042941A1 (es) 2003-01-27 2005-07-06 Fujisawa Pharmaceutical Co Derivados de tiazol, su preparacion, composiciones farmaceuticas que los contienen y su uso en la fabricacion de medicamentos inhibidores de la proteina-1 de adhesion vascular (vap-1)
AU2005259231A1 (en) * 2004-07-02 2006-01-12 Genmedica Therapeutics Sl Arylalkylamine vanadium (V) salts for the treatment and/or prevention of diabetes mellitus
TWI437986B (zh) 2008-01-31 2014-05-21 R Tech Ueno Ltd 噻唑衍生物及使用該衍生物作為ｖａｐ－１抑制劑之用途
TWI490214B (zh) 2008-05-30 2015-07-01 艾德克 上野股份有限公司 苯或噻吩衍生物及該等作為ｖａｐ－１抑制劑之用途
PL2479165T3 (pl) 2009-09-16 2018-05-30 Astellas Pharma Inc. Związek glicynowy
LT3002278T (lt) 2011-03-15 2017-06-26 Astellas Pharma Inc. Guanidino junginys
JP2018076236A (ja) 2015-06-05 2018-05-17 株式会社アールテック・ウエノ がんを処置するための医薬組成物

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0264278A1 (en) * 1986-10-16 1988-04-20 Barry I. Posner Vanadium-peroxide compositions as insulin mimickers
FR2686511A1 (fr) * 1992-01-28 1993-07-30 Ir2M Composition pharmaceutique contenant des associations de vanadium et/ou de niobium avec des acides amines ou des derives d'acides amines.

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0264278A1 (en) * 1986-10-16 1988-04-20 Barry I. Posner Vanadium-peroxide compositions as insulin mimickers
FR2686511A1 (fr) * 1992-01-28 1993-07-30 Ir2M Composition pharmaceutique contenant des associations de vanadium et/ou de niobium avec des acides amines ou des derives d'acides amines.

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ENRIQUE-TARANCoN, G. y col. Role of Semicarbazide-sensitive Amine Oxidase on glucose transport and GLUT 4 recruitment to the Cell Surface in Adipose Cells. The Journal of Biological Chemistry. 1998, Volumen 273, No 4, paginas 8025-8032. Introduccion. *
ENRIQUE-TARANCoN, G. y col. Substrates of semicarbazide-sensitive amine oxidase co-operate with vanadate to stimulate tyrosine phosphorylation of insulin-receptor-substrate proteins, phosphoinositide 3-kinase activity and GLUT 4 translocation in adipose cells. Biochemical Journal, 15 Agosto 2000, Volumen 35, paginas 171-180. Introduction. *
MARTI, LUC y col. Tyramine and Vanadate Synergistically Stimulate Glucose Transport in Rat Adipocytes by Amine Oxidase-Dependent Generation of Hydrogen Peroxide 1. The Journal of Pharmacology and Experimental Therapeutics. 1998, Volumen 285, No 1, paginas 342-349. Resumen. *

Also Published As

Publication number Publication date
WO2002038152A1 (es) 2002-05-16
AU2002215059A1 (en) 2002-05-21
EP1338280A1 (en) 2003-08-27
ZA200302730B (en) 2005-03-17
CA2425192A1 (en) 2003-04-07
ES2168084B1 (es) 2003-11-16

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