ES2171743T3 - Derivados de amidinas e isotioureas como inhibidores de la enzima sintasa de oxido nitrico. - Google Patents

Derivados de amidinas e isotioureas como inhibidores de la enzima sintasa de oxido nitrico.

Info

Publication number
ES2171743T3
ES2171743T3 ES96938584T ES96938584T ES2171743T3 ES 2171743 T3 ES2171743 T3 ES 2171743T3 ES 96938584 T ES96938584 T ES 96938584T ES 96938584 T ES96938584 T ES 96938584T ES 2171743 T3 ES2171743 T3 ES 2171743T3
Authority
ES
Spain
Prior art keywords
isotioures
amidines
inhibitors
derivatives
nitric oxide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96938584T
Other languages
English (en)
Inventor
James Macdonald
James Matz
William Shakespeare
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE9600275A external-priority patent/SE9600275D0/xx
Priority claimed from SE9603301A external-priority patent/SE9603301D0/xx
Priority claimed from SE9603300A external-priority patent/SE9603300D0/xx
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Application granted granted Critical
Publication of ES2171743T3 publication Critical patent/ES2171743T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Treating Waste Gases (AREA)
  • Exhaust Gas Treatment By Means Of Catalyst (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Gas Separation By Absorption (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

SE PROPORCIONAN NUEVOS COMPUESTOS DE FORMULA (I), DONDE X, R 1 , R 2 , R 3 , R 4 Y R 5 SON GRUPOS FUNCIONALES DEFINIDOS EN LA ESPECIFICACION E ISOMEROS OPTICOS Y RACEMATOS DE LOS MISMOS Y SALES FARMACEUTICAMENTE ACEPTABLES DE LOS MISMOS; JUNTO CON PROCESOS PARA SU PREPARACION, COMPOSICION QUE LOS CONTIENE Y SU USO TERAPEUTICO.
ES96938584T 1995-11-07 1996-11-06 Derivados de amidinas e isotioureas como inhibidores de la enzima sintasa de oxido nitrico. Expired - Lifetime ES2171743T3 (es)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US627695P 1995-11-07 1995-11-07
US625395P 1995-11-07 1995-11-07
SE9600275A SE9600275D0 (sv) 1996-01-25 1996-01-25 Compounds
SE9603301A SE9603301D0 (sv) 1996-09-11 1996-09-11 Compounds and compositions
SE9603300A SE9603300D0 (sv) 1996-09-11 1996-09-11 Compounds
PCT/SE1996/001425 WO1997017344A1 (en) 1995-11-07 1996-11-06 Amidine and isothiourea derivatives as inhibitors of nitric oxide synthase

Publications (1)

Publication Number Publication Date
ES2171743T3 true ES2171743T3 (es) 2002-09-16

Family

ID=27532790

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96938584T Expired - Lifetime ES2171743T3 (es) 1995-11-07 1996-11-06 Derivados de amidinas e isotioureas como inhibidores de la enzima sintasa de oxido nitrico.

Country Status (24)

Country Link
EP (1) EP0861250B1 (es)
JP (1) JP2000500132A (es)
KR (1) KR19990067349A (es)
AT (1) ATE213241T1 (es)
AU (1) AU701329B2 (es)
BR (1) BR9611276A (es)
CA (1) CA2235301A1 (es)
CZ (1) CZ139298A3 (es)
DE (1) DE69619259T2 (es)
DK (1) DK0861250T3 (es)
EE (1) EE9800141A (es)
ES (1) ES2171743T3 (es)
HU (1) HUP9900142A3 (es)
IL (1) IL124296A0 (es)
IS (1) IS4725A (es)
NO (1) NO982072L (es)
NZ (1) NZ322227A (es)
PL (1) PL326554A1 (es)
PT (1) PT861250E (es)
SI (1) SI0861250T1 (es)
SK (1) SK61098A3 (es)
TR (1) TR199800813T2 (es)
TW (1) TW458978B (es)
WO (1) WO1997017344A1 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4947197A (en) * 1996-10-16 1998-05-11 Glaxo Group Limited Tetrahydro-6h-pyrazino{1,2-b}isoquinoline 1,4-diones as apoprotein b-100 inhibitors
SE9701681D0 (sv) * 1997-05-05 1997-05-05 Astra Ab New compounds
SE9901901D0 (sv) * 1999-05-26 1999-05-26 Astra Ab Compounds
US7393652B2 (en) 2000-05-10 2008-07-01 The Trustees Of Columbia University In The City Of New York Methods for identifying a chemical compound that directly enhances binding of FKBP12.6 to PKA-phosphorylated type 2 ryanodine receptor (RyR2)
US7312044B2 (en) 2003-03-07 2007-12-25 The Trustees Of Columbia University In The City Of New York Type 1 ryanodine receptor-based methods
AU2002351733A1 (en) * 2001-12-19 2003-06-30 H. Lundbeck A/S 3,4-dihydro-1h-isoquinoloin-2-yl-derivatives
US6608193B2 (en) * 2001-12-21 2003-08-19 The Procter & Gamble Company Methods for synthesis of amino-tetrahydroisoquinoline ring compounds
WO2004014885A1 (en) * 2002-08-07 2004-02-19 Neuraxon Inc. Amino benzothiazole compounds with nos inhibitory activity
US7544678B2 (en) 2002-11-05 2009-06-09 The Trustees Of Columbia University In The City Of New York Anti-arrythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2)
US8710045B2 (en) 2004-01-22 2014-04-29 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the ryanodine receptors
EP1910321A4 (en) * 2005-07-05 2010-09-01 Astrazeneca Ab NEW COMPOUNDS, METHOD FOR THE PRODUCTION THEREOF, INTERMEDIATE PRODUCTS, PHARMACEUTICAL COMPOSITIONS AND THEIR USE IN THE TREATMENT OF 5-HT6-MEDIATED ILLNESSES SUCH AS ALZHEIMER'S DISEASE, COGNITIVE ILLUSTRATIONS, SCHOISOPHRENIC ASSOCIATED COGNITIVE DISORDERS, OBESITAS AND PARKINSON DISEASE
EP2123644B1 (en) 2007-03-07 2014-12-17 Takeda Pharmaceutical Company Limited Benzoxazepine derivatives and use thereof
BR112019012782A2 (pt) 2016-12-23 2020-03-31 Daiichi Sankyo Company, Limited Composto, composição farmacêutica, inibidor de tnap, uso de um composto, e, método para tratamento ou profilaxia de uma doença ou condição e para inibir tnap em um indivíduo.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0690851B1 (en) * 1993-03-23 1999-05-19 Astra Aktiebolag Guanidine derivatives useful in therapy
SK16396A3 (en) * 1993-08-12 1996-09-04 Astra Ab Amidine derivatives with nitric oxide synthetase activities
EP0723438A1 (en) * 1993-10-04 1996-07-31 The Wellcome Foundation Limited Substituted urea and isothiourea derivatives as no synthase inhibitors
TW397812B (en) * 1995-02-11 2000-07-11 Astra Ab Bicyclic isothiourea derivatives useful in therapy

Also Published As

Publication number Publication date
DE69619259D1 (de) 2002-03-21
NO982072L (no) 1998-07-03
DK0861250T3 (da) 2002-04-29
HUP9900142A2 (hu) 1999-05-28
SK61098A3 (en) 1999-01-11
JP2000500132A (ja) 2000-01-11
IL124296A0 (en) 1998-12-06
EP0861250B1 (en) 2002-02-13
MX9803453A (es) 1998-09-30
AU701329B2 (en) 1999-01-28
CZ139298A3 (cs) 1998-09-16
AU7592796A (en) 1997-05-29
WO1997017344A1 (en) 1997-05-15
DE69619259T2 (de) 2002-09-19
TW458978B (en) 2001-10-11
CA2235301A1 (en) 1997-05-15
TR199800813T2 (xx) 1998-07-21
PT861250E (pt) 2002-07-31
SI0861250T1 (en) 2002-06-30
PL326554A1 (en) 1998-09-28
ATE213241T1 (de) 2002-02-15
BR9611276A (pt) 1999-01-26
NO982072D0 (no) 1998-05-06
IS4725A (is) 1998-04-24
KR19990067349A (ko) 1999-08-16
NZ322227A (en) 1999-11-29
EE9800141A (et) 1998-10-15
EP0861250A1 (en) 1998-09-02
HUP9900142A3 (en) 2001-08-28

Similar Documents

Publication Publication Date Title
ECSP941104A (es) Derivados de 2,6 diaminopurina, procedimiento para su preparacion y composiciones farmaceuticas que los contienen
ES2126766T3 (es) 7-azaindol-3-ilcarboxiamidas de tropilo como agente antitusivo.
ES2167377T3 (es) Derivados de piridina farmacologicamente activos y procedimientos para la preparacion de los mismos.
MX9301129A (es) Nuevas ciclosporinas y composiciones farmaceuticas que las contienen.
AR005703A1 (es) Oxazolidinonas sustituidas, procedimiento para su preparacion, uso de las mismas para preparar medicamentos y medicamentos que las contienen
ES2096560T3 (es) Compuestos de benzocicloheptapiridina sustituida con fluor, composiciones y metodos para uso como compuestos antihistaminicos.
MX9504332A (es) Derivados de amino(tio)eter y procedimiento para su preparacion.
NO303540B1 (no) Sulfonylalkanoylamino-hydroksyetylaminosulfonamider som er nyttige som retrovirale proteaseinhibitorer, farmas°ytiske preparater inneholdende forbindelsene samt anvendelse av forbindelsene for fremstilling av medikamenter
ES2145318T3 (es) Imidazo(4,5-c)quinolin-aminas.
MX9705296A (es) Compuestos novedosos de imidazol 1,4,5-susbtituidos y el uso de los mismos para preparar composiciones para uso en terapia.
PT758248E (pt) Formulacoes para o factor ix
ES2170252T3 (es) Tetrahidroimidazopiridoindoldionas como inhibidores de cgmp especifico pde.
ES2191208T3 (es) Oxiimino-pregnano-carbolactonas.
ES2160640T3 (es) Nuevos (r)-5-carbamoil-8-fluoro-3-amino disustituido en n,n-3,4-dihidro-2h-1-benzopiranos.
AR023777A1 (es) Nuevos compuestos
PA8432901A1 (es) Compuestos de piridilpirrol
IT1285770B1 (it) Composti corticoidei
ES2178055T3 (es) Derivados aminicos substituidos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
DK0869965T3 (da) Steroidnitritesterderivater anvendelige som antiinflammatoriske lægemidler
AR003451A1 (es) Derivados de piperazina, una composicion farmaceutica que los comprende, el uso de los mismos y un metodo para su preparacion.
ES2059534T3 (es) Nuevos derivados benzopiranos antihipertensivos.
PT861250E (pt) Derivados de amidina e de isotioureia como inibidores de oxido nitrico sintase
ES2135722T3 (es) 1,5-benzodiacepinas 5-heterociclicas moduladoras de la cck o de la gastrina.
MX9300628A (es) Nuevos derivados de taxano, procedimiento para su preparacion y composicion farmaceutica que los contiene.
MX9704034A (es) Derivados y composiciones de 1,1-dioxido de 2-arilcarboniloximetil-1,2,5-tiadiazolidin-3-ona substituido y metodo de uso.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 861250

Country of ref document: ES