ES2168258T3 - Vectores virales recombinantes que codifican para proteinas de papilomavirus humano. - Google Patents

Vectores virales recombinantes que codifican para proteinas de papilomavirus humano.

Info

Publication number
ES2168258T3
ES2168258T3 ES92906294T ES92906294T ES2168258T3 ES 2168258 T3 ES2168258 T3 ES 2168258T3 ES 92906294 T ES92906294 T ES 92906294T ES 92906294 T ES92906294 T ES 92906294T ES 2168258 T3 ES2168258 T3 ES 2168258T3
Authority
ES
Spain
Prior art keywords
virus vector
pct
nucleotide sequences
proteins
pair
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92906294T
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English (en)
Inventor
Michael Edward Griff Boursnell
Stephen Charles Inglis
Alan James Munro
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cantab Pharmaceuticals Research Ltd
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Cantab Pharmaceuticals Research Ltd
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Publication date
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Publication of ES2168258T3 publication Critical patent/ES2168258T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/004—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of alcohol- or thiol groups in the enantiomers or the inverse reaction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/24011—Poxviridae
    • C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
    • C12N2710/24141—Use of virus, viral particle or viral elements as a vector
    • C12N2710/24143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Plant Pathology (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A UN VECTOR VIRAL RECOMBINANTE PARA UTILIZARLO COMO AGENTE INMUNOTERAPEUTICO O VACUNA. EL VECTOR VIRAL RECOMBINANTE CONTIENE POR LO MENOS UN PAR DE SECUENCIAS NUCLEOTIDAS HETEROLOGAS AL VIRUS Y QUE TIENEN UNA HOMOLOGIA DE SECUENCIA SUFICIENTE COMO PARA QUE SE PUEDA ESPERAR QUE SE PRODUZCA UNA RECOMBINACION ENTRE ELLAS. EL PAR DE SECUENCIAS NUCLEOTIDAS SE ENCUENTRAN DISPUESTAS EN EL VECTOR VIRAL DE TAL MODO QUE SE ENCUENTRAN INVERTIDAS UNA RESPECTO A LA OTRA. EL VECTOR VIRAL PUEDE INFECTAR A LA CELULA HUESPED DE UN MAMIFERO Y EXPRESAR COMO POLIPEPTIDO LAS SECUENCIAS NUCLEOTIDAS HETEROLOGAS EN LA CELULA HUESPED. PARA LAS INFECCIONES QUE SE PIENSA SON CAUSADAS POR LA INFECCION DEL HPV, EL PAR DE SECUENCIAS NUCLEOTIDAS CODIFICA PARTE O TODAS LAS PROTEINAS DE TIPO SALVAJE DEL VIRUS DEL PAPILOMA HUMANO (HPV) O LAS PROTEINAS MUTANTES QUE REACCIONAN EN CRUZ INMUNOLOGICAMENTE CON LAS MISMAS. PARA UN AGENTE INMUNOTERAPEUTICO O UNA VACUNA CONTRA EL CANCER DE CERVIX, ELVECTOR VIRAL RECOMBINANTE CODIFICA PARTE O TODAS LAS PROTEINAS DE TIPO SALVAJE DEL HPV HPV16E7 Y HPV18E7 O LAS PROTEINAS MUTANTES QUE REACCIONAN EN CRUZ INMUNOLOGICAMENTE CON LAS MISMAS.
ES92906294T 1991-03-14 1992-03-10 Vectores virales recombinantes que codifican para proteinas de papilomavirus humano. Expired - Lifetime ES2168258T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB919105383A GB9105383D0 (en) 1991-03-14 1991-03-14 An immunotherapeutic for cervical cancer

Publications (1)

Publication Number Publication Date
ES2168258T3 true ES2168258T3 (es) 2002-06-16

Family

ID=10691550

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92906294T Expired - Lifetime ES2168258T3 (es) 1991-03-14 1992-03-10 Vectores virales recombinantes que codifican para proteinas de papilomavirus humano.

Country Status (17)

Country Link
US (1) US5719054A (es)
EP (1) EP0576471B1 (es)
JP (1) JPH06505626A (es)
KR (1) KR100240183B1 (es)
CN (1) CN1090239C (es)
AT (1) ATE208824T1 (es)
AU (1) AU665531B2 (es)
BR (1) BR9205771A (es)
CA (1) CA2106069A1 (es)
DE (1) DE69232201T2 (es)
DK (1) DK0576471T3 (es)
ES (1) ES2168258T3 (es)
GB (1) GB9105383D0 (es)
MX (1) MX9205131A (es)
NO (1) NO310033B1 (es)
OA (1) OA10085A (es)
WO (1) WO1992016636A1 (es)

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NO933260L (no) 1993-10-22
NO310033B1 (no) 2001-05-07
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MX9205131A (es) 1994-06-30
OA10085A (en) 1996-12-18
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DE69232201T2 (de) 2002-07-11
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BR9205771A (pt) 1994-06-07
EP0576471B1 (en) 2001-11-14
GB9105383D0 (en) 1991-05-01
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CN1064892A (zh) 1992-09-30
ATE208824T1 (de) 2001-11-15
CA2106069A1 (en) 1992-09-15
EP0576471A1 (en) 1994-01-05
AU1414792A (en) 1992-10-21
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NO933260D0 (no) 1993-09-13
DE69232201D1 (de) 2001-12-20

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