ES2172376A1 - Nuevos derivados de isoquinoleinas, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen. - Google Patents

Nuevos derivados de isoquinoleinas, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.

Info

Publication number
ES2172376A1
ES2172376A1 ES200000185A ES200000185A ES2172376A1 ES 2172376 A1 ES2172376 A1 ES 2172376A1 ES 200000185 A ES200000185 A ES 200000185A ES 200000185 A ES200000185 A ES 200000185A ES 2172376 A1 ES2172376 A1 ES 2172376A1
Authority
ES
Spain
Prior art keywords
sub
pharmaceutical compositions
group
preparation
compositions containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES200000185A
Other languages
English (en)
Other versions
ES2172376B1 (es
Inventor
Martinez Diego Ma Cortes
Escrig Nuria Cabedo
Ros Inmaculada Andreu
Del Castillo Almudena Bermejo
Ghanem Atassi
Alain Pierre
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Les Laboratoires Servier SAS
Original Assignee
Les Laboratoires Servier SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Les Laboratoires Servier SAS filed Critical Les Laboratoires Servier SAS
Priority to ES200000185A priority Critical patent/ES2172376B1/es
Priority to PCT/FR2001/000245 priority patent/WO2001055117A1/fr
Priority to AU35606/01A priority patent/AU3560601A/en
Publication of ES2172376A1 publication Critical patent/ES2172376A1/es
Application granted granted Critical
Publication of ES2172376B1 publication Critical patent/ES2172376B1/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Nuevos derivados de isoquinoleinas, su procedimiento de preparación y las composiciones farmacéuticas que los contienen. Compuesto de fórmula (I): **FIGURA01** en la cual: - R{sub,1} representa un grupo alcoxi, alqueniloxi o arilalquiloxi, - R{sub,2}, R{sub,3} y R{sub,4}, idénticos o diferentes, representan cada uno un átomo de hidrógeno o de halógeno o un grupo hidroxi, alcoxi, alquilo, arilalquiloxi, nitro o amino eventualmente sustituido, = representa un enlace sencillo o doble. - n representa 0 ó 1 - X representa un átomo de carbono o un grupo S(O)-, - Y representa un enlace, un grupo alquileno, alquenileno o -NH-, sus isómeros así como sus sales de adición de un ácido farmacéuticamente aceptable. Medicamentos.
ES200000185A 2000-01-28 2000-01-28 Nuevos derivados de isoquinoleinas, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen. Expired - Lifetime ES2172376B1 (es)

Priority Applications (3)

Application Number Priority Date Filing Date Title
ES200000185A ES2172376B1 (es) 2000-01-28 2000-01-28 Nuevos derivados de isoquinoleinas, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
PCT/FR2001/000245 WO2001055117A1 (fr) 2000-01-28 2001-01-26 Nouveaux derives d'isoquinoleines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
AU35606/01A AU3560601A (en) 2000-01-28 2001-01-26 Novel isoquinoline derivatives, preparation method and pharmaceutical compositions containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200000185A ES2172376B1 (es) 2000-01-28 2000-01-28 Nuevos derivados de isoquinoleinas, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.

Publications (2)

Publication Number Publication Date
ES2172376A1 true ES2172376A1 (es) 2002-09-16
ES2172376B1 ES2172376B1 (es) 2003-11-16

Family

ID=8492086

Family Applications (1)

Application Number Title Priority Date Filing Date
ES200000185A Expired - Lifetime ES2172376B1 (es) 2000-01-28 2000-01-28 Nuevos derivados de isoquinoleinas, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.

Country Status (3)

Country Link
AU (1) AU3560601A (es)
ES (1) ES2172376B1 (es)
WO (1) WO2001055117A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2478909A1 (en) 2002-03-13 2003-09-25 Duane D. Miller Substituted tetrahydroisoquinoline compounds, methods of making, and their use
FR2853649B1 (fr) * 2003-04-09 2006-07-14 Servier Lab Nouveaux derives d'isoquinoleine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US7067529B2 (en) * 2003-05-19 2006-06-27 Hoffmann-La Roche Inc. Glutamine fructose-y-phosphate amidotransferase (GFAT) inhibitors
RU2355686C2 (ru) 2003-10-16 2009-05-20 Ф.Хоффманн-Ля Рош Аг Ингибиторы глутаминфруктозо-6-фосфатамидотрансферазы
EP2099764B1 (en) 2006-09-20 2011-07-27 Mallinckrodt Inc. Preparation of substituted morphinan-6-ones and salts and intermediates thereof
US8445682B2 (en) * 2006-12-11 2013-05-21 Mallinckrodt Llc Preparation of 3,4-dihydroisoquinolines from an acid and an amine
EP2137189B1 (en) 2007-03-06 2015-05-06 Mallinckrodt LLC Process for the preparation of quaternary n-alkyl morphinan alkaloid salts
US9040726B2 (en) 2007-03-06 2015-05-26 Mallinckrodt Llc Process for the preparation of quaternary N-alkyl morphinan alkaloid salts
US8148528B2 (en) 2008-05-27 2012-04-03 Mallinckrodt Llc Processes and compounds for the preparation of normorphinans
EP2331508B1 (en) 2008-09-03 2014-11-12 Mallinckrodt LLC Substituted berbines and processes for their synthesis
WO2021192726A1 (ja) * 2020-03-24 2021-09-30 学校法人東京医科大学 コリン取り込み抑制剤、細胞死誘導剤、抗がん剤、およびその用途

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999020608A1 (en) * 1997-10-16 1999-04-29 Pfizer Limited Isoquinolines as urokinase inhibitors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999020608A1 (en) * 1997-10-16 1999-04-29 Pfizer Limited Isoquinolines as urokinase inhibitors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Journal Natural Products, Vol. 52, 1989, paginas 516-521. M. LEBOEUF et al. "Velucryptine, a new isoquinoline alkaloid". *

Also Published As

Publication number Publication date
ES2172376B1 (es) 2003-11-16
AU3560601A (en) 2001-08-07
WO2001055117A1 (fr) 2001-08-02

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