ES2170533T3 - Cemento quirurgico hidraulico. - Google Patents

Cemento quirurgico hidraulico.

Info

Publication number
ES2170533T3
ES2170533T3 ES98954344T ES98954344T ES2170533T3 ES 2170533 T3 ES2170533 T3 ES 2170533T3 ES 98954344 T ES98954344 T ES 98954344T ES 98954344 T ES98954344 T ES 98954344T ES 2170533 T3 ES2170533 T3 ES 2170533T3
Authority
ES
Spain
Prior art keywords
beta
particles
tcp
component
component includes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98954344T
Other languages
English (en)
Inventor
Jaques Lemaitre
Marc Bohner
Landuyt Pascale Van
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ROBERT MATHYS STIFTUNG
Synthes GmbH
Dr HC Robert Mathys Stiftung
Original Assignee
ROBERT MATHYS STIFTUNG
Stratec Medical AG
Dr HC Robert Mathys Stiftung
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ROBERT MATHYS STIFTUNG, Stratec Medical AG, Dr HC Robert Mathys Stiftung filed Critical ROBERT MATHYS STIFTUNG
Application granted granted Critical
Publication of ES2170533T3 publication Critical patent/ES2170533T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0015—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/15—Compositions characterised by their physical properties
    • A61K6/17—Particle size
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/50—Preparations specially adapted for dental root treatment
    • A61K6/58—Preparations specially adapted for dental root treatment specially adapted for dental implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/60—Preparations for dentistry comprising organic or organo-metallic additives
    • A61K6/69—Medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/70—Preparations for dentistry comprising inorganic additives
    • A61K6/71—Fillers
    • A61K6/74—Fillers comprising phosphorus-containing compounds
    • A61K6/75—Apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
    • A61K6/849—Preparations for artificial teeth, for filling teeth or for capping teeth comprising inorganic cements
    • A61K6/864—Phosphate cements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/0047—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L24/0073—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix
    • A61L24/0084—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix containing fillers of phosphorus-containing inorganic compounds, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/02—Surgical adhesives or cements; Adhesives for colostomy devices containing inorganic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/12—Phosphorus-containing materials, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00179—Ceramics or ceramic-like structures
    • A61F2310/00293—Ceramics or ceramic-like structures containing a phosphorus-containing compound, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A61L2300/406—Antibiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/41—Anti-inflammatory agents, e.g. NSAIDs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A61L2300/414—Growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/45—Mixtures of two or more drugs, e.g. synergistic mixtures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Transplantation (AREA)
  • Materials Engineering (AREA)
  • Surgery (AREA)
  • Dermatology (AREA)
  • Composite Materials (AREA)
  • Plastic & Reconstructive Surgery (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Materials For Medical Uses (AREA)
  • Curing Cements, Concrete, And Artificial Stone (AREA)
  • Saccharide Compounds (AREA)
  • Dental Preparations (AREA)

Abstract

Cemento para aplicaciones quirúrgicas comprendiendo un primer componente: Unas partículas de beta-fosfato de calcio terciario -Ca3(PO4)2 (-TCP); y unas partículas de fosfato monocálcico Ca (H2PO4)2 (MCPA) o de monohidrato de fosfato monocálcico Ca(H2PO4)2.H2O (MCPM) o de ácido fosfórico; un segundo componente comprendiendo agua: y un tercer componente comprendiendo unas partículas de un diámetro medio que es más grande que el diámetro medio de partículas de beta-fosfato de calcio terciario -Ca3(PO4)2 (TCP) precitadas del primer componente, de tal forma que después de la mezcla de los tres componentes precitados se forma una masa endurecida comprendiendo la brusita CaHPO4.H2O (DCPD), caracterizado porque: a) las partículas de -TCP tienen una área de superficie especifica media inferior a 10.000 m 2 /g; b) el tercer componente es un fosfato de calcio con un relación Ca/P diferente de 1,5; c) el tercer componente constituye de 1 al 99 % en volumen de la masa endurecida precitada; y d) el primer componente comprende además un agente de control de la velocidad de fraguado.
ES98954344T 1997-10-07 1998-10-06 Cemento quirurgico hidraulico. Expired - Lifetime ES2170533T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP9705495 1997-10-07

Publications (1)

Publication Number Publication Date
ES2170533T3 true ES2170533T3 (es) 2002-08-01

Family

ID=8166753

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98954344T Expired - Lifetime ES2170533T3 (es) 1997-10-07 1998-10-06 Cemento quirurgico hidraulico.

Country Status (7)

Country Link
US (1) US6425949B1 (es)
AT (1) ATE211379T1 (es)
CA (1) CA2306562A1 (es)
DE (1) DE69803398T2 (es)
DK (1) DK1023032T3 (es)
ES (1) ES2170533T3 (es)
WO (1) WO1999017710A1 (es)

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WO2000007639A1 (en) * 1998-08-07 2000-02-17 Tissue Engineering, Inc. Bone precursor compositions
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DE19853832A1 (de) * 1998-11-21 2000-05-25 Merck Patent Gmbh Polyalkensäuren enthaltende Calcium-Phosphatzemente
DE19938704C1 (de) * 1999-08-14 2001-10-31 Ivoclar Vivadent Ag Verfahren zur Herstellung von Reaktionssystemen zur Implantation in den menschlichen und tierischen Körper als Knochenersatz, die u.a. Calcium und Phosphor enthalten
ATE245456T1 (de) * 1999-12-09 2003-08-15 Robert Mathys Stiftung Mit einem magnesiumsalz stabilisierter hydraulischer brushitzement
SE517168C2 (sv) * 2000-07-17 2002-04-23 Bone Support Ab En komposition för ett injicerbart ersättningsmaterial för benmineral
US20020114795A1 (en) 2000-12-22 2002-08-22 Thorne Kevin J. Composition and process for bone growth and repair
US7294187B2 (en) * 2001-01-24 2007-11-13 Ada Foundation Rapid-hardening calcium phosphate cement compositions
EP1228772A1 (en) * 2001-02-01 2002-08-07 AM-Pharma B.V. Novel bone cement containing bioactive agents
US20030055512A1 (en) * 2001-05-21 2003-03-20 Genin Francois Y. Calcium based neutral and bioresorbable bone graft
CA2463742C (fr) 2001-11-14 2010-08-10 Ecole Polytechnique Federale De Lausanne (Epfl) Multicomposants pateux ou liquides pour ciments phosphocalciques injectables
USRE45561E1 (en) 2003-05-23 2015-06-16 Ortus Medical Limited Calcium phosphate bone cements
GB0311846D0 (en) * 2003-05-23 2003-06-25 Univ Birmingham High strength and injectable apatitic calcium phosphate cements
SE0302983D0 (sv) 2003-11-11 2003-11-11 Bone Support Ab Anordning för att förse spongiöst ben med benersättnings- och/eller benförstärkningsmaterial och förfarande i samband därmed
GB0502493D0 (en) * 2005-02-07 2005-03-16 Orthogem Ltd Bone cement
US8025903B2 (en) 2005-09-09 2011-09-27 Wright Medical Technology, Inc. Composite bone graft substitute cement and articles produced therefrom
ES2402651T3 (es) * 2005-09-09 2013-05-07 Agnovos Healthcare, Llc Cemento sustituto de injerto óseo de material compuesto y artículos producidos del mismo
WO2008041846A2 (en) 2006-10-05 2008-04-10 Cam Aesthetics B.V. I.O. Hydroxyapatite tissue filler and its preparation and use
FR2908775B1 (fr) * 2006-11-17 2012-08-31 Biomatlante Hydrogel et ses applications biomedicales
US7718616B2 (en) 2006-12-21 2010-05-18 Zimmer Orthobiologics, Inc. Bone growth particles and osteoinductive composition thereof
CN101157734B (zh) * 2007-09-07 2010-06-16 中国科学院海洋研究所 壳聚糖α-氨基烷基膦酸酯类衍生物及其制备方法
US9138509B2 (en) * 2007-09-14 2015-09-22 Musculoskeletal Transplant Foundation Composition for filling bone defects
WO2009077210A1 (en) * 2007-10-15 2009-06-25 Universidad Complutense De Madrid Monetite matrices and their application in bone regeneration
US8226719B2 (en) * 2007-11-14 2012-07-24 Cook Medical Technologies Llc Method and bone cement substitute kit for stabilizing a collapsed vertebra of a patient
TWI427050B (zh) * 2009-06-12 2014-02-21 Univ Kaohsiung Medical 鈣磷酸鹽類骨水泥、其前驅物及其製法
US8945511B2 (en) * 2009-06-25 2015-02-03 Paul Weinberger Sensitive methods for detecting the presence of cancer associated with the over-expression of galectin-3 using biomarkers derived from galectin-3
US9180137B2 (en) 2010-02-09 2015-11-10 Bone Support Ab Preparation of bone cement compositions
CN102335456A (zh) * 2010-07-21 2012-02-01 苏州大学附属第一医院 一种磷酸钙骨水泥及其制备方法
WO2012068135A1 (en) 2010-11-15 2012-05-24 Zimmer Orthobiologics, Inc. Bone void fillers
TWI573557B (zh) * 2010-12-10 2017-03-11 星瑟斯有限公司 固定系統
RU2477120C2 (ru) * 2011-04-04 2013-03-10 Федеральное государственное автономное образовательное учреждение высшего профессионального образования "Белгородский государственный национальный исследовательский университет"(НИУ "БелГУ") Способ получения цемента брушитного типа для замещения костных дефектов
US20130066327A1 (en) * 2011-09-09 2013-03-14 Håkan Engqvist Hydraulic cement compositions with low ph methods, articles and kits
RU2490031C2 (ru) * 2011-09-29 2013-08-20 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Российский химико-технологический университет им. Д.И. Менделеева (РХТУ им. Д.И. Менделеева) Брушитовый цемент для костной хирургии
EP2931325B1 (en) * 2012-12-14 2020-02-19 OssDsign AB Cement-forming compositions, monetite cements, implants and methods for correcting bone defects
CA2901528C (en) 2013-02-20 2022-07-26 Bone Support Ab Heat-treated, sintered and micronized hydroxyapatite powder for use in a hardenable bone substitute composition
TWI651103B (zh) 2013-12-13 2019-02-21 萊特醫技股份有限公司 多相骨移植替代材料
SG11201702700UA (en) * 2014-10-02 2017-04-27 Polypid Ltd Methods for the treatment of peri-implantitis
KR20170100634A (ko) 2014-12-29 2017-09-04 바이오벤터스 엘엘씨 골 복구에서의 골유도 분자의 전달 향상을 위한 시스템 및 방법
CA2986702C (en) 2015-05-21 2023-04-04 David Wang Modified demineralized cortical bone fibers
RU2623211C1 (ru) * 2016-08-02 2017-06-22 Общество с ограниченной ответственностью "КСЕНОПЛАНТ" Цемент для костной хирургии и способ его получения
RU2697396C1 (ru) * 2018-05-30 2019-08-14 Федеральное государственное бюджетное учреждение науки Институт металлургии и материаловедения им. А.А. Байкова Российской академии наук (ИМЕТ РАН) Способ получения биоцемента для заполнения костных дефектов на основе дикальцийфосфата дигидрата и сульфата кальция двуводного
SE2250154A1 (en) * 2022-02-16 2022-11-15 Cavix Ab Macroporous hydroxyapatite composition and methods of making such

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US5338356A (en) * 1991-10-29 1994-08-16 Mitsubishi Materials Corporation Calcium phosphate granular cement and method for producing same
ES2040626B1 (es) 1991-11-22 1994-05-16 Boltong Maria G Procedimiento para la obtencion de cementos de fosfatos de calcio y su empleo como biomteriales.
DE4216496C2 (de) 1992-05-19 1994-09-22 Werner Prof Dr Med Sattel Verwendung eines Plombenkörpers zum Einsetzen in eine Knochenhöhle, insbesondere in den Markraum eines Röhrenknochens

Also Published As

Publication number Publication date
DK1023032T3 (da) 2002-04-22
CA2306562A1 (en) 1999-04-15
DE69803398D1 (de) 2002-02-28
WO1999017710A1 (en) 1999-04-15
US6425949B1 (en) 2002-07-30
DE69803398T2 (de) 2002-09-26
ATE211379T1 (de) 2002-01-15

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